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Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

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Science China Chemistry 2024年第8期67卷 2497-2523页

作者： Yuan Zeng Shuhan Zhang Yuecong Guo Yalin Cong Xu Ding Peihua Li Yunxiang Lin Wenzhi Ren Hui Su Weigang Sun Liuxin Xu Guikai Zhang Shihua Chen Yu Chen Weiren Cheng Shengqi Chu Yong Guan Jinru Han Jie Lin Hengjie Liu Zheyi Liu Pan Luo Fanchun Meng Sicong Qiao Zongyin Song ying Wang Zhao Wu Chenyu Yang Meng Yang Shirui Yang Zi yin zhibin yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia Zhou Wanlin Zhou Pengfei An He Cheng Chunhai Fan Xingjiu Huang Yong Lei Lina Li Mu Li Qinghua Liu Shuming Peng Li Song Zhihu Sun Yangchao Tian Fangjun Wang Lihua Wang Liming Wang Shiqiang Wei Aiguo Wu Chunlei Xiao Xueming Yang Panchao yin Jing Zhang Mingxin Zhang Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science LaboratoryNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China State Key Laboratory of Luminescent Materials and Devices South China Advanced Institute for Soft Matter Science and TechnologySouth China University of TechnologyGuangzhou 510640China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Advanced Science Facilities Shenzhen 518107China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Acade

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron *** further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： large scientific facilities synchrotron radiation FEL light sources neutron sources spectroscopic analysis methods X-ray imaging techniques structural information chemical dynamics

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侧方入路及中间入路腹腔镜手术治疗结直肠癌的围手术期指标比较

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中国医学创新 2024年第9期21卷 52-56页

作者：孙鋆泽谢亮海尹志斌无锡市惠山区第三人民医院普外科江苏无锡214183

目的:观察侧方入路及中间入路腹腔镜手术治疗结直肠癌的围手术期指标的差异。方法:选取2018年12月—2022年12月无锡市惠山区第三人民医院收治的122例结直肠癌患者,采用随机数字表法将其分为观察组和对照组,各61例。两组均行腹腔镜结直... 详细信息

目的:观察侧方入路及中间入路腹腔镜手术治疗结直肠癌的围手术期指标的差异。方法:选取2018年12月—2022年12月无锡市惠山区第三人民医院收治的122例结直肠癌患者,采用随机数字表法将其分为观察组和对照组,各61例。两组均行腹腔镜结直肠癌根治术,观察组选择中间入路,对照组选择侧方入路。比较两组手术时间、术中出血量、淋巴结清扫个数、肛门排气时间、肠鸣音恢复时间、进食时间;比较两组手术前后血清糖类抗原19-9(CA19-9)、糖类抗原242(CA242)、癌胚抗原(CEA)水平;比较两组术后并发症发生率。结果:与对照组相比,观察组手术时间、肛门排气时间、肠鸣音恢复时间、进食时间均较短,术中出血量较少,淋巴结清扫个数较多,差异均有统计学意义(P0.05);观察组术后并发症发生率为8.20%(5/61),包括切口感染3例、肠梗阻1例、吻合口出血1例,对照组术后并发症发生率为9.84%(6/61),包括切口感染2例、尿路感染1例、肠梗阻2例、吻合口瘘1例,两组术后并发症发生率比较差异无统计学意义(P>0.05)。结论:腹腔镜结直肠癌根治术选择侧方入路或中间入路治疗结直肠癌患者在控制血清肿瘤标志物水平方面效果相当,而中间入路有利于缩短手术时间、降低术中出血量,促进患者术后恢复。

关键词：结直肠癌腹腔镜手术手术入路围手术期

Naive-LSTM based services awareness of edge computing elastic optical networks

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Optoelectronics Letters 2023年第5期19卷 279-283页

作者： HUO Chao BAI Huifeng yin zhibin YAN Bo Beijing SmartChip Microelectronics Technology Company Limited Beijing 102200China Huakeyinnuo(Tianjin)Energy Technology Co. Ltd.Tianjin 300143China

Great challenges and demands are presented by increasing edge computing services for current elastic optical networks(EONs)to deal with serious diversity and complexity of these *** improve the match degree between edge computing and optical network,the services awareness function is necessary for *** article proposes a Naive long short-term memory(Naive-LSTM)based services awareness strategy of the EON,where the Naive-LSTM model makes full use of the most simplified structure and conducts discretization of the LSTM ***,the proposed algorithm can generate the probability output result to determine the quality of service(Qo S)policy of *** well learning operation,these Naive-LSTM classification agents in edge nodes of EONs are able to perform services awareness by obtaining data traffic characteristics from services *** results show that the proposed approach is feasible and efficient to improve edge computing ability of EONs.

