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β肾上腺素能受体基因多态性与原发性高血压的关系

2012年湖北生物产业发展高端论坛暨湖北省生物工程学会2012年度学术交流会

作者： Gong XY yin yh Huang ZJ Lu B Xu PH Zheng H School of Chemical Engineering Wuhan University of Technology

In this work,an amphophilic polymeric prodrug Cis-3-(9H-purin-6-ylthio) -acrylic acid-graft-carboxymethyl chitosan(PTA- g-CMCS) was designed and *** aqueous solution,this grafted polymer can self-assemble into spherical micelles with a size ranging from 104 to 285 nm and zeta potential ranging from—12.3 to—20.1 *** the release study,less than 24%of 6-Mercaptopurine(6-MP) was released from PTA-g-CMCSl in the media containing 2 and 100 M glutathione(GSH),whereas 37%,54%and 75%of 6-MP was released from the media with GSH of 1,2 and 10 mM,***,pH and drug content of the polymeric prodrug only presented slight influence an the 6-MP *** assay demonstrated that this system had higher inhibition ratio on HL-60 cells(human promyelocytic leukemia cells) in the presence of GSH and lower cytotoxicity on mouse fibroblast cell line(L929).There-fore,this nano-sized system is glutathione-dependent,and it can be employed as a potential carrier for the controlled release of 6-MP.

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来源： cnki会议评论

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中国组织工程研究与临床康复 2007年第12期11卷 2243-2246页

作者：牛永红谢正祥殷跃辉清华大学第一附属医院心内科北京市100016 重庆医科大学生物医学工程研究室重庆市400016 重庆医科大学第二附属医院重庆市心律失常治疗中心重庆市400010

目的:β肾上腺素能受体包括β1,β2和β3三种亚型,分析其基因多态性与原发性高血压的关系。方法:试验于2003-02/2005-09在重庆医科大学生物医学工程研究室进行。选择在清华大学第一附属医院和重庆医科大学第二附属医院就诊和体检的150... 详细信息

目的:β肾上腺素能受体包括β1,β2和β3三种亚型,分析其基因多态性与原发性高血压的关系。方法:试验于2003-02/2005-09在重庆医科大学生物医学工程研究室进行。选择在清华大学第一附属医院和重庆医科大学第二附属医院就诊和体检的150例原发性高血压患者,男80例,女70例,年龄(56.53±5.60)岁;130例正常对照者,男70例,女60例,年龄(55.62±8.63)岁,对试验均知情同意。测试受试者坐位血压。用聚合酶链反应-限制性片段长度多态性技术和等位基因特异性聚合酶链反应法分析β1-肾上腺素能受体的Ser49Gly和Arg389Gly,β2-肾上腺素能受体的Arg16Gly和Gln27Glu,β3-肾上腺素能受体的Trp64Arg基因多态性,并分析其基因多态性与原发性高血压的相关性。结果:①β1-389原发性高血压组和对照组的Arg/Arg,Arg/Gly和Gly/Gly基因型频率分别为:0.56,0.32,0.12和0.74,0.22,0.04(P0.05)。所有组的基因多态性分布均符合Hardy-Weinberg定律。结论:在所研究的中国人群中,β1-389Arg/Gly和β2-16Arg/Gly基因多态性与原发性高血压的发病有联系。

关键词：受体肾上腺素能β/遗传学多态现象遗传血压

Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

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Neural Regeneration Research 2024年第3期19卷 563-570页

作者： Bo Han Weishi Liang Yong Hai Duan Sun Hongtao Ding Yihan Yang Peng yin Department of Orthopedics Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal *** the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and *** few studies have been published on the specific characteristics of distraction spinal cord *** this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this *** addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord *** provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease.

关键词： animal models behavior distraction heterogeneity histology mechanism neurophysiology spinal cord injury systematic review tension

比较胺碘酮、胺碘酮联合氯沙坦与胺碘酮联合培哚普利对孤立阵发心房颤动患者心房颤动复发的预防作用的前瞻性随机研究

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心血管病学进展 2006年第5期27卷 673-673页

作者： yin yh Dalal DS Liu ZC 张晔（译）王玉堂（校）不详中国人民解放军总医院

心房颤动(房颤)是临床最常见的心律失常。虽然在过去几年中出现了许多侵入性的治疗方法,但药物治疗仍是重建和维持窦性心律的最主要方法。基础和临床研究均已证明房颤会引起心房组织电生理及结构的重构,而电及结构重构又会使房颤复发、... 详细信息

