检索结果-南通市图书馆

Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma

引用

Nano Research 2021年第5期14卷 1326-1334页

作者： Ling-Xiao Zhang ying-bo jia Ya-Ru Huang Hui-Na Liu Xia-Mei Sun Ting Cai Rui-Tian Liu Zhi Ping Xu Hwa Mei Hospital University of Chinese Academy of Sciences(Ningbo No.2 Hospital)Ningbo315010China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo315010China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt LuciaQLD4072Australia State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Cancer therapeutic nanovaccines are ideal tools to inhibit tumor growth and provide the body with continuous protecting immune ***,the conventional subcutaneous(SC)vaccination normally induces limited anti-tumor immune responses with low therapeutic ***,we devised clay-based nanovaccines and directly delivered them to the spleen via intravenous(IV)injection to induce the stronger anti-tumor immunity with higher efficacy for tumor prevention and *** clay,i.e.,layered double hydroxide(LDH)was prepared as nanoadjuvant with the average size from 77 to 285 nm and co-loaded with the model antigen ovalbumin(OVA)and bioadjuvant CpG to form CpG/OVA-LDH(CO-LDH)*** found that CO-LDH-215(the size of LDH was 215 nm)promoted dendritic cells to present the most antigen,and moreover showed the highest spleen enrichment(~1.67%of CO-LDH-215 enriched in the spleen at 24 h post IV injection).The in vivo immunologic data showed that CO-LDH-215 induced the most potent anti-tumor immune responses and completely prevented the growth of E.G7-OVA tumor in the mouse ***,IV injected CO-LDH-215 nanovaccine more effectively delayed tumor growth than that SC injected,largely due to the direct and quick delivery of more nanovaccines to the *** study demonstrates that the therapeutic efficacy of nanovaccines can be greatly enhanced by targeted delivery of nanovaccines to the spleen via the proper vaccination route.

关键词： cancer immunotherapy nanovaccine layered double hydroxide targeted delivery to the spleen lymphoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Perenniality:From model plants to applications in agriculture

引用

Molecular Plant 2024年第1期17卷 141-157页

作者： bo Zhao jia-Wei Wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing *** such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth *** intrinsic phenology is primarily genetic and can be altered by environmental *** evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round *** proportion,however,is reversed in ***,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate *** significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further *** findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle *** implies that engineering plant life history strategy can be achieved by manipulating only a few key *** this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New method for multibody dynamics based on unknown constraint force

引用

Science China(Technological Sciences) 2024年第3期67卷 791-808页

作者： TIAN ying jia yingHong ZHANG Jun School of Astronautics Beihang UniversityBeijing 100191China Beijing Institute of Control Engineering Beijing 100190China National Laboratory of Space Intelligent Control Beijing 100190China

This paper presents a new method for the dynamics of multibody systems based on unknown constraint force. The method can uniformly solve multibody systems with typical configurations, including the system with rigid-flexible coupling, the system in tree topology, and the system with loop constraints. Unlike common methods, the proposed method can model the loop system without “cutting off” loop constraints, leading to the exact same modelling process as the tree-like system performs. Based on graph theory, a topological record matrix M_(rec) is proposed to capture the arbitrary system configuration. Moreover, constraint forces are selected as the key variables in semi-recursive framework. With the recursive kinematics relationship between adjacent bodies, the constraint force equation is further assembled to achieve the full-state system solution. The numerical simulations demonstrate the accuracy of the proposed method.

