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Nano-Micro Letters 2021年第2期13卷 180-206页

作者： Dongyoon Kim yina wu Qiaoyun Li Yu-Kyoung Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea

We report the activation of anticancer effector functions of T cells through nanoparticle-induced lipid metabolic *** was encapsulated in amphiphilic polygamma glutamic acid-based nanoparticles(F/ANs),and the surfaces of F/ANs were modified with an anti-CD3e f(ab′)2 fragment,yielding aCD3/F/*** in vitro study reveals enhanced delivery of aCD3/F/ANs to T cells compared with plain F/***3/F/AN-treated T cells exhibited clear mitochondrial cristae,a higher membrane potential,and a greater mitochondrial oxygen consumption rate under glucose-deficient conditions compared with T cells treated with other nanoparticle *** proliferatoractivated receptor-αand downstream fatty acid metabolismrelated genes are expressed to a greater extent in aCD3/F/AN-treated T *** of fatty acid metabolism by aCD3/F/ANs supports the proliferation of T cells in a glucose-deficient environment mimicking the tumor ***-time video recordings show that aCD3/F/AN-treated T cells exerted an effector killing effect against B16F10 melanoma *** vivo administration of aCD3/F/ANs can increase infiltration of T cells into tumor *** treatment of tumor-bearing mice with aCD3/F/ANs enhances production of various cytokines in tumor tissues and prevented tumor *** findings suggest the potential of nanotechnology-enabled reprogramming of lipid metabolism in T cells as a new modality of immunometabolic therapy.

关键词： Metabolic reprogramming T cells Fatty acid metabolism Immunometabolic therapy Mitochondrial function

Cell membrane-coated mRNA nanoparticles for enhanced delivery to dendritic cells and immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第6期19卷 123-137页

作者： Qiaoyun Li Junho Byun Dongyoon Kim yina wu Jaiwoo Lee Yu-Kyoung Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea

Cationic polymers such as polyethylenimine have been considered promising carriers for mRNA ***,their application is hindered by their inherent toxicity and a lack of targeted delivery *** issues need to be addressed to develop effective cancer *** this study,we investigated whether dendritic cell membrane-coated polyethylenimine/mRNA nanoparticles(DPN)could effectively deliver mRNA to dendritic cells and induce immune *** comparison,we employed red blood cell membrane-coated polyethylenimine/mRNA(RPN)and plain polyethylenimine/mRNA polyplex(PN).The dendritic cell membrane coating altered the zeta potential values and surface protein patterns of *** demonstrated significantly higher uptake in dendritic cells compared to PN and RPN,and it also showed greater mRNA expression within these ***,carrying mRNA encoding luciferase,enhanced green fluorescent protein,or ovalbumin(OVA),exhibited higher protein expression in dendritic cells than the other ***,DPN exhibited favorable mRNA escape from lysosomes post-internalization into dendritic ***,subcutaneous administration of DPN containing ovalbumin mRNA(DPN_(OVA))elicited higher titers of anti-OVA IgG antibodies and a greater population of OVA-specific CD8^(+)T cells than the other *** a B16F10-OVA tumor model,DPNOVA treatment resulted in the lowest tumor growth among the treated ***,the population of OVA-specific CD8^(+)T cellswas the highest in the DPNOVA-treated *** we demonstrated DPN’s feasibility as an mRNA delivery system in a tumor model,the potential of DPN can be broadly extended for immunotherapeutic treatments of various diseases through mRNA delivery to antigen-presenting cells.

关键词： Cell membrane coating Dendritic cells mRNA delivery Immune response Antitumor effect

Nanomaterials for modulating innate immune cells in cancer immunotherapy

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 16-29页

作者： Quoc-Viet Le Geon Yang yina wu Ho Won Jang Mohammadreza Shokouhimehr Yu-Kyoung Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea

Cancer immunotherapy has been intensively investigated in both preclinical and clinical *** chemotherapies use cytotoxic drugs to kill tumor cells,cancer immunotherapy is based on the ability of the immune system to fight *** are intimately associated with the immune system:they can suppress the immune response and/or control immune cells to support tumor *** has yielded promising results in clinical practice,but some patients show limited *** may reflect the complexities of the relationship between a tumor and the immune *** an effort to improve the current immunotherapies,researchers have exploited nanomaterials in creating new strategies to cure tumors via modulation of the immune system in tumor *** extensive studies have examined the use of immune checkpoint-based immunotherapy,rather less work has focused on manipulating the innate immune *** review examines the recent approaches and challenges in the use of nanomaterials to modulate innate immune cells.

