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沙利度胺对类风湿关节炎T淋巴细胞的免疫调节作用

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中华风湿病学杂志 2008年第8期12卷 524-526页

作者：严利文李晶裘影影尤海燕焦志军吴忠宋晓丽江苏大学附属医院风湿科镇江212001 江苏大学附属医院中心实验室镇江212001

目的探讨沙利度胺（Thd）对类风湿关节炎（RA）患者外周血T淋巴细胞的免疫调节作用。方法在植物血凝素（PHA）刺激下，RA患者外周血T淋巴细胞与不同浓度的Thd（2．5、25、100、300、500μg/ml）共同培养。用四甲基噻唑蓝（MTT）比色法检... 详细信息

目的探讨沙利度胺（Thd）对类风湿关节炎（RA）患者外周血T淋巴细胞的免疫调节作用。方法在植物血凝素（PHA）刺激下，RA患者外周血T淋巴细胞与不同浓度的Thd（2．5、25、100、300、500μg/ml）共同培养。用四甲基噻唑蓝（MTT）比色法检测T淋巴细胞的增殖，用流式细胞术检测T淋巴细胞的凋亡和T淋巴细胞CDl52、CD28的表达情况，用Real—time聚合酶链反应（PCR）检测T淋巴细胞的白细胞介素（IL）-6、IL-10、肿瘤坏死因子（TNF）一QmRNA表达水平。结果在体外，与阴性对照组相比，500μg/ml Thd组显著抑制T淋巴细胞的增殖，促进T淋巴细胞早期凋亡，抑制T淋巴细胞CD3＋CD28＋表达，促进CD8＋CD152＊3K达，而≤300μg/ml，对T淋巴细胞未见明显影响。与对照组相比，（100～500）μg/ml剂量组可抑制T淋巴细胞IL-6、TNF—dmRNA表达，（2．5～500）μg/ml可促进IL-10mRNA的表达。结论Thd可能通过影响RA患者外周血T淋巴细胞增殖、早期凋亡、CD3＋CD28＋和CD8＋CD152＋表达，以及IL-6、IL-10、TNF—dmRNA表达，反转RA患者的免疫平衡失控。

关键词：沙利度胺关节炎类风湿 T淋巴细胞免疫调节

基于万古霉素治疗药物监测的重症肺炎伴肾功能亢进患者的药学监护

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中国临床药理学杂志 2024年第23期40卷 3458-3461页

作者：韩艳颖何娜应颖秋杜毅鹏郑佳佳沈宁北京大学第三医院药学部北京100191 北京大学第三医院呼吸与危重症医学科北京100191 北京大学第三医院检验科北京100191 北京大学治疗药物监测和临床毒理中心北京100191 北京大学医学部药物评价中心北京100191 国家药品监督管理局仿制药研究与评价重点实验室北京100191

1例重症肺炎患者血和痰宏基因下一代测序均检测到金黄色葡萄球菌(携带mecA基因),初始给予万古霉素(1 g,q12 h,静脉滴注)疗效不佳,稳态谷浓度为1μg·mL^(-1),临床药师会诊后考虑患者肾功能亢进,导致药物清除增加,使得在常规剂量下万古... 详细信息

1例重症肺炎患者血和痰宏基因下一代测序均检测到金黄色葡萄球菌(携带mecA基因),初始给予万古霉素(1 g,q12 h,静脉滴注)疗效不佳,稳态谷浓度为1μg·mL^(-1),临床药师会诊后考虑患者肾功能亢进,导致药物清除增加,使得在常规剂量下万古霉素的血药浓度偏低,通过上调药物剂量至1 g q6 h后,患者血药浓度达标且感染症状减轻,经过持续监测药物浓度并评估优化给药方案。最终患者病情明显改善,好转出院。

关键词：万古霉素治疗药物监测重症肺炎肾功能亢进药学监护

铁路中转换乘站推荐系统设计与Matlab实现

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软件导刊 2019年第5期18卷 142-145页

作者：霍雷刚钟雅婷李永玉邱莹莹严伟民广西师范学院科学计算与智能信息处理广西高校重点实验室广西南宁530023 广西师范学院计算机与信息工程学院曙光大数据学院广西南宁530299

