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Fatigue Crack Propagation Analysis of Orthotropic Steel Bridge with Crack Tip Elastoplastic Consideration

Computer Modeling in Engineering & Sciences 2021年第5期127卷 549-574页

作者： ying Wang Zheng yan Zhen Wang Jiangsu Key Laboratory of Engineering Mechanics Southeast UniversityNanjing211189China China Railway Major Bridge Reconnaissance and Design Institute Co. Ltd.Wuhan430056China

Due to the complex structure and dense weld of the orthotropic steel bridge deck(OSBD),fatigue cracks are prone to occur in the typical welding *** residual stress(WRS)will cause a plastic zone at the crack *** this paper,an elastoplastic constitutive model based on the Chaboche kinematic hardening model was introduced,and the extended finite element method(XFEM)was used to study the influence of material elastoplasticity and crack tip plastic zone on the law of fatigue crack *** judging the stress state of the residual stress field at the crack tip and selecting different crack propagation rate models to investigate the crack propagation law when plastic deformation was considered,the propagation path and propagation rate of fatigue crack of the OSBD were *** results show that,whether the residual stress field is considered or not,the plastic deformation at the crack tip will not cause the obvious closure of the fatigue crack at the U-rib toe during the crack propagation process,but will significantly affect the crack propagation *** material plasticity is considered,the propagation angle of fatigue crack at the U-rib toe basically remains unchanged along the short-axis direction of the initial crack,but is going up along the long-axis direction,and the crack tip plastic zone inhibits the propagation of the crack tip on one *** with linear elastic materials,the crack propagation law considering material plasticity is more consistent with that in actual bridge *** terms of the propagation rate,if the residual stress field is not considered,the fatigue crack propagation rate at U-rib toe with plasticity considered is slightly higher than that without plasticity considered,because plastic deformation will affect the amplitude of energy release *** considering the WRS field,the fatigue crack propagation rate at U-rib toe is increased due to the combined actions of plastic deformation and stress ratio R

关键词： Extended finite element fatigue crack propagation orthotropic steel bridge deck welding residual stress plastic deformation

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基于网络药理学和分子对接技术探讨蒙药梅花草治疗肝损伤的潜在作用机制

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中医康复 2025年第2期2卷 70-75页

作者：张金艳孔梦梦红艳辛颖内蒙古民族大学蒙医药学院内蒙古通辽028000 内蒙古自治区蒙药工程技术研究中心内蒙古通辽028000

目的:应用网络药理学和分子对接技术探究蒙药梅花草治疗肝损伤的作用机制,为梅花草的进一步研究与应用提供参考依据。方法:基于TCMSP和Swiss Target Prediction数据库筛选蒙药梅花草的活性成分及靶点,通过GeneCards和OMIM数据库查找肝... 详细信息

目的:应用网络药理学和分子对接技术探究蒙药梅花草治疗肝损伤的作用机制,为梅花草的进一步研究与应用提供参考依据。方法:基于TCMSP和Swiss Target Prediction数据库筛选蒙药梅花草的活性成分及靶点,通过GeneCards和OMIM数据库查找肝损伤的相关靶点,再将梅花草活性成分靶点与疾病靶点映射,采用Cytoscape 3.8.0绘制PPI网络构建图,并进行GO功能富集和KEGG通路富集分析,进一步构建活性成分-靶点-信号通路网路图,最后运用AutoDock软件将蒙药梅花草主要活性成分与肝损伤核心靶点进行分子对接。结果:通过筛选得到梅花草活性成分28个;药物与疾病共同作用靶点751个;蛋白互作用网络中核心靶点为TP53(肿瘤蛋白P53)、SRC(酪氨酸蛋白激酶)、HSP90AA1(蛋白质编码基因)、AKT1(丝氨酸/苏氨酸蛋白激酶)、MAPK3(丝裂原活化蛋白激酶3)、STAT3(信号转导子和转录激活子3)、CTNNB1(β-连环蛋白)、MAPK1(丝裂原激活的蛋白激酶1)、EGFR(人表皮生长因子受体)、EP300(E1A结合蛋白P300)等。分子对接结合能均<-7kcal/mol,表明药物活性成分与靶点蛋白对接效果良好,与网络药理预测结果相符。结论:蒙药梅花草以多成分、多靶点、多通路的复杂形式发挥治疗肝损伤的作用,TP53、AKT1、MAPK1、MAPK3等可能参与其中。