关键词： Cancer immunotherapy Nanomaterials Innate immune cells Tumor-associated macrophages

Early Diagnosis of Bipolar Disorder Coming Soon:Application of an Oxidative Stress Injury Biomarker(BIOS)Model

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Neuroscience Bulletin 2022年第9期38卷 979-991页

作者： Zhiang Niu Xiaohui wu Yuncheng Zhu Lu Yang Yifan Shi Yun Wang Hong Qiu Wenjie Gu yina wu Xiangyun Long Zheng Lu Shaohua Hu Zhijian Yao Haichen Yang Tiebang Liu Yong Xia Zhiyu Chen Jun Chen Yiru Fang Clinical Research Center and Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai200030China Division of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai200083China Information and Statistics Department Shanghai Mental Health CenterShanghai200030China Department of Psychiatry Tongji HospitalTongji University School of MedicineShanghai200333China Department of Psychiatry First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Nanjing Brain Hospital The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing210029China Shenzhen Mental Health Center Shenzhen518003China Affiliated Mental Health Center Zhejiang University School of MedicineHangzhou Seventh People’s HospitalHangzhou310013China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai201108China

Early distinction of bipolar disorder(BD)from major depressive disorder(MDD)is difficult since no tools are available to estimate the risk of *** this study,we aimed to develop and validate a model of oxidative stress injury for predicting *** were collected from 1252 BD and 1359 MDD patients,including 64 MDD patients identified as converting to BD from 2009 through 2018.30 variables from a randomly-selected subsample of 1827(70%)patients were used to develop the model,including age,sex,oxidative stress markers(uric acid,bilirubin,albumin,and prealbumin),sex hormones,cytokines,thyroid and liver function,and glycolipid *** analyses and the Least Absolute Shrinkage and Selection Operator were applied for data dimension reduction and variable *** logistic regression was used to construct a model for predicting bipolar disorder by oxidative stress biomarkers(BIOS)on a *** validation was assessed in the remaining 784 patients(30%),and independent external validation was done with data from 3797 matched patients from five other hospitals in China.10 predictors,mainly oxidative stress markers,were shown on the *** BIOS model showed good discrimination in the training sample,with an AUC of 75.1%(95%CI:72.9%–77.3%),sensitivity of 0.66,and specificity of *** discrimination was good both in internal validation(AUC 72.1%,68.6%–75.6%)and external validation(AUC 65.7%,63.9%–67.5%).In this study,we developed a nomogram centered on oxidative stress injury,which could help in the individualized prediction of *** better real-world practice,a set of measurements,especially on oxidative stress markers,should be emphasized using big data in psychiatry.

关键词： Early recognition Bipolar disorder Big data Oxidative stress BIOS model

Study of brain morphology change in Alzheimer’s disease and amnestic mild cognitive impairment compared with normal controls

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General Psychiatry 2019年第2期32卷 75-83页

作者： Huanqing Yang Hua Xu Qingfeng Li Yan Jin Weixiong Jiang Jinghua Wang yina wu Wei Li Cece Yang Xia Li Shifu Xiao Feng Shi Tao Wang Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China Alzheimer's Disease and Related Disorders Center Shanghai Jiao Tong University Shanghai China Shanghai United Imaging Intelligence Co. Ltd Shanghai China IDEA Lab Department of Radiology and BRIC University of North Carolina at Chapel Hill Chapel Hill NC United States Informational Science and Engineering Department Hunan First Normal University Changsha China

Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer's disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic. Aims The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC). Methods 20 AD patients, 21 aMCIs and 25 NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups. Results The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found. Conclusion AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD.

关键词： brain morphology change amnestic mild cognitive impairment compared aMCI NC

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国内服饰品牌的商品企划现状和趋势研究

服装设计师 2019年第12期 140-145页

作者：吴毅娜天创时尚股份有限公司蹀愫品牌

互联网的出现改变了人们的生活方式。在多元化的消费观念中,消费者对产品的需求逐渐升级,原有商品企划模式下研发的产品较难满足多元化的市场需求,我国服饰品牌在寻求转型期间遇到瓶颈。本文研究了国内服饰品牌的商品企划现状,并对服饰... 详细信息

互联网的出现改变了人们的生活方式。在多元化的消费观念中,消费者对产品的需求逐渐升级,原有商品企划模式下研发的产品较难满足多元化的市场需求,我国服饰品牌在寻求转型期间遇到瓶颈。本文研究了国内服饰品牌的商品企划现状,并对服饰行业的发展趋势加以分析,为国内服饰品牌的商品企划方向提供参考。

关键词：商品企划服饰品牌复兴文化大数据

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面向多用户环境的弹性云缓存系统研究与实现

南京航空航天大学学报 2017年第6期49卷 883-891页

作者：陆悠杜鹏程吴帅吴一娜苏州科技大学电子与信息工程学院苏州215000 东南大学计算机科学与工程学院南京211189

由于在改善网络带宽性能、缓解堵塞、提升用户体验等方面的优势,缓存技术在网络应用中被广泛使用,然而当前越来越多的网络应用迁移至云平台,原来针对单一业务和主机环境的缓存管理机制在面对云计算下多用户、多业务混杂环境时暴露出诸... 详细信息

