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Advances of nanotechnology applied to cancer stem cells

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World Journal of Stem Cells 2023年第6期15卷 514-528页

作者： Miao Yue Ting Guo Deng-Yun Nie yin-xing Zhu Mei Lin Clinical Laboratory Nanjing University of Chinese MedicineTaizhou 225300Jiangsu ProvinceChina Taizhou School of Clinical Medicine The Affiliated Taizhou People's Hospital of Nanjing Medical UniversityTaizhou 225300Jiangsu ProvinceChina

Cancer stem cells(CSCs)are a small proportion of the cells that exist in cancer *** are considered to be the culprit of tumor genesis,development,drug resistance,metastasis and recurrence because of their self-renewal,proliferation,and differentiation *** elimination of CSCs is thus the key to cure cancer,and targeting CSCs provides a new method for tumor *** to the advantages of controlled sustained release,targeting and high biocompatibility,a variety of nanomaterials are used in the diagnosis and treatments targeting CSCs and promote the recognition and removal of tumor cells and *** article mainly reviews the research progress of nanotechnology in sorting CSCs and nanodrug delivery systems targeting ***,we identify the problems and future research directions of nanotechnology in CSC *** hope that this review will provide guidance for the design of nanotechnology as a drug carrier so that it can be used in clinic for cancer therapy as soon as possible.

关键词： Cancer stem cells Nanotechnology Nanoparticles Nanodrug delivery systems Drug resistance Therapy

Corrosion Resistance on High Strength Bainitic Steel and 09CuPCrNi After Wet-Dry Cyclic Conditions

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Journal of Iron and Steel Research International 2013年第2期20卷 72-78页

作者： WANG Zhi-fen yin Fu-xing WU Li-xin SUN Yi-qiang ZHANG Wan-lin Research and Development Center Wuhan Iron and Steel (Group) Corporation National Institute for Materials Science

The accelerated wet-dry cyclic corrosion tests have been carried out of a high strength bainitic steel and 09CuPCrNi. The results indicated that the corrosion resistance of 09CuPCrNi was better than that of the bainitic steel based on the mass loss measurements. The morphology and composition of the rusting products have been investigated in order to realize the mechanism of rust formation on the two steels. The rust scale on both steels was composed of a dense inner layer and a loose outer layer. The inner layer grew thicker and denser as the test proceeding. Both of inner and outer layers were mainly composed of magnetite （Fe3O4） and maghemite （γ-Fe2O3） with a small amount of lepidocrocite （γ-FeOOH） and akaganeite （β-FeOOH）. The rust phase of γ-Fe2O3 was detected in a higher amount of the inner layer, resulting in a much denser inner layer. The inner rust layer of 09CuPCrNi being denser and thicker than that of the high strength bainitic steel was attributed to the alloying elements such as copper, chromium and phosphorus enriched in it. The protective inner rust layer plays an important role in the corrosion resistance of the steel.

关键词： high strength bainitic steel 09CuPCrNi rust layer corrosion resistance

HYDRODYNAMIC ANALYSIS AND SIMULATION OF A SWIMMING BIONIC ROBOT TUNA

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Journal of Hydrodynamics 2007年第4期19卷 412-420页

作者： CHEN Hong ZHU Chang-an yin Xie-zhen xing Xiao-zheng CHENG Gang College of Mechatronics and Control Engineering Shenzhen University Shenzhen 518060 China School of Engineering Science University of Science and Technology of China Hefei 230027 China

A dynamic model for undulatory locomotion was proposed to study the swimming mechanism of a developed bionic robot tuna. On the basis of inviscid hydrodynamics and rigid-body dynamics, the momentum and propulsive force required for propelling the swimming robot tuna＇s flexible body was calculated. By solving the established dynamic equations and efficiency formula, the swimming velocity and propulsive efficiency of the bionic robot tuna were obtained. The relationship between the kinematic parameters of the robot tuna＇s body curve and the hydrodynamic performances was established and discussed after hydrodynamic simulations. The results presented in this article can be used to increase the swimming speed, propulsive thrust, and the efficiency of underwater vehicles effectively.

