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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU Sheng Hui HU Dan He XU Chong xiao yin Jia Yu yin Qi Kai HE ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng WANG Huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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肝内胆管结石与肝内胆管癌相关性研究进展

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中国实用外科杂志 2024年第3期44卷 287-291页

作者：殷晓煜石殷浩中山大学附属第一医院胆胰外科广东广州510080

肝内胆管结石是指发生于左、右肝管汇合部之上的结石,在我国是一种常见的胆道良性疾病。肝内胆管癌是第二常见的肝脏原发性恶性肿瘤,其发生可能与肝内胆管结石、原发性硬化性胆管炎、先天性胆管囊性扩张症、乙肝与丙肝病毒感染以及胆道... 详细信息

肝内胆管结石是指发生于左、右肝管汇合部之上的结石,在我国是一种常见的胆道良性疾病。肝内胆管癌是第二常见的肝脏原发性恶性肿瘤,其发生可能与肝内胆管结石、原发性硬化性胆管炎、先天性胆管囊性扩张症、乙肝与丙肝病毒感染以及胆道寄生虫病等有关。鉴于我国肝内胆管结石具有高发的特点,其在诱发肝内胆管癌中的作用及潜在机制应予高度重视。从病理解剖来看,与肝内胆管结石相关的肝内胆管癌包含了从胆管内乳头状肿瘤(IPNB)、胆管上皮内瘤变(BilIN)到胆管癌不同阶段的特征。从分子层面来看,肝内胆管癌组织中炎症因子的过表达及转录因子、生长因子的功能紊乱,诱导了正常胆管上皮细胞的癌变。同时,肿瘤微环境中免疫细胞分群的变化进一步加重了肿瘤的恶性行为。这些特点提示结石对所在胆管部位的慢性机械及炎症刺激是造成胆管上皮癌变的重要原因。针对肝内胆管癌恶性程度高、治疗效果差的特点,有关肝内胆管结石诱发胆管癌的具体机制需要更多、更深入的研究,以便在早期发现胆管细胞癌变的证据及潜在的药物靶点,做到早期干预,提高这类病人的治疗效果及远期预后。

关键词：肝内胆管结石肝内胆管癌危险因素机制

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Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI Ya-ru HOU Yun-long yin Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG xiao-qi HAO Yuan-jie MA Kun GU Jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Hebei Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was established by left anterior descending coronary artery ligation for 45 *** to a random number table,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the benazepril(BNPL)*** day after modeling,TXL and BNPL were administered by *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fibrosis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed by immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase B(p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fibrosis,increased the expression of CD31 and inhibited the expression ofα-SMA,thus inhibited the occurrence of EndMT(P0.05).In addition,the use of the PI3K/AKT pathway-specific inhibitor LY-294002 to block this pathway and combination with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice.

关键词： myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway

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Using choroidal thickness to detect myopic macular degeneration

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 317-323页

作者： Ran Liu Meng Xuan De-Cai Wang Ou xiao Xin-Xing Guo Jian Zhang Wei Wang Monica Jong Padmaja Sankaridurg Kyoko Ohno-Matsui Qiu-Xia yin Ming-Guang He Zhi-Xi Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina New England College of Optometry BostonMassachusetts 02115USA Wilmer Eye Institute Johns Hopkins UniversityBaltimoreMD 21231USA Brien Holden Vision Institute Sydney 2052Australia School of Optometry and Vision Science University of New South WalesSydney 2052Australia Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan School of Optometry the Hong Kong Polytechnic UniversityHong Kong SARChina Research Centre for SHARP Vision the Hong Kong Polytechnic UniversityHong Kong SARChina Center for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkHong Kong SARChina

