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Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy

World Journal of Gastroenterology 2014年第47期20卷 18013-18021页

作者： Rong Zhu Kan Chen Yuan-Yuan Zheng Hua-Wei Zhang Jun-Shan Wang Yu-Jing Xia Wei-Qi Dai Fan Wang Miao Shen Ping Cheng Yan Zhang Cheng-Fen Wang Jing Yang Jing-Jing Li Jie Lu ying-qun zhou Chuan-Yong Guo Department of Gastroenterology Shanghai Tenth People’s HospitalTongji University School of Medicine Department of First Clinical Medical College Nanjing Medical University

AIM: To evaluate the role of probiotics in the standard triple Helicobacter pylori therapy. METHODS: In this meta-analysis, we investigated the efficacy of probiotics in a standard triple H. pylori therapy in adults. Searches were mainly conducted in MEDLINE/PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. Fourteen studies met our criteria, and the quality of these studies was assessed using the Jadad scale. We used STATA version 12.0 to extract data and to calculate the odds ratios (ORs), which are presented with the corresponding 95% confidence intervals (CIs). The data are presented as forest plots. RESULTS: The pooled ORs for the eradication rates calculated by intention-to-treat analysis and per-protocol analysis in the probiotic group vs the control group were 1.67 (95%CI: 1.38-2.02) and 1.68 (95%CI: 1.35-2.08), respectively, using the fixed-effects model. The sensitivity of the Asian studies was greater than that of the Caucasian studies (Asian: OR = 1.78, 95%CI: 1.40-2.26; Caucasian: OR = 1.48, 95%CI: 1.06-2.05). The pooled OR for the incidence of total adverse effects was *** lower in the probiotic group (OR = 0.49, 95%CI: 0.26-0.94), using the random effects model, with significant heterogeneity (I-2 = 85.7%). The incidence of diarrhea was significantly reduced in the probiotic group (OR = 0.21, 95%CI: 0.06-0.74), whereas the incidence of taste disorders, metallic taste, vomiting, nausea, and epigastric pain did not differ significantly between the probiotic group and the control group. CONCLUSION: Supplementary probiotic preparations during standard triple H. pylori therapy may improve the eradication rate, particularly in Asian patients, and the incidence of total adverse effects. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Helicobacter pylori Eradication Probiotics Meta-analysis Adult

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某砂铀矿地浸单元酸浸初期溶质运移与溶液渗流关系

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有色金属（冶炼部分） 2017年第6期 24-27,31页

作者：黄群英周义朋刘科陈梅芳新疆中核天山铀业有限公司新疆伊犁835000 东华理工大学江西南昌330013

采用水文化学分析及数值模拟方法,对新疆某砂岩铀矿地浸单元酸法地浸初期SO_4^(2-)、H^+、Ca^(2+)等主要溶质离子的运移与溶液渗流之间的关系进行了探讨。SO_4^(2-)前锋用时8d运移至抽孔,40d后抽、注液SO_4^(2-)浓度开始同幅变化,表明... 详细信息

采用水文化学分析及数值模拟方法,对新疆某砂岩铀矿地浸单元酸法地浸初期SO_4^(2-)、H^+、Ca^(2+)等主要溶质离子的运移与溶液渗流之间的关系进行了探讨。SO_4^(2-)前锋用时8d运移至抽孔,40d后抽、注液SO_4^(2-)浓度开始同幅变化,表明大部分溶液已渗流至抽孔,根据渗流模拟计算,在流向抽液孔的溶液中,最快的可在5~6d抵达,40d时83%的溶液抵达;H^+在水岩作用过程中被部分消耗,其前锋21d运移抽液孔,而由H^+溶蚀出来的Ca^(2+)、Mg^(2+)则与SO_4^(2-)同步运移;66d地浸流场达到H^+的补给与消耗平衡,表明绝大部分溶液已经达到抽液孔,而根据计算,这一比例已经达到94%。水文化学分析与水动力计算结果吻合。

