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Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG ying QU jin-yu GUO hua ZHOU Hai-ying RUAN Xia PENG ying-chun SHEN Xue-fang XIONG jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

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Biomimetic leaf structures for ultra-thin electromagnetic wave absorption

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Nano Research 2024年第5期17卷 4507-4516页

作者： Shikun Hou ying Wang Feng Gao Fei jin Benfeng Zhu Qiong Wu Hongliang Ge Zhihai Cao hua Yang Magnetism Key Laboratory of Zhejiang Province&College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Materials Science and Engineering Guangdong Technion-Israel Institute of TechnologyShantou 515063China Key Laboratory of Advanced Textile Materials and Manufacturing Technology and Engineering Research Center for Eco-Dyeing&Finishing of Textiles Ministry of EducationZhejiang Sci-Tech UniversityHangzhou 310018China

Ultra-thin electromagnetic wave(EMW)absorbers present challenging demands on EMW absorption *** inspiration from heather leaf structures,this study introduces an innovative design strategy for EMW absorbing material,proposing biomimetic leaf SnO_(2) structures(bio-SnO_(2))on carbon fabric(CF).By employing leaf-shaped SnS2 as precursors,biomimetic leaf SnO_(2) nanostructures are constructed on CF surface after a simple thermal treatment,resulting in bio-SnO_(2)@CF *** results indicate that bio-SnO_(2)@CF exhibits an exceptional minimum reflection loss of-54.8 dB at an incredibly thin thickness of 1.2 *** cross section(RCS)simulations further validate the outstanding EMW attenuation ability of bio-SnO_(2)@CF,attaining a maximum RCS reduction value of 16.9 dBm^(2) at an incident wave angle ofθ=0°.This novel research showcases the biomimetic structural design strategy and its remarkable function in enhancing the EMW absorbing performance at ultra-thin absorber thickness.

关键词： biomimetic leaf structures electromagnetic wave absorption ultra-thin thickness

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Electrochemical anodic oxidation assisted fabrication of memristors

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International Journal of Extreme Manufacturing 2024年第3期6卷 250-272页

作者： Shuai-Bin hua Tian jin Xin Guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Owing to the advantages of simple structure,low power consumption and high-density integration,memristors or memristive devices are attracting increasing attention in the fields such as next generation non-volatile memories,neuromorphic computation and data ***,the deposition of memristive films often requires expensive equipment,strict vacuum conditions,high energy consumption,and extended processing *** contrast,electrochemical anodizing can produce metal oxide films quickly(e.g.10 s) under ambient *** means of the anodizing technique,oxide films,oxide nanotubes,nanowires and nanodots can be fabricated to prepare *** film thickness,nanostructures,defect concentrations,etc,can be varied to regulate device performances by adjusting oxidation parameters such as voltage,current and *** memristors fabricated by the anodic oxidation technique can achieve high device consistency,low variation,and ultrahigh yield *** article provides a comprehensive review of the research progress in the field of anodic oxidation assisted fabrication of ***,the principle of anodic oxidation is introduced;then,different types of memristors produced by anodic oxidation and their applications are presented;finally,features and challenges of anodic oxidation for memristor production are elaborated.

关键词： anodic oxidation anodized aluminium oxide memristor resistive switching electrical properties

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Influence of laser parameters on the microstructures and surface properties in laser surface modification of biomedical magnesium alloys

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Journal of Magnesium and Alloys 2024年第1期12卷 72-97页

作者： Chee ying Tan Cuie Wen hua Qian Ang School of Engineering RMIT UniversityMelbourneVictoria 3001Australia

Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and *** primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the *** surface modification has recently received attention because it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the *** composition and microstructures including textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques including laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant ***,we explore how different laser process parameters affect its composition,microstructure,and surface properties in each laser surface modification technique.

