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Research Progress of Organic Selenium in Animal Nutrition

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Asian Agricultural Research 2024年第12期16卷 43-46页

作者： yina lu College of Life Sciences Zhaoqing UniversityZhaoqing 526061China

Selenium,an essential trace element that is critical for animal health,primarily exists in nature in both inorganic and organic *** selenium exhibits high toxicity,whereas organic selenium is noteworthy due to its reduced toxicity and enhanced *** the field of animal feeding,the incorporation of organic selenium has been shown to markedly enhance various aspects of animal performance,including immunity,fertility,antioxidant capacity,and meat ***,it can contribute to a reduction in farming costs while simultaneously improving the overall quality of animal *** deficiencies can lead to the onset of various diseases in animals,in addition to causing stunted growth and diminished reproductive *** paper presents a thorough review of the existing research on the application of organic selenium in animal ***,it investigates the potential for integrating modern technology with selenium,with a specific emphasis on the prospective use of nano-selenium as a novel source of *** objective of this study is to establish a foundational reference for the role of selenium in the field of animal nutrition research and its practical applications.

关键词： Selenium Animal nutrition Application research

Anti-inflammatory and Scalp Care Efficacy of a Multi-herb Extraction against Malassezia furfur

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China Detergent & Cosmetics 2020年第4期5卷 60-66页

作者： lu yina Jun Tian Wang Guoxun Liu Dong Shanghai JAKA Biotech Co.Ltd ShanghaiChina Suzhou Greenleaf Daily Commodity Co. Ltd.China

Malassezia furfur is a lipophilic and dermatological pathogenic yeast,which normally exists on human skin,and causes tinea versicolor,seborrhoeic dermatitis,and atopic dermatitis,especially on human *** multi-herb extraction VGP which consists of Vitex trifolia fruit,Gentiana scabra,and Polygonum multiflorum root extract was used to study its effect of anti-inflammation,controlling sebum and dandruff on scalp *** showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur,VGP can inhibit the expression of interleukin 6(IL-6),prostaglandin E2(PGE-2),monocyte chemoattractant protein 1(MCP-1)and interleukin 1β(IL-1β)in a dose-dependent manner under 0.01%to 0.125%*** the inflammatory model of 3D reconstructed skin induced by H2O2,VGP significantly improved the cell viability and skin structure,and reduced the production of interleukin 8(IL-8),PGE-2,and leukotriene B4(LTB4).During 4 week’s treatment with test shampoo contained 0.5%VGP thrice a week on 16 subjects met with different symptom,VGP reduced the sebum content and TEWL,improved the redness,itching and dandruff on human scalp ***,as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation.

关键词： a multi-herd extraction VGP anti-inflammation M.furfur scalp care

Antibacterial,Anti-Keratinized and Anti-Inflammatory Effects of the GMP,A Multi-Herb Extraction on Acne Vulgaris

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China Detergent & Cosmetics 2018年第4期3卷 69-76页

作者： lu yina Wang Guangyin Xie Hong Tian Jun Shanghai Greaf Biotech Co.Ltd.

Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinization, and the role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Propionibacterium acnes (***) has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity on keratinocytes by acting on TLR-2, leads to the development of comedones. GMP, a multi-herb extraction, targeted most of the major pathogenic features of acne with desired physicochemical traits. It strongly suppressed *** growth, and reduced inflammation by suppressing the TLR-2/NF- kB pathway in SZ-95 sebocytes and HaCaT keratinocytes. GMP exhibited a marginal effect on cell viability and may have modulated hyper-keratinization of the epidermis. These results demonstrate the clinical feasibility of applying GMP for the treatment of acne.