由于在改善网络带宽性能、缓解堵塞、提升用户体验等方面的优势,缓存技术在网络应用中被广泛使用,然而当前越来越多的网络应用迁移至云平台,原来针对单一业务和主机环境的缓存管理机制在面对云计算下多用户、多业务混杂环境时暴露出诸如不具备多业务类型的普适性、管理策略与云平台的资源配置脱节、未考虑多用户环境下缓存数据的复杂性、重复性等不足,最终影响缓存效果和资源利用效率,因此研究一种面向多用户环境的弹性云缓存系统,首先分析多用户、多业务的云环境对缓存管理的需求特点,提出基于双层映射的缓存存取模型,然后设计缓存系统框架与功能模块,并研究相应的逻辑、物理资源的配置算法及其他功能的实现方案,最后在校园网环境下实现缓存系统并对其进行验证,分析结果表明本文提出的缓存系统能够有效满足用户需求同时提高资源利用率。

关键词：缓存管理云计算双层映射资源配置

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经阴道超声对异位妊娠的诊断价值

中国现代医生 2011年第22期49卷 102-103页

作者：吴伊娜浙江省宁波市北仑区小港医院B超室浙江宁波315801

目的探讨经阴道超声对异位妊娠的诊断价值。方法采用回顾性分析的方法,分析我院收治的异位妊娠超声检查资料,依据检查方式不同分为经腹组和经阴道组。结果经阴道组敏感度、特异度、阳性预测值、阴性预测值均明显高于经腹组,差异均有统... 详细信息

目的探讨经阴道超声对异位妊娠的诊断价值。方法采用回顾性分析的方法,分析我院收治的异位妊娠超声检查资料,依据检查方式不同分为经腹组和经阴道组。结果经阴道组敏感度、特异度、阳性预测值、阴性预测值均明显高于经腹组,差异均有统计学意义(P<0.05)。结论经阴道超声检查无症状异位妊娠可为临床早期诊断和治疗提供可靠的理论依据。

关键词：经阴道超声异位妊娠

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非英语专业学生的写作思辨能力培养研究

文化创新比较研究 2020年第4期4卷 128-130页

作者：吴艺娜厦门大学嘉庚学院大学外语教学部福建漳州363105

近年来关于英语专业学生思辨能力缺席的研究很多,却少有针对非英语专业学生的研究。非英语专业学生的思辨能力现状如何?该研究随机选取某高校40名非专业学生参与批判思维倾向性测试,发现学生思辨能力尚有较大的提升空间,其中分析能力和... 详细信息

近年来关于英语专业学生思辨能力缺席的研究很多,却少有针对非英语专业学生的研究。非英语专业学生的思辨能力现状如何?该研究随机选取某高校40名非专业学生参与批判思维倾向性测试,发现学生思辨能力尚有较大的提升空间,其中分析能力和系统化能力这两个维度得分最低,处于负面倾向值。鉴于此,笔者结合教学实践提出从话题设置、范文评价、写前构思和教师反馈四个方面培养非英语专业学生的写作思辨能力。

关键词：非英语专业学生写作思辨能力批判思维倾向性

彩色多普勒血流显像技术对乳腺肿瘤的诊断价值

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中国现代医生 2011年第21期49卷 96-97,F0003页

作者：吴伊娜浙江省宁波北仑小港医院B超室浙江宁波315801

目的探讨彩色多普勒血流显像技术对乳腺肿瘤的诊断效果。方法回顾性分析乳腺肿瘤患者90例临床资料,依据乳腺肿瘤患者的良性和恶性进行分组。结果良性肿瘤组0级、Ⅰ级比例明显高于恶性肿瘤组,但Ⅱ级、Ⅲ级比例明显低于恶性肿瘤组,恶性肿... 详细信息

目的探讨彩色多普勒血流显像技术对乳腺肿瘤的诊断效果。方法回顾性分析乳腺肿瘤患者90例临床资料,依据乳腺肿瘤患者的良性和恶性进行分组。结果良性肿瘤组0级、Ⅰ级比例明显高于恶性肿瘤组,但Ⅱ级、Ⅲ级比例明显低于恶性肿瘤组,恶性肿瘤组肿瘤内血流丰富比例明显高于良性肿瘤组,良性肿瘤组肿瘤周围血流丰富比例明显高于恶性肿瘤组,差异均有统计学意义(P<0.05)。结论彩色多普勒血流显像技术对乳腺肿瘤良性和恶性的鉴别诊断价值较高,值得临床推广应用。

关键词：彩色多普勒血流显像乳腺肿瘤