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Exosomal transfer of microRNA-590-3p between renal tubular epithelial cells after renal ischemia-reperfusion injury regulates autophagy by targeting TRAF6

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Chinese Medical Journal 2022年第20期135卷 2467-2477页

作者： yimeng Chen Congya Zhang Yingjie du Xiying Yang Min Liu Wenjing Yang Guiyu Lei Guyan Wang Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Weifang Medical University School of AnesthesiologyShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaWeifangShandong 261053China

Background:Acute kidney injury(AKI)is a common complication in patients,especially elderly patients,who undergo cardiac surgery with cardiopulmonary bypass.Studies have indicated a protective role of autophagy in AKI.However,the mechanisms underlying the regulatory effect of autophagy in AKI among patients undergoing cardiac surgeries are poorly understood.In this study,we aimed to test the hypothesis that exosomal microRNAs(miRNAs)regulate autophagy in tubular epithelial cells after AKI.Methods:Plasma exosomal RNA was extracted from young and elderly AKI patients undergoing cardiac surgery,and the miRNAs expression during the perioperative period were analyzed using next-generation sequencing.The screened miRNAs and their target genes were subjected to gene oncology function and Kyoto Encyclopedia of Genes and Genome enrichment analyses.Renal tubular epithelial cell line(HK-2 cells)was cultured and hypoxia/reoxygenation(H/R)model was established,which is an in vitro renal ischemia/reperfusion(I/R)model.We used Western blot analysis,cell viability assay,transfection,luciferase assay to investigate the mechanisms underlying the observed increases in the levels of renal I/R injury-mediated exosomal miRNAs and their roles in regulating HK-2 cells autophagy.Results:miR-590-3p was highly enriched in the plasma exosomes of young AKI patients after cardiac surgery.Increased levels of miR-590-3p led to the increases in the expression of autophagy marker proteins,including Beclin-1 and microtubule associated protein 1 light chain 3 beta(LC3II),and prolonged the autophagic response in HK-2 cells after H/R treatment.These effects were achieved mainly via increases in the exosomal miR-590-3p levels,and the tumor necrosis factor receptor-associated factor 6 protein was shown to play a key role in I/R injury-mediated autophagy induction.Conclusion:Exosomes released from HK-2 cells after renal I/R injury regulate autophagy by transferring miR-590-3p in a paracrine manner,which suggests that increasing the miR-590-3p levels in H

关键词： Acute kidney injury Autophagy Exosome Hypoxia Ischemia miR-590-3p Reperfusion

A Meta-analysis of Major Complications between Traditional Pacemakers and Leadless Pacemakers

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Cardiovascular Innovations and Applications 2021年第1期5卷 145-153页

作者： Diyu Cui yimeng Liao Jianlin du Yunqing Chen Department of Cardiology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Objectives:We aim to compare the major complications between leadless pacemakers and traditional pacemakers.Background:Leadless pacemakers,which are increasingly used in clinical practice,have several advantages compared with traditional pacemakers in avoiding pocket-and lead-related complications.However,the clinical effect of leadless pacemakers remains controversial.Methods:PubMed,Embase,the Cochrane Central Register of Controlled Trials(CENTRAL),the CNKI database,and the Wanfang database were searched from July 2013 to December 2019.Studies comparing leadless pacemakers and traditional pacemakers were included.The primary end point was major complications.The secondary end points were cardiac perforation/pericardial effusion,device revision or extraction,loss of device function,and death.Results:Six studies fulfi lled the inclusion criteria.Only four of the six studies reported data on major complications.Leadless pacemakers were associated with a lower incidence of major complications(risk ratio 0.33,95%confi dence interval 0.25–0.44,P<0.00001,I²=49%).We extracted data on cardiac perforation/pericardial effusion,device revision or extraction,loss of device function,and death from six studies.Our meta-analysis showed that leadless pacemakers have a higher risk of cardiac perforation or pericardial effusion(risk ratio 4.28,95%confi dence interval 1.66–11.08,P=0.003,I²=0%).No statistically signifi cant differences were found for mortality,device revision or extraction,and loss of device function.Conclusion:Compared with traditional pacemakers,leadless pacemakers have a signifi cantly decreased risk of major complications,but have a higher risk of cardiac perforation or pericardial effusion.

