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Effects of biochar-amended alkali-activated slag on the stabilization of coral sand in coastal areas

Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 760-772页

作者： Xiaole Han Ningjun jiang Fei Jin Krishna RReddy yijie Wang Kaiwei Liu Yanjun Du Department of Civil and Environmental Engineering University of Hawaii at ManoaHonoluluUSA Institute of Geotechnical Engineering Southeast UniversityNanjing210096China School of Engineering Cardiff UniversityCardiffUK Department of Civil Materialsand Environmental EngineeringUniversity of Illinois at ChicagoChicagoUSA College of Materials and Chemical Engineering Anhui Jianzhu UniversityHefei230601China

Coral sand is widely encountered in coastal areas of tropical and subtropical *** with silica sand,it usually exhibits weaker performance from the perspective of engineering *** improve the geomechanical performance of coral sand and meet the requirement of foundation construction in coastal areas,a novel alkali activation-based sustainable binder was *** alkaliactivated slag(AAS)binder material was composed of ground granulated blast-furnace slag(GGBS)and hydrated lime with the amendment of biochar,an agricultural waste-derived *** biocharamended AAS stabilized coral sand was subjected to a series of laboratory tests to determine its mechanical,physicochemical,and microstructural *** show that adding a moderate amount of biochar in AAS could improve soil strength,elastic modulus,and water holding capacity by up to 20%,70%,and 30%,***,the addition of biochar in AAS had a marginal effect on the sulfate resistance of the stabilized sand,especially at high biochar ***,the resistance of the AAS stabilized sand to wet-dry cycles slightly deteriorated with the addition of *** on these observations,a conceptual model showing biochar-AAS-sand interactions was proposed,in which biochar served as an internal curing agent,micro-reinforcer,and mechanically weak point.

关键词： Coral sand Soil stabilization Biochar Alkali activation

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A Microfluidic System with Active Mixing for Improved Real-Time Isothermal Amplification

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Journal of Beijing Institute of Technology 2022年第3期31卷 275-284页

作者： Dianlong Yang Xiaodan jiang yijie Zhou Xiaobin Dong Luyao Liu Lulu Zhang Xianbo Qiu College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

To improve the performance of real-time recombinase polymerase amplification(RPA),a microfluidic system with active mixing is developed to optimize the reaction *** of adopting a single typical reaction chamber,a specific reactor including a relatively large chamber in center with two adjacent zig-zag channels at two sides is integrated into the microfluidic *** mixing is achieved by driving the viscous reagent between the chamber and the channel back and forth periodically with an outside compact peristaltic *** avoid reagent evapora-tion,one end of the reactor is sealed with paraffin oil.A hand-held companion device is developed to facilitate real-time RPA amplification within 20 *** whole area of the reactor is heated with a resistance heater to provide uniform reaction *** achieve real-time monitoring,a compact fluorescence detection module is integrated into the hand-held device.A smartphone with custom application software is adopted to control the hand-held device and display the real-time fluorescence *** performances of two cases with and without active on-chip mixing are compared between each other by detecting African swine fever *** has been demonstrated that,with active on-chip mixing,the amplification efficiency and detection sensitivity can be signifi-cantly improved.

关键词： recombinase polymerase amplification(RPA) microfluidic chip active mixing optical detection smartphone

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风险管理在医院抗肿瘤药物安全管理中的应用分析

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首都食品与医药 2017年第14期24卷 124-125页

作者：刘义杰姜宏梅姚文李广育吕健张喜东赵宏业青岛大学附属医院 266000

目的分析风险管理在医院抗肿瘤药物安全管理中的应用情况。方法选择2015年1月~2017年1月我院肿瘤科收治的80例患者为研究对象,我院于2015年7月在抗肿瘤药物安全管理中实施风险管理。依照时间顺序,实施前组(42例)以及实施后组(38例)。分... 详细信息