关键词： Biocompatibility Biodegradability Corrosion Implant applications Laser surface modification Magnesium alloys

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Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 125-135页

作者： Sijie Zhou Junyanrui Li Xichen Cui ying Wang ying-jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and driving species *** chromosome rearrangement and modification by LoxP-mediated evolution(SCRaMbLE)has been applied to explore large-scale genomic rearrangements,yet it has been observed that these rearrangements occur exclusively in genomic regions containing loxPsym ***,we found that SCRaMbLE of synthetic yeast harboring synthetic chromosome V and X can generate a variety of synthetic segment insertions into wild-type chromosomes,ranging from 1 to 300 ***,it was revealed that the novel insertions impacted the transcriptional level of neighboring regions and affected the production of exemplar pathway of ***,our results improve the understanding of the ability of SCRaMbLE to generate complex structural variations in nonsynthetic regions and provide a potential model to explore genomic transposable events.

关键词： genomic rearrangements synthetic yeast genome SCRaMbLE inter-chromosomal insertions synthetic biology

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Ginsenoside Rg5 induces apoptosis by activating two apoptotic pathways in human esophageal cancer cells

Ginsenoside Rg5 induces apoptosis by activating two apoptoti...

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第十二届中国酶工程学术研讨会

作者： Yang Li ying-hua jin Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education College of Life Science Jilin University

＜正＞We have recently found that Ginsenoside Rg5（G-Rg5）,a trace compound of red ginseng induces human esophageal cancer cell *** mechanism study showed that G-Rg5 stimulated the activation of both caspase-8 and cas...

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Optimal investment based on relative performance and weighted utility

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 328-342页

作者： WANG Lei DONG ying-hui hua Chun-rong Department of Mathematics Suzhou University of Science and TechnologySuzhou 215009China Changshu Institute of Technology Changshu 215500China

This paper studies the optimal portfolio allocation of a fund manager when he bases decisions on both the absolute level of terminal relative performance and the change value of terminal relative performance comparison to a predefined reference point. We find the optimal investment strategy by maximizing a weighted average utility of a concave utility and an Sshaped utility via a concavification technique and the martingale method. Numerical results are carried out to show the impact of the extent to which the manager pays attention to the change of relative performance related to the reference point on the optimal terminal relative performance.

关键词： relative performance weighted utility S-shaped utility concavification

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Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

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Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： ying-ying Xu Chan jin Meng Wu Jian-Ye Zhou Hui-Ling Wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

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Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences

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Science China(Life Sciences) 2024年第9期67卷 2045-2047页

作者： Bing-Zhi Li ying-jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a significant role in disease,evolution,and tumorigenesis(Mani and Chinnaiyan,2010).While single nucleotide polymorphisms(SNPs)and small insertions/deletions contribute substantially to gen... 详细信息

关键词： insertion sequences

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Research on Sarcasm Detection Technology Based on Image-Text Fusion

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Computers, Materials & Continua 2024年第6期79卷 5225-5242页

作者： Xiaofang jin Yuying Yang YinanWu ying Xu School of Information and Communication Engineering Communication University of ChinaBeijing100024China Cable Television Technology Research Institute Academy of Broadcasting ScienceBeijing100053China

The emergence of new media in various fields has continuously strengthened the social aspect of social *** tend to express emotions in social interactions,and many people even use satire,metaphors,and other techniques to express some negative emotions,it is necessary to detect sarcasm in social comment *** sarcasm,the more reference data modalities used,the better the experimental *** paper conducts research on sarcasm detection technology based on image-text fusion *** effectively utilize the features of each modality,a feature reconstruction output algorithm is *** algorithm is based on the attention mechanism,learns the low-rank features of another modality through cross-modality,the eigenvectors are reconstructed for the corresponding modality through weighted *** only the image modality in the dataset is used,the preprocessed data has outstanding performance in reconstructing the output model,with an accuracy rate of 87.6%.When using only the text modality data in the dataset,the reconstructed output model is optimal,with an accuracy rate of 85.2%.To improve feature fusion between modalities for effective classification,a weight adaptive learning algorithm is *** algorithm uses a neural network combined with an attention mechanism to calculate the attention weight of each modality to achieve weight adaptive learning purposes,with an accuracy rate of 87.9%.Extensive experiments on a benchmark dataset demonstrate the superiority of our proposed model.

关键词： Sentiment analysis sarcasm detection feature fusion feature reconstruction

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