关键词： multibody system dynamic modelling rigid-flexible coupling unknown constraint force graph theory semi-recursive algorithm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reactive transport modeling constraints on the complex genesis of a lacustrine dolomite reservoir: A case from the Eocene Qaidam Basin,China

引用

Petroleum Science 2024年第4期21卷 2240-2256页

作者： ying Xiong bo Liu Xiu-Cheng Tan Zheng-Meng Hou jia-Shun Luo Ya-Chen Xie Kai-bo Shi Kun-Yu Wu School of Earth and Space Sciences Peking University Institute of Oil and Gas Peking University China National Petroleum Corporation Key Laboratory of Carbonate Reservoirs Southwest Petroleum University Institute of Subsurface Energy Systems Clausthal University of Technology Research Institute of Exploration and Development PetroChina Qinghai Oil Field Company

Reactive transport modeling(RTM) is an emerging method used to address geological issues in diagenesis research. However, the extrapolation of RTM results to practical reservoir prediction is not sufficiently understood. This paper presents a case study of the Eocene Qaidam Basin that combines RTM results with petrological and mineralogical evidence. The results show that the Eocene Xiaganchaigou Formation is characterized by mixed siliciclastic-carbonate-evaporite sedimentation in a semiclosed saline lacustrine environment. Periodic evaporation and salinization processes during the syngeneticpenecontemporaneous stage gave rise to the replacive genesis of dolomites and the cyclic enrichment of dolomite in the middle-upper parts of the meter-scale depositional sequences. The successive change in mineral paragenesis from terrigenous clastics to carbonates to evaporites was reconstructed using RTM simulations. Parametric uncertainty analyses further suggest that the evaporation intensity(brine salinity) and particle size of sediments(reactive surface area) were important rate-determining factors in the dolomitization, as shown by the relatively higher reaction rates under conditions of higher brine salinity and fine-grained sediments. Combining the simulation results with measured mineralogical and reservoir physical property data indicates that the preservation of original intergranular pores and the generation of porosity via replacive dolomitization were the major formation mechanisms of the distinctive lacustrine dolomite reservoirs(widespread submicron intercrystalline micropores) in the Eocene Qaidam Basin. The results confirm that RTM can be effectively used in geological studies, can provide a better general understanding of the dolomitizing fluid-rock interactions, and can shed light on the spatiotemporal evolution of mineralogy and porosity during dolomitization and the formation of lacustrine dolomite reservoirs.

关键词： Reactive transport modeling Lacustrine dolomite Mineralogy and porosity evolution Reservoir genesis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system

引用

World Journal of Gastroenterology 2024年第6期30卷 607-609页

作者： Bai-Wei Zhao ying-jia Chen Ruo-Peng Zhang Yong-Ming Chen bo-Wen Huang Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina Health Science Center Peking UniversityBeijing 100191China

The present letter to the editor is related to the study titled‘Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells’.Angiotensin-converting enzyme 2 can alleviate liver fibrosis by regulating autophagy of hepatic stellate cells and affecting the renin-angiotensin system.

关键词： Angiotensin-converting enzyme 2 Hepatic stellate cells Liver fibrosis Angiotensin II Angiotensin 1-7 Renin-angiotensin system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Difference Between the Skew-rank of an Oriented Graph and the Rank of Its Underlying Graph

引用

Acta Mathematicae Applicatae Sinica 2024年第1期40卷 129-136页

作者： jia-min Zhu bo-jun Yuan Yi Wang School of Mathematical Sciences Anhui UniversityHefei230601China School of Science Zhejiang University of Science and TechnologyHangzhou310023China

Let G be a simple graph and G~σ be the oriented graph with G as its underlying graph and orientation σ.The rank of the adjacency matrix of G is called the rank of G and is denoted by r(G).The rank of the skew-adjacency matrix of G~σ is called the skew-rank of G~σ and is denoted by sr(G~σ).Let V(G)be the vertex set and E(G) be the edge set of *** cyclomatic number of G,denoted by c(G),is equal to |E(G)|-|V(G)|+ω(G),where ω(G) is the number of the components of *** is proved for any oriented graph G~σ that-2c(G)≤sr(G~σ)-r(G)≤2c(G).In this paper,we prove that there is no oriented graph G~σwith sr(G~σ)-r(G)=2c(G)-1,and in addition,there are infinitely many oriented graphs G~σ with connected underlying graphs such that c(G)=k and sr(G~σ)-r(G)=2c(G)-l for every integers k,l satisfying 0 ≤l≤4k and l≠1.

