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Increased retinal venule diameter as a prognostic indicator for recurrent cerebrovascular events:a prospective observational study

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Neural Regeneration Research 2024年第5期19卷 1156-1160页

作者： ying zhao Dawei Dong Ding Yan Bing Yang Weirong Gui Man Ke Anding Xu Zefeng tan Department of Neurology and Stroke Center the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Clinical Neuroscience Institute the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurology the First People’s Hospital of FoshanFoshanGuangdong ProvinceChina

Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy ***,the ability of retinal vasculature changes,specifically focusing on retinal vessel diameter,to predict the recurrence of cerebrovascular events in patients with ischemic stroke has not been determined *** previous studies have shown a link between retinal vessel diameter and recurrent cerebrovascular events,they have not incorporated this information into a predictive ***,this study aimed to investigate the relationship between retinal vessel diameter and subsequent cerebrovascular events in patients with acute ischemic ***,we sought to establish a predictive model by combining retinal veessel diameter with traditional risk *** performed a prospective observational study of 141 patients with acute ischemic stroke who were admitted to the First Affiliated Hospital of Jinan *** of these patients underwent digital retinal imaging within 72 hours of admission and were followed up for 3 *** found that,after adjusting for related risk factors,patients with acute ischemic stroke with mean arteriolar diameter within 0.5-1.0 disc diameters of the disc margin(MAD_(0.5-1.0DD))of≥74.14μm and mean venular diameter within 0.5-1.0 disc diameters of the disc margin(MVD_(0.5-1.0DD))of≥83.91μm tended to experience recurrent cerebrovascular *** established three multivariate Cox proportional hazard regression models:model 1 included traditional risk factors,model 2 added MAD_(0.5-1.0DD)to model 1,and model 3 added MVD0.5-1.0DD to model *** 3 had the greatest potential to predict subsequent cerebrovascular events,followed by model 2,and finally model *** findings indicate that combining retinal venular or arteriolar diameter with traditional risk factors could improve the prediction of recurrent cerebrovascular events in patients with acute ischemic stroke,and that retinal imaging c

关键词： acute ischemic stroke arteriolar cerebrovascular events diameter digital retinal imaging microvasculature prediction recurrent retina venular

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Autophagy in pancreatic cancer

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Journal of Molecular Cell Biology 2021年第11期13卷 786-790页

作者： Congting Guo ying zhao Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Macroautophagy(hereafter referred to as autophagy)is a conserved eukaryotic process,in which dysfunctional proteins,organelles,and other macromolecules are wrapped in intracellular vesicles called autophagosomes and delivered to lysosomes for degradation(Mizushima et al.,2008;Mizushima and Komatsu,2011).Autophagy restores cellular energy and recycles cytoplasmic precursors,sustaining cell homeostasis and cell survival(Mizushima et al.,2008;Mizushima and Komatsu,2011).Elevated autophagy can be detected in both cancer cells and surrounding stromal cells in pancreatic cancer(PC),affecting tumor initiation and progression as well(Yang et al.,2011;Endo et al.,2017).The role of autophagy in PC is highly ***,we illustrate the multifactorial role of autophagy in PC,and the significance of autophagy will be emphasized not only in cancer cells but also in the tumor microenvironment.

关键词： al. cancer homeostasis

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Residents′Activity-travel Behavior Variation by Communities in Beijing,China

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Chinese Geographical Science 2013年第4期23卷 492-505页

作者： zhao ying CHAI Yanwei Department of Urban and Economic Geography College of Urban and Environmental SciencesPeking University

China's transition from a planned economy to a market economy has resulted in many changes in its urban structure and society and provided an opportunity for a quasi-longitudinal case study on the relationship between the built environment and activity-travel *** paper draws upon data from an activity diary survey conducted in Beijing in *** survey sample comprised 652 residents living in Danwei(work unit),commodity housing,and affordable housing *** the basis of the three-dimensional geo-visualization analysis of the space-time path and statistical multivariate regression models of daily travel and leisure time,it was found that both residential spatial factors and socio-demographics influence residents' daily *** findings show that Danwei residents have less daily travel time than those who live in commodity housing,but people living in affordable housing endure the longest travel *** leisure time is associated more with individual *** argue that although China's transition is currently gradual,the Danwei system may continue to play significant roles in daily life,and it might provide a valuable model for neighborhood spatial planning.

