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B细胞在肿瘤免疫中作用的研究进展

现代免疫学 2024年第4期44卷 358-362页

作者：王安然郭富颖查皓然张元元大理大学第八附属医院康复医学科临沧677000 大理大学第八附属医院感染管理科临沧677000 陆军军医大学第二附属医院肿瘤科重庆400037 大理大学第一附属医院内科学教研室大理671013

B细胞是肿瘤微环境中的主要细胞成分,并且在肿瘤免疫中发挥重要作用。既往的研究更多认为B细胞及其产生的抗体能够分别通过分泌免疫抑制性细胞因子和激活补体系统等机制促进肿瘤进展。然而近来的研究显示,B细胞在促进抗肿瘤免疫应答中... 详细信息

B细胞是肿瘤微环境中的主要细胞成分,并且在肿瘤免疫中发挥重要作用。既往的研究更多认为B细胞及其产生的抗体能够分别通过分泌免疫抑制性细胞因子和激活补体系统等机制促进肿瘤进展。然而近来的研究显示,B细胞在促进抗肿瘤免疫应答中发挥了重要的作用。文章综述B细胞在肿瘤免疫中的多种作用,讨论其不同效应的内在机制及其对肿瘤患者预后的影响。

关键词：肿瘤免疫 B细胞调节性B细胞肿瘤微环境

Effect of transient space-charge perturbation on carrier transport in high-resistance CdZnTe semiconductor

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Chinese Physics B 2019年第11期28卷 304-307页

作者： Yu guo gang-qia.g zha ying-Rui Li Ting-Ting Tan Hao Zhu Sen Wu MIIT Key Laboratory of Radiation Detection Materials and Devices State Key Laboratory of Solidification ProcessingSchool of Materials Science and EngineeringNorthwestern Polytechnical University(NWPU)Xi’an 710072China

The polarization effect introduced by electric field deformation is the most important bottleneck of CdZnTe detector in x-ray imaging. Currently, most of studies focus on electric field deformation caused by trapped carriers;the perturbation of electric field due to drifting carriers has been rarely reported. In this study, the effect of transient space-charge perturbation on carrier transport in a CdZnTe semiconductor is evaluated by using the laser-beam-induced current(LBIC) *** appear in the current curves of CdZnTe detectors with different carrier transport performances under intense excitation, indicating the deformation of electric field. The current signals under different excitations are compared. The results suggest that with the increase of excitation, the amplitude of cusp increases and the electron transient time gradually decreases. The distortion in electric field is independent of carrier transport performance of detector. Transient space-charge perturbation is responsible for the pulse shape and affects the carrier transport process.

关键词： CdZnTe transient space-charge perturbation laser-beam-induced current(LBIC) technique carrier transport

行业特色本科高校《环境工程原理》课程教学改革探讨——以安徽理工大学为例

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当代化工研究 2024年第16期 158-160页

作者：刘英范廷玉陈孝杨查世娇周育智安徽理工大学地球与环境学院安徽232001

工程教育模式的提出给我国高等学校本科生实践能力的培养、工程教育质量的提高设定了更高的要求。环境工程原理是面向安徽理工大学环境工程专业大二学生开设的专业基础课,课程团队教师认真研究分析课程的目标和特点,针对当前课程与教学... 详细信息

工程教育模式的提出给我国高等学校本科生实践能力的培养、工程教育质量的提高设定了更高的要求。环境工程原理是面向安徽理工大学环境工程专业大二学生开设的专业基础课,课程团队教师认真研究分析课程的目标和特点,针对当前课程与教学改革要解决的重点问题,结合学校和专业人才培养方案实际情况,通过课程内容重构、产学研教学模式构建、课程知识框架优化整合等角度提出了环境工程原理课程教学改革思路。以此提高该门课程教学质量,锻炼学生将理论结合实践来解决环境问题的能力。

关键词：环境工程原理工程教育课程体系教学改革

Factors influencing postoperative anxiety and depression following Iodine-131 treatment in patients with differentiated thyroid cancer:A cross-sectional study

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World Journal of Psychiatry 2023年第7期13卷 486-494页

作者： ying-Rui Su Xiao-Peng Yu Li-Qun Huang Long Xie Jin-Shun zha Department of Nuclear Medicine The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKgROUND Differentiated thyroid cancer(DTC)often seriously impacts patients’*** Iodine-131(131I)is widely used in treating patients with ***,most patients know little about radionuclide therapy,and the treatment needs to be performed in a special isolation ward,which can cause anxiety and *** To explore anxiety and depression status and their influencing factors after 131I treatment in patients with *** A questionnaire survey was conducted among postoperative patients with DTC who received 131I treatment at our hospital from June 2020 to December *** patient data were collected using a self-administered demographic characteristics *** self-rating depression scale and self-rating anxiety scale were used to determine whether patients were worried about their symptoms and the degree of anxiety and *** patients were categorized into anxiety,non-anxiety,depression,and non-depression *** and multiple-variable analyses were used to determine the risk factors for anxiety and depression in patients with thyroid cancer after *** A total of 144 patients were included in this *** baseline mean score of self-rating anxiety and depression scales were 50.06±16.10 and 50.96±16.55,***,48.62%(70/144)had anxiety and 47.22%(68/144)of the patients had ***,age,education level,marital status,household income,underlying diseases,and medication compliance significantly differed among groups(Pgistic regression analysis showed that education level,per capita monthly household income,and medication compliance level affected anxiety(P=0.015,0.001,and 0.001 respectively).Patient’s sex,marital status,and underlying diseases affected depression(P=0.007,0.001,and 0.009,respectively).CONCLUSION Nursing interventions aiming at reducing the risk of anxiety and depression should target unmarried female patients with low education