关键词： undulatory locomotion swimming propulsive force efficiency body curve hydrodynamic simulations

Effect of Ti and rare earth on microsegregation and large-sized precipitates of H13 steel

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Journal of Iron and Steel Research International 2021年第12期28卷 1591-1604页

作者： Fa Ji Rui Xu Yu-long Gao Qing-chao Tian Lu Wang Zhi-xia Xiao Fu-xing yin School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China Research Institute for Energy Equipment Materials Hebei University of TechnologyTianjin300130China State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy&School of Materials Science and Engineering Shanghai UniversityShanghai200444China

Large-sized precipitates are fatal to the thermal fatigue of H13 hot work die *** amounts of Ti and/or rare earth(RE)were added in H13 steel during electroslag remelting to improve the element segregation and refine the large-sized *** results show that as Ti content increases from 0.0032 to 0.057 wt.%,the segregation of Cr,Mo and V becomes more severe.V-rich M(C,N)carbides are shorter,and their branches are denser in 3D ***,the number density of V-rich M(C,N)carbides with a size less than 2μm increases and that with other sizes *** addition,Ti-rich MN nitrides with the size greater than 4μm increases significantly at high Ti *** RE content increases from 0.0051 to 0.036 wt.%,the segregation of main alloying elements is first weakened and then *** with that in RE-free H13 steel,V-rich M(C,N)carbides are less developed in 3D observation,and the change in number density is similar to that of Ti-modified *** composite modification of 0.024 wt.%Ti and 0.011 wt.%RE,the segregation of alloying element and V-rich M(C,N)carbides are not significantly improved.

关键词： H13 steel Segregation Primary carbide Ti Rare earth Precipitate

circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis

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International Journal of Oral Science 2022年第3期14卷 360-370页

作者： Liyuan Yu Kai Xia Jing Zhou Zhiai Hu xing yin Chenchen Zhou Shujuan Zou Jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Stomatology Kunming Yan’an hospitalKunmingChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Human adipose-derived stem cells(hASCs)are a promising cell type for bone tissue *** RNAs(circRNAs)have been shown to play a critical role in regulating various cell differentiation and involve in mesenchymal stem cell ***,how circRNAs regulate hASCs in osteogenesis is still ***,we found circ_0003204 was significantly downregulated during osteogenic differentiation of *** of circ_0003204 by si RNA or overexpression by lentivirus confirmed circ_0003204 could negatively regulate the osteogenic differentiation of *** performed dual-luciferase reporting assay and rescue experiments to verify circ_0003204 regulated osteogenic differentiation via sponging *** predicted and confirmed that miR-370-3p had targets in the 3′-UTR of HDAC4 m *** following rescue experiments indicated that circ_0003204 regulated the osteogenic differentiation of hASCs via miR-370-3p/HDAC4 *** in vivo experiments showed the silencing of circ_0003204 increased the bone formation and promoted the expression of osteogenic-related proteins in a mouse bone defect model,while overexpression of circ_0003204 inhibited bone defect *** findings indicated that circ_0003204 might be a promising target to promote the efficacy of hASCs in repairing bone defects.

关键词： regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis miR

Optical monitoring of the Seyfert galaxy NGC 4151 and possible periodicities in its historical light curve

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Research in Astronomy and Astrophysics 2014年第8期14卷 923-932页

作者： Di-Fu Guo Shao-Ming Hu Jun Tao Hong-xing yin Xu Chen Hong-Jian Pan Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesSchool of Space Science and PhysicsShandong University Shanghai Astronomical Observatory Chinese Academy of Sciences

We report B, V and R band CCD photometry of the Seyfert galaxy NGC 4151 obtained with the 1.0m telescope at Weihai Observatory of Shandong University and the 1.56 m telescope at Shanghai Astronomical Observatory from 2005 December to 2013 February. Combining all available data from literature, we have constructed a historical light curve from 1910 to 2013 to study the periodicity of the source using three different methods （the Jurkevich method, the Lomb-Scargle periodogram method and the Discrete Correlation Function method）. We find possible periods of P1 = 4 ± 0.1,/92 = 7.5 ±0.3 and P3 = 15.9± 0.3 yr.

关键词： methods data analysis -- galaxies: active -- galaxies individual (NGC 4151)

Fluorescence emission from excited molecular ions in intense femtosecond laser fields

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Frontiers of physics 2013年第1期8卷 34-38页

作者： Yun-Chen Wang Cheng-yin Wu Yuan-xing Liu Shao-Hua Xu Qi-Huang Gong State Key Laboratory for Mesoscopic Physics Department of Physics Peking University Beijing 100871 China

Strong fluorescence emissions were observed for nitrogen, carbon monoxide, and carbon dioxide molecules in intense femtosecond laser fields. These emissions can be assigned to the transitions of the molecular ions from the excited electronic states to the ground electronic states. The formation mechanisms were discussed and the lifetimes were measured for these excited molecular ions in intense laser fields.

