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Journal of Pharmaceutical Analysis 2010年第4期22卷 211-217页

作者： Zhuo-Min Zhang1,zong-Ning Guo1,Gui-hua Ruan1,2,jian-Chao Deng1,Xiao-hua Xiao1,Gong-Ke li11.school of chemistry and chemical engineering,sun yat-sen university,guangzhou 510275 2.Department of Material and chemistry,Guilin university of Technology,Guilin 541004,China school of chemistry and chemical engineering Sun Yat-sen University Guangzhou 510275 China Department of Material and chemistry Guilin University of Technology Guilin 541004 China

Microwave-assisted extraction(MAE)was used for extraction of effective components of sarcandra glabra(Thunb.),and then chromatographic fingerprint of sarcandra glabra(Thunb.)was studied by high performance liquid chromatography/diode array detector(HPLC/DAD).The conditions of MAE were optimized by an orthogonal experiment,and then the authentication and validation of the chromatographic fingerprint were *** peaks were identified as common peaks in the fingerprint chromatograms,and isofraxidin was considered as a reference compound and *** standard deviations of retention time and peak area of each component were less than 3% and 8%,*** and difference analysis were conducted by use of PCA and relation *** batches of sarcandra glabra(Thunb.)samples from two different producing areas could be classified into two different groups in the PCA *** results showed that MAE-HPLC/DAD method was simple,efficient and stable for the study of complex chromatographic fingerprint of sarcandra glabra(Thunb.),which could provide more reliable and precise information for quality evaluation.

关键词： chromatographic fingerprint sarcandra glabra(thunb.) microwave-assisted extraction high performance liquid chromatography/diode array detector

Toward Acetylcholine sensor Devices: Facile Synthesis of 2-Cyanoresorcin[4]arene and Its High Affinity toward Acetylcholine

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Toward Acetylcholine Sensor Devices: Facile Synthesis of 2-C...

CEPC Technical Design Report

第三届全国有机化学学术会议

作者： TAN, Song-De WEI, ying wang, bo XU, Zun-Le CHEN, Wen-hua (school of chemistry and chemical engineering, sun yat-sen university, guangzhou 510275) ( CREST, Japan Science and Technology Corporation (JST), Japan)

＜正＞ The biological importance of acetylcholine spurs the efforts to construct its synthetic receptors with the aims to develop acetylcholine sensor devices. Among the various building blocks used to synthesize artificial acetylcholine receptors, resorcin arenes, which can be conveniently obtained from the acid-catalyzed condensation of resorci-nol with aldehyde, were shown to serve as one of the most strongest synthetic receptors for choline type guests. How-ever, their alkali measuring conditions are far from biological ones, which prevents their use in really interesting

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha bai Yu bai Yang bai Vipul bairathi Csaba balazs Philip bambade Yong ban Tripamo bandyopadhyay Shou-Shan bao Desmond P.barber Ayse bat Varvara batozskaya Subash Chandra behera Alexander belyaev Michele bertucci Xiao-Jun bi Yuanjie bi Tianjian bian Fabrizio bianchi Thomas biekotter Michela biglietti Shalva bilanishvili Deng binglin Denis bodrov Anton bogomyagkov Serge bondarenko Stewart boogert Maarten boonekamp Marcello borri Angelo bosotti Vincent boudry Mohammed boukidi Igor boyko Ivanka bozovic Giuseppe bozzi Jean-Claude brient Anastasiia budzinskaya Masroor bukhari Vladimir bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen Huirun Chen jinhui Chen ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng bhupal Dev Tang Dewen biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad banaras Hindu university Institute of ScienceVaranasi bandirma Onyedi Eylul university Bandirma beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal university Beijing brown university ProvidenceRI budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China jiliang university HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China university of Geosciences Beijing China university of Geosciences WuhanHubei China university of Mining and Technology XuzhouJiangsu China West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jiNR) Dubna East China university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Synthesis of Jatrorrhizine-based Dimers as New DNA-binding Agents

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Synthesis of Jatrorrhizine-based Dimers as New DNA-binding A...