关键词： Iodine-131 Thyroid gland Neoplasms Anxiety Depression Prognosis

Self-assembled semiconductor quantum dots decorating the facets of gaAs nanowire for single-photon emission

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National Science Review 2017年第2期4卷 196-209页

作者： ying Yu guo-Wei zha Xiang-Jun Shang Shuang Yang Ban-Quan Sun Hai-qia. Ni Zhi-Chuan Niu State Key laboratory for Superlattice and Microstructures Institute of SemiconductorsChinese Academy of Sciences State Key Laboratory of Optoelectronic Materials and Technologies School of electronics and information technologySun Yat-sen University College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences Synergetic Innovation Center of Quantum Information& Quantum Physics University of Science and Technology of China

In this chapter, we discuss the epitaxial growth of self-assembled quantum dots(QDs) in gaAs nanowires(NWs) and the characteristics of their single-photon emissions. We demonstrate ga droplet-induced gold-free vapor-liquid-solid growth of hexagonal gaAs/Al gaAs core–shell NWs, branched gaAs NWs and tailored nanostructured morphologies on the NW facets. Particularly, we show two new types of QD-in-NW systems: one is a single InAs QD formed at the corner of a branched gaAs NW, and the other is a single gaAs QD formed on the NW facet. Sharp excitonic emission spectral lines are observed with vanishing two-photon emission probability. Furthermore, a single gaAs QD is achieved at the site of a single Al gaAs quantum ring(QR) on the NW facet. In addition, these NW-based single QDs are in-situ probed and integrated with single-mode optical ibers to achieve all-iber-output single-photon sources for potential application in quantum integrated networks.

关键词： self-assembled nanowires quantum dots single photon emitters molecular beam epitaxy

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全膝关节置换术多用途挡板设计与应用

中国矫形外科杂志 2024年第6期32卷 557-560页

作者：袁札根卿勇孙淑梅李治敏苏展影李泽晖陈瑞娟曹学伟广东省中医院广东广州510120

[目的]介绍全膝关节置换术(total knee arthroplasty,TKA)多用途挡板设计与应用技术和初步临床结果。[方法]本多用途挡板结构包括相互连接的挡板、手柄与负压吸气器。挡板上设有圆形通透窗口、圆形通透窗口通道、矩形通透窗口。矩形通... 详细信息

[目的]介绍全膝关节置换术(total knee arthroplasty,TKA)多用途挡板设计与应用技术和初步临床结果。[方法]本多用途挡板结构包括相互连接的挡板、手柄与负压吸气器。挡板上设有圆形通透窗口、圆形通透窗口通道、矩形通透窗口。矩形通透窗口设置在挡板顶边的中部,圆形通透窗口设置在挡板的几何中心位置的一侧。手柄与挡板的下部连接;负压吸气器与手柄连接在挡板的下部,其前端开口延伸到挡板的中部形成吸气口,其后端开口连接外部负压抽气管道,将靠近挡板或附着在挡板表面上的血液、碎屑吸出。[结果]86例TKA患者术中应用多用途挡板,高效遮挡了飞溅的血液和碎骨渣,大大降低手术感染率,有效保护医护人员从而预防血源性职业暴露。86例患者均顺利完成手术,术后手术切口愈合良好。膝关节功能恢复良好,随访过程中未出现感染等严重并发症。[结论]本多用途挡板遮挡并吸附TKA手术过程中飞溅的血液和碎骨渣等污染物,降低了感染率,减少对医务人员的污染和伤害。

关键词：多用途挡板全膝关节置换术感染率职业暴露

临床研究兴趣小组教学在住院医师规范化培训中的应用

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中华医学教育杂志 2024年第5期44卷 375-378页

作者：王伟周彦许悦心万小祥施国伟徐炯查英复旦大学附属上海市第五人民医院泌尿外科上海200240 复旦大学附属上海市第五人民医院中医科上海200240 复旦大学附属上海市第五人民医院全科医学科上海200240 复旦大学附属上海市第五人民医院教育科上海200240

