Synthesis of Jatrorrhizine-based Dimers as New DNA-binding Agents

作     者：LONG,Yu-Hua QIN,Yong PANG, Ji-Yan BAI, Li-Ping CAI, Zong-Wei XU, Zun-Le CHEN, Wen-Hua JIANG, Zhi-Hong (School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275) (School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong) (Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong) 

会议名称：《中国化学会第四届有机化学学术会议》

会议日期：2005年

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

摘      要：正A number of small molecules are endowed with attractive biological activities through their non-covalent binding to specific DNA. Many studies have indicated that jatrorrhizine 1 and berberine 2, two typical protober-berine alkaloids having a wide range of biological activities, can bind to DNA. Most recently, we have reported a remarkable enhancement of DNA binding affinity by bridging two berberines. This result, together with the structural similarity between jatrorrhizine and berberine, made us to postulate that jatrorrhizine dimers may be also