目的分析风险管理在医院抗肿瘤药物安全管理中的应用情况。方法选择2015年1月~2017年1月我院肿瘤科收治的80例患者为研究对象,我院于2015年7月在抗肿瘤药物安全管理中实施风险管理。依照时间顺序,实施前组(42例)以及实施后组(38例)。分析实施风险管理前后的药品错发率以及患者护理满意度。结果和实施前相比,实施后的药品误发率显著较低,护理满意度较高,组间数据存在显著差异,P<0.05。结论将风险管理应用于医院抗肿瘤药物安全管理工作中,降低药物错发风险,提升护理质量和满意度,值得进一步推广。

关键词：风险管理抗肿瘤药物安全管理应用价值

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富水砂层类矩形盾构上跨既有隧道实测分析

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低温建筑技术 2022年第6期44卷 141-145页

作者：成广谋桂焱平丁智刘帅玺姜宜杰杨志德董毓庆杭州市地铁集团有限责任公司杭州30003 浙江华东测绘与工程安全技术有限公司杭州11122 浙大城市学院土木工程系杭州310015 杭州岩通科技有限责任公司杭州310000

为研究类矩形盾构上跨既有地铁隧道对周围环境的影响,对杭州地铁某类矩形盾构施工的实测数据进行分析,结果表明地表沉降呈现快速沉降、沉降平稳2个阶段,主要发生在盾构通过阶段;上跨既有线时,断面最大沉降由右线中心线上方转为左线中心... 详细信息

为研究类矩形盾构上跨既有地铁隧道对周围环境的影响,对杭州地铁某类矩形盾构施工的实测数据进行分析,结果表明地表沉降呈现快速沉降、沉降平稳2个阶段,主要发生在盾构通过阶段;上跨既有线时,断面最大沉降由右线中心线上方转为左线中心线上方;道床竖向在穿越范围内为隆起,其两侧40环内为沉降;道床差异沉降以交叉点为中心呈中心对称分布;既有隧道净空收敛分布呈V型曲线,主要影响区在盾构交叉范围。研究结果可为类似盾构隧道顺利掘进和变形控制提供借鉴。

关键词：富水砂层类矩形盾构上跨隧道实测分析

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ATP homeostasis and signaling in plants

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Plant Communications 2024年第4期5卷 52-66页

作者： Jiaqi Xiao yijie Zhou Yunyun Xie Taotao Li Xinguo Su Junxian He Yueming jiang Hong Zhu Hongxia Qu Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China University of Chinese Academy of Sciences Beijing 100049China Guangdong AIB Polytechnic Guangzhou 510507China School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatinNew TerritoriesHong KongChina

ATP is the primary form of energy for plants,and a shortage of cellular ATP is generally acknowledged to pose a threat to plant growth and development,stress resistance,and crop *** overall metabolic processes that contribute to the ATP pool,from production,dissipation,and transport to elimination,have been studied *** evidence has revealed that in addition to its role in energy supply,ATP also acts as a regulatory signaling molecule to activate global metabolic *** of the eATP receptor DORN1 contributed to a better understanding of how plants cope with disruption of ATP homeostasis and of the key points at which ATP signaling pathways intersect in cells or whole *** functions of SnRK1a,the master regulator of the energy management network,in restoring the equi-librium of the ATP pool have been demonstrated,and the vast and complex metabolic network mediated by SnRK1a to adapt tofluctuating environments has been *** paper reviews recent advances in understanding the regulatory control of the cellular ATP pool and discusses possible interactions among key regulators of ATP-pool homeostasis and crosstalk between iATP/eATP signaling *** of ATP deficit and modulation of cellular ATP homeostasis mediated by SnRK1a in plants are discussed at the physiological and molecular ***,we suggest future research directions for modulation of plant cellular ATP homeostasis.

关键词： ATP DORN1 SnRK1a ATP homeostasis and signaling

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Microstructural Characteristics of the 2nd Member Shale of Kongdian Formation in Cangdong Sag,Baohai Bay Basin,China

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Acta Geologica Sinica(English Edition) 2015年第A1期89卷 218-221页

作者： XU Zuxin ZHANG yijie WANG Jufeng jiang Wenya Research Institution of Petroleum Exploration andDevelopment PetroChina Beijing 100083 Exploration and Development Research Institute of Dagang Oilfield PetroChina Tianjin 300280

1 Introduction In recent years, shale gas has attracted wide attention. Research on pore structure is one of the important content for the evaluation of shale gas reservoirs, many scholars are aware of the importance of pore structure in the storage and flow of shale gas. he pore types, pore size and the distribution of pores have impact on the aggregation of shale gas.

