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Screening Safflower Injection for Constituents with Activity against Stroke Using Comprehensive Chemical Profiling Coupled with Network Pharmacology

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World Journal of Traditional Chinese Medicine 2021年第3期7卷 347-360页

作者： xin-Yue Shi Qiu-Yun Miao xin-Guang liu Ping Li Wen Gao State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjingChina

Objective:This study aimed to explore safflower injection(SI)for constituents with activity against ischemic stroke using a combination of chemical analysis and a network pharmacology *** and Methods:The main ingredients of SI were comprehensively identified using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry,and the core targets and pathways associated with stroke were predicted using PharmMapper and Kyoto Encyclopedia of Genes and Genomes *** software was used to visualize and analyze the active compound-target-pathway network of SI regulating ischemic ***:A total of76 chemical compounds were identified from the SI sample,including 63,which regulated 88 targets that were ultimately enriched in 12 key ischemia stroke-related signaling ***-3-O-sophoroside,kaempferol-3-O-rutinoside,carthamoside B6,neoeriocitrin,and6-hydroxykaempferol-3-O-rutinoside-6-O-glucoside were determined to be important for stroke treatment because they had a higher degree value in the network than other constituents ***,the characteristic components isolated from SI showed protective effect mainly by acting on multiple targets including AKT1,epidermal growth factor receptor,transforming growth factor-beta receptor(TGFBR),Ras homolog,mTORC1 binding,caspase 3,and glycogen synthase kinase 3 beta,which were involved in different signaling pathways including phosphoinositide 3-kinase-Akt,mitogen-activated protein kinase,neurotrophin,ErbB,mechanistic target of rapamycin,and tumor necrosis ***:This study proposed a network pharmacology and chemical component profiling strategy for the systematic understanding of the therapeutic material basis of using SI against ischemic stroke.

关键词： Chemical composition ischemic stroke network pharmacology safflower injection ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

Robust interface layers with redox shuttle reactions suppress the dendrite growth for stable solid-state Li metal batteries

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Journal of Energy Chemistry 2020年第12期29卷 222-229页

作者： Shuaibo Zeng Gowri Manohari Arumugam Wentao Li Xiahu liu xin Li Hai Zhong Fei Guo Yaohua Mai Institute of New Energy Technology College of Information Science and TechnologyJinan UniversityGuangzhou 510006GuangdongChina National Engineering Research Center for Advanced Polymer Processing Technology Zhengzhou UniversityZhengzhou 450000HenanChina

Designing a durable lithium metal anode for solid state batteries requires a controllable and uniform deposition of lithium, and the metal lithium layer should maintain a good interface contact with solid state electrolyte during cycles. In this work, we construct a robust functional interface layer on the modified LiB electrode which considerably improves the electrochemical stability of lithium metal electrode in solid state batteries. It is found that the functional interface layer consisting of polydioxolane, polyiodide ion and Li TFSI effectively restrains the growth of lithium dendrites through the redox shuttle reaction of I-/I3-and maintains a good contact between lithium anode and solid electrolyte during cycles. Benefit from these two advantages, the modified Li-B anode exhibits a remarkable cyclic performance in comparison with those of the bare Li-B anode.

关键词： Redox shuttle reaction Robust interface layer Lithium dendrites Long-lasting effect Solid-state batteries

Compaction Performance of Biomimetic Press Roller to Soil

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Journal of Bionic Engineering 2015年第1期12卷 152-159页

作者： Jin Tong Qingzhu Zhang Li Guo Yuan Chang yingjie Guo Fengwu Zhu Donghui Chen xin liu The Key Laboratory of Bionic Engineering (Ministry of Education of China) Jilin University Changchun 130025 China The College of Biological and Agricultural Engineering Jilin University Changchun 130025 China. The School of Engineering Huzhou University Huzhou 313000 China The College of Engineering Technique Jilin Agriculture University Changchun 130118 China

The compaction characteristics of biomimetic press roller with ridge structures, inspired from the geometrical features of the ventral surface of dung beetle （Copris ochus Motschulsky）, were investigated in this work. Field tests were carried out at three weights （300 N, 500 N and 700 N） and two forward velocities （0.64 m·s^-1 and 1.04 m·s^-1） for biomimetic press roller and conventional press roller. To determine compaction performance, rolling resistance, soil bulk density, soil moisture content, emergence rate and percent change of plant spacing were measured. Roller weight was proved to be the major contributory factor on soil compaction. Biomimetic press roller decreased rolling resistance by 2.98% -17.69% at the velocity of 0.64 m·s^-1, and by 6.59% -18.57% at the velocity of 1.04 m·s^-1 compared with the conventional press roller. Both biomimetic roller and conventional roller can achieve proper bulk density for corn seeds under the experimental conditions. However, compared with the conventional roller, biomimetic roller helped soil conserve more moisture. The highest emergence rate was found when the biomimetic roller worked with a weight of 700 N and velocity of 0.64 m·s^-1. Percent change of plant spacing was lower using the biomimetic press roller compared with that using the conventional roller, because that adjacent ridge structures of the biomi- metic roller can well constrain the flow of soil during compacting process.

