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Science China Chemistry 2022年第10期65卷 1873-1878页

作者： Chu-Hong Ou ying-ming pan Hai-Tao Tang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China

N-heterocyclic carbene(NHC) is a potent organic small-molecule ***,its high synthetic price and frequent use in combination with excess oxidants have limited its utilization in industrial *** designed and synthesized a porous organic polymer with NHC as the core structure to solve the above *** catalytic performance of the polymer was tested in this *** polymer can successfully catalyze the cycloaddition reaction of aldehyde and ethyl isocyanoacetate under *** results showed that the polymer catalyst can be recycled and had higher catalytic activity than homogeneous *** developed catalytic system(organic electrochemistry and NHC polymer) solves the existing problems of NHC catalysis and provides a reference for the development of new green catalytic systems.

关键词： NHC catalysis electrochemistry heterogeneous catalysis cycloaddition

Trace amount of single-atom palladium-catalyzed selective hydrosilylation of allenes

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Nano Research 2022年第8期15卷 7091-7098页

作者： Li-Ping pang Xin-Yu Li Shi-Cheng Ren Hong-Min Lin ying-Chun Wang ying-ming pan Hai-Tao Tang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China College of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China

Using fewer catalysts to promote the chemical conversion of more substrates is the dream synthesis pursued by synthetic *** highly selective reactions using trace amounts(100:1).The catalyst could be recycled numerous times in a continuous flow system without reductions in activity and *** work demonstrated the application prospect of the SAC in the synthesis of complex organic compounds and trace amount catalysis,which can lay the foundation for its large-scale and industrialized application in drug synthesis and other fields.

关键词： trace catalysis single-atom catalysts hydrosilylation allenes

Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-Jie Wei Xin-Yu Wang Hai-Tao Tang Fei-Hu Cui Yun-Qi Wu ying-ming pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

Photocatalyst-controlled and visible light-enabled selective oxidation of pyridinium salts

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Science China Chemistry 2021年第5期64卷 753-760页

作者： Xiang-Jun Peng Hai-Ping He Qian Liu Kun She Bao-Qi Zhang Heng-Shan Wang Hai-Tao Tang ying-ming pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education Gannan Medical UniversityGanzhou 341000China

This study proposes two different methods of photocatalytic-controlled and visible light-induced selective oxidation of pyridiniums with air as the terminal *** key to these transformations is to choose the appropriate light source and *** are successfully converted into pyrroles through oxygen-mediated cycloaddition,proton-coupled electron transfer(PCET),pyridine ring opening,and *** other route is that pyridiniums selectively form 4-carbonyl pyridines through free radical rearrangement/aerobic oxidation under the catalysis of cobalt(Ⅱ).

关键词： photocatalytic-controlled reaction proton-coupled electron transfer ring opening/recyclization process rearrangement/aerobic oxidation the Ladenburg rearrangement pyridinium

Electrochemically-mediated C-H functionalization of allenes and 1,3-dicarbonyl compounds to construct tetrasubstituted furans

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Organic Chemistry Frontiers 2022年第3期9卷 781-787页

作者： Mu-Xue He Yan Yao Chun-Zhi Ai Zu-Yu Mo Yu-Zheng Wu Qi Zhou ying-ming pan Hao-Tao Tang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Public Health Guilin Medical UniversityGuilin 541004China Pharmacy School Guilin Medical UniversityGuilin 541004China Adesis Inc.A Universal Display company New CastleDelaware 19720USA

C-H functionalization of allenes is an available strategy to construct heterocyclic *** we propose a sus-tainable electrocatalytic C-H activation for the synthesis of novel highly functionalized tetrasubstituted furan... 详细信息

关键词： compounds substituted furan

Regioselective palladium-catalyzed direct C-C coupling of coumarins with alkenyl acid via C-H functionalization

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Regioselective palladium-catalyzed direct C-C coupling of co...

中国化学会全国第十一届有机合成化学学术研讨会

作者： Xu Wang ying-ming pan School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University

Coumarins have been extensively investigated with regard to their outstanding optical properties,and therefore they are a powerful tool for the study of simple molecules in complex biological *** are effective fluorophores characterized by high fluorescence quantum *** the course of developing efficient C-H bond activation methods,our group recently described a new samarium-catalyzed C（sp3）-H bond activation of2-alkylazaarenes with propargylic alcohols for the formation of *** finding prompted us to explore the feasibility of the expeditious synthetic approach for the installation of an olefin at the C3 position of coumarins to extend theπ-electron system,yielding enhanced optical properties.

关键词： 3-苯乙烯基香豆素荧光活性抗肿瘤活性

Silver-mediated C-H bond functionalization:one-pot to construct substituted indolizines from 2-alkylazaarenes with alkynes

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Silver-mediated C-H bond functionalization:one-pot to constr...

中国化学会全国第十一届有机合成化学学术研讨会

作者： Xian-chun Tan ying-ming pan 广西师范大学化学与药学学院

Indolizines and their derivatives,which exhibit intriguing molecular structures featured by an N-bridgehead bicyclic ring system fused with both a π-excessive pyrrole and a π-deficient pyridine,have been employed as an important basic building block in a wide range of natural products and *** indolizines have shown important biological activities,such as antibacterial,antiviral,anti-HIV,anti-inflammatory,5-HT3 receptor antagonist,muscular relaxant,as well as antioxidant.A new silver-mediated highly selective C-H functionalization of 2-alkylazaarenes with internal and terminal alkynes for the creation of substituted indolizines in one-pot has been *** process firstly represents a simple,efficient and atom-economic way to construct polysubstituted indolizines in good yields from internal and terminal alkynes through C-H functionalization of 2-alkylazaarenes.

关键词： indolizines alkynes 2-alkylazaarenes C-H functionalization

Scandium-Catalyzed Cyclization of Bispropargyl Alcohols with 1,3-Diketones

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Scandium-Catalyzed Cyclization of Bispropargyl Alcohols with...

中国化学会全国第十一届有机合成化学学术研讨会

作者： Qing-hu Teng Na Wu ying-ming pan School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University

In recent years,various cascade reactions of propargyl alcohols have been reported,except for the reaction of bispropargyl alcohols with 1,*** is known that bispropargyl alcohols are symmetric molecules with multiple reaction sites,which lead to diverse types of interesting cyclization *** the results of development on the transition-metal-catalyzed reactions which usually lead to unexpected consequences in our group,herein,we report a highly efficient scandium-catalyzed reaction of bispropargyl alcohols with 1,3-diketones via cleavage of C-Cσ-bonds give the substituted benzenes in good yields.

关键词： Bispropargyl alcohol C-C σ-Bond Cleavage Cyclization

Chemical constituents from Mappianthus iodoides Hand.-Mazz.

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Chemical constituents from Mappianthus iodoides Hand.-Mazz.

中国化学会第十届全国天然有机化学学术会议

作者： Feng Hu Gui-Jie Zhang Dong Liang ying-ming pan State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University College of Pharmacy Guilin Medical University

＜正＞OBJECTIVE To study the chemical constituents of 95%Et OH extract of Mappianthus iodoides Hand.-Mazz..METHODS Various chromatographic techniques were used to separate and purify the *** spectral data（MS and NMR...

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Cu（Ⅱ）-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

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Cu（Ⅱ）-catalyzed Mannich-type–cyclization–oxidation tand...