关键词：蒙药梅花草肝损伤网络药理分子对接

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Bifidobacterium infantis regulates the programmed cell death 1 pathway and immune response in mice with inflammatory bowel disease

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World Journal of Gastroenterology 2022年第26期28卷 3164-3176页

作者： Lin-yan Zhou ying Xie yan Li Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)is caused by an abnormal immune *** cell death 1(PD-1)is an immunostimulatory molecule,which interacts with PD ligand(PD-L1)playing a prime important role among autoimmune *** infantis(***)can promote the differentiation of CD(cluster of differentiation)4^(+)T cells into regulatory T cells(Tregs).Tregs participate in the development of IBD and may be related to disease *** amplify the expression level of PD-1,PD-L1 and Tregs’nuclear transcription factor forkhead box protein 3(Foxp3).But the mechanism of *** on PD-1/PD-L1 signaling remains *** To explore the mechanism of *** regulating the immune response in *** Forty-eight-week-old BALB/c mice were randomly divided into five groups:The control group,dextran sulphate sodium(DSS)model group,DSS+*** group,DSS+***+anti-PD-L1 group,and DSS+anti-PD-L1 *** control group mice were given drinking water freely,the other four groups were given drinking water containing 5%DSS *** control group,DSS model group,and DSS+anti-PD-L1 group were given normal saline(NS)400μL daily by gastric lavage,and the DSS+*** group and DSS+***+anti-PDL1 group were given NS and 1×109 colony-forming unit of *** daily by gastric *** DSS+***+anti-PD-L1 group and DSS+anti-PD-L1 group were given 200μg of PD-L1 blocker intraperitoneally at days 0,3,5,and 7;the control group,DSS+anti-PD-L1 group,and DSS+*** group were given an intraperitoneal injection of an equal volume of phosphate buffered saline(PBS).Changes in PD-L1,PD-1,Foxp3,interleukin(IL)-10,and transforming growth factorβ(TGF-β)1 protein and gene expression were *** cytometry was used to observe changes in CD4^(+),CD25^(+),Foxp3^(+)cell numbers in the blood and *** Compared to the control group,the expression of PD-1,Foxp3,IL-10,and TGF-β1 was significantly decreased in the int

关键词： Bifidobacterium infantis Enteritis Programmed cell death ligand T-Lymphocytes

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Seasonal Predictions of Summer Precipitation in the Middle-lower Reaches of the yangtze River with Global and Regional Models Based on NUIST-CFS1.0

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Advances in Atmospheric Sciences 2022年第9期39卷 1561-1578页

作者： Wushan ying Huiping yan Jing-Jia LUO Institute for Climate and Application Research(ICAR)/ILCEC Key Laboratory of Meteorological DisasterNanjing University of Information Science and TechnologyNanjing 210044China

Accurate prediction of the summer precipitation over the middle and lower reaches of the yangtze River(MLYR)is of urgent demand for the local economic and societal *** study assesses the seasonal forecast skill in predicting summer precipitation over the MLYR region based on the global Climate Forecast System of Nanjing University of Information Science and Technology(NUIST-CFS1.0,previously SINTEX-F).The results show that the model can provide moderate skill in predicting the interannual variations of the MLYR rainbands,initialized from 1 *** addition,the nine-member ensemble mean can realistically reproduce the links between the MLYR precipitation and tropical sea surface temperature(SST)anomalies,but the individual members show great discrepancies,indicating large uncertainty in the ***,the NUIST-CFS1.0 can predict five of the seven extreme summer precipitation anomalies over the MLYR during 1982-2020,albeit with underestimated *** Weather Forecast and Research(WRF)downscaling hindcast experiments with a finer resolution of 30 km,which are forced by the large-scale information of the NUIST-CFS1.0 predictions with a spectral nudging method,display improved predictions of the extreme summer precipitation anomalies to some ***,the performance of the downscaling predictions is highly dependent on the global model forecast skill,suggesting that further improvements on both the global and regional climate models are needed.

