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Code Component Composition Reuse Is a New Programming Paradigm

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wuhan university Journal of Natural Sciences 2001年第Z1期6卷 292-297页

作者： ying shi 1,yuan sheng qiong 1,xu gang 1,He Ke Qing 2 1.State key laboratory of software engineering, wuhan university, wuhan 430072, china 2.School of Computer Science and Technology, wuhan university, wuhan 430072, china State key laboratory of software engineering Wuhan University Wuhan China School of Computer Science and Technology Wuhan University Wuhan China

After describing the characteristics of programming paradigm, this paper introduces the approach of code component composition reuse in detail, proposes and discusses viewpoint that code component composition reuse is a kind of new programming paradigm. This paper also specifies the characteristics of this new programming paradigm in detail, and points out some issues that must be resolved for using this new programming paradigm.

关键词： programming paradigm code component code component composition reuse

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui chen LI Yan ZHANG Jun Feng LIU sheng Hui HU Dan He xu Chong Xiao YIN Jia Yu YIN Qi Kai HE ying LI Fan FU shi Hong NIE Kai LIANG Guo Dong TAO Yong xu Song Tao MA Chao Feng WANG Huan Yu Shaanxi university of Chinese Medicine Xianyang 712000ShaanxiChina National key laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca^(2+)-dependent AMPK/mTOR pathway

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 420-434页

作者： Liu-Hui Huang Jiao Lyu sheng chen Ting-Yi Liang Yu-Qing Rao Ping Fei Jing Li Hai-ying Jin Pei-Quan Zhao Department of Ophthalmology Shanghai Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Ophthalmology Shanghai Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVictoria 3002Australia Shenzhen Eye Hospital Shenzhen Key Laboratory of OphthalmologyAffiliated Shenzhen Eye Hospital of Jinan UniversityShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

●AIM:To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells(LECs)under hyperosmotic stress.●METHODS:LECs were treated with hyperosmotic stress at the concentration of 270,300,400,500,or 600 mOsm for 6,12,18,24h in *** chain reaction(PCR)was employed for the mRNA expression of autophagyrelated genes,while Western blotting detected the targeted protein *** transfection of stub-RFP-sens-GFPLC3 autophagy-related double fluorescence lentivirus was conducted to detect the level of autophagy *** electron microscopy was used to detect the existence of *** interfering RNA of autophagy-related gene(ATG)7,transient receptor potential vanilloid(TRPV)1 overexpression plasmid,related agonists and inhibitors were employed to their influence on autophagy related *** cytometry was employed to test the apoptosis and intracellular Ca^(2+)*** membrane potential was measured by JC-1 *** cell counting kit-8 assay was used to calculate the cellular *** wound healing assay was used to evaluate the wound closure *** 6.0 software was utilized to evaluate the data.●RESULTS:The hyperosmotic stress activated autophagy in a pressure-and time-dependent manner in *** 1 protein expression and conversion of LC3B II to LC3B I increased,whereas sequestosome-1(SQSTM1)protein expression *** Ca^(2+)influx was stimulated caused by hyperosmotic stress,levels of mammalian target of rapamycin(mTOR)phosphorylation decreased,and the level of AMP-activated protein kinase(AMPK)phosphorylation increased in the early *** on this evidence,autophagy activation through the Ca^(2+)-dependent AMPK/mTOR pathway might represent an adaptation process in LECs under hyperosmotic *** stress decreased cellular viability and accelerated apoptosis in LECs and cellular migration *** of autophagy by ATG7 knockdown had sim

关键词： cataract posterior capsular opacification lens epithelial cell hyperosmotic stress autophagy apoptosis transient receptor potential vanilloid 1

The In-Flight Realtime Trigger and Localization software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-yuan Liao Yan-Qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang Jing Duan chen-Wei Wang Dong-Li shi Peng Zhang Qi-Bin Yi Chao-Yang Li Yan-Bing xu Xiao-Hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang gang chen Huan-Yu Wang sheng Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-chen xue Chao Zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-ying Song Li-Ming Song shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-yuan Yang Zhi-Long Wen Zhi Chang yuan-yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li gang Li xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng shi Hui Wang Hui-Zhen Wang Yu-Peng xu Jia-Wei Yang xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang cheng-Mo Zhang Zhi-cheng Tang cheng cheng key laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China key laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Optimal Policies for Quantum Markov Decision Processes