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Manipulating dielectric property of polymer coatings toward highretention-rate lithium metal full batteries under harsh critical conditions

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Nano Research 2023年第7期16卷 9240-9249页

作者： Qi Kang Zechao Zhuang Yong Li Yinze Zuo Jian Wang yijie Liu Chaoqun Shi Jie Chen Hongfei Li Pingkai jiang Xingyi Huang Department of Polymer Science and Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Applied and Physical Chemistry and Center for Environmental Research and Sustainable Technology University of BremenBremen 28359Germany Institute for Sustainable Energy/College of Sciences Shanghai UniversityShanghai 200444China Helmholtz Institute Ulm(HIU) Ulm D89081Germany School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049China

Lithium(Li)metal batteries(LMBs)can potentially deliver much higher energy density but remain plagued by uncontrollable Li plating with dendrite growth,unstable interfaces,and highly abundant excess Li(>50 mAh·cm^(-2)).Herein,different from the artificial layer or three-dimensional(3D)matrix host constructions,various dielectric polymers are initially well-comprehensively investigated from experimental characterizations to theoretical simulation to evaluate their functions in modulating Li ion *** a proof of concept,a 3D interwoven high dielectric functional polymer(HDFP)nanofiber network with polar C-F dipole moments electrospun on copper(Cu)foil is designed,realizing uniform and controllable Li deposition capacity up to 5.0 mAh·cm^(-2),thereby enabling stable Li plating/stripping cycling over 1400 h at 1.0 mA·cm^(-2).More importantly,under the highcathode loading(~3.1 mAh·cm^(-2))and only 0.6×excess Li(N/P ratio of 1.6),the full cells retain capacity retention of 97.4%after 200 cycles at 3.36 mA·cm^(-2)and achieve high energy density(297.7 Wh·kg^(-1)at cell-level)under lean electrolyte conditions(15μL),much better than ever-reported *** work provides a new direction for designing high dielectric polymer coating toward high-retention-rate practical Li full batteries.

关键词： high dielectric functional polymer nanofiber Li metal full cell low N/P ratio high-retention capacity

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Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetin-mediated leverage of glycolysis and OXPHOS

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Acta Pharmaceutica Sinica B 2024年第11期14卷 5026-5036页

作者： Yi Zhang Junyu Shi Jie Zhu Xinxin Ding Jianxu Wei Xue jiang yijie Yang Xiaomeng Zhang Yongzhuo Huang Hongchang Lai Department of Implant Dentistry Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai 200011China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528437China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients Shanghai 201203China

Periodontitis is a chronic inflammatory disease marked by a dysregulated immune microenvironment, posing formidable challenges for effective treatment. The disease is characterized by an altered glucose metabolism in macrophages, specifically an increase in aerobic glycolysis, which is linked to heightened inflammatory responses. This suggests that targeting macrophage metabolism could offer a new therapeutic avenue. In this study, we developed an immunometabolic intervention using quercetin (Q) encapsulated in bioadhesive mesoporous polydopamine (Q@MPDA) to treat periodontitis. Our results demonstrated that Q@MPDA could reprogram inflammatory macrophages to an anti-inflammatory phenotype (i.e., from-M1-to-M2 repolarization). In a murine periodontitis model, locally administered Q@MPDA reduced the presence of inflammatory macrophages, and decreased the levels of inflammatory cytokines (IL-1β and TNF-α) and reactive oxygen species (ROS) in the periodontium. Consequently, it alleviated periodontitis symptoms, reduced alveolar bone loss, and promoted tissue repair. Furthermore, our study revealed that Q@MPDA could inhibit the glycolysis of inflammatory macrophages while enhancing oxidative phosphorylation (OXPHOS), facilitating the shift from M1 to M2 macrophage subtype. Our findings suggest that Q@MPDA is a promising treatment for periodontitis via immunometabolic rewiring.