关键词： seasonal forecast summer precipitation global climate model WRF downscaling

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An Azoester-containing Photoresponsive Linear Liquid Crystal Polymer with Good Mesophase Stability

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Chinese Journal of Polymer Science 2020年第8期38卷 806-813,I0005页

作者： Shu-Qiang Han ying-ying Chen Bo Xu Jia Wei yan-Lei Yu Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200433China

Photoresponsive linear liquid crystal polymers(LLCPs)are attractive because of the excellent stimuli-responsibility and the good *** this study,a new photoresponsive LLCP containing azoester(PC11AE6)with good mesophase stability was synthesized by ringopening metathesis *** introducing photoresponsive azoester mesogenic unit,which has high rigidity and a large lengthdiameter ratio,the resultant polymer possesses a broad mesophase temperature interval(isotropic temperature=180℃).A study on mesophase by 2D-wide angle X-ray diffraction indicated that the mesogens were orientated spontaneously into smectic A phase after *** orientated films and fibres exhibited macroscopic,rapid and reversible deformations under light irradiation as a result of the photoisomerization of azoester as confirmed by UV-Vis absorption *** anticipate that this work provides a strategy for preparing LLCP with a broad mesophase temperature range,which is positive for potential applications.

关键词： Ring-opening metathesis polymerization Liquid crystal polymers Azoester Photodeformation

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Molecular recognition and biological application of modified β-cyclodextrins

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Science China Chemistry 2019年第5期62卷 549-560页

作者： ying-Ming Zhang Qiao-yan Xu Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The molecular recognition based on cyclodextrins(CDs) has become a focus of interest in modern supramolecular *** are known to encapsulate various ions and organic/inorganic molecules in their hydrophobic cavities and form stable inclusion complexes through cooperative noncovalent interactions. During the past few decades, a large variety of modified CDs have been elaborately designed and synthesized, which significantly promotes our molecular-level understanding of the structure–function relationship in many supramolecular systems. Through the accurate analysis on the molecular binding behaviors, one can create a library of CD-based nanoassemblies with controlled physicochemical properties. In this review, we will focus on the stability constant-directed molecular recognition and the biological activities of β-CDs toward some representative bioactive substrates, including metal ions, steroids, porphyrins, amino acids and oligopeptides, as well as drug molecules, with the final goal of promoting their practical applications in the biomedical field.

关键词： Host-guest chemistry molecular recognition cyclodextrin biological function

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Design of adiabatic two's complement multiplier-accumulator based on CTGAL

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 172-178页

作者： Peng-jun WANG Jian XU Shi-yan ying Institute of Circuits and Systems Ningbo University Ningbo 315211 China College of Information Engineering Zhej iang University of Technology Hangzhou 310014 China

We propose a new design scheme for a Booth encoder based on clocked transmission gate adiabatic logic(CTGAL). In the new design the structural complexity of the Booth encoder is reduced while the speed of the multiplier is improved. The adiabatic two's complement multiplier-accumulator(MAC) is furthermore a design based on the CTGAL. The computer simulation results indicate that the designed circuit has the correct logic function and remarkably less energy consumption compared to that of the MAC based on complementary metal oxide semiconductor(CMOS) logic.

