检索结果-南通市图书馆

Postsynaptic signaling of new players at synapses

在线全文

cnki会议

学校读者我要写书评

暂无评论

Postsynaptic signaling of new players at synapses

中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Nancy Y. ip Department of Biochemistry Biotechnology Research Institute and Molecular Neuroscience Center Hong Kong University of Science and TechnologyClear Water Bay

＜正＞Neurons communicate with each other at synapses. Most of our knowledge about how synaptic connections are formed and maintained is derived from studies of the neuromuscular junction （NMJ）. During the past decade, enormous progress has been made in identifying and characterizing the molecular players at the postsynaptic side of synapses. Several receptor tyrosine kinases, such as MuSK, ErbB and TrkB, have been implicated to play critical roles in mediating the formation and maintenance of the NMJ. In this talk, I will discuss some of the novel signaling mechanisms identified in our laboratory, involving molecules such as cyclin-dependent kinase Cdk5 which belongs to the Cdk family, and EphA4, a member of the largest family of receptor tyrosine kinases. While early studies on these molecules focused on the roles in axonal guidance, their unexpected involvement in modulating synaptic functions has recently begun to be unraveled. Elucidating the functional significance of these proteins in muscle not only expands our understanding of the molecular mechanisms underlying synaptic development, it also provides new insights into the modulation of neurotrophic factor signaling in the nervous system.

关键词： postsynaptic sinaling communication

Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第9期9卷 1963-1967页

作者： Wen-MingZhao Zhi-NanChen PengShang Ai-RongQian Tie-HongYang MinJia Qi-BingMei chi-HinCho SchoolofLifeScienceandTechnology Xi'anJiaotongUniversityXi’an710054ShaanxiProvinceChina DepartmentofCellBiology ForthMilitaryMedicalUniversity.Xi'an710032ShaanxiProvinceChina DepamnentofPharmacology FourthMilitaryMedicalUniversityXi’an710032ShaanxiProvinceChina DepartmentofPharmacology FacultvofMedicine.UniversityofHongKongHongKongChina

AIM: To investigate the in vivo anti-tumor effects of total polysaccharide (AP-0) isolated from Angelica sinensis (Oliv.)Diels (Danggui) on mice and thein vitro inhibitory effects of AP-0 and its sub-constituents (AP-1, AP-2 and AP-3) on invasion and metastasis of human hepatocellular ***: Three kinds of murine tumor models in vivo,sarcoma 180 (S180), leukemia L1210 and Ehrlich ascitic cancer (FAC) were employed to investigate the anti-tumor effects of AP-0. For each kind of tumor model, three experimental groups were respectively given AP-0 at doses of 30, 100 and 300 mg/kg byip once a day for 10 *** control groups were respectively given Cy at a dose of 30 mg/kg for S180 and leukemia L1210, and 5-FU at a dose of 20 mg/kg for EAC. On d 11, mice bearing S180were sacrificed and the masses of tumors, spleens and thymus were weighed. The average living days of mice bearing EAC and of mice bearing L1210 were observed,and the rates of life prolongation of each treatment were calculated, respectively. The inhibitory effects of APs on hepatoma invasion and metastasis in vitro were investigated by employing human hepatocellular carcinoma cell line (HHCC) with the Matrigel invasion chamber, adhesion to extracelluler matrix and chemotatic migration tests, ***: AP-0 had no obviously inhibitory effect on the growth of S180, but it could significantly decrease the thymus weights of the mice bearing S180. AP-0 could significantly reduce the production of ascitic liquids and prolong the life of mice bearing EAC. AP-0 could also increase the survival time of mice bearing L1210. AP-0 and AP-2 had significantly inhibitory effects on the invasion of HHCC into the Matrigel reconstituted basement membrane with the inhibitory rates of 56.4% and 68.3%, respectively. AP-0, AP-1, AP-2 and AP-3 could influence the adhesion of HHCC to extracellular matrix proteins (Matrigel and fibronectin) at different degrees, among them only AP-3 had significant blo

关键词：当归中药多糖抗肿瘤作用

澳门特别行政区初三学生的睡眠质量、睡眠模式与抑郁、焦虑情绪

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国心理卫生杂志 2012年第10期26卷 761-765页

作者：叶智恒潘集阳刘亚平暨南大学附属第一医院精神心理科广州510630 澳门卫生局

目的:了解澳门特别行政区初三年级学生的睡眠质量、模式与抑郁、焦虑情绪的关系。方法:抽取澳门535名初中三年级学生,用匹兹堡睡眠质量指数量表(PSQI)评估睡眠质量,爱泼沃斯思睡量表(ESS)以及清晨型和夜晚型量表(MEQ)调查白天思睡与睡... 详细信息