关键词：砂岩型铀矿酸法地浸溶液渗流溶质运移数值模拟

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Regulation of TAZ in cancer

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Protein & Cell 2016年第8期7卷 548-561页

作者： Xin zhou qun-ying Lei Key Laboratory of Metabolism and Molecular Medicine Ministry of Education and Department of Biochemistry and Molecular Biology and Institutes of Biomedical Sciences Fudan University Shanghai Medical College Shanghai 200032 China Department of Cancer Biology University of Texas MD Anderson Cancer Center Houston TX 77030 USA

TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene （WW domain containing transcription regulator 1）. TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled recep- tors （GPCRs）, cellular energy status, hypoxia and osmo- tic stress. Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition （EMT）, and stemness in multiple human cancers. We discuss here the regulators and regulation of TAT. We also highlight the tumorigenic roles of TAZ. and its potential therapeutic impact in human cancers.

关键词： TAZ the Hippo pathway cancer

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抽注流量分配及抽注比对地浸溶液扩散的影响

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铀矿冶 2017年第3期36卷 172-181页

作者：吉宏斌黄群英周义朋张青林东华理工大学江西南昌330013 新疆中核天山铀业有限公司新疆伊宁835000

根据新疆某铀矿床4#采区地质、水文地质条件以及地浸钻孔数据,运用地下水数值模拟软件Visual MODFLOW建立地浸溶液渗流与溶质运移模型,研究了抽注流量在采区各钻孔的不同分配方式以及不同抽注比对地浸溶液渗流运移的影响。结果表明:影... 详细信息

根据新疆某铀矿床4#采区地质、水文地质条件以及地浸钻孔数据,运用地下水数值模拟软件Visual MODFLOW建立地浸溶液渗流与溶质运移模型,研究了抽注流量在采区各钻孔的不同分配方式以及不同抽注比对地浸溶液渗流运移的影响。结果表明:影响地浸溶液向采区外围扩散的主要因素是采区单孔流量的分配方式,即采区单孔流量的空间分布状况;在抽注流量分配方式一定的情况下,采区总抽注比的变化对溶液扩散的影响并不明显。加权平均方法可使采区各局部的抽注流量分配更均衡,采区以3 840m3/d的总抽液规模、抽注比为1.0005运行5a,地浸溶液向外围扩散的范围不超过200m,采区下游是溶液扩散外流的主要区域,需要重点关注。无论是从控制溶液外流的角度,还是从采场均衡浸出的角度,更应该关注采区各钻孔的流量合理分配和各子单元的抽注平衡,而非采区的总体抽注比。

关键词：地浸采铀流量分配抽注比溶质运移

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Laws of the Iterated Logarithm for-mixing Random Variables with Normal Distribution

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 385-394页

作者： qun-ying WU College of Science Guilin University of Technology

Consider a ρ-mixing sequence of identically distributed random variables with the underlying dis- tribution in the domain of attraction of the normal distribution. This paper proves that law of the iterated logarithm holds for ρ-mixing sequences of random variables. Our results generalize and improve Theorems 1.2-1.3 of Qi and Cheng （1996） from the i.i.d, case to ρ-mixing sequences.

关键词： ρ-mixing sequence of random variables law of the iterated logarithm domain of attraction

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Almost sure central limit theory for products of sums of partial sums

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Applied Mathematics(A Journal of Chinese Universities) 2012年第2期27卷 169-180页

作者： WU qun-ying College of Science Guilin University of TechnologyGuilin 541004China

Consider a sequence of *** random *** universal result in almost sure limit theorem for products of sums of partial sums is *** will show that the almost sure limit theorem holds under a fairly general condition on th... 详细信息

关键词： almost sure central limit theorem weight product of sums of partial sums.

