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An expression atlas of miRNAs in Arabidopsis thaliana

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Science China(Life Sciences) 2018年第2期61卷 178-189页

作者： Le Xu Yugang Hu Ying Cao Jingrui Li Ligeng Ma Yan Li yijun qi Center for Plant Biology School of Life Sciences Tsinghua University Beijing 100084 China Tsinghua-Peking Center for Life Sciences Beijing 100084 China College of Biologieal Sciences China Agricultural University Beijing 100094 China College of Life Sciences-Beijing Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement Capital Normal University Beijing 100048 China

MicroRNAs(miRNAs) are small non-coding RNAs that regulate a variety of biological processes. miRNA expression often exhibits spatial and temporal specificity. However, genome-wide miRNA expression patterns in different organs during development of Arabidopsis thaliana have not yet been systemically investigated. In this study, we sequenced small RNA libraries generated from 27 different organ/tissue types, which cover the entire life cycle of Arabidopsis. Analysis of the sequencing data revealed that most miRNAs are ubiquitously expressed, whereas a small set of miRNAs display highly specific expression patterns. In addition, different miRNA members within the same family have distinct spatial and temporal expression patterns. Moreover, we found that some miRNAs are produced from different arms of their hairpin precursors at different developmental stages. This work provides new insights into the regulation of miRNA biogenesis and a rich resource for future investigation of miRNA functions in Arabidopsis.

关键词： Arabidopsis miRNAs 地图集生物过程织物类型生命周期表示模非编码

Regulation of Rice Tillering by RNA-Directed DNA Methylation at Miniature Inverted-Repeat Transposable Elements

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Molecular Plant 2020年第6期13卷 851-863页

作者： Le Xu Kun Yuan Meng Yuan Xiangbing Meng Min Chen Jianguo Wu Jiayang Li yijun qi Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Vector-borne Virus Research Center State Key Laboratory of Ecological Pest Control for Fujian and Taiwan CropsFujian Province Key Laboratory of Plant VirologyInstitute of Plant VirologyFujian Agriculture and Forestry UniversityFuzhou 350002China

Tillering is a major determinant of rice plant architecture and grain ***,we report that depletion of rice OsNRPD1a and OsNRPD1b,two orthologs of the largest subunit of RNA polymerase IV,leads to a high-tillering phenotype,in addition to dwarfism and smaller ***1a and OsNRPD1b are required for the production of 24-nt small interfering RNAs that direct DNA methylation at transposable elements(TEs)including miniature inverted-repeat TEs(MITEs).Interestingly,many genes are regulated either positively or negatively by TE *** them,OsMIR156d and OsMIR156j,which promote rice tillering,are repressed by CHH methylation at two MITEs in the *** contrast,D14,which suppresses rice tillering,is activated by CHH methylation at an MITE in its *** findings reveal regulation of rice tillering by RNA-directed DNA methylation at MITEs and provide potential targets for agronomic trait enhancement through epigenome editing.

关键词： RdDM siRNA MITEs OsMIR156 D14 tiller

Turnip Yellow Mosaic Virus P69 Interacts with and Suppresses GLK Transcription Factors to Cause Pale-Green Symptoms in Arabidopsis

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Molecular Plant 2017年第5期10卷 764-766页

作者： Ni, Fangrui Wu, Liang Wang, qiang Hong, Jian qi, yijun Zhou, Xueping Zhejiang Univ Inst Biotechnol State Key Lab Rice Biol Hangzhou 310058 Zhejiang Peoples R China Tsinghua Univ Sch Life Sci Ctr Plant Biol Beijing 100084 Peoples R China Tsinghua Peking Ctr Life Sci Beijing 100084 Peoples R China Zhejiang Univ Coll Agr & Biotechnol Hangzhou 310058 Zhejiang Peoples R China

Dear Editor,Plant viral infections often induce genetic, hormonal, and meta- bolic perturbations, leading to disease symptoms such as leaf yellowing, leaf distortion, stunting, wilting, necrosis, and other abnormalities （Wang et al., 2012）. Turnip yellow mosaic virus （TYMV） is a positive-strand RNA virus that infects Arabidopsis thaliana and plant species in the Brassica genus and causes bright yellow mosaic symptoms （Morch et al., 1988; Skotnicki et al., 1992）.

关键词： Plant viral infections induce genetic hormonal

In memory of Professor Biao Ding(1960–2015)

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Journal of Integrative Plant Biology 2015年第8期57卷 730-731页

作者： Asuka Itaya William J.Lucas yijun qi Feng Qu Ying Wang Xuehua Zhong Chun-Ming Liu Agriculture and Agri-Food Canada Department of Plant Biology University of California Center for Plant Biology School of Life Sciences Tsinghua University Department of Plant Pathology Ohio State University Department of Molecular Genetics Ohio State University Wisconsin Institute for Discovery& Laboratory of Genetics University of Wisconsin Institute of Botany Chinese Academy of Sciences

It is with profound sadness that we mourn the loss of Dr. Biao Ding, a full-professor in the Department of Molecular Genetics, Ohio State University （OSU）, and a world-renowned plant biologist with leading authority in viroid research. He died suddenly on June 26, 2015 in Prague, Czech Republic, while attending the international Conference on Viroids and Viroid-Like RNAs as a Keynote Speaker. Dr. Ding was born in 196., in Kunming, Yunnan Province, China. He received his B.S. from Beijing Forestry University in 1982, and was then selected as one of the first group of outstanding young students to study abroad since the imolementation of China＇s Reform and Open Policy.