关键词： Leadless pacemaker traditional pacemaker treatment effect complication meta-analysis

HASM quantum machine learning

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Science China Earth Sciences 2023年第9期66卷 1937-1945页

作者： Tianxiang YUE Chenchen WU Yi LIU Zhengping du Na ZHAO yimeng JIAO Zhe XU Wenjiao SHI State Key Laboratory of Resources and Environment Information System Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Yanqi Lake Beijing Institute of Mathematical Sciences and Applications Beijing 101408China College of Resources and Environment University of Chinese Academy of SciencesBeijing 101499China College of Land Resources and Environment Jiangxi Agricultural UniversityNanchang 330045China

The miniaturization of transistors led to advances in computers mainly to speed up their computation.Such miniaturization has approached its fundamental limits.However,many practices require better computational resources than the capabilities of existing computers.Fortunately,the development of quantum computing brings light to solve this problem.We briefly review the history of quantum computing and highlight some of its advanced achievements.Based on current studies,the Quantum Computing Advantage(QCA)seems indisputable.The challenge is how to actualize the practical quantum advantage(PQA).It is clear that machine learning can help with this task.The method used for high accuracy surface modelling(HASM)incorporates reinforced machine learning.It can be transformed into a large sparse linear system and combined with the Harrow-Hassidim-Lloyd(HHL)quantum algorithm to support quantum machine learning.HASM has been successfully used with classical computers to conduct spatial interpolation,upscaling,downscaling,data fusion and model-data assimilation of ecoenvironmental surfaces.Furthermore,a training experiment on a supercomputer indicates that our HASM-HHL quantum computing approach has a similar accuracy to classical HASM and can realize exponential acceleration over the classical algorithms.A universal platform for hybrid classical-quantum computing would be an obvious next step along with further work to improve the approach because of the many known limitations of the HHL algorithm.In addition,HASM quantum machine learning might be improved by:(1)considerably reducing the number of gates required for operating HASM-HHL;(2)evaluating cost and benchmark problems of quantum machine learning;(3)comparing the performance of the quantum and classical algorithms to clarify their advantages and disadvantages in terms of accuracy and computational speed;and(4)the algorithms would be added to a cloud platform to support applications and gather active feedback from users of the algorithms.

关键词： Quantum computing Machine learning Eco-environmental surface High accuracy surface modelling Quantum computational advantage Practical quantum advantage

Numerical study of vortex breaker optimization in a first stage oxygen tank

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Propulsion and Power Research 2023年第3期12卷 322-335页

作者： Yixiu Shen yimeng Li Zhenggang du College of Design and Engineering National University of Singapore9 Engineering Drive 1Block EA#07-08117575Singapore Department of Mechanical Engineering University of CaliforniaBerkeley2521 Hearst AveBerkeleyCA 94709United States Propulsion Department Landspace Company13 Ronghua South RoadYizhuang Economic and Technological Development ZoneBeijing 100176China

One of the crucial factors affecting the carrying capacity of the cryogenic liquid launch vehicle is the effective volume of the tank.Theoretical and experimental investigations on vortex breaker mechanisms have proposed promising schemes applied in the oxygen tank of the liquid-propellant launch vehicle to ensure the normal operation of the engine.In this paper,the liquid surface profile functions of the laminar core when the vortex generates were derived based on the Rankine vortex model.The dimensionless residual volume V/d3 and the Froude number were applied to compare the theoretical prediction of critical height with the actual simulation data of liquid oxygen.This comparison method can improve the model’s accuracy.The efficiency of different basic shapes of vortex breakers was tested by conducting CFD modelling on a non-vertical outflow tank under a specific operating condition.Simulation results suggest negligible effects of heat transfer and surface tension.A circular plate is considered the optimal vortex breaker shape in traditional vertical outflow tanks,while a higher optimize efficiency was discovered in the half baffle basic shape in a non-vertical outflow tank by comparing the dimensionless residual volume and flow coefficient.A 34.26%reduction in flow resistance of half baffle breaker can be reached when applying a twenty-degree outlet pipe chamfering setting compared to a zero-degree chamfer.Considering practical operating limitations,it is concluded that a vortex breaker mechanism in a half baffle basic shape with a radius of 2.5d and a height of 4/d is the optimal scheme,which is suitable for all types of tanks.Its optimization efficiency of the residual volume reduction is about 56.68%compared to a nobreaker installation case.Lastly,a general equation based on CFD simulation for predicting the residual volume under a certain outflow velocity was proposed:V=d3yaFr0:3,which trend is consistent with that of mathematical prediction V=d3yaFr1=3.This consistency proves the accuracy and applicabilit