关键词： CTGAL circuit Adiabatic circuit Booth arithmetic Multiplier Two's complement MAC

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Crystal Structure and Characterization of Bis(4-isoniazidylthioformyl) Disulfide Hydration Sodium Coordination Polymer:n[(4-Pyridyl-CONHNCS_2)_2^(2-)]·[Na_2(H_2O)_8^(2+)]_n

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Chinese Journal of Structural Chemistry 2006年第6期25卷 740-746页

作者： WANG ying BEI Feng-Li yan Lian-He School of Chemical Engineering Nanjing Universityof Science and Technology Nanjing 210094 China

The title compound has been prepared and characterized by elemental analysis, infrared spectra, NMR and thermal analyses, and its crystal structure was determined by X-ray diffraction method. The crystal crystallizes in the monoclinic system, space group C2/c with a = 2.3066（5）, b = 0.53320（ 11）, c = 2.3236（5） nm,β= 102.76（3）°, V = 2.7872（ 10） nm^3, Mr = 612.67, Z = 4, Dc = 1.460 g/cm^3, R = 0.0570 and wR = 0.1271. In the title compound, two 4-isoniazidylthioformyl units are bridged by S-S bond （0.2037（3） nm）. The Na ions are linked by O（4）, O（4A）, O（1） and O（1A） to form a one-dimensional hydration sodium coordination polymer. The Na ion is coordinated by a meridional arrangement of the six O atoms to assume a slightly distorted octahedron as a result of intermolecular hydrogen bonds. The thermal analytical data indicate that it decomposes completely at the temperature of 609.26 ℃.

关键词： crystal structure bridging isoniazide coordination polymer

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Multi-style video stylization based on texture advection

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Science China(Information Sciences) 2015年第11期58卷 90-102页

作者： TANG ying ZHANG yan SHI Xiaoying FAN Jing School of Computer Science and Technology Zhejiang University of Technology Key Laboratory of Visual Media Intelligent Process Technology of Zhejiang Province School of Software Engineering Hangzhou Dianzi University

Artistic video stylization, which is widely used in multimedia entertainment, transforms a given video into different artistic styles. Most of the existing video stylization algorithms can simulate single or limited video artistic styles. Although some algorithms can achieve multi-style video processing, these algorithms are complex and difficult to implement. To solve this problem, we propose a multi-styled video stylization algorithm based on texture advection, where different artistic styles are synthesized and transferred from user-specified texture samples of desired styles. We use the direction field-guided texture synthesis to compute the texture layer that represents the artistic style. Painterly directional video styles are simulated competently by the orientation changes in the synthesized anisotropic textures. There appeared local distorted region of the texture layer during texture advection under the optical flow field. To address this issue, we propose the texture inpaint to synthesize the limited distorted region and make the stylized video temporally coherent. We also accelerate the video stylization by using the CUDA parallel computing framework that parallelly computes the morphological operations used for video abstraction. Finally, we produce stylized videos of multiple artistic styles with satisfactory experimental results, including the styles of oil painting, watercolor painting and stylized lines drawing.

关键词： non-photorealistic rendering video stylization texture synthesis direction field CUDA

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Investigation of Geiger-mode detector in multi-hit model for laser ranging

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Science China(Technological Sciences) 2015年第5期58卷 943-950页

作者： ZHAO Peng ZHANG yan QIAN WeiPing XUAN ying Beijing Institute of Tracking and Telecommunications Technology Key Laboratory of Space Object Measurement China Defense Science and Technology Information Center

The performance of detector limits the overall performance of laser ranging system. And the design of multi-hit detector is one of the feasible ways to promote the performance of detector. Currently, the segmentation method or the recursive method is commonly used to analyze the multi-hit detector model. To the best of our knowledge, this paper is the first to propose a combinatorial method to solve the multi-hit detector model from the perspective of discrete time. Then, universal formulas of total signal detection probability and the average count are deduced based on the Poisson distribution signal. Furthermore, analysis is made to figure out how the average count changes with different parameters, such as the dead time, gating time, rate intensity. As a result, for GM-APD, the multi-hit detector model is verified advantageously compared to the single-hit detector model in improving the average count theoretically. Meanwhile, a discrete step feature is presented when average count changes with dead time or the gating time, which is of great significance in gating time optimization.

关键词： segmentation gating verified recursive combinatorial deduced figure trigger feasible universal

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