关键词： memory Professor Biao Ding

Inhibitory activity of Bifidobacterium adolescent combined with cisplatin on melanoma in mice and its mechanism

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Frontiers of Medicine 2008年第2期2卷 186-190页

作者： Hongying HUANG Guangchao LIU yijun qi Yaowu DU Jugao CHEN Yuanfang MA Key Laboratory of Cellular and Molecular Immunology Institute for ImmunologyHenan UniversityKaifeng 475004China

The aim of this study is to explore inhibitory activity of Bifidobacterium adolescent combined with cis-platin on the growth of melanoma(B16)in mice and the underlying mechanism.C57 mice were inoculated with B16 cancer cells to construct mouse model of melanoma and treated with bifidobacterium adolescent combined with *** of inhibitory activity on the growth of melanoma(B16)were *** changes of the tumor were observed by HE staining.B16 cell cycles were examined on a flow *** prolif-eration was measured with MTT assay and the T-cell sub-set was measured by double marked *** bifidobacterium of 1010 cfu/L was injected,the ratio of inhibitory activity on the growth of melanoma(B16)reached 54%,which was similar to that of cisplatin *** ratio of inhibitory activity reached 74.45%when the mice were treated by bifidobacterium combined with *** staining shows that bifidobacterium inhibited B16 cell proliferation and enhanced the cisplatin`s killing activity on B16 *** results of flow cytometry demonstrated that B16 cell proliferation was arrested at G1 stage after treatment with *** B16 cell proliferation was arrested at S stage after treatment with *** CD4+percentage increased and the difference was significant compared with the normal group after treatment with bifidobacterium,indicating that T-cell immune activity was *** with bifidobacterium combined with cisplatin can enhance the inhibitory activity on the growth of melanoma(B16)of *** mechanism of the inhibitory activity on B16 cell proliferation is correlated with the enhanced immune activity in mice.

关键词： Bifidobacterium adolescent cisplatin mela-noma,experimental

Transcriptional Regulation by Small RNAs and Argonautes

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Transcriptional Regulation by Small RNAs and Argonautes

中国生物化学与分子生物学会2016年全国学术会议

作者： yijun qi Centre for Plant Biology School of Life Sciences Tsinghua University

Small RNAs associated with Argonaute(AGO)family proteins are important components in the eukaryotic gene regulatory *** have evolved a complex system of small RNAs,among which the predominant species are herterochromatic si RNAs(hc-si RNAs)and micro RNAs(mi RNAs).Hc-si RNAs are associated with AGO4 and direct de novo DNA methylation at homologous loci through a pathway

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Transcriptional regulation by small RNAs and Argonautes

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Transcriptional regulation by small RNAs and Argonautes

2016年全国植物生物学大会

作者： yijun qi Centre for Plant Biology School of Life SciencesTsinghua University

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Phase separation in plant miRNA processing

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Phase separation in plant miRNA processing

2021年全国生物相分离和相变学术研讨会

作者： yijun qi Center for Plant Biology School of Life SciencesTsinghua University Tsinghua University-Peking University Joint Center for Life SciencesTsinghua University

miRNA production in Arabidopsis entails step-wise processing of primary miRNAs(pri-miRNAs) into precursor miRNAs(pre-miRNAs) and miRNA/duplexes by Dicing complexes containing DICER-LIKE 1(DCL1),Hyponastic leaves 1(HYL1)and Serrate(SE),which are localized in nuclear dicing bodies(D-bodies).How D-bodies are formed and whether D-bodies are places for miRNA processing remain *** this talk,I will present our recent findings that D-bodies are assembled through SE-mediated phase separation and recruitment of DCL1,HYL1 and pri/*** are processed in D-bodies,and after processing,mature miRNA/ duplexes exit D-bodies with the aid of HYL1.I will also present some preliminary data on two newly identified proteins that also phase separate and promote miRNA processing and discuss how they work with *** processing,miRNAs are loaded into Argonaute 1(AGO1) to form effector complexes that direct target mRNA cleavage and/or translational repression.I will discuss the possibility of phase separation in miRNA loading.

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Small RNAs and genome stability

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Small RNAs and genome stability

中国生物化学与分子生物学会第十一次会员代表大会暨201...

作者： yijun qi Center for Plant Biology School of Life Sciences Tsinghua University

Small RNAs are important components in the eukaryotic gene regulatory *** have evolved a complex system of small RNAs,among which the predominant species are microRNAs(miRNAs)and herterochromatic siRNAs(hc-siRNAs).miRNAs mediate post-transcriptional gene regulation through target mRNA cleavage or translational repression,whereas hc-siRNAs direct de novo DNA methylation at homologous loci through a pathway known as RNA-directed DNA methylation(RdDM).We have recently discovered a novel class of small RNAs that are induced by DNA double-strand breaks(DSBs)in Arabidopsis and humans.

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