目的:了解澳门特别行政区初三年级学生的睡眠质量、模式与抑郁、焦虑情绪的关系。方法:抽取澳门535名初中三年级学生,用匹兹堡睡眠质量指数量表(PSQI)评估睡眠质量,爱泼沃斯思睡量表(ESS)以及清晨型和夜晚型量表(MEQ)调查白天思睡与睡眠模式,用贝克抑郁量表(BDI)、状态-特质焦虑量表(STAI)调查抑郁、焦虑状况。结果:PSQI和ESS得分分别为(5.2±2.6)和(8.4±4.7),女生PSQI[(5.5±2.5)vs.(4.8±2.6)]和ESS[(8.9±4.6)vs.(8.0±4.8)]得分高于男生(均P<0.05)。MEQ平均得分(13.3±3.1),女生得分低于男生[(12.8±3.0)vs.(13.7±3.2),P<0.01]。学生周末和假日的总睡眠时间长于平日总睡眠时间[(608±106)min,(605±109)min vs.(457±75)min],女生周末[(628±110)min vs.(590±97)min]和假期[(631±109)min vs.(581±103)min]平均睡眠时间长于男生(均P<0.01)。BDI和STAI得分分别为(13.5±10.3)、(78.9±17)。睡眠质量差和白天思睡者MEQ得分、上学日睡眠时间低于睡眠质量好和无白天思睡者MEQ得分,而睡眠质量差和白天思睡者BDI得分高于睡眠质量好和无白天思睡者BDI得分(均P<0.05)。PSQI分别与ESS、BDI,以及STAI中的TAI分呈正相关(r=0.27、0.37、0.12,均P<0.05),而与M EQ和上学日总睡眠时间呈负相关(r=-0.30、-0.30,均P<0.05)。结论:睡眠质量差和白天思睡在澳门初三学生中较为普遍,他们在上学日的平均睡眠时间不足,但在周末和假日则延长睡眠时间以作补充,其中女生更易出现上述睡眠模式。大部分学生有轻度抑郁,睡眠质量差可能与其抑郁、焦虑状况相关。

关键词：澳门初三学生睡眠质量睡眠模式抑郁焦虑

Functional roles of Mst3 in radial migration during the development of mouse cerebral cortex

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional roles of Mst3 in radial migration during the deve...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jacque P K ip Amy K Y FU Nancy Y ip Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience CenterThe Hong Kong University of Science and TechnologyClear Water Bay

＜正＞Objective Radial migration is critical for the lamination of cerebral cortex during early brain development. Whereas the migration of neurons requires a precise regulation of the organization and dynamics of cytoskeleton including microtubule and actin network,the underlying signaling mechanisms are not well *** the present study,we investigate the functional roles of a kinase Mst3 in radial migration during cortical *** The radial migration in mouse neocortex was investigated by in utero *** cone collapse assay in cultured hippocampal neurons was performed using confocal ***（1） We identified that Mst3, a serine/threonine kinase highly expressed in the developing mouse brain,regulates the neuronal differentiation. （2） Silencing of Mst3 by in utero electroporation resulted in a significant delay on the neuronal migration in the developing mouse neocortex.（2） Kinase activity of Mst3 was essential for its functions in neuronal morphogenesis and migration.（3） Mst3 was co-localized with F-actin at the growth cones of cultured hippocampal neurons,and regulated actin *** Kinase activity of Mst3 is important for neuronal morphogenesis and radial migration through modulation of actin dynamics.

关键词： mammalian Sterile 20-like kinase 3 Mst3 neuronal migration actin dynamics

The testing of multiple RAM Cores in Soc system

在线全文

cnki会议

学校读者我要写书评

暂无评论

The testing of multiple RAM Cores in Soc system

2006 8th International Conference on Solid-State and Integrated Circuit Technology

作者： Wang ying Wang Hong Shenyang Institute of Automation Chinese Academy of Sciences Graduate University of chinese Academy of Sciences Information Engineering School Shenyang Institute of Chemical Technology

ISBN: (纸本)1424401607

＜正＞*** The development of the sub-micro technology makes it possible that the manufacturer of ASIC integrates ip into a single *** embedded memory is difficult to test because of the compact ***,BIST and processor-based are the mainly three *** BIST method decreases the test time by sacrificing the *** BIST has been the main test method due to the better *** cost of the area and pad is large if every memory possesses a BIST controller in the *** paper adopts a BIST controller to control dozens of *** method has the advantage of better flexibility,shorter time and lower area.

关键词： System testing Built-in self-test Communication system control Read-write memory Manufacturing Application specific integrated circuits Random access memory Semiconductor device measurement Costs Control systems

Research on Application-layer Routing Mechanism of ip Communication System

在线全文

cnki会议

学校读者我要写书评

暂无评论

Research on Application-layer Routing Mechanism of IP Commun...

