Targeting ferroptosis and ferritinophagy:new targets for cardiovascular diseases

作     者：Yi LUAN Yang YANG Ying LUAN Hui LIU Han XING Jinyan PEI Hengdao LIU Bo QIN Kaidi REN Yi LUAN;Yang YANG;Ying LUAN;Hui LIU;Han XING;Jinyan PEI;Hengdao LIU;Bo QIN;Kaidi REN

作者机构：Clinical Systems Biology Research LaboratoriesTranslational Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China State Key Laboratory for Artificial Microstructures and Mesoscopic PhysicsSchool of PhysicsPeking UniversityBeijing100871China School of Laboratory MedicineXinxiang Medical UniversityXinxiang453003China Quality Management DepartmentHenan No.3 Provincial People’s HospitalZhengzhou450052China Department of Cardiologythe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Center for Translational Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Pharmacythe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Henan Key Laboratory of Precision Clinical PharmacyZhengzhou UniversityZhengzhou450052China Henan Engineering Research Center for Application&Translation of Precision Clinical PharmacyZhengzhou UniversityZhengzhou450052China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2024年第25卷第1期

页      面：1-22页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.82204389 and 82000454) the Medical Science and Technology Research Project of Henan Province(No.SBGJ202103079) the Henan Medical Science and Technology Joint Building Program(Nos.LHGJ20230283,LHGJ20190236,LHGJ20190227,LHGJ20190092,LHGJ20200310,and LHGJ20200284),China 

主　　题：Cardiovascular disease Iron Ferroptosis Ferritinophagy Therapeutic target 

摘      要：Cardiovascular diseases(CVDs)are a leading factor driving mortality ***,an essential trace mineral,is important in numerous biological processes,and its role in CVDs has raised broad discussion for ***-mediated cell death,namely ferroptosis,has attracted much attention due to its critical role in cardiomyocyte damage and ***,ferritinophagy is the upstream mechanism that induces ferroptosis,and is closely related to *** review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy,and the regulatory pathways and molecular targets involved in ferritinophagy,and to determine their roles in ***,we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating ***,this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.