关键词： multi-herb extraction acne vulgaris Propionibacterium acnes anti-inflammation hyper-keratinization

Survey and Analysis on Present Situation of Biological Experiment Teaching in Some Middle Schools in Yangjiang Area

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Asian Agricultural Research 2021年第5期13卷 53-56页

作者： Sainan LI Haoyao WU yina lu Liping ZHOU Department of Biology Zhaoqing UniversityZhaoqing 526061China

Experimental teaching is an important part of biology teaching in middle *** the form of questionnaire,this paper conducts a survey on some leading teachers of biology in the middle schools in the Yangjiang area about the biological experiment teaching in the implementation of the new curriculum,and analyzes the results of the *** problems and deficiencies in the implementation of biological experiment teaching in some middle schools in this area are found,and the relevant reform measures and suggestions are put forward in order to promote the better development of biological experiment teaching in middle schools.

关键词： Biological experiment teaching in middle school Present situation Questionnaire survey Analysis

Conventional IVF and ICSI for sibling oocytes in couples with moderate oligoasthenoteratozoospermia:a prospective randomized study

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Conventional IVF and ICSI for sibling oocytes in couples wit...

第一届中华医学会生殖医学分会、中国动物学会生殖生物学分会联合年会

作者： Haining luo Yunshan Zhang Huiying Xu Yongrui Du yina Wang Zhenyu lu

Objective:This study was conducted to compare outcomes of conventional IVF and ICSI using sibling oocytes in cases of moderate ***:Sibling oocyte cumulus-corona complexes(OCCC)in cases of moderate oligoasthenoteratozoospermia were randomly inseminated either by conventional IVF or ***:A total of 1290 sibling OCCCs were collected in 76 cycles.64 of the 76 cycles resulted in fertilization both after IVF and ICSI,10 in fertilization after ICSI only and 2 in fertilization failure neither after IVF nor *** differences were found in sperm motility,progressive motility and total motile count(Plure group and the difference was significant(Plusion:Performing ICSI on some oocytes of a cohort may avoid total fertilization failures in patients with moderate *** poor yield of the progressive motile sperm after sperm preparation seems to be as a predictor for fertilization failure after conventional IVF.

关键词： oligoasthenoteratozoospermia IVF ICSI

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青皮提取物缓解皮肤敏感的作用机制研究

日用化学工业 2022年第4期52卷 418-424页

作者：周利丹卢伊娜刘青上海珈凯生物科技有限公司上海200241

青皮提取物(CR)是将未成熟的柑橘幼果经过特定工艺制备而成,富含黄酮和生物碱。本项目通过瞬时电位受体香草酸亚型1(TRPV1)高表达细胞、前列腺素受体1(EP1)高表达细胞、神经母细胞,研究CR通过TRPV1缓解皮肤敏感的作用机制。于TRPV1高表... 详细信息

青皮提取物(CR)是将未成熟的柑橘幼果经过特定工艺制备而成,富含黄酮和生物碱。本项目通过瞬时电位受体香草酸亚型1(TRPV1)高表达细胞、前列腺素受体1(EP1)高表达细胞、神经母细胞,研究CR通过TRPV1缓解皮肤敏感的作用机制。于TRPV1高表达细胞和正常细胞上对比研究发现,辣椒素(CAP)、苯氧乙醇可通过激活TRPV1引起伤害性细胞因子白介素8、趋化因子MCP-1、前列腺素E2(PGE-2)的表达量增加,细胞划痕损伤后的迁移速度下降。而CR能显著降低细胞因子的过表达,特别是针对PGE-2,也可加速划痕损伤后的细胞迁移。再对PGE-2-EP1信号通路进行研究发现,0.5%体积分数的CR也可显著抑制PGE-2通过其受体EP1引发的荧光素酶激活。最后于神经母细胞上进行验证,发现0.06%~0.25%体积分数的CR也能抑制CAP、苯氧乙醇通过激活TRPV1导致的细胞外Ca^(2+)内流,进而抑制皮肤敏感或受刺激后的信号传导,最终缓解皮肤热、痒、痛等症状。因此,CR可通过调控TRPV1激活,进而抑制伤害性细胞因子分泌及下游信号传导,促进皮肤屏障修复,缓解皮肤因受到外界刺激过度反应后,导致的敏感和刺激。