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A Joint Laplace Transform for Pre-exit Diffusion of Occupation Times

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Acta Mathematica Sinica,English Series 2017年第4期33卷 509-525页

作者： Ye CHEN Xiang qun YANG ying Qiu LI Xiao Wen zhou College of Mathematics and Computer Science Hu'nan Normal University College of Mathematics and Computational Science Hu’nan University of Arts and Science College of Mathematics and Statistics Changsha University of Science and Technology Department of Mathematics and Statistics Concordia University

For a < r < b, the approach of Li and zhou(2014) is adopted to find joint Laplace transforms of occupation times over intervals(a, r) and(r, b) for a time homogeneous diffusion process before it first exits from eithe... 详细信息

For a zhou(2014) is adopted to find joint Laplace transforms of occupation times over intervals(a, r) and(r, b) for a time homogeneous diffusion process before it first exits from either a or b. The results are expressed in terms of solutions to the differential equations associated with the diffusions generator. Applying these results, we obtain more explicit expressions on the joint Laplace transforms of occupation times for Brownian motion with drift, Brownian motion with alternating drift and skew Brownian motion, respectively.

关键词： Laplace transform occupation time time-homogeneous diffusion exit time Brownian motion with alternating drift skew Brownian motion

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Dynamic Mechanical Behavior and Prediction for PP/POE Blends

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Chemical Research in Chinese Universities 2009年第4期25卷 573-578页

作者： ying Ji-ru XIE Xiao-lin zhou Xing-ping zhou Hua-min LI De-qun State Key Laboratory of Plastic Forming Simulation and Die ＆ Mould Technology Wuhan 430074 P. R. China Hubei Key Laboratory of Materials Chemistry and Service Failure Department of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China School of Chemical and Environmental Engineering Hubei University of Technology Wuhan 430068 P. R. China

Polypropylene（PP）/ethylene-octene copolymer（POE） blends were prepared with a twin-screw *** dynamic mechanical behavior were systematically *** results show that PP/POE blends are heterogeneities with a partial compatible two-phase structure,the glass transition temperature of PP phases in the blends tends to shift towards high temperature with increasing the POE content,and the glass transition temperature of POE phases shifts towards the low temperature with increasing the PP *** Kerner＇s dispersed phase model and co-continuous phase model can reasonably predict the visco-elasticity of PP/POE blends with different ***,the morphological structure of the blends can be estimated via comparing the predicted DMA behavior with the experimental data.

关键词： PP/POE blend Dynamic mechanical behavior Dispersed phase model Co-continuous phase model

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Environmental influence of Wuhan urban agglomeration development and strategies of environmental protection

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Journal of Environmental Sciences 2006年第3期18卷 616-623页

作者： GAO qun LIU ying-tao MAO Han-ying Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Chinese Academy of Agricultural Sciences Beijing 100081 China

In Wuhan urban agglomeration （WUA）, the population growth and concentration, the industrial development and urban sprawl have been affecting the environment ftmdamentally. Comparing with Yangtze delta metropolitan region, the level of urbanization and industrialization of WUA has lagged behind for about 10 years; but the problems in environmental protection and rehabilitation are commonly serious. In the future, WUA should avoid unnecessary mistakes and seek a win-win strategy for economy and environment in its large-scale development stage. Based on the analysis of the changing of main environmental pollutants and the coupled curves in past decades, the paper discussed the important links among the urban environmental pollutions, industry growth and urban sprawl in WUA. It is concluded that the integration of economic and environmental policies in urban development is more required and significant at the large urban agglomeration region. Four proactive and long-term strategies need to be adopted to provide prior guidance and better protection for the development of WUA.

关键词： environmental problem urban development Wuhan urban agglomeration strategies

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Rewiring local immune milieu by boosting dendritic cell for pancreatic cancer treatment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1445-1446页

作者： Yifan Zhang qun-ying Lei Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences Cancer InstitutesKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Medical CollegeFudan UniversityShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology Fudan UniversityShanghaiChina

A recent article by Hedge et al.(Cancer Cell 37,289–307.e289,2020)demonstrated that decreased dendritic cell and elevated Th17 cell could explain the immunosuppressive environment of PDAC when compared with that in lung *** DC population using Flt3L and CD40 agonist showed improved efficacy on PDAC mouse models and shed new light on its immunotherapeutic strategies.

关键词： al elevated lung

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