心房颤动(房颤)是临床最常见的心律失常。虽然在过去几年中出现了许多侵入性的治疗方法,但药物治疗仍是重建和维持窦性心律的最主要方法。基础和临床研究均已证明房颤会引起心房组织电生理及结构的重构,而电及结构重构又会使房颤复发、持续,最终演变为慢性房颤。也有研究发现肾素-血管紧张素-醛固酮系统在心房重构中发挥重要作用,且血管紧张素转换酶抑制剂(ACEI)及血管紧张素Ⅱ受体阻滞剂(ARB)类药物可以预防或逆转心房电重构及结构重构,减少房颤复发。[第一段]

关键词：心房颤动患者房颤复发预防作用前瞻性随机研究肾素-血管紧张素-醛固酮系统胺碘酮培哚普利血管紧张素Ⅱ受体阻滞剂

Constrained Crystal Growth Behaviour under Unidirectional Melt Flow

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Journal of Materials Science & Technology 1996年第2期12卷 156-158页

作者： Liu, S Zhou, yh National Laboratory of Solidification Processing Northwestern Polytechnical University Xi'an 710072 China

Melt flow has an important influence on the microstructure formation of alloys. In this paper the growth behaviour of constrained crystals is systematically studied. It is discovered that the constrained crystals have a quite complicated response to melt flow. It may grow upstream or downstream or keep its growth direction unchanged with the influence of melt flow. Also low growth velocity and high flow velocity favour the formation of spike-like crystal. A new model is suggested to explain these experimental results.

关键词： Crystal growth from melt

Intermolecular [4+3] Cycloaddition of Cyclic Oxyallyl

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Chinese Chemical Letters 1997年第7期8卷 563-564页

作者： Hu, yh Bai, DL CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

The [4+3] cycloaddition of the 6-substituted-2-chlorocyclohexanone and furans under the Fohlish conditions (Et3N in CF3CH2OH) has been accomplished to give tricyclic cycloadducts with good yields.

关键词： KBr IR cm MS MHz Intermolecular Cycloaddition of Cyclic Oxyallyl

Total Synthesis of dl-Ligustiphenol

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Chinese Chemical Letters 1996年第10期7卷 896-897页

作者： Huang, yh Yu, DQ CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

----(-)S-Ligustiphenol is a new sesquiterpene compound with antiinflammatory and immunosuppressive activities. The total synthesis of its racemate was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m-cresol, protection of phenolic hydroxyl, Grignard reaction,aldol condensation, etc. The target compound was characterized by comparing its H-1 NMR,MS and IR spectra with natural (-) ligustiphenol.

关键词： Total Synthesis of dl-Ligustiphenol

A Safe and Brief Way for Preparing Anhydrous LnCl_3 (Ln=Sc, Y, La to Lu)

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Rare Metals 2000年第2期19卷 157-161,152页

作者： Li, Y Wang, LS Wang, yh Department of Chemistry Northeastern University Shenyang 110006 China

Anhydrous lanthanide chlorides LnCl 3 (Ln=Sc, Y, La to Lu except for Pm), which are difficult to prepare in other ways, were prepared by chemical vapor transport (CVT) process. Rare earth oxide reacted with Al 2Cl 6 at 300℃ to produce LnCl 3, which was then separated from other solids by means of CVT at a temperature gradient from 400 to 180℃. Residual Al 2Cl 6 (g) was removed by carrier of dry N 2 gas at 200℃. The yielding rates were >90%, and the purity of products was >99.5%.

关键词： Anhydrous lanthanide chlorides AlCl 3 Chemical vapor transport

Dissolution-facilitating Dislocation Emission, Motion andInitiation of SCC in 310 Stainless Steel

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Journal of Materials Science & Technology 1997年第6期13卷 483-486页

作者： Huang, yh Chen, QZ Chu, WY Univ Sci & Technol Beijing Dept Mat Phys Beijing 100083 Peoples R China

Using a special constant deflection device, the in situ TEM observations of dislocation emission, motion and the initiation of nanocrack in 310 stainless steel in water were carried out. The results show that SCC in thin foil specimen of 310 stainless steel can occur in water. A nanocrack initiated in the DFZ or at the blunt crack tip in corrosion solution after dislocation emission, multiplication and motion, which were induced by the localized anodic dissolution, reached a critical condition. The nanocrack propagated by a cleavage mode because of the influence of the corrosion solution.

关键词： Stainless steel