关键词： tunneling ionization molecular orbital fluorescence

Preparation and physicochemical characterization of T-OA PLGA microspheres

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Chinese Journal of Natural Medicines 2017年第12期15卷 912-916页

作者： FU Jing DONG Xiao-Xu ZENG Zu-Ping yin xing-Bin LI Fa-Wei NI Jian Beijing Institute of Traditional Chinese Medicine Beijing Hospital of Traditional Chinese Medicine Beijing 100010 China School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 100102 China

As the carrier of water-insoluble drugs, microspheres can play a role in increasing solubility and delaying releasing essence. The objective of this study was to improve the solubility and to delay the release of a newly discovered antitumor compound 3β-hydroxyolea-12-en-28-oic acid-3, 5, 6-trimethylpyrazin-2-methyl ester(T-OA). Early-stage preparation discovery concept(EPDC) was employed in the present study. The preparation, physicochemical characterization, and drug release properties of PLGA microspheres were evaluated. T-OA-loaded PLGA microspheres were prepared by an oil-in-water(O/W) emulsification solvent evaporation method. Characterization and release behaviors of the T-OA PLGA microspheres were evaluated by X-ray diffract(XRD), differential scanning calorimetry(DSC), Fourier transform infrared spectroscopy(FTIR), scanning electron microscopy(SEM), and high performance liquid chromatography(HPLC). The results demonstrated that T-OA-loaded PLGA microspheres could be successfully obtained through solvent evaporation method with appropriate morphologic characteristics and high encapsulation efficiency. The XRD analysis showed that T-OA would be either molecularly dispersed in the polymer or distributed in an amorphous form. The DSC and FTIR analysis proved that there were interactions between T-OA and PLGA polymer. SEM observations displayed the morphology of the microspheres was homogeneous and the majority of the spheres ranged between 50 and 150 μm. The drug release behavior of the microspheres in the phosphate buffered saline medium exhibited a sustained release and the duration of the release lasted for more than 23 days, which was fit with zero-order release pattern with r^2 = 0.994 7. In conclusion, TOA-loaded PLGA microspheres might hold great promise for using as a drug-delivery system in biomedical applications.

关键词： T-OA PLGA Microspheres Solubility Release

MBG/PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features

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Bioactive Materials 2022年第9期7卷 53-67页

作者： Jiangfeng Li Chunyi Wang Guoxing Gao xing yin Ximing Pu Bing Shi Yang Liu Zhongbing Huang Juan Wang Jingtao Li Guangfu yin College of Biomedical Engineering Sichuan UniversityChengdu610065PR China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu610041PR China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041PR China Shandong Provincial Key Laboratory of Biomedical Polymers Shandong Academy of Pharmaceutical SciencesJinan250101PR China

It remains a challenge to achieve satisfactory balance between biodegradability and osteogenic capacity in biosynthetic bone *** this study,we aimed to address this challenge by incorporating mesoporous bioactive glass(MBG)into poly(caprolactone-co-glycolide)(PGA-PCL)at gradient ***/PGA-PCL(PGC/M)scaffolds with MBG incorporation ratio at 0,10%,25%and 40%(PGC/M0-40)were synthesized using a modified solvent casting-particulate leaching method,and their physiochemical and biological properties were comprehensively ***/M scaffolds exhibited highly perforated porous structure with a large-pore size of 300-450μm,with ordered MBGs of around 6.0 nm mesopores size uniformly *** increase in MBG incorporation ratio significantly improved the scaffold surface hydrophilicity,apatite-formation ability and pH stability,increased the weight loss rate while insignificantly influenced the molecular chains degradation of PGA-PCL component,and facilitated the attachment,spreading,viability and proliferation of rat bone marrow stromal cells(rBMSCs)on ***,rBMSCs cultured on PGC/M10-40 scaffolds demonstrated enhanced ALP activity and osteogenesis-related gene expression in a MBG dose-dependent manner as compared with those cultured on PGC/M0 *** implanted to the rat cranial bone defect,PGC/M25 and PGC/M40 scaffolds induced significantly better bone repair as compared to PGC/M0 and PGC/M10 ***,the biodegradability of PGC/M scaffolds correlated with the MBG incorporation *** data suggested this novel PGC/M scaffolds as promising bone repair biomaterial with highly tunable hydrophilicity,bioactivity,cytocompatibility,osteogenic activity as well as biodegradability.

关键词： Mesoporous bioactive glasses Poly(caprolactone-co-glycolide) Osteogenic differentiation Bone repair