为改善铁路乘客购票及出行体验,针对售票系统换乘站推荐功能不全的缺陷,设计和实现基于Matlab的铁路中转换乘站推荐系统,实现数据采集、整理、换乘站点推荐等功能。采用Matlab语言编程,利用爬虫技术获取各铁路站点信息和车次信息,将获... 详细信息

为改善铁路乘客购票及出行体验,针对售票系统换乘站推荐功能不全的缺陷,设计和实现基于Matlab的铁路中转换乘站推荐系统,实现数据采集、整理、换乘站点推荐等功能。采用Matlab语言编程,利用爬虫技术获取各铁路站点信息和车次信息,将获取的信息进行整理和网络化建模,确定模型各条边的权值,最后采用最短路径算法得到换乘站。实验结果表明,结合列车信息和最短路径算法可为乘客推荐有效的换乘站。

关键词：铁路中转换乘最短路径算法 Matlab

Self-organized Criticality in Hierarchical Brain Network

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Communications in Theoretical Physics 2008年第11期50卷 1189-1192页

作者： YANG qiu-ying ZHANG ying-Yue CHEN Tian-Lun College of Physics and Electronic Engineering Changshu Institute of Technology Changshu 215500 China Department of Physics Nankai University Tianjin 300071 China

It is shown that the cortical brain network of the macaque displays a hierarchically clustered organizationand the neuron network shows small-world *** the two factors will be considered in our model and thedynamical behavior of the model will be *** study the characters of the model and find that the distribution ofavalanche size of the model follows power-law behavior.

关键词： avalanche self-organized criticality hierarchical network

Service Function Chain Orchestration across Multiple Clouds

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China Communications 2018年第10期15卷 99-116页

作者： Xuxia Zhong ying Wang Xuesong qiu State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications

Network function virtualization is a new network concept that moves network functions from dedicated hardware to software-defined applications running on standard high volume severs. In order to accomplish network services, traffic flows are usually processed by a list of network functions in sequence which is defined by service function chain. By incorporating network function virtualization in inter-data center(DC) network, we can use the network resources intelligently and deploy network services faster. However, orchestrating service function chains across multiple data centers will incur high deployment cost, including the inter-data center bandwidth cost, virtual network function cost and the intra-data center bandwidth cost. In this paper, we orchestrate SFCs across multiple data centers, with a goal to minimize the overall cost. An integer linear programming(ILP) model is formulated and we provide a meta-heuristic algorithm named GBAO which contains three modules to solve it. We implemented our algorithm in Python and performed side-by-side comparison with prior algorithms. Simulation results show that our proposed algorithm reduces the overall cost by at least 21.4% over the existing algorithms for accommodating the same service function chain requests.

关键词： network function virtualization service function chain orchestration inter-DC network

Regulating the oxygen-atom configuration of carbon anode enabling extremely fast-charging potassium-ion hybrid capacitors

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Nano Research 2025年第1期18卷 373-381页

作者： Daping qiu Yuehui Wang Lulu Zhang Hang Lei Haizhou ying Jin Niu Min Li Xuelin Yang Feng Wang Ru Yang Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering and New EnergyChina Three Gorges UniversityYichang 443002China State Key Laboratory of Chemical Resource Engineering Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials and Chemical Engineering China Three Gorges UniversityYichang 443002China

Metal-ion hybrid capacitors,such as potassium-ion hybrid capacitors(PIHCs),are regarded as promising fast-charging energy storage ***,the kinetics mismatch between the battery anode and the capacitive cathode restricts their fastcharging *** constructing carbon anodes with enhanced kinetics is an innovative approach to address this ***,using epigallocatechin gallate with high oxygen content as the precursor,oxygen-enriched carbon materials(OEC)with tunable C=O content are successfully ***,the C=O content of OEC is regulated by adjusting the pyrolysis *** as an anode for PIHCs,OEC-600 with the highest C=O content exhibits an attractive fast-charging specific capacity of 135.2 mAh·g^(-1)at 20 A·g^(-1),along with a superior fast-charging cycling *** theoretical calculations,comprehensive kinetics analysis and in-situ Raman,the positive effects of C=O on the potassium storage capability and reversibility of OEC-600 are ***,PIHCs assembled based on an OEC-600 anode deliver impressive energy/power density of 145.1 Wh·kg^(-1)/45.9 kW·kg^(-1)and superior fast-charging cycling stability with 87.5%of capacity retention over 20,000 cycles at 5 A·g^(-1).This work is anticipated to provide an optional design concept toward the carbon anode for fast-charging PIHCs.

