Nanomaterials for modulating innate immune cells in cancer immunotherapy

作     者：Quoc-Viet Le Geon Yang Yina Wu Ho Won Jang Mohammadreza Shokouhimehr Yu-Kyoung Oh 

作者机构：College of Pharmacy and Research Institute of Pharmaceutical SciencesSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Materials Science and EngineeringResearch Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2019年第14卷第1期

页      面：16-29页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by research grants from the Ministry of Science and Future Planning,Republic of Korea(NRF2018R1A2A1A05019203 NRF-2018R1A5A2024425) the Korean Health Technology R&D Project(No.HI15C2842),Ministry of Health&Welfare,Republic of Korea 

主　　题：Cancer immunotherapy Nanomaterials Innate immune cells Tumor-associated macrophages 

摘      要：Cancer immunotherapy has been intensively investigated in both preclinical and clinical *** chemotherapies use cytotoxic drugs to kill tumor cells,cancer immunotherapy is based on the ability of the immune system to fight *** are intimately associated with the immune system:they can suppress the immune response and/or control immune cells to support tumor *** has yielded promising results in clinical practice,but some patients show limited *** may reflect the complexities of the relationship between a tumor and the immune *** an effort to improve the current immunotherapies,researchers have exploited nanomaterials in creating new strategies to cure tumors via modulation of the immune system in tumor *** extensive studies have examined the use of immune checkpoint-based immunotherapy,rather less work has focused on manipulating the innate immune *** review examines the recent approaches and challenges in the use of nanomaterials to modulate innate immune cells.