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Remote-controlled module-assisted synthesis of O-(2-[^(18)F]fluoroethyl)-L-tyrosine as tumor PET tracer using two different radiochemical routes

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Nuclear Science and Techniques 2006年第3期17卷 148-153页

作者： WANG Ming-Wei yin duan-Zhi ZHANG Lan ZHOU Wei WANG Yong-Xian Radiopharmaceutical Centre Shanghai Institute of Applied Physics the Chinese Academy of Sciences Shanghai 201800 China

The positron-emitter fluorine-18 labeled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) has shown very promising perspectives for brain tumor diagnosis with positron emission tomography (PET). There have been two existing preparation routes of [18F]FET named direct nucleophilic radiofluorination of protected L-tyrosine and radiofluoroalkylation of unprotected L-tyrosine, respectively. A general module was designed specifically for the routine synthesis of [18F]FET, which could be suitable for the present two chemical methods with simple modifica- tions. The fluorinated intermediates and the final product were separated and purified using solid phase extraction (SPE) on the Sep-Pak silica plus cartridge instead of the time-consuming high performance liquid chromatography (HPLC) procedures. The total synthesis time was about 50—60 min with good radiochemical yield (about 20—40%, no-decay-corrected) and good radiochemical purity (more than 97%) for both the synthetic methods.

关键词： PET 氟化作用合成模块正电子发射亲质子

Transverse Joint Aperture Simulation of High Arch Dam Based on Measured Temperature in Construction Period

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Wuhan University Journal of Natural Sciences 2014年第4期19卷 361-368页

作者： ZHANG Chao CHANG Xiaolin LIU Xinghong duan yin State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University School of Civil and Architectural Engineering Wuhan University Changjiang Survey Planning Design & Research Co. Ltd

Transverse joint aperture is of certain reference value to ensure joint grouting quality and overall safety of high arch dam. A 3D isoparametric joint element model with spherical surface key grooves and finite thickness is used to simulate a transverse joint. A set of program is developed to simulate the transverse joint ap- erture of Dagangshan high arch dam. Combined with the measured temperatures, the whole developing process of Dagangshan arch dam＇s transverse joint aperture is simulated. The real work behav- ior of transverse joint, thermal and mechanical properties of con- crete, pouring process, joint grouting temperature and cantilever height of high arch dam are considered during the simulation. The simulation results show that the lower of the joint grouting tem- perature, the larger value of transverse joint aperture; the higher of cantilever height during the construction period, the smaller value of transverse joint aperture.

关键词： high arch dam simulation analysis transverse jointaperture temperature field cantilever height

Effect Analysis of the Contributions of Financial Investment in Education and Human Capital to Local Economic Growth——Empirical tests based on data from Sichuan Province

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Effect Analysis of the Contributions of Financial Investment...

Effects of intrathecal NMDA and AMPA receptors agonists or antagonists on antinociception of propofol

2013年教育技术与管理科学国际会议

作者： duan yin-ying LI Ya-xiang Southwest Jiaotong University School of Ecnomics and Management Southwest Jiaotong University School of Economics and Management

This thesis conducts empirical tests for the contributions made by financial investment in education as well as human capital to the local economic growth in Sichuan Province according to the relevant statistics of Sichuan Province from 1997 to 2011. The results show that compared to the relatively less influence from financial investment in education, human capital exerts a obviously positive effect on the economic growth in Sichuan Province. And its effect on economy is lasting and continuous with a contribution rate on economic growth as high as 35% to 40%. Regarding the adjustments of factors of growth in the economic development and the overall urban-rural comprehensive reform pilot trial, this conclusion provides reference and instruction for the Sichuan provincial government.

关键词： financial investment in education human capital economic growth

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Acta Pharmacologica Sinica 2004年第1期 11-16页

作者： Ai-jun XU, Shi-ming duan, yin-ming ZENGJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China

AIM: To study the effects of intrathecal (it) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors and NMDAR1 antisense oligodeoxynucleotides (AS ODN) on the antinociception of propofol. METHODS: Hot-plate test (HPPT) and acetic acid-induced writhing test were used to measure the nociceptive thresholds in mice. The effects of intrathecal NMDA,

关键词： N-methyl-D-aspartate receptors AMPA receptors spinal injections antinociception propofol

Synthesis of highly concentrated,carrier free ^(188)Re-mercaptoacetyltriglycine

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Nuclear Science and Techniques 2002年第4期13卷 237-243页

作者： ZHANG Xiu-Li, WANG Yong-Xian, LI Jun-Ling, ZHANG Chun-Fu, WANG Li-Hua,yin duan-Zhi(Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) Shanghai Institute of Nuclear Research the Chinese Academy of Sciences 201800

Chelation of 188Re to compounds such as MAG3 will further reduce the radiation dose to the patient in case of balloon rupture through the rapid excretion from the body. In order to prepare highly concentrated, carrier free 188Re-MAG3, Sbenzoyl mercaptoacetyltriglycine (S-Bz-MAG3) was synthesized, labeled with carrier free 188Re. The overall yield of S-Bz-MAG3 is higher than those published in theliterature. Dependence of the labeling yield of 1ssRe-MAG3 upon concentrations of reducing agent, pH, reaction time, etc. was examined and optimum conditions were confirmed. The concentration procedure was succeeded with Sep-Pak C18 cartridge to obtain highly concentrated 1s8Re-MAG3. In the case of optimun conditions, the labeling yield of 188Re-MAG3 was more than 98%. Radiochemical purity of 188ReMAG3 was more than 92% after 24 hour storage at room temperature.