关键词： built environment activity-travel behavior Danwei(work unit) housing reform Beijing

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基于化学强化的连续流类颗粒污泥工艺中试研究

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水处理技术 2025年第1期51卷 128-132,138页

作者：朱榕鑫王胤吴嘉利赵志勇中国市政工程西南设计研究总院有限公司四川成都610000 中交集团城乡水环境技术研发中心四川成都610000 四川省黄河流域城乡水系统工程技术研究中心四川成都610000

采用絮凝强化连续流类颗粒污泥工艺对四川省某乡镇污水厂进行了生产性改造试验研究,基于侧流运行模式,评估了该工艺对于进水浓度低、水质和水量波动大的适应性、最佳运行参数和实际处理效果。研究发现,通过复合絮凝剂的投加,污泥的自聚... 详细信息

采用絮凝强化连续流类颗粒污泥工艺对四川省某乡镇污水厂进行了生产性改造试验研究,基于侧流运行模式,评估了该工艺对于进水浓度低、水质和水量波动大的适应性、最佳运行参数和实际处理效果。研究发现,通过复合絮凝剂的投加,污泥的自聚集和颗粒化特性逐渐显现,菌胶团的宏观粒径以及颗粒密度显著增大,当系统污泥浓度控制在7~8 g/L时,污泥粒径可稳定维持在200μm,相较于传统絮状污泥,沉降性能得以大幅提高。当回流比为200%,溶解氧控制在1~2 mg/L,采用5 mg/L CPAM+60 mg/L PAC的絮凝剂复配组合时,出水COD、NH_(3)-N、TN、TP平均浓度分别为25.84、0.55、9.01、0.11 mg/L,均满足《四川省岷江、沱江流域水污染物排放标准》(DB 51/2311-2016)要求。

关键词：颗粒污泥连续流低浓度乡镇污水提标改造絮凝强化

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Microbiome harbored within tumors:a new chance to revisit our understanding of cancer pathogenesis and treatment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1255-1257页

作者： Kunming zhao ying Hu Shenzhen Graduate School of Harbin Institute of Technology Shenzhen 518055China School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001 HLChina

In a recent study in Science,Nejmen et *** the first comprehensive characterization of the tumor *** data reveal that the microbiome mostly resides intracellularly in both tumor and immune cells,and that its compositi... 详细信息

关键词： al pathogenesis tumor

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3D laser scanning strategy based on cascaded deep neural network

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Defence Technology（防务技术） 2022年第9期18卷 1727-1739页

作者： Xiao-bin Xu Ming-hui zhao Jian Yang Yi-yang Xiong Feng-lin Pang Zhi-ying tan Min-zhou Luo College of Mechanical&Electrical Engineering Hohai UniversityChangzhou213022China Jiangsu Key Laboratory of Special Robot Technology Hohai UniversityChangzhou213022China College of Mechanical Engineering Yangzhou UniversityYangzhou225127China

A 3D laser scanning strategy based on cascaded deep neural network is proposed for the scanning system converted from 2D Lidar with a pitching motion device. The strategy is aimed at moving target detection and monitoring. Combining the device characteristics, the strategy first proposes a cascaded deep neural network, which inputs 2D point cloud, color image and pitching angle. The outputs are target distance and speed classification. And the cross-entropy loss function of network is modified by using focal loss and uniform distribution to improve the recognition accuracy. Then a pitching range and speed model are proposed to determine pitching motion parameters. Finally, the adaptive scanning is realized by integral separate speed PID. The experimental results show that the accuracies of the improved network target detection box, distance and speed classification are 90.17%, 96.87% and 96.97%, respectively. The average speed error of the improved PID is 0.4239°/s, and the average strategy execution time is 0.1521 *** range and speed model can effectively reduce the collection of useless information and the deformation of the target point cloud. Conclusively, the experimental of overall scanning strategy show that it can improve target point cloud integrity and density while ensuring the capture of target.

关键词： Scanning strategy Cascaded deep neural network Improved cross entropy loss function Pitching range and speed model Integral separate speed PID

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Catalytic Oxidation of NO over La_(0.8)Sr_(0.2)MnO_3 Perovskite

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Chemical Research in Chinese Universities 2008年第5期24卷 620-627页

作者： zhao ying-xian WEI Feng YU ying Ningbo Institute of Technology Zhejiang University Ningbo 315100 P. R. China

Catalytic oxidation of NO by O2 over La0.8Sr0.2MnO3 was tested in a tubular *** reaction temperature ranged from 373 to 473 K,space time from 0.090 to 0.720 s,inlet NO concentration from 300 to 2000μL/L, and O2 volume fraction from 3%to 9%.The steady-state conversion of NO was increased significantly with increasing reaction temperature and the space time,slightly with increasing the O2 concentration but decreased with increasing the inlet NO concentration at a lower *** the conditions of 0.720 s space time,500μL/L NO concentration, 5%O2 volume fraction and 473 K,NO conversion reached 90%.A kinetic model including a network of 12 elementary reactions with the desorption of NO2 as the rate-limiting step is established and fits the experimental data *** activation energy of NO2 desorption from the catalyst surface is determined to be 101 kJ/mol.