关键词： cyclomatic number rank skew-rank

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Constructing the metabolic network of wheat kernels based on structure-guided chemical modification and multi-omics data

引用

Journal of Genetics and Genomics 2024年第7期51卷 714-722页

作者： Zhitao Tian Jingqi jia bo Yin Wei Chen National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Metabolic network construction plays a pivotal role in unraveling the regulatory mechanism of biological activities,although it often proves to be challenging and labor-intensive,particularly with non-model *** this study,we develop a computational approach that employs reaction models based on the structure-guided chemical modification and related compounds to construct a metabolic network in *** construction results in a comprehensive structure-guided network,including 625 identified metabolites and additional 333 putative reactions compared with the Kyoto Encyclopedia of Genes and Genomes *** a combination of gene annotation,reaction classification,structure similarity,and correlations from transcriptome and metabolome analysis,a total of 229 potential genes related to these reactions are identified within this *** validate the network,the functionality of a hydroxycinnamoyltransferase(TraesCS3D01G314900)for the synthesis of polyphenols and a rhamnosyltransferase(TraesCS2D01G078700)for the modification of flavonoids are verified through in vitro enzymatic studies and wheat mutant tests,*** research thus supports the utility of structure-guided chemical modification as an effective tool in identifying causal candidate genes for constructing metabolic networks and further in metabolomic genetic studies.

关键词： Metabolic network Chemical modification Genetic study Wheat kernel Multi-omics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structure engineering of cathode host materials for Li-S batteries

引用

Rare Metals 2024年第4期43卷 1370-1389页

作者： jia-Jun Long Hua Yu Wen-bo Liu School of New Energy and Materials Southwest Petroleum UniversityChengdu610500China School of Mechanical Engineering Sichuan UniversityChengdu610065China

Although lithium-sulfur batteries are one of the favorable candidates for next-generation energy storage devices,a few key challenges that have not been addressed have limited its *** challenges include lithium dendrite growth in the anode side,volume change of the active material,poor electrical conductivity,dissolution and migration of poly sulfides,and slow rate of solid-state reactions in the cathode *** the electrochemical performance of lithium-sulfur batteries is greatly affected by the design of the cathode host material,it has also been widely discussed in addressing the abovementioned *** this paper,three design ideas of cathode host materials in terms of microstructure,crystal structure and electronic structure are introduced and ***,the current progress of these three structural design strategies and their effects on the electrochemical performance of lithium-sulfur batteries are discussed in ***,future directions in the structural design of cathode materials for lithium-sulfur batteries are discussed and further perspectives are provided.

关键词： Lithium-sulfur batteries Structure engineering Cathode Host materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on Risk Identification and Industrial Governance of Digital Education Products Based on Data Annotation Technology

引用

China Communications 2024年第3期21卷 273-282页

作者： Tong Lili Zeng jia Di ying Wang Nan Faculty of Education Beijing Normal University Beijing 100875China China Unicom Beijing 102211China

The social transformation brought aboutby digital technology is deeply impacting various *** education products, with core technologiessuch as 5G, AI, IoT (Internet of Things),etc., are continuously penetrating areas such as teaching,management, and evaluation. Apps, miniprograms,and emerging large-scale models are providingexcellent knowledge performance and flexiblecross-media output. However, they also exposerisks such as content discrimination and algorithmcommercialization. This paper conducts anevidence-based analysis of digital education productrisks from four dimensions: “digital resourcesinformationdissemination-algorithm design-cognitiveassessment”. It breaks through corresponding identificationtechnologies and, relying on the diverse characteristicsof governance systems, explores governancestrategies for digital education products from the threedomains of “regulators-developers-users”.

关键词： digital education products industry governance risk identification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

引用

Journal of Thermal Science 2024年第2期33卷 564-577页

作者： WANG Zhibin LI Zilong jia Lisi DING Bin CHEN ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer *** this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat *** results show that particles of MEPCMS are mainly subjected to drag force during the *** so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change ***,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat ***,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually ***,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM *** result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：