Size,shape,charge and“stealthy”surface:Carrier properties affect the drug circulation time in vivo

作     者：Jinwei Di Xiang Gao Yimeng Du Hui Zhang Jing Gao Aiping Zheng Jinwei Di;Xiang Gao;Yimeng Du;Hui Zhang;Jing Gao;Aiping Zheng

作者机构：State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Institute of Pharmacology and ToxicologyBeijing 100850China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2021年第16卷第4期

页      面：444-458页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Military Medical Innovation Project(16CXZ032) National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2018ZX09J18107-03,2018ZX09721003-005-009) 

主　　题：Drug carrier Circulation time Physical and chemical properties Macrophages Phagocytosis 

摘      要：The present review sets out to discuss recent developments of the effects and mechanisms of carrier properties on their circulation *** most drugs,sufficient in vivo circulation time is the basis of high *** carrier plays an irreplaceable role in helping drug avoid being quickly recognized and cleared by mononuclear phagocyte system,to give drug enough time to arrive at targeted organ and tissue to play its therapeutic *** physical and chemical properties of drug carriers,such as size,shape,surface charge and surface modification,would affect their in vivo circulation time,metabolic behavior and *** final circulation time of carriers is determined by the balance between macrophage recognitions,blood vessel penetration and urine ***,when designing the drug delivery system,we should pay much attention to the properties of drug carriers to get enough in vivo circulation time to arrive at target site *** article mainly reviews the effect of carrier size,size,surface charge and surface properties on its circulation time in vivo,and discusses the mechanism of these properties affecting circulation *** review has reference significance for the research of long-circulation drug delivery system.