关键词： Catalytic oxidation Nitric oxide La0.8Sr0.2MnO3 catalyst Kinetics

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MULTI-AGENT AGGREGATION BEHAVIOR ANALYSIS: THE DYNAMIC COMMUNICATION TOPOLOGY

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Journal of Systems Science & Complexity 2008年第2期21卷 209-216页

作者： Sheng CHEN Lindu zhao ying HAN Institute of Systems Engineering Southeast University Nanjing 210018 China

The authors extend the Gazi＇s swarm model with local neighbor rules and the dynamic communication topology, and study its aggregation properties. Results of analysis show that all agents in the models aggregate and eventually form a cohesive cluster of finite size around the swarm center or the appointed point. Finally, simulations are provided to testify some of the results. Models in the paper are more applicable to the reality for the advantage that each agent only needs the partial information of the entire dynamic system when making motion decision.

关键词： Aggregation behavior dynamic communication topology local neighbor rules multi-agent system.

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Formation of local heterogeneity under energy collection in neural networks

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Science China(Technological Sciences) 2023年第2期66卷 439-455页

作者： XIE ying YAO zhao MA Jun Department of Physics Lanzhou University of TechnologyLanzhou 730050China School of Physics and Electronics Central South UniversityChangsha 410083China School of Science Chongqing University of Posts and TelecommunicationsChongqing 430065China

Static distribution of intracellular and extracellular ions can induce the spatial distribution of electric field in the cell,while stochastic diffusion and propagation of ions can generate channel current accompanied by the magnetic *** fact,the field energy(including magnetic and electric fields)in each cell or neuron can be changed under external stimuli or the deformation of ***,energy pumping occurs,and the synaptic connection is created adaptively to keep energy balance when more neurons are clustered in the same region because of electromagnetic field *** a synchronous and homogeneous network,all neurons keep energy balance with the adjacent neurons,and the network becomes uniform and *** cardiac tissue and biological media,local heterogeneity such as sinoatrial node can emit continuous wave front,and target waves are propagated to regulate the neural activities and heartbeat *** this paper,the Hamilton energy in a simple neuron model is calculated according to the Helmholtz theorem,and more neurons are clustered to build a regular network(chain network and square array).The creation and growth of synapse connection are controlled to pump energy,and local heterogeneity is formed by taming one intrinsic parameter when more energy is accumulated in a few neurons in the *** results indicate that asymmetrical energy transport will induce the occurrence of heterogeneity in the network,and adaptive synaptic regulation on neurons is activated to keep local energy balance before reaching perfect *** external stimuli with diversity in intensity are applied,neurons are excited with energy diversity,and possible shape deformation is induced to keep local energy *** a result,heterogeneity is developed in a local area.

关键词： energy balance synapse coupling heterogeneity neural network

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Synthesis and Characterization of PEG Polymer Brushes via Cyclopolymerization of 1,2,3-Triazole Tethered Diacrylates

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Chinese Journal of Chemical Physics 2015年第6期28卷 -页

作者： Xiao-ying zhao He-wen Liu Key Laboratory of Soft Matter Chemistry Chinese Academy of Sciences Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 China

Poly(ethylene glycol) (PEG) macromolecular brushes were synthesized directly via reversible addition-fragmentation chain transfer polymerization cyclopolymerization of diacrylate monomers bearing PEG functional groups through the formation of 11-member rings. The diacrylate monomers bearing PEG functional groups are the 1,2,3-triazole-tethered diacrylate macromolecular monomers with di erent PEG lengths synthesized via the so-called “click” chemistry. The bulky hindrance of PEG chains affected the polymerization behavior of the diacrylate macromolecular monomers, and the diacrylate monomers showed strong tendency to cyclopolymerization rather than crosslinking. NMR analysis and gel permeation chromatography profiles proved the high efficiency of cyclopolymerization without side reactions. The aqueous solutions of the obtained PEG macromolecular brushes were fluorescent under UV excitation. The fluorescence depended dramatically on the concentration of brush-like polymers due to the aggregation of cyclopolymer in water, and could be quenched by the addition of DNA.

关键词： Cyclopolymerization Macromolecular brush Fluorescence quenching DNA

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