住院医师规范化培训以临床技能与临床思维为核心,但临床研究能力培养的需求日益凸显。目前,临床研究方法的教学存在着内容枯燥、模式落后、实践不足等问题。为了提高住院医师的临床研究实践能力,复旦大学附属上海市第五人民医院于2022年... 详细信息

住院医师规范化培训以临床技能与临床思维为核心,但临床研究能力培养的需求日益凸显。目前,临床研究方法的教学存在着内容枯燥、模式落后、实践不足等问题。为了提高住院医师的临床研究实践能力,复旦大学附属上海市第五人民医院于2022年3月至2023年2月在住院医师规范化培训中开展了临床研究兴趣小组教学。本文介绍了临床研究兴趣小组教学的教学目标、教学模块、教学形式、教学组织,并通过问卷调查、临床研究设计评阅进行教学效果评价。评价结果显示,参与临床研究兴趣小组教学的22名住院医师均对该教学活动感到满意,认为该教学有助于提高住院医师的临床研究实践和自主学习能力。临床研究兴趣小组教学体现了“以学生为中心”的教学理念,有助于提升住院医师人才培养质量。

关键词：实习医师和住院医师职务规范化培训临床研究兴趣小组

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磷化时间对常温锌系磷化膜防腐蚀性能的影响

东方汽轮机 2024年第1期 55-60页

作者：李智赵强李全德隆彬姜英倪荣巩秀芳罗春晖清洁高效透平动力装备全国重点实验室四川德阳618000 东方电气集团东方汽轮机有限公司四川德阳618000 四川大学化学工程学院四川成都610065

针对碳钢材料采用某常温锌系磷化工艺进行磷化加工的优化问题,文章分析了磷化时间对磷化膜形貌(表面形貌和横截面形貌),磷化膜化学状态(元素含量和分布,结晶情况和亲水性),耐腐蚀特性(盐水浸泡实验和Tafel曲线实验)的影响。发现15~20 mi... 详细信息

针对碳钢材料采用某常温锌系磷化工艺进行磷化加工的优化问题,文章分析了磷化时间对磷化膜形貌(表面形貌和横截面形貌),磷化膜化学状态(元素含量和分布,结晶情况和亲水性),耐腐蚀特性(盐水浸泡实验和Tafel曲线实验)的影响。发现15~20 min该工艺磷化膜生长速度较快,而20~30 min磷化膜生长速度显著下降。该研究为碳钢材料在该工艺中磷化时间的选择提供了参考。

关键词：锌系磷化膜常温碳钢磷化时间耐腐蚀性

Effect of Home Blood Pressure Telemonitoring Plus Additional Support on Blood Pressure Control:A Randomized Clinical Trial

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Biomedical and Environmental Sciences 2023年第6期36卷 517-526页

作者： MENg Wen Wen BAI Yong Yi YAN Li ZHENg Wei ZENg qia.g ZHENg Yan Song zha Lin PI Hong ying SAI Xiao Yong The Northern Medical District Chinese PLA General HospitalBeijing 100094China Cardiovascular Department the Second Medical CenterChinese PLA General HospitalBeijing 100853China National Clinical Research Center for geriatric Diseases Chinese PLA General HospitalBeijing100853China Department of Epidemiology and Statistics The Graduate School of the Chinese PLA General HospitalBeijing 100853China Anesthesiology Department the 80th Army Hospital of Chinese PLAWeifang 261021ShandongChina Health Management and Research Institute Chinese PLA General HospitalBeijing100853China Nursing Department Chinese PLA General HospitalBeijing 100853China

Objective Current clinical evidence on the effects of home blood pressure telemonitoring(HBPT)on improving blood pressure control comes entirely from developed ***,we performed this randomized controlled trial to evaluate whether HBPT plus support(patient education and clinician remote hypertension management)improves blood pressure control more than usual care(UC)in the Chinese *** This single-center,randomized controlled study was conducted in Beijing,*** aged 30-75 years were eligible for enrolment if they had blood pressure[systolic(SBP)≥140 mmHg and/or diastolic(DBP)≥90 mmHg;or SBP≥130 mmHg and/or DBP≥80 mmHg with diabetes].We recruited 190 patients randomized to either the HBPT or the UC groups for 12 *** primary endpoints were blood pressure reduction and the proportion of patients achieving the target blood *** Totally,172 patients completed the study,the HBPT plus support group(n=84),and the UC group(n=88).Patients in the plus support group showed a greater reduction in mean ambulatory blood pressure than those in the UC *** plus support group had a significantly higher proportion of patients who achieved the target blood pressure and maintained a dipper blood pressure pattern at the12th week of ***,the patients in the plus support group showed lower blood pressure variability and higher drug adherence than those in the UC *** HBPT plus additional support results in greater blood pressure reduction,better blood pressure control,a higher proportion of dipper blood pressure patterns,lower blood pressure variability,and higher drug adherence than *** development of telemedicine may be the cornerstone of hypertension management in primary care.

关键词： Hypertension Telemonitoring Blood pressure control Additional support