2011 4th IEEE International Conference on Computer Science and Information Technology(ICCSIT 2011)

作者： Bin Wang ying Ma College of Computer and Communication china University of Petroleum School of humanities and social science china University of Petroleum

ISBN: (纸本)9781612848334

A lot of works have been done to improve the service quality of ip communications, and so we need to improve the important factor- media flow control. This paper first reviews the common application-layer routing mechanism, such as overlay network, multi-homing technology, ASAP protocol, etc. Through the analysis of the advantages and disadvantages of these schemes, we found all these solutions can not apply to ip communications very well. Further, we analyzed the application-layer routing problem and need of ip communications. On this basis, this paper puts forward a kind of Sip2P application layer routing framework to solve the transmission control problems of ip communications. In this framework, we respectively describes path quality evaluation model, relay researching model based on topology optimization, relay routing consultation, and path switching algorithm, and other key technology.

关键词： ip communication Relay Routing Consultation Path Switching

Incidence Rate of Urinary Tract Infection Between Indwelling Foley’s Catheter and Intermittent Catheterization

在线全文

cnki会议

学校读者我要写书评

暂无评论

Incidence Rate of Urinary Tract Infection Between Indwelling...

中国康复医学会第四届会员代表大会暨第三届中国康复医学学术大会

作者： HOJYL WONG LMW ip FSH Sha Wan Drive PokfulamHong Kong

Most of the spinal cord injury patients will have urinary *** of them willneed indwelling Foley‘s catheter or intermittent catheterization as their long-term method of *** order to help patients to decide which method to use,this report is intended to comparethe incidence of urinary tract infection in spinal cord injury patients between indwelling Foley’s catheter(IC) and intermittent catheterization(IMC) in MacLehose Medical Rehabilitation Centre in Hong Kongover the period between 1995 to 2001(until May 31 2001).Urinary tract infection in this report is de-fined as patients having fever greater than 38℃ elsius,change in character of urine,(*** withurine culture result with significant growth of bacteria),and treated with antibiotic(s).Objective the ob-jective is to find out the incidence rate of urinary tract infection between using Foley’s catheter and inter-mittent *** we can decide which method of bladder management is safer for the spinalcord injury patients who require long--term bladder *** Retrospective review for 85spinal cord injury patients over the period of 1995 to 2001 were *** obtained including demo-graphic characteristics,methods of bladder management,and frequency of urinary tract infection for eachtype of bladder *** There were 83 out of 85 patients who needed long--term *** of 83 patients,56 were male with a mean age of 48,and 27 were female with a meanage of *** incidence of urinary tract infection was expressed as the number of episodes per 1,000 pa-tient *** average incidence of urinary tract infection over the 6 years and 5 months‘ time related toIC was 0.26,whereas 0.08 was related to *** we compared the incidence rate between IC and IMCeach year,the incidence rate for IC remains *** annual relative risk(RR) between the two meth-ods was also *** average,the RR was 0.75 which in favour of *** Sp

关键词：

A Successful Pregnancy Outcome after Surgical Decompression of Type I Arnold-chiari Malformation

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2015年第1期5卷 44-48页

作者： Patricia ip Susmita Pankaja Fidelma O’Mahony Department of Obstetrics & Gynaecology University Hospital of North Staffordshire NHS Trust Stoke-on-Trent UK

Type I Arnold-chiari malformation (ACM) usually presents in adulthood and consists of a downward displacement of the cerebellar tonsils through the foramen magnum. A 25-year-old woman presented with a 5-month history of headache associated with blurred vision, tinnitus and sickness. Imaging recognised the need for surgical intervention, but whilst awaiting for surgery she fell pregnant. Considering the risks of neurological deterioration, the woman underwent surgical decompression of type I ACM at 15 weeks gestation. She subsequently presented with progressively worsening headaches during late pregnancy from 35 weeks. The obstetric plan was initially induction of labour at term but since the onset of worsening symptoms, this date was brought forward to 39 + 1 weeks gestation. She proceeded to have a normal delivery with no neonatal complications and an uneventful puerperium followed. Since the delivery, the patient reported fewer symptoms, showed no signs of neurological deficit and a repeat magnetic resonance imaging of the head showed good relief of neural compression. This case illustrates how judicious selection of the appropriate mode of delivery of women following surgically corrected ACM and a multidisciplinary approach is critical in the successful management of the antepartum period and labour.

关键词： Arnold-chiari Malformation Pregnancy Anaesthetics

Latest Logistic Developments at Hong Kong Port

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上海海事大学学报 2004年第2期25卷 94-94页

作者： Stephen ip Director Hong Kong Economic Development and Labor Administration

An explanation is made of the role of the government and businesses in the development of port logistic and the new measures to sharpen the competitive edge of Hong Kong’s logistics. Also discussed are the importance of regional cooperation and development in logistics and the interaction between Shanghai and Hong Kong in developing port logistics.

关键词： Latest Logistic Developments at Hong Kong Port