固相微萃取-高效液相色谱联用分析环境水样中的痕量■

中国化学会第四届有机化学学术会议

作者： LONG,Yu-hua QIN,Yong PANG, ji-Yan bAI, li-Ping CAI, zong-Wei XU, Zun-Le CHEN, Wen-hua jiANG, Zhi-Hong (school of chemistry and chemical engineering, sun yat-sen university, guangzhou 510275) (school of Chinese Medicine, Hong Kong baptist university, Kowloon Tong, Hong Kong) (Department of chemistry, Hong Kong baptist university, Kowloon Tong, Hong Kong)

＜正＞A number of small molecules are endowed with attractive biological activities through their non-covalent binding to specific DNA. Many studies have indicated that jatrorrhizine 1 and berberine 2, two typical protober-berine alkaloids having a wide range of biological activities, can bind to DNA. Most recently, we have reported a remarkable enhancement of DNA binding affinity by bridging two berberines. This result, together with the structural similarity between jatrorrhizine and berberine, made us to postulate that jatrorrhizine dimers may be also

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色谱 2002年第1期20卷 59-62页

作者：王超英陶敬奇李碧芳马志玲李攻科中山大学化学与化学工程学院广东广州510275

应用固相微萃取与高效液相色谱联用技术 (SPME HPLC)分析了环境水样中的痕量艹屈。对SPME的条件如萃取时间、萃取温度、离子强度、解吸方式、解吸溶剂、解吸时间和HPLC条件进行了优化 ,建立了SPME HPLC分析环境水样中痕量艹屈的方... 详细信息

应用固相微萃取与高效液相色谱联用技术 (SPME HPLC)分析了环境水样中的痕量艹屈。对SPME的条件如萃取时间、萃取温度、离子强度、解吸方式、解吸溶剂、解吸时间和HPLC条件进行了优化 ,建立了SPME HPLC分析环境水样中痕量艹屈的方法 ,并将其用于分析自来水、雨水、矿泉水和江水等实际水样。方法的线性范围为 0 0 13μg/L～ 3 0 μg/L ,检出限为 2 7ng/L ,相对标准偏差 (RSD ,n =6 )为 5 6 % ,回收率为 10 3 2 %～ 119 3%。该方法适合于环境水样中痕量艹屈的分析 ,体现了SPME在样品前处理中快速、灵敏、简单、无溶剂的特点。

关键词：固相微萃取高效液相色谱环境水样 Qiu 联用技术痕量分析水质监测

Porous boronate affinity monolith for on-line extraction coupled to high-performance liquid chromatography for sensitive analysis of heterocyclic aromatic amines in food samples

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Chinese chemical Letters 2015年第12期26卷 1470-1477页

作者： Qian-Chun Zhang ying-Yi Cheng Gong-Ke li Xiao-hua Xiao school of chemistry and chemical engineering Sun Yat-sen University school of biology and chemistry Xingyi Normal University for Nationalities

A novel on-line solid-phase microextraction–high-performance liquid chromatography（SPME–HPLC）system was developed for the determination of heterocyclic aromatic amines（HAAs） in food samples. A poly（vinylphenylboronic acid-co-ethylene glycol dimethacrylate） polymer monolith was prepared for on-line efficient extraction and large-volume injection was used to increase the sensitivity of *** polymermonolith, based on a ternary porogen, was prepared by in situ polymerization of vinylphenylboronic acid（VPbA） and ethylene glycol dimethacrylate（EGDMA） in a fused-silica capillary column. It showed good permeability, high extraction capacity, and high selectivity. The column-tocolumn reproducibility was satisfactory, and the enrichment factors for HAAs were 3746–*** influencing the on-line extraction efficiency, including p H of sample solutions, flow rate of extraction and desorption, and desorption volume, were investigated. The proposed method had low limit of detection（0.10–0.15 ng/L） and good linearity. Trace HAAs in roast beef and lamb samples were determined, and the amounts of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, and 2-amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-f]quinoxaline in these samples were 0.235–2.08 ng/g. The recoveries for the five HAAs ranged from74.3% to 119%, and the relative standard deviation（RSDs） were less than 8.2%. The results showed that the proposed on-line method was highly sensitive for monitoring HAAs in different food samples.