关键词： Liquid launch vehicle Cryogenic propellant Vortex breaker CFD simulation Surface collapse

Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

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Cancer Biology & Medicine 2023年第2期20卷 155-168页

作者： yimeng Chen Xue Wang Feng du Jian Yue Yiran Si Xiaochen Zhao Lina Cui Bei Zhang Ting Bei Binghe Xu Peng Yuan Department of Medical Oncology and Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China The Medical Department 3D Medicines Inc.Shanghai 201114China

Objective:The choice of chemotherapeutic regimen for triple-negative breast cancer(TNBC)remains controversial.Homologous recombination deficiency(HRD)has attracted increasing attention in informing chemotherapy treatment.This study was aimed at investigating the feasibility of HRD as a clinically actionable biomarker for platinum-containing and platinum-free therapy.Methods:Chinese patients with TNBC who received chemotherapy between May 1,2008 and March 31,2020 were retrospectively analyzed with a customized 3D-HRD panel.HRD positivity was defined by an HRD score≥30 or deleterious BRCA1/2 mutation.A total of 386 chemotherapy-treated patients with TNBC were screened from a surgical cohort(NCT01150513)and a metastatic cohort,and 189 patients with available clinical and tumor sequencing data were included.Results:In the entire cohort,49.2%(93/189)of patients were identified as HRD positive(40 with deleterious BRCA1/2 mutations and 53 with BRCA1/2 intact with an HRD score of≥30).In the first-line metastatic setting,platinum therapy was associated with longer median progression-free survival(mPFS)than platinum-free therapy[9.1 vs.3.0 months;hazard ratio(HR),0.43;95%confidence interval 0.22–0.84;P=0.01].Among HRD-positive patients,the mPFS was significantly longer in those treated with platinum rather than platinum-free therapy(13.6 vs.2.0 months;HR,0.11;P=0.001).Among patients administered a platinum-free regimen,HRD-negative patients showed a PFS significantly superior to that of HRD-positive patients(P=0.02;treatment-biomarker P-interaction=0.001).Similar results were observed in the BRCA1/2-intact subset.In the adjuvant setting,HRD-positive patients tended to benefit more from platinum chemotherapy than from platinum-free chemotherapy(P=0.05,P-interaction=0.02).Conclusions:HRD characterization may guide decision-making regarding the use of platinum treatment in patients with TNBC in both adjuvant and metastatic settings.

关键词： Homologous recombination deficiency triple-negative breast cancer platinum survival BRCA

The Imperfection of Democracy

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Contemporary International Relations 2011年第1期21卷 43-56页

作者： Zhang Yimeng Du Weiwei

Generally speaking, democracy has promoted prosperity and peace. In most people's opinion, democracy is about respect for the individual. The vote embodies the respect we have for each other. This is not to say that d... 详细信息

关键词：民主促进中国民主制度政府工作

金喉健喷雾剂和利多卡因气雾剂在全身麻醉气管插管中的应用比较

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上海交通大学学报（医学版） 2022年第1期42卷 90-94页

作者：吴雷杜重临夏一梦河南科技大学附属许昌市中心医院麻醉科许昌461000 上海交通大学医学院附属瑞金医院消化内科上海200025 上海交通大学医学院附属瑞金医院麻醉科上海200025

目的·比较金喉健喷雾剂和利多卡因气雾剂在全身麻醉气管插管中的临床应用效果。方法·纳入上海交通大学医学院附属瑞金医院100例择期行腹腔镜胆囊切除术的全身麻醉气管插管的患者,按随机数字表分为金喉健喷雾剂组(研究组)和利多卡因气... 详细信息