关键词：青皮提取物皮肤敏感屏障修复

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医疗机构专利管理工作存在的问题与对策

科技管理研究 2008年第12期28卷 450-452页

作者：吕依娜袁淑兰敬静四川大学华西医院科技发展中心四川成都610041

通过专利检索,了解论文发表排名前十位的国内医疗机构专利工作的现状,分析专利工作中存在的问题,探讨在新形势下提高专利工作质量的对策,以期为医院专利管理工作提供参考。

关键词：专利管理问题对策

金融集聚对技术创新的影响研究——以西北五省为例

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西安石油大学学报（社会科学版） 2020年第2期29卷 21-29页

作者：鲁怡娜西安石油大学经济管理学院陕西西安710065

选取西北五省2008—2017年省级面板数据为研究样本,实证检验了金融集聚对我国西北地区技术创新的影响。结果发现:西北地区整体金融集聚对技术创新研发投入、创新产出有显著的负向挤出作用;保险业集聚显著正向影响研发投入,证券业集聚显... 详细信息

选取西北五省2008—2017年省级面板数据为研究样本,实证检验了金融集聚对我国西北地区技术创新的影响。结果发现:西北地区整体金融集聚对技术创新研发投入、创新产出有显著的负向挤出作用;保险业集聚显著正向影响研发投入,证券业集聚显著负向影响研发投入;证券业集聚显著正向影响创新产出;银行业集聚显著正向影响创新成果转化,保险业集聚显著负向挤出创新成果转化。

关键词：金融集聚技术创新技术外溢逆向挤出担保能力

望春花(***)花提取物缓解UVB导致皮肤损伤的作用研究

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日用化学工业（中英文） 2023年第9期53卷 1065-1072页

作者：黄芳张营熊玥周利丹卢伊娜上海珈凯生物科技有限公司上海200241

富含木兰脂素的望春花(***)花提取物(MB)被用来研究其缓解紫外线导致的皮肤损伤作用。在中波紫外线(UVB)诱导的人永生化表皮细胞(HaCaT)和以UVB诱导的HaCaT细胞培养上清液作为刺激物诱导的血管内皮细胞(HUVEC)上,通过免疫荧光染色、酶... 详细信息

富含木兰脂素的望春花(***)花提取物(MB)被用来研究其缓解紫外线导致的皮肤损伤作用。在中波紫外线(UVB)诱导的人永生化表皮细胞(HaCaT)和以UVB诱导的HaCaT细胞培养上清液作为刺激物诱导的血管内皮细胞(HUVEC)上,通过免疫荧光染色、酶联免疫吸附法检测细胞损伤下的不同关键指标的变化。结果显示,HaCaT细胞经UVB照射后16~72 h,环丁烷嘧啶二聚体(CPD)产生量显著升高,高迁移率族蛋白B1(HMGB1)表达上升,且逐步从细胞核迁移至细胞质,热休克家族蛋白27(Hsp27)表达量也上升,同时白介素6(IL-6)、白介素8(IL-8)、前列腺素E2(PGE-2)的表达量显著增加。而HaCaT细胞培养上清液刺激HUVEC细胞24 h后,内皮素-1(ET-1)、细胞间粘附分子-1(ICAM-1)表达量均显著升高。0.1%~0.5%的MB同步处理下,可显著抑制HaCaT细胞中CPD的产生量、HMGB1的表达量,减少HMGB1的核转移,促进Hsp27的表达,降低细胞因子的表达量,同时可显著减少HUVEC细胞中的ET-1,ICAM-1表达量。因此,MB可通过降低DNA损伤,减少HMGB1的合成与核转移,减少细胞因子表达量,降低血管通透性,来缓解皮肤受到紫外线照射后的损伤作用。

关键词：望春花(M.biondi)花提取物紫外线 HMGB1 ICAM-1 皮肤损伤