AIM:To explore the usage of choroidal thickness measured by swept-source optical coherence tomography(SS-OCT)to detect myopic macular degeneration(MMD)in high myopic ***:Participants with bilateral high myopia(≤−6 diopters)were recruited from a subset of the Guangzhou Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort ***-OCT was performed to determine the choroidal thickness,and myopic maculopathy was graded by the International Meta-Analysis for Pathologic Myopia(META-PM)Classiﬁ*** of MMD was defined as META-PM category 2 or ***:A total of 568 right eyes were included for *** with MMD(n=106,18.7%)were found to have older age,longer axial lengths(AL),higher myopic spherical equivalents(SE),and reduced choroidal thickness in each Early Treatment Diabetic Retinopathy Study(ETDRS)grid sector(P<0.001).The area under the receiver operating characteristic(ROC)curves(AUC)for subfoveal choroidal thickness(0.907)was greater than that of the model,including age,AL,and SE at 0.6249,0.8208,and 0.8205,*** choroidal thickness of the inner and outer nasal sectors was the most accurate indicator of MMD(AUC of 0.928 and 0.923,respectively).An outer nasal sector choroidal thickness of less than 74μm demonstrated the highest odds of predicting MMD(OR=33.8).CONCLUSION:Choroidal thickness detects the presence of MMD with high agreement,particularly of the inner and outer nasal sectors of the posterior pole,which appears to be a biometric parameter more precise than age,AL,or SE.

关键词： high myopia choroidal thickness myopic macular degeneration swept-source optical coherence tomography

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Supramolecular systems for bioapplications:recent research progress in China

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Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang Liu xiao-Yong Yu Yu-Chen Pan Hang yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng Jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang Yuxin Pei Zhichao Pei Jiang-Fei Xu xiao-Yu Hu Chunju Li Qing-Zheng Yang Leyong Wang Yu Liu Zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

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Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold

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Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： Yu-Zhuo Chen Yi-Hong Zhou Min-Bo Yan Ming xiao Biao Liu ying-Hao yin xiao-Li Tan Yong-Quan Huang Yu-Hong Lin Ting Xie Jia-Li Tian Qi Wang Jian-ying Li Zi-Zhou Meng Zheng Li Emily Xing Yu-Xin Tang Ya-Wei Li Zhong-Zhen Su Liang-Yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medical Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus cavernosum(cc)can be used to explore the tissue structural changes and complex signaling *** present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed scaffolds are used to solve the scarcity of primary penis tissue ***,inconvenience and high costs limit the wide application of such ***,we describe a simple,fast,and economical method of constructing artificial CC-like *** Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial *** Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell *** the C-like tissue,ECs covered the surface of the lumen,and SMCs were located inside the trabeculae,similar to the structure of the primary *** cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th ***/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary *** study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus cavernosum ex vivo fibroblasts

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A Bayesian network for estimating hypertension risk due to occupational aluminum exposure

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Chronic Diseases and Translational Medicine 2024年第2期10卷 130-139页

作者： Le Zhao Jinzhu yin Jiaping Huan xiao Han Dan Zhao Jing Song Linping Wang Huifang Zhang Baolong Pan Qiao Niu xiaoting Lu Department of Occupational Health School of Public HealthShanxi Key Laboratory of Environmental Health Impairment and PreventionMOE Key Laboratory of Coal Environmental Pathogenicity and PreventionShanxi Medical UniversityTaiyuanShanxiChina Sinopharm Tongmei General Hospital Shanxi Health Commission Key Laboratory of Nervous System Disease Prevention and TreatmentDatongShanxiChina Sixth Hospital of Shanxi Medical University(General Hospital of Tisco) TaiyuanShanxiChina