目的·比较金喉健喷雾剂和利多卡因气雾剂在全身麻醉气管插管中的临床应用效果。方法·纳入上海交通大学医学院附属瑞金医院100例择期行腹腔镜胆囊切除术的全身麻醉气管插管的患者,按随机数字表分为金喉健喷雾剂组(研究组)和利多卡因气雾剂组(对照组),每组50例。麻醉诱导后l min,在UE可视喉镜暴露声门后,将金喉健喷雾剂或利多卡因气雾剂于咽喉部分别按2揿。观察插管前(T0)、插管即刻(T1)、插管后3 min (T2)、插管后5 min (T3)、插管后10min (T4)、拔管即刻(T5)、拔管后3 min (T6)和拔管后5 min (T7)的平均动脉压(mean arterial pressure, MAP)和心率(heart rate, HR)变化。记录患者拔管前后苏醒期躁动评分和对气管导管的耐受度。术后24 h进行随访,观察患者咽喉疼痛、声音嘶哑及拔管反应等情况。结果·2组患者一般情况具有可比性。2组患者经药物处理后,都能预防气管插管和拔管引起的心血管应激反应,MAP、HR、苏醒期躁动评分比较,差异均无统计学意义。与对照组相比,研究组对气管导管的耐受满意度(P=0.021)和可接受度(P=0.021)明显提高,且术后24 h内咽痛发生率显著减低(P=0.020)。结论·应用金喉健喷雾剂能有效降低全身麻醉气管插管引起的心血管应激反应,提高行腹腔镜胆囊切除术患者对气管导管的耐受度,减轻术后咽痛发生率。

关键词：金喉健喷雾剂利多卡因气管插管血流动力学咽痛

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马达加斯加语言政策的变迁对语言生态的影响

法语国家与地区研究（中法文） 2022年第1期 11-20,89页

作者：杜怡濛苏晓楠北京外国语大学非洲学院

马达加斯加与大多数非洲国家一样拥有多元的语言环境,但是在殖民之前形成的通用的民族语言是不同族群间交流的工具。马达加斯加独立以来的语言政策确立了马达加斯加语和法语的双官方语言格局。近年来,马达加斯加政府提出了一系列保护民... 详细信息

马达加斯加与大多数非洲国家一样拥有多元的语言环境,但是在殖民之前形成的通用的民族语言是不同族群间交流的工具。马达加斯加独立以来的语言政策确立了马达加斯加语和法语的双官方语言格局。近年来,马达加斯加政府提出了一系列保护民族语言的规划措施,不断探讨如何完善语言和文化教育政策,以期促进国家全面发展。这些旨在提升民族语言地位的语言政策是否达到了预期的目标?当今的语言生态格局中马达加斯加语和法语是否延续了殖民时期的双层关系?语言政策的变迁对马达加斯加当今语言生态产生了怎样的影响?当今的语言规划还面临着怎样的挑战?本文将针对以上问题进行探究。

关键词：语言政策语言生态马达加斯加法语民族语言

Antibacterial hydroxyapatite coatings on titanium dental implants

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Frontiers of Materials Science 2023年第1期17卷 69-85页

作者： Ziming Liao Jingxuan Li yimeng Su Fenyan Miao Xiumei Zhang Yu Gu Jingjing du Ruiqiang Hang Yan Wei Weiyi Chen Di Huang Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Analytical&TestingCenter Hainan UniversityHaikou570028China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Titanium and its alloys are often used as substrates for dental implants due to their excellent mechanical properties and good biocompatibility.However,their ability to bind to neighboring bone is limited due to the lack of biological activity.At the same time,they show poor antibacterial ability which can easily cause bacterial infection and chronic inflammation,eventually resulting in implant failure.The preparation of composite hydroxyapatite coatings with antibacterial ability can effectively figure out these concerns.In this review,the research status and development trends of antibacterial hydroxyapatite coatings constructed on titanium and its alloys are analyzed and reviewed.This review may provide valuable reference for the preparation and application of high-performance and multi-functional dental implant coatings in the future.

关键词： composite dental implant hydroxyapatite titanium antibacterial