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International Journal of Automation and computing 2021年第3期18卷 410-421页

作者： Ming-sheng ying yuan Feng sheng-gang ying Centre for Quantum software and Information University of Technology SydneyNSW 2007Australia State key laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China

Markov decision process(MDP)offers a general framework for modelling sequential decision making where outcomes are *** particular,it serves as a mathematical framework for reinforcement *** paper introduces an extension of MDP,namely quantum MDP(q MDP),that can serve as a mathematical model of decision making about quantum *** develop dynamic programming algorithms for policy evaluation and finding optimal policies for q MDPs in the case of *** results obtained in this paper provide some useful mathematical tools for reinforcement learning techniques applied to the quantum world.

关键词： Quantum Markov decision processes quantum machine learning reinforcement learning dynamic programming decision making

基于指纹图谱结合化学模式识别法评价不同产地蒲桃叶药材质量

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天然产物研究与开发 2024年第9期36卷 1564-1572页

作者：魏爱红曾伟龙区泳茵聂华曾煌庄远杯张声源嘉应学院广东省山区特色农业资源保护与精准利用重点实验室梅州514015 嘉应学院医学院客家药用生物资源研究所梅州514031

建立蒲桃叶HPLC指纹图谱并指认其中2种成分,结合主成分和聚类分析对不同产地蒲桃叶综合品质进行分析,为其质量评价提供理论和数据基础。采用Sonoma C_(18)(2)(4.6 mm×250 mm,5μm)色谱柱,0.1%甲酸水-甲醇为流动相,梯度洗脱,检测波长290... 详细信息

建立蒲桃叶HPLC指纹图谱并指认其中2种成分,结合主成分和聚类分析对不同产地蒲桃叶综合品质进行分析,为其质量评价提供理论和数据基础。采用Sonoma C_(18)(2)(4.6 mm×250 mm,5μm)色谱柱,0.1%甲酸水-甲醇为流动相,梯度洗脱,检测波长290 nm,流速1.0 mL/min,进样量10μL,柱温30℃,采用《中药色谱指纹图谱相似度评价系统(2012版)》进行相似度评价,确定共有峰。采用SPSS 22.0统计软件进行聚类分析、主成分分析,建立不同产地蒲桃叶的综合评价表。10批蒲桃叶HPLC指纹图谱标定12个共有峰,指认了2种化学成分,1号峰为没食子酸,4号峰为对羟基苯甲酸。10批蒲桃叶可聚为三类,茂名产蒲桃叶聚为一类,肇庆蒲桃叶聚为一类,其余地区产蒲桃叶聚为一类。主成分、因子分析表明肇庆蒲桃叶质量总体优于其他产地,1、2、4、5、6、12共有峰可作为蒲桃叶质量评价主要成分。10批样品相似度为0.591~0.994,表明不同批次蒲桃叶样品存在差异。所建HPLC指纹图谱和含量测定方法简便、稳定性好,结合化学模式可为蒲桃叶药材质量控制与评价提供参考。

关键词：蒲桃叶 HPLC指纹图谱相似度聚类分析主成分分析

BENCHIP： Benchmarking Intelligence Processors

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Journal of Computer Science & Technology 2018年第1期33卷 1-23页

作者： Jin-Hua Tao Zi-Dong Du Qi Guo Hui-ying Lan Lei Zhang sheng-yuan Zhou Ling-Jie xu Cong Liu Hai-Feng Liu Shah Tang Allen Rush Willian chen Shao-Li Liu Yun-Ji chen Tian-shi chen State key laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China School of Computer and Control engineering University of Chinese Academy of Sciences Beijing 100049 China Intelligent Processor Research Center Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China Cambricon Ltd. Beijing 100190 China A libaba Infrastructure Service A libaba Group Hangzhou 311121 China Iflytek Co. Ltd. Hefei 230088 China Beijing Jingdong Century Trading Co. Ltd. Beijing 100176 China RDA Microdectronics Inc. Shanghai 201203 China Advanced Micro Devices Inc. Sunnyvale CA 94085 U.S.A.