关键词： optical services LSTM

Recent advances in proteomics and metabolomics in plants

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Molecular Horticulture 2022年第1期2卷 225-262页

作者： Shijuan Yan Ruchika Bhawal zhibin yin Theodore W.Thannhauser Sheng Zhang Guangdong Key Laboratory for Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhouChina Proteomics and Metabolomics Facility Institute of BiotechnologyCornell University139 Biotechnology Building526 Campus RoadIthacaNY 14853USA R.W.Holley Center for Agriculture&Health USDA/ARSIthacaNYUSA

Over the past decade,systems biology and plant-omics have increasingly become the main stream in plant biology *** developments in mass spectrometry and bioinformatics tools,and methodological schema to inte-grate multi-omics data have leveraged recent advances in proteomics and *** progresses are driv-ing a rapid evolution in the field of plant research,greatly facilitating our understanding of the mechanistic aspects of plant metabolisms and the interactions of plants with their external ***,we review the recent progresses in MS-based proteomics and metabolomics tools and workflows with a special focus on their applications to plant biology research using several case studies related to mechanistic understanding of stress response,gene/protein function characterization,metabolic and signaling pathways exploration,and natural product *** also present a projection concerning future perspectives in MS-based proteomics and metabolomics development including their applications to and challenges for system *** review is intended to provide readers with an overview of how advanced MS technology,and integrated application of proteomics and metabolomics can be used to advance plant system biology research.

关键词： LC-MS GC-MS Single cell proteomics Phosphoproteomics Tandem mass tag Fluxomics Spatially resolved metabolomics Mass spectrometry imaging

Plasmonic polydopamine-modified TiO_(2)nanotube substrates for surface-assisted laser desorption/ionization mass spectrometry imaging

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Nano Research 2023年第2期16卷 3028-3039页

作者： Dong Chen Mingyi Du Yudi Huang Yizhu Xu yingying Chen Lianlian Ma Qingrong Xie Xinhai Zhu Zilong Chen Hanhong Xu Xinzhou Wu zhibin yin State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources and Key Laboratory of Natural Pesticide and Chemical Biology of the Ministry of Education South China Agricultural UniversityGuangzhou 510642China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China Instrumental Analysis and Research Center Sun Yat-sen UniversityGuangzhou 510275China

Mass spectrometry imaging(MSI)has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues ***,available matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)suffers from severe background interferences in low-mass ranges and inhomogeneous matrix ***,surface-assisted LDI-MS(SALDI-MS)has been an attractive alternative for high-sensitivity detection and imaging of small *** this study,we construct a new composite substrate,hydrophobic polydopamine(hPDA)-modified TiO_(2)nanotube(TDNT)coated with plasmonic gold nanoparticle(AuNP-hPDA-TDNT),as a dual-polarity SALDI substrate using an easy and cost-effective fabrication *** from the synergistic effects of TDNT semiconductor and plasmonic PDA modification,this SALDI substrate exhibits superior performance for dual-polarity detection of a vast diversity of small *** reduced background interferences,lower detection limits,and spot-to-spot repeatability can be achieved using AuNP-hPDA-TDNT *** to its unique imprinting performance,various metabolites and lipids can be visualized within jatropha integerrima petals,ginkgo leaves,strawberry fruits,and latent *** valuably,the universality of this matrix-free substrate is demonstrated for mapping spatial distribution of lipids within mouse brain tissue *** together,this AuNP-hPDA-TDNT material is expected to be a promising SALDI substrate in various fields,especially in nanomaterial development and life sciences.

关键词： TiO_(2)nanotube surface-assisted laser desorption/ionization(SALDI) mass spectrometry imaging latent fingerprint tissue imaging

Subcellular chemical imaging of structurally similar acridine drugs by near-field laser desorption/laser postionization mass spectrometry

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Nano Research 2020年第3期13卷 745-751页

作者： Xiaoling Cheng zhibin yin Liu Rong Wei Hang Department of Chemistry and the MOE Key Lab of Spectrochemical Analysis&Instrumentation College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China

Insights into the pharmacologic effect on cellular processes and the potential toxicological effects are vital to new drug development and evaluation,yet research on these subjects remains a great challenge due to the lack of information regarding the spatiotemporal distribution of drugs and metabolites within a single *** spectrometry imaging(MSI)has proven to be a label-free and high-throughput approach for visualizing drug distribution in spatial and temporal ***,single-cell drug imaging has been limited so far by detection sensitivity and microscale lateral ***,we report near-field laser desorption/laser postionization mass spectrometry(NDPI-MS)for single-cell imaging of two structurally similar drugs,proflavine and ethacridine,and subcellular distributions of proflavine at different drug concentrations were *** NDPI-MS imaging results indicate that proflavine was accumulated in lysosomes,which was verified by laser scanning confocal microscopy(LSCM).Additionally,a distinguished subcellular distribution pattern of ethacridine from proflavine could be visualized,highlighting the complexity of the interaction between the drugs and biological environment even though these two drugs possess similar *** together,the present results demonstrate the great potential of the integrated single-cell MSI platform for characterizing the drug distribution and its phenotype changes within individual cells,expediting the identification and evaluation of newly developed drugs.