关键词： press roller soil compaction biomimetics geometrical structure compaction performance

Lipid-albumin nanoassemblies co-loaded with borneol and paclitaxel for intracellular drug delivery to C6 glioma cells with P-gp inhibition and its tumor targeting

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Asian Journal of Pharmaceutical Sciences 2015年第5期10卷 363-371页

作者： Bo Tang Guihua Fang ying Gao Yi liu Jinwen liu Meijuan Zou Lihong Wang Gang Cheng School of Pharmacy Shenyang Pharmaceutical University103Wenhua RoadShenyang 110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical University103Wenhua RoadShenyang 110016China

Successful chemotherapy with paclitaxel(PTX)is impeded by multidrug resistance(MDR)in tumor *** this study,lipid-albumin nanoassemblies co-loaded with borneol and paclitaxel(BOR/PTX LANs)were prepared to circumvent MDR in C6 glioma *** physiochemical properties including particle size,encapsulation efficiency and morphology were evaluated in *** and qualitative investigations of cellular uptake were carried out in C6 glioma *** cytotoxicity of the BOR/PTX LANs was determined by MTT *** that,the tumor targeting was also evaluated in C6 glioma bearing mice by in vivo imaging ***/PTX LANs have a higher entrapment efficiency(90.4±1.2%),small particle size(107.5±3.2 nm),narrow distribution(P.I.=0.171±0.02).The cellular uptake of PTX was significantly increased by BOR/PTX LANs compared with paclitaxel loaded lipidalbumin nanoassemblies(PTX LANs)in quantitative *** result was further confirmed by confocal laser scanning microscopy *** cellular uptake was energy-,timeand concentration-dependent,and clathrin-and endosome/lysosome-associated pathways were *** BOR/PTX LANs displayed a higher cytotoxicity agaist C6 glioma cells in comparion with PTX LANs and ***,the encapsulation of BOR in LANs obviously increased the accumulation of the drug in tumor tissues,demonstrating the tumor targeted ability of BOR/PTX *** results indicated that BOR/PTX LANs could overcome MDR by combination of drug delivery systems and P-gp inhibition,and shown the potential for treatment of gliomas.

关键词： Borneol Paclitaxel Lipid-albumin nanoassemblies C6 glioma cells P-gp inhibition

Experimental measurement of bipartite entanglement using parameterized quantum circuits

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Science China(Physics,Mechanics & Astronomy) 2022年第8期65卷 73-84页

作者： Shunzhong Xue Yulei Huang Dafa Zhao Chao Wei Jun Li ying Dong Jiancun Gao Dawei Lu Tao xin Gui-Lu Long State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing100084China Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and TechnologyShenzhen518055China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China Research Center for Quantum Sensing Zhejiang LabHangzhou311121China Frontier Science Center for Quantum Information Beijing100084China Beijing National Research Center for Information Science and Technology Beijing100084China Beijing Academy of Quantum Information Sciences Beijing100193China

Entanglement in quantum systems plays a crucial role in various quantum information tasks. Measuring entanglement has been an important issue in both experiments and theories. In this work, we use parameterized quantum circuits(PQCs) to diagonalize density matrices of quantum states and obtain entanglement by only measuring the diagonal elements. With this method, full quantum state tomography can be bypassed, greatly reducing the number of measurements. A comprehensive characterization of entanglement was performed by using Rényi entropy and partially transposed moments. Mutual information, calculated from entropy is also used to characterize dynamical quantum phase transitions. We experimentally demonstrated the method on a four-qubit nuclear magnetic resonance quantum simulator. Our results agree with the theoretical descriptions. The measurement complexity of our PQC-based method grows linearly with the number of diagonal elements in the density matrix, a square root reduction over the full quantum tomography. The proposed method can have great potential in quantum systems with a large number of particles.

关键词： quantum information entanglement characterization quantum tomography

Effect prediction of stiffened-ring cylindrical shells subjected to drop mass impact

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Defence Technology（防务技术） 2022年第2期18卷 305-323页

作者： Sheng-zhuo Lu Jing-xin Ma Lan liu Chun-long Xu Shi-bo Wu Wei-dong Chen College of Aerospace and Civil Engineering Harbin Engineering UniversityHarbin150001PR China

This study focuses on the effect of lateral mass impact on ring-stiffened thin-walled cylindrical *** shells were fabricated to validate the numerical modeling and analytical techniques,and drop tests were performed using a rigid spherical ***,stiffened-ring cylindrical shells with various structural size parameters were simulated using ABAQUS *** relationships between the impact force,deformation displacement,and rebound velocity were established,on the basis of impact mechanics theory and simulation *** derived fitting functions to analyse the relationship between the maximum load and maximum displacement of ring-stiffened cylindrical shell under dynamic mass *** on the validation of the simulation model,the fitting function data were compared with the simulation results,and the functions showed a good ***,the parameters,mass ratio and stiffened-ring mass ratio were used to reflect the effect of the mass change in the ring-stiffened cylindrical ***,parametric studies on ring-stiffened cylindrical shell models were conducted to analyse the progressive impact responses.