关键词：放射同位素 ^188Re 放射免疫疗法

Clinical value of CT three-dimensional imaging in diagnosing gastrointestinal tract diseases

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World Journal of Gastroenterology 2006年第18期12卷 2945-2948页

作者： Shao-yin duan Dan-Tong Zhang Qing-Chi Lin Yan-Huan Wu Medical Imaging Department Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China Gastroenterology and Endocrinology Department Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

AIM： To discuss the clinical value of CT three-dimensional （3-D） imaging in diagnosing gastrointestinal tract diseases.METHODS： Three-D imaging findings of 52 patients were retrospectively analyzed. Three-D imaging methods included shaded surface display （SSD）, volume rendering （VR）, virtual endoscopy （VE） and multiplanar reformatting （MPR）. The diagnosis results of CT 3-D were evaluated by comparison with those of endoscopy and/or surgical finding.RESULTS： Fifty-two patients with gastrointestinal tract diseases were diagnosed by CT 3-D imaging, of whom 50 cases were correctly diagnosed and 2 were misdiagnosed. There were 33 cases of gastric diseases （27 with carcinoma, 5 with peptic ulcer and 1 with leiomyoma） and 19 large intestinal diseases （10 with colon carcinoma, 2 with carcinoma of the rectum, 5 with colon polypus and 2 with tuberculosis of the ileocecal junction）. Twenty-two cases with prominent lesions （9 with subsequent hollow lesions）, 20 with stenosis of cavity （8 with concomitant prominent lesions） and 10 with hollow lesions （5 with concomitant prominent lesions） were shown in 3-D images. The minimal lesion shown was 1.0 cm × 0.8 cm × 0.5 cm.CONCLUSION： CT 3-D imaging, a non-invasive examination without pain, can display clearly and directly the lesions of gastrointestinal tract with accurate location and high diagnosis accuracy. It is an important complementary technique to endoscopy.

关键词： Gastrointestinal tract, disease X-ray computed, Tomograph Image processing Computerassisted

Vascular reconstruction of a ruptured and infected aneurysm of extracranial carotid artery

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Chinese Medical Journal 2008年第7期121卷 671-672页

作者： SONG Jin-qiu ZHANG Jian yin Ming-di SHAN Shao-yin WU Bin duan Zhi-quan XIN Shi-jie Department of General Surgery Section of Vascular Surgery FirstHospital China Medical University Shenyang Liaoning 110001China

Extracranial carotid artery aneurysm represents an ,uncommon vascular condition with relatively higherincidence in China than in the West.1 The complication with infection and rupture is even rarer, but potentially lethal. Management of this condition is challenging but urgent because of high risks for embolization, generalized sepsis, further expansion, rupture, and life threatening.L2 We present an exceptional case of carotid aneurysm at bifurcation complicated with rupture and infection and discuss the pathogenesis and various aspects of diagnosis and surgical management.

关键词： carotid artery aneurysm rupture

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季节调整后的蔬菜价格与CPI之间关系研究

广东农业科学 2014年第17期41卷 201-205页

作者：殷端华中农业大学经济管理学院湖北武汉430070

在采用X-12-ARIMA季节调整模型剥离白菜、菜椒、黄瓜价格与CPI季节性影响的基础上,分析了此三类大宗蔬菜价格与CPI间的关系。协整分析结果表明,3类蔬菜价格与CPI间均存在长期稳定的均衡关系;Granger因果关系检验结果表明,CPI在短期和长... 详细信息

在采用X-12-ARIMA季节调整模型剥离白菜、菜椒、黄瓜价格与CPI季节性影响的基础上,分析了此三类大宗蔬菜价格与CPI间的关系。协整分析结果表明,3类蔬菜价格与CPI间均存在长期稳定的均衡关系;Granger因果关系检验结果表明,CPI在短期和长期均为影响3类蔬菜价格的原因,而白菜、黄瓜价格短期内对CPI的影响差异不显著,但其在长期内对CPI的作用显著。为正确把握我国蔬菜价格动态,保障居民生活质量水平,应尽快健全蔬菜价格风险预警体系,完善信息流通渠道,加强蔬菜基础设施的优化。

关键词：蔬菜价格 CPI X-12-ARIMA季节调整模型 VECM模型

非常规拔牙矫治外伤致上前牙牙根-骨粘连一例

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中华口腔医学杂志 2009年第3期44卷 175-176页

作者：陈磊段银钟第四军医大学口腔医学院正畸科西安710032

牙齿外伤脱位再行复位固定后，常出现牙根部牙骨质与牙槽骨骨性愈合，牙周膜消失，因而不能进行正畸移动，有时还会影响邻牙的正畸移动。为该类患者制定正畸矫治计划时，必须通过设计特殊的正畸矫治方案才能获得良好的矫治效果。现对1... 详细信息

牙齿外伤脱位再行复位固定后，常出现牙根部牙骨质与牙槽骨骨性愈合，牙周膜消失，因而不能进行正畸移动，有时还会影响邻牙的正畸移动。为该类患者制定正畸矫治计划时，必须通过设计特殊的正畸矫治方案才能获得良好的矫治效果。现对1例前牙外伤复位后发生骨粘连的病例矫治过程报告如下。

关键词：骨性愈合拔牙矫治外伤脱位牙根部粘连上前牙正畸移动复位固定