The increasing attention on deep learning has tremendously spurred the design of intelligence processing hardware. The variety of emerging intelligence processors requires standard benchmarks for fair comparison and system optimization （in both software and hardware）. However, existing benchmarks are unsuitable for benchmarking intelligence processors due to their non-diversity and nonrepresentativeness. Also, the lack of a standard benchmarking methodology further exacerbates this problem. In this paper, we propose BENCHIP, a benchmark suite and benchmarking methodology for intelligence processors. The benchmark suite in BENCHIP consists of two sets of benchmarks： microbenchmarks and macrobenchmarks. The microbenchmarks consist of single-layer networks, They are mainly designed for bottleneck analysis and system optimization. The macrobenchmarks contain state-of-the-art industrial networks, so as to offer a realistic comparison of different platforms. We also propose a standard benchmarking methodology built upon an industrial software stack and evaluation metrics that comprehensively reflect various characteristics of the evaluated intelligence processors, BENCHIP is utilized for evaluating various hardware platforms, including CPUs, GPUs, and accelerators. BENCHIP will be open-sourced soon.

关键词： deep learning intelligence processor benchmark

Transfer synthetic over-sampling for class-imbalance learning with limited minority class data

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Frontiers of Computer Science 2019年第5期13卷 996-1009页

作者： xu-ying LIU sheng-Tao WANG Min-Ling ZHANG School of Computer Science and engineering Southeast University Nanjing 210096 China key laboratory of Computer Network and Information Integration (Southeast university) Ministry of Education Nanjing 210096 China Collaborative Innovation Center for Wireless Communications Technology Nanjing 210096 China

The problem of limited minority class data is encountered in manyclass imbalanced applications, but has received little attention. Synthetic over-sampling, as popular class-imbalance learning methods, could introduce much noise when minority class has limited data since the synthetic samples are not i.i.d. samples of minority class. Mos t sophisticated synthetic sampling methods tackle this problem by denoising or generating samples more consistent with ground-truth data distribution. But their assumptions about true noise or ground-truth data distribution may not hold. To adapt synthetic sampling to the problem of limited minority class data, the proposed Traso framework treats synthetic minority class samples as an additional data source, and exploits transfer learning to transfer knowledge from them to minority class. As an implementation, TrasoBoost method firstly generates synthetic samples to balance class sizes. Then in each boosting iteration, the weights of synthetic samples and original data decrease and increase respectively when being misclassified, and remain unchanged otherwise. The misclassified synthetic samples are potential noise, and thus have smaller influence in the following iterations. Besides, the weights of minority class instances have greater change than those of majority class instances to be more influential. And only original data are used to estimate error rate to be immune from noise. Finally, since the synthetic samples are highly related to minority class, all of the weak learners are aggregated for prediction. Experimental results show TrasoBoost outperforms many popular class-imbalance learning methods.

关键词： machine learning data mining class imbalance over sampling boosting transfer learning

关于社区花园设计的中西方研究综述——基于CiteSpace软件的可视化分析

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湖北科技学院学报 2024年第5期44卷 106-116页

作者：刘瑛伍旭坤郭圣能张妍崔盈盈皖江工学院艺术设计学院安徽马鞍山243001 马鞍山景观生态修复研究重点实验室安徽马鞍山243001 安徽工业大学艺术与设计学院安徽马鞍山243002

在倡导城市更新的新政下,在全球气候变化日趋紧张的今天,社区花园这一概念在理论实践中日益深入人心。基于CiteSpace软件可视化系统重点分析了国内外文献的重要研究,包括关键词、研究方法和主要发现,对社区花园的研究进行了综述。通过分... 详细信息

在倡导城市更新的新政下,在全球气候变化日趋紧张的今天,社区花园这一概念在理论实践中日益深入人心。基于CiteSpace软件可视化系统重点分析了国内外文献的重要研究,包括关键词、研究方法和主要发现,对社区花园的研究进行了综述。通过分析,主要研究了当前社区花园领域的知识结构、研究热点和研究趋势,为应用于社区花园研究理论及其设计实践提供参考,启发针对不同场地、人群、情境、需求的社区花园设计思路。研究表明了社区花园对于改善生物多样性和生态环境治理的重要性,综合考虑对于健康的促进及幸福感的增加,同时公众参与共治共建也促进了社区的认同感和可持续发展。

关键词：社区花园气候变化可持续设计微更新 CiteSpace 公众参与

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