关键词： Drop mass impact Stiffened ring Cylindrical shell Impact load Dynamic response Parametric studies

Wetting and corrosion behavior between magnesia-carbon refractory and converter slags with different MgO contents

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Journal of Iron and Steel Research International 2022年第7期29卷 1073-1079页

作者： Rui-qiang Bai Si-yang liu Fei-xiong Mao Yuan-yuan Zhang xin Yang Zhi-jun He School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina Ningbo Key Laboratory of Marine Protection Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201ZhejiangChina

The influence of MgO content in slag on wetting and corrosion behavior between slag and MgO–C refractory was *** can be known from the high-temperature wetting experiment that as the MgO content in the slag increases,the final contact angle between the slag and the MgO–C refractory gradually increases and the penetration depth of the slag into the refractory gradually decreases from 60.54μm(when the MgO content is 8%)to 28.11μm(when the MgO content is 12%).The CaO and SiO_(2)in the slag penetrate into the MgO–C refractory along the pores or surface cracks formed by carbon oxidation and react with MgO to generate a large amount of low-melting compound CaO–MgO–SiO_(2),which accelerates the corrosion of the *** the MgO content in slag increases,the viscosity of the slag increases and the fluidity becomes worse,so that the mass transfer and diffusion of molecules or ions in the slag are *** addition,the increase in MgO reduces the activity of FeO in the slag,which inhibits the interfacial chemical reaction,thereby weakening the wetting effect caused by the reaction.

关键词： Converter slag MgO–C refractory MgO content Wetting Corrosion

Heteroatom tuning in agarose derived carbon aerogel for enhanced potassium ion multiple energy storage

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Carbon Energy 2024年第3期6卷 239-254页

作者： Kaijun Xie xin liu Haolin Li Long Fang Kai Xia Dongjiang Yang Yihui Zou Xiaodong Zhang State Key Laboratory of Bio-fibers and Eco-textiles Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsCollege of Chemistry and Chemical EngineeringCollege of Environmental Science and EngineeringQingdao UniversityQingdaoChina

The incorporation of heteroatoms into carbon aerogels(CAs)can lead to structural distortions and changes in active sites due to their smaller size and electronegativity compared to pure ***,the evolution of the electronic structure from single-atom doping to heteroatom codoping in CAs has not yet been thoroughly investigated,and the impact of codoping on potassium ion(K+)storage and diffusion pathways as electrode material remains *** this study,experimental and theoretical simulations were conducted to demonstrate that heteroatom codoping,composed of multiple heteroatoms(O/N/B)with different properties,has the potential to improve the electrical properties and stability of CAs compared to single-atom *** states near the Fermi level have revealed that doping with O/N/B generates a greater number of active centers on adjacent carbon atoms than doping with O and O/N *** a result of synergy with enhanced wetting ability(contact angle of 9.26°)derived from amino groups and hierarchical porous structure,ON-CA has the most optimized adsorption capacity(−1.62 eV)and diffusion barrier(0.12 eV)of K^(+).The optimal pathway of K^(+)in ON-CA is along the carbon ring with N or O *** K^(+)storage material for supercapacitors and ion batteries,it shows an outstanding specific capacity and capacitance,electrochemical stability,and rate ***,the assembled symmetrical K^(+)supercapacitor demonstrates an energy density of 51.8 Wh kg^(−1),an ultrahigh power density of 443Wkg^(−1),and outstanding cycling stability(maintaining 83.3%after 10,000 cycles in 1M KPF6 organic electrolyte).This research provides valuable insights into the design of highperformance potassium ion storage materials.

关键词： agarose carbon aerogels O/N/B codoping potassium-ion battery potassium-ion supercapacitor

Tailoring the microstructure and mechanical properties of the final Al-Mn foils by different intermediate annealing process

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Journal of Materials Science & Technology 2017年第9期33卷 961-970页

作者： Li Huang Guangjie Huang Yunchang xin Lingfei Cao Xiaodong Wu Zhihong Jia Qilei Li Qing liu College of Materials Science and Engineering Chongqing University

In this work, two different intermediate annealing processes, single-step annealing（SSA, 530?C/15 h）and two-step annealing（TSA, 450?C/5 h + 530?C/15 h）, were used to tailor microstructure before coldrolling and annealing of the final twin-roll cast Al-Mn foils. The recrystallization behavior and mechanical properties during annealing of severely cold-rolled foils were systematically studied. Our results show that discontinuous recrystallization occurs in SSA-foils during annealing at 150–310?C, in contrast with continuous recrystallization in TSA-foils. The continuous recrystallization develops much finer grains（;.35 μm） in the TSA-foils than those by discontinuous recrystallization in the SSA-foils（;4.7 μm）. The texture components in cold-rolled TSA-foils hardly change（retained rolling-textures） after continuous recrystallization, while those in the cold-rolled SSA-foils mainly transform into a strong cube component{001} after discontinuous recrystallization. Finally, a maximized elongation to fracture of;3.9%was achieved in the TSA-foil, much higher than that of the SSA-counterparts,;.3%. The relationships between the microstructure and mechanical properties were discussed.

关键词： Al-Mn alloys Foil Annealing Recrystallization mechanism Size effect Mechanical property