关键词： near-field mass spectrometry acridine drugs single cell imaging laser postionization

c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model

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Animal Models and Experimental Medicine 2024年第2期7卷 136-144页

作者： yin Ye Xiaojun Yang Feifei Li Wei Liu Wenqing Zhang zhibin Huang Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouChina

Background:Despite the success of tyrosine kinase inhibitors in chronic myeloid leukemia(CML)therapy,CML still faces the challenges of drug resistance and progression to blast ***-five percent of patients have imatinib resistance and treatment difficulties due to heterogeneity after progression,but little is known about the mechanism.A key transcription factor in hematopoiesis,MYB,has been reported to increase abnormally in several types of aggressive blood disorders including ***:This study used a zebrafish model to explore the relationship between BCR/ABL1 and c-myb in CML progression.A CML zebrafish model was crossed with a c-myb hyperactivity transgenic ***:It was found that both exogenous BCR/ABL1 and c-myb could up-regulate the expression of neutrophil-related *** seriously,neutrophil accumulation was observed when BCR/ABL1 was combined with c-myb *** studies showed that c-myb may be one of the downstream targets of BCR/ABL1 and the effect of BCR/ABL1 on neutrophils was c-myb *** advantage of this inheritable in vivo model,it was shown that a combination of imatinib and flavopiridol,a cyclin-dependent kinase inhibitor targeting MYB,could more effectively alleviate the aggressive phenotype of the double transgene ***:In summary,this study suggests that c-myb acts downstream of BCR/ABL1 and is involved in CML progression and is therefore a risk factor and a valuable target for the treatment of CML *** model used in the study could be helpful in high-throughput drug screening in CML transformation.

关键词： chronic myeloid leukemia c-myb flavopiridol zebrafish model

Gravitational waves and primordial black hole productions from gluodynamics by holography

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 31-42页

作者： Song He Li Li zhibin Li Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Golm 14476Germany CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Understanding the nature of quantum chromodynamics(QCD)matter is important but challenging due to the presence of nonperturbative dynamics under extreme *** construct a holographic model describing the gluon sector of QCD at finite temperatures in the non-perturbative *** equation of state as a function of temperature is in good accordance with the lattice QCD ***,the Polyakov loop and the gluon condensation,which are proper order parameters to capture the deconfinement phase transition,also agree quantitatively well with the lattice QCD *** obtain a strong first-order confinement/deconfinement phase transition at Tc=276.5 Me V that is consistent with the lattice QCD *** on our model for a pure gluon hidden sector,we compute the stochastic gravitational waves and primordial black hole(PBH)productions from this confinement/deconfinement phase transition in the early *** resulting stochastic gravitational-wave backgrounds are found to be within detectability in the International Pulsar Timing Array and Square Kilometre Array in the near future when the associated productions of PBHs saturate the current observational bounds on the PBH abundances from the LIGO-Virgo-Collaboration O3 data.

关键词： AdS/QCD confinement/deconfinement phase transition gravitational wave primordial black hole

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Organic Synthesis through Radical Innovation:Frustrated Radical Pairs

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Chinese Journal of Chemistry 2024年第10期42卷 1157-1160页

作者： zhibin Hu Zengrui Cheng Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Frustrated Lewis Pairs(FLPs)represent a unique class of interactions in Lewis acid-base chemistry,driven by spatial hindrance or incongruent orbital energy levels that hinder the formation of effective coordination *** have received significant attention for their application in activating small molecules and facilitating organic synthesis *** developments have led to the emergence of Frustrated Radical Pairs(FRPs)as an extension of the radical *** are formed from FLPs through Single Electron Transfer(SET)and exhibit the ability to activate a variety of chemical *** research on FLPs is well-established,investigations into FRPs in organic reactions remain *** review highlights the current state of FRPs in organic synthesis,delves into mechanistic insights,explores their potential,and underscores the challenges in this emerging field.

关键词： Radicals Frustrated Lewis Pairs Frustrated Radical Pairs Methodology and reactions Reaction mechanisms