关键词： Quercetin Periodontitis Macrophage Glycolysis Oxidative phosphorylation(OXPHOS) Mesoporous polydopamine Mitochondrial reactive oxygen species

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Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1

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Genes & Diseases 2024年第6期11卷 510-524页

作者： Yan Dong Yanrong Chen yijie Wang Xiang Zhao Ruiyang Zi Jie Hao Qiong Ding Haoran jiang Xuesong Wang Fanghao Lu Houjie Liang Zhihao Wei Jianjun Li Department of Oncology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Brain Research Center and State Key Laboratory of Trauma Burnsand Combined InjuryThird Military Medical University(Army Medical University)Chongqing 400038China

Resistance to sorafenib,an effective first-line treatment for advanced hepatocellular carcinoma(HCC),greatly compromised the prognosis of *** extracellular matrix is one of the most abundant components of the tumor *** acting as a physical barrier,it remains unclear whether cell interactions and signal transduction mediated by the extracellular matrix contribute to sorafenib *** the analysis of primary HCC organoid RNA-seq data combined with in vivo and in vitro experiments validation,we discovered that fibronectin extra domain A(FN-EDA)derived from cancer-associated fibroblasts played a critical role in sorafenib ***,FN-EDA stimulates the up-regulation of the key one-carbon metabolism enzyme SHMT1 in HCC cells via the TLR4/NF-κB signaling pathway,thereby countering the oxidative stress induced by ***,we reinforced the clinical significance of our discoveries by conducting in vivo assays with an immunodeficiency subcutaneous xenograft tumor model,which was established using primary cancer-associated fibroblasts derived from clinical HCC tissues,and through the analysis of HCC samples obtained from The Cancer Genome Atlas(TCGA)*** findings suggest that targeting the FN-EDA/SHMT1 pathway could be a potential strategy to improve sorafenib responsiveness in HCC patients.

关键词： Cancer-associated fibroblasts Fibronectin extra domain A Hepatocellular carcinoma Serine hydroxymethyl transferase1 Sorafenib resistance

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Biological perspectives in geotechnics:Application and monitoring

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2854-2878页

作者： Partha Narayan Mishra Surabhi Jain Thierry Bore Ilhan Chang Yeong-Man Kwon yijie Wang Hirak Ranjan Dash Ashutosh Kumar Satyam Tiwari Ningjun jiang Sarat Kumar Das Alexander Scheuermann Department of Civil Engineering Indian Institute of Technology KanpurKanpur208016India School of Civil Engineering University of QueenslandSt LuciaQLD4072Australia Department of Civil Engineering Indian Institute of Technology DhanbadDhanbad826004India Department of Civil System Engineering Ajou UniversitySuwon-si16499Republic of Korea School of Engineering and IT University of New South WalesCanberraACT2600Australia Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIL60208USA Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina National Forensic Sciences University New Delhi110085India Southeast University Nanjing211189China

This paper builds on exploring the applications of biomediated pathways to solve geotechnical ***,the state of the art of biological remediation strategies including microbial remediation and phytoremediation have been introduced and critically reviewed in the context of decontaminating the ***,biopolymerisation,biomineralisation and bioneutralisation processes have been depicted with a special emphasis on the applications including but not limited to soil stabilisation,soil erosion prevention,anti-desertification and pH *** of these methods have their own limitations and bottlenecks while scaling up,and these challenges have been summarised and some possible paths to overcome the challenges have also been *** state of the art of electromagnetic(EM)monitoring methods to capture the effects of biomediation on spatio-temporal soil properties are then highlighted as a non-invasive and rapid pathway to track the progress of biomediated soil ***,each of the technologies discussed have been evaluated for their maturity level using the principles of technology readiness level(TRL).A majority of the technologies amounting to around 77%are still in the TRL 4e7,*** the valley of *** is thus evident that development of these technologies needs to be supported with appropriate funding for improving their maturity to a level of industrial deployment.

关键词： Biogeotechnics Bioremediation Phytoremediation Biopolymers Biomineralisation Electromagnetic(EM)methods technology readiness level(TRL)

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