Background The correlation between metals and hypertension,such as sodium,zinc,potassium,and magnesium,has been confirmed,while the relationship between aluminum and hypertension is not very *** study aimed to evaluate the correlation between plasma aluminum and hypertension in electrolytic aluminum workers by the Bayesian networks(BN).Methods In 2019,476 male workers in an aluminum factory were *** plasma aluminum concentration of workers was measured by inductively coupled plasma mass *** influencing factors on the prevalence of hypertension were analyzed by the *** The prevalence of hypertension was 23.9%in 476 male *** risk of hypertension from plasma aluminum in the Q2,Q3,and Q4 groups was 5.20(1.90–14.25),6.92(2.51–19.08),and 7.33(2.69–20.01),respectively,compared with that in the Q1 *** risk of hypertension from the duration of exposure to aluminum of>10 years was 2.23(1.09–4.57),compared without aluminum *** under the curve was 0.80 of plasma aluminum and the duration of exposure to aluminum was based on covariates,indicating that aluminum exposure had important predictive value in the prevalence of hypertension in the occupational *** results of the study using the BN model showed that if the plasma aluminum of all participants was higher than Q4(≥47.86µg/L)and the participants were drinking,smoking,diabetes,central obesity,dyslipidemia,and aged>50 years,the proportion of hypertension was 71.2%.Conclusions The prevalence of hypertension increased significantly with the increase of plasma aluminum level.

关键词： Bayesian networks hypertension occupational aluminum exposure

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共同富裕目标下企业新质生产力的收入分配效应

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山西财经大学学报 2024年第8期46卷 32-45页

作者：梁孝成吕康银唐志东东北师范大学经济与管理学院

基于2015—2022年A股上市企业数据，实证检验企业新质生产力对劳动收入份额的影响。研究结果表明，企业新质生产力可以显著提升劳动收入份额。机制检验发现，企业新质生产力通过扩大就业规模和提高资源配置效率，从而提升劳动收入份额... 详细信息

基于2015—2022年A股上市企业数据，实证检验企业新质生产力对劳动收入份额的影响。研究结果表明，企业新质生产力可以显著提升劳动收入份额。机制检验发现，企业新质生产力通过扩大就业规模和提高资源配置效率，从而提升劳动收入份额。异质性分析发现，在数字经济水平较高地区企业、高科技行业企业和劳动密集型企业样本中，企业新质生产力对劳动收入份额的影响效果更显著。进一步分析发现，企业新质生产力可以缩小管理层与普通员工之间的收入差距。

关键词：新质生产力劳动收入份额就业规模资源配置效率收入差距

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Chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2024年第2期22卷 163-179页

作者： Tian-tian Meng Ya-ping You Min Li Jian-bo Guo Xin-bin Song Jing-yi Ding xiao-long Xie An-qi Li Shang-jin Li Xiang-jun yin Peng Wang Zhe Wang Bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese Medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biological Medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the *** to the PRISMA statement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplemental therapy for ***,because of the low quality of the existing eviden

关键词： statement synthesis alone

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开挖作用下滑剪破坏下盘边坡扰动范围计算及稳定性评价方法

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Journal of Central South University 2024年第2期31卷 589-601页

作者：秦辉汤华尹小涛程谞 State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

滑剪破坏型下盘边坡是矿山工程中经常出现的一种顺层边坡,具有突发性强、破坏范围广的特点。如何快速、准确地确定开挖塑性扰动区并评估其稳定性对边坡安全控制至关重要。本文首先通过数值模拟揭示了该类边坡的破坏模式和特征。然后,根... 详细信息

滑剪破坏型下盘边坡是矿山工程中经常出现的一种顺层边坡,具有突发性强、破坏范围广的特点。如何快速、准确地确定开挖塑性扰动区并评估其稳定性对边坡安全控制至关重要。本文首先通过数值模拟揭示了该类边坡的破坏模式和特征。然后,根据其破坏模式,建立了描述开挖扰动区的数学方程。最后,提出了一种计算下盘边坡开挖扰动区和稳定性的力学截断新方法(MTM)。主要结果有,MTM方法考虑岩体单轴抗压强度,计算过程无需一般极限平衡方法需要的多次循环迭代,计算过程简便。MTM方法可以准确地表征扰动区,计算得到的极限边坡高度、扰动厚度和安全系数与数值模拟结果较吻合,且评价结果比数值模拟更安全。扰动区的最大厚度决定了锚索锚固端的深度,分区是为了指明加固的重点范围。该方法为下盘边坡的工程施工和监测提供指导。

关键词：下盘边坡滑剪破坏失效机制力学截断法扰动区稳定性分析

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