关键词： carbon anode oxygen epigallocatechin gallate potassium-ion hybrid capacitor

Collective radiance of giant atoms in non-Markovian regime

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Science China(Physics,Mechanics & Astronomy) 2023年第2期66卷 79-86页

作者： Qing-Yang qiu ying Wu Xin-You Lü School of Physics Huazhong University of Science and TechnologyWuhan 430074China

We investigate the non-Markovian dynamics of two giant artificial atoms interacting with a continuum of bosonic modes in a onedimensional(1D) *** on the diagrammatic method,we present the exact analytical solutions,which predict the rich phenomena of collective *** the certain collective states,the decay rates are found to be far beyond that predicted in the the Dicke model and standard Markovian framework,which indicates the occurrence of *** superadiance-to-subradiance transition could be realized by adjusting the exchange symmetry of giant ***,there exist multiple bound states in continuum(BICs),with photons/phonons bouncing back and forth in the cavity-like geometries formed by the coupling *** trapped photons/phonons in the BICs can also be re-released conveniently by changing the energy level splitting of giant *** mechanism relies on the joint effects of the coherent time-delayed feedback and the interference between the coupling points of giant *** work fundamentally broadens the fields of giant atom collective radiance by introducing *** also paves the way for a clean analytical description of the nonlinear open quantum system with more complex retardation.

关键词： collective symmetry conveniently

Lung Nodules Detection in CT Images Using Gestalt-Based Algorithm

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Chinese Journal of Electronics 2016年第4期25卷 711-718页

作者： qiu Shi WEN Desheng CUI ying FENG Jun Xi'an Institute of Optics and Precision Mechanics of CAS University of Chinese Academy of Sciences College of Equipment Engineering Engineering University of Chinese Armed Police Force School of Information Science and Technology Northwest University

To overcome low accuracy and high false positive of existing computer-aided lung nodules *** propose a novel lung nodule detection scheme based on the Gestalt visual cognition *** proposed scheme involves two parts which simulate human eyes cognition features such as simplicity,integrity and ***,lung region was segmented from lung Computed tomography(CT) *** local threedimensional information was integrated into the Maximum intensity pro jection(MIP) images from axial,coronal and sagittal *** this way,lung nodules and vascular are strengthened and discriminated based on pathologic image characteristics of lung *** experimental database includes fifty-three high resolution CT images contained lung nodules,which had been confirmed by *** experimental results show that,the accuracy rate of the proposed algorithm achieves 91.29%.The proposed framework improves performance and computation speed for computer aided nodules detection.

关键词： Computer-aided detection(CAD) Lung nodules Maximum intensity pro jection(MIP)

Corrosion behavior of three Ag–50Cu alloys prepared by different processes in NaCl solutions

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Rare Metals 2017年第1期36卷 61-68页

作者： Zhong-qiu Jia qiu-ying Liang qiu-Yue Tian Zhong-qiu Cao Yan Wang College of Chemistry-and Chemical Engineering Shenyang Normal University Shenyang 110034 China

Corrosion behavior of two nanocrystalline bulk Ag–50Cu alloys and one coarse-grained counterpart prepared by liquid-phase reduction(LPR), mechanical alloying(MA) and powder metallurgy(PM) methods,respectively, were investigated in Na Cl solutions. They were finished by means of PARM273 A and M5210 electrochemical apparatus through potentiodynamic polarization method and electrochemical impedance spectroscopy(EIS) technique. The results show that corrosion rates of three Ag–50Cu alloys increase with the increment of Na Cl solution concentrations. Corrosion rates of LPRAg–50Cu alloy are a little higher than those of PMAg–50Cu alloy,but evidently lower than those of MAAg–50Cu alloy. The difference in corrosion rates is attributed to the large reduction in the grain size and homogeneous microstructure of nanocrystalline alloys. Passive current densities decrease and afterward increase for PMAg–50Cu alloy,decrease for MAAg–50Cu alloy, and increase for LPRAg–50Cu alloy with the increment of Na Cl solution concentrations. After the grain sizes are refined, passive current densities become lower.

关键词： Copper alloys Corrosion Corrosion rate Corrosive effects Electrochemical corrosion Electrochemical impedance spectroscopy Electrochemistry Grain size and shape Mechanical alloying Nanocrystals Powder metallurgy Reduction Silver Silver alloys