关键词： heterocyclic aromatic amines polymerization glycol tetramethyl selectivity desorption permeability silica

Epitranscriptomic technologies and analyses

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Science China(life Sciences) 2020年第4期63卷 501-515页

作者： Xiaoyu li Qiao-Xia liang jin-Ran lin jinying Peng jian-hua Yang Chengqi Yi Yang Yu Qiangfeng Cliff Zhang Ke-Ren zhou State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China MOE Key Laboratory of Gene Function and Regulation State Key Laboratory for BiocontrolSchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275China The Fifth Affiliated Hospital Sun Yat-Sen UniversityZhuhai 519000China Department of chemical biology and Synthetic and Functional biomolecules Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Key Laboratory of RNA biology CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101 China MOE Key Laboratory of bioinformatics Beijing Advanced Innovation Center for Structural BiologyCenter for Synthetic and Systems BiologyTsinghua-Peking Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

RNA can interact with RNA-binding proteins(RbPs),mRNA,or other non-coding RNAs(ncRNAs)to form complex regulatory ***-throughput CliP-seq,degradome-seq,and RNA-RNA interactome sequencing methods represent powerful approaches to identify biologically relevant ncRNA-target and protein-ncRNA ***,assigning ncRNAs to their regulatory target genes or interacting RNA-binding proteins(RbPs)remains technically *** modifications to mRNA also play important roles in regulating gene *** of the functional roles of these modifications relies highly on the detection methods *** structure is also critical at nearly every step of the RNA life *** this review,we summarize recent advances and limitations in CliP technologies and discuss the computational challenges of and bioinformatics tools used for decoding the functions and regulatory networks of *** also summarize methods used to detect RNA modifications and to probe RNA structure.

关键词： ncRNA bioinformatics CliP-seq RNA modification quantification and locus-specific detection methods transcriptome-wide sequencing technologies RNA structuromes RNA structure probing methods

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biomarkers of aging

Science China(life Sciences) 2023年第5期66卷 893-1066页

作者： Aging biomarker Consortium Hainan bao jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan jia Haiping jiang ying jing Dingfeng li jiaming li jingyi li Qinhao liang Rui liang Feng liu Xiaoqian liu Zuojun liu Oscar Junhong Luo jianwei Lv jingyi Ma Kehang mao jiawei Nie Xinhua Qiao Xinpei sun Xiaoqiang Tang jianfang wang Qiaoran wang Siyuan wang Xuan wang Yaning wang Yuhan wang Rimo Wu Kai Xia Fu-Hui Xiao lingyan Xu yingying Xu Haoteng Yan liang Yang Ruici Yang Yuanxin Yang Yilin ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min zhou Rui zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci bi-sen Ding Qiurong Ding Feng Gao jing-Dong JHan Kai huang Zhenyu Ju Qing-Peng Kong ji li jian li Xin li baohua liu Feng liu lin liu Qiang liu Qiang liu Xingguo liu Yong liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong mao jing Nie Yaojin Peng jing Qu jie Ren Ruibao Ren Moshi Song zhou Songyang Yi Eve sun Yu sun Mei Tian Shusen wang Si wang Xia wang Xiaoning wang Yan-jiang wang Yunfang wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu jing Ye Rui Yue Cuntai Zhang Hongbo Zhang liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui liu Aging biomarker Consortium(AbC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

sensing mechanism of Ag/α-MoO_(3) nanobelts for H_(2)S gas sensor

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Rare Metals 2021年第6期40卷 1545-1553页

作者： Shi-Kai Shen Xin-Lei Cui Chuan-Yu Guo Xin Dong Xian-Fa Zhang Xiao-li Cheng li-hua Huo ying-Ming Xu school of Electrical engineering Suihua UniversitySuihua 152000China Key Laboratory of Functional Inorganic Material chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Guangdong Engineering Technology Research Center for High-Performance Organic and Polymer Photoelectric Functional FilmsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

sensing mechanism is still a big problem in the field of gas ***-depth study of the sensing mechanism can provide better ideas for the design of sensing materials,and it is also more conducive to the improvement in gas-sensing *** this work,Ag/α-MoO_(3) material was obtained by loading Ag in α-MoO_(3) nanobelts prepared by hydrothermal *** material was characterized by field electron scanning electron microscopy(SEM),high-resolution transmission electron microscopy(HRTEM),X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS).Comparing the gas sensing properties of α-MoO_(3) and Ag/α-MoO_(3),it is found that Ag effectively improves the selectivity of the material to H_(2)S at 133℃.The response of the 5 wt% Ag/α-MoO_(3) sensor to 100 × 10-6 hydrogen sulfide(H_(2)S) is 225 and the detection limit is 100 ×10^(-9).The sensing mechanism was verified by gas chromatography and mass spectrometer(GC-MS),XPS and Fourier transform infrared spectroscopy(FTIR).

关键词： Ag/α-MoO_(3) Nanobelt Gas sensor Hydrogen sulfide sensing mechanism