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Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats

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Neural Regeneration Research 2014年第14期9卷 1386-1388页

作者： Xiaoyang Chen yifei yin Tingting Zhang Yahong Zhao Yumin Yang Xiaomei Yu Hongkui Wang Department of Doppler Ultrasound Affiliated Hospital of Nantong University Jiangsu Key Laboratory of Neuroregeneration Nantong University School of Biology and Basic Medical Sciences Soochow University

The repair of peripheral nerve injuries with autologous nerve remains the gold standard （Wang et al., 2005; Yao et al., 2010; Deal et al., 2012; Kriebel et al., 2014; Liu et al., 2014; Tamaki et al., 2014; Yu et al., 2014; Zhu and Lou, 2014）. With advances in tissue engineering and biomaterials, tissue-engineered nerve conduits with various biomaterials and structures, such as collagen and chitosan nerve conduits, have already been used in the clinic as alternatives to autologous nerve in the repair of peripheral nerve injury （Wang et al., 2012; Svizenska et al., 2013; Eppenberger et al., 2014; Gu et al., 2014; Koudehi et al., 2014; MoyaDiaz et al., 2014; Novajra et al., 2014; Okamoto et al., 2014; Shea et al., 2014; Singh et al., 2014; Tamaki et al., 2014; Yu et al., 2014）. Therefore, new simple and effective methods

关键词： Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats

Research in the Securitization of the Non-performing Loans of China＇s State-owned Banks

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Chinese Business Review 2005年第7期4卷 63-67页

作者： yifei yin Xi＇an Jiaotong University

In this paper, through analyzing the necessity of the securitization of the non-performing loans of China＇s state-owned banks, the author proposes some tentative ideas for the securitization of the non-performing loa... 详细信息

关键词： securitization non-performing loans

Identification and Validation of HYAL1 DNA Methylation in Differentiating Malignant from Benign Thyroid Nodules

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Identification and Validation of HYAL1 DNA Methylation in Di...

The association between MGRN1 methylation in peripheral blood and breast cancer in the Chinese population

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Mengxia Li yin yifei Li Hong Yang Rongxi 徐州医科大学附属淮安医院淮安市第二人民医院

Background: Thyroid cancer(TC) is the most common endocrine cancer around the world, of which papillary thyroid cancer(PTC) accounts for about 85%. Fine-needle aspiration biopsy(FNAB) is the preferred method for the diagnosis of thyroid nodules in the clinical application. However, about 20-30% of cases are indeterminate nodules according to FNAB, of which approximately 69% are classified as benign by postoperative pathology. Besides, the sensitivities of FNAB are 65-99% across studies. It is thus of great importance to develop novel biomarkers to distinguish the malignant tumors from the benign ones. DNA methylation is commonly dysregulated in a variety of diseases including cancers. Our previous Infinium Methylation EPIC 850 K beadchip assay indicated a differentially methylated CpG site(cg02183083) within hyaluronidase 1(HYAL1) gene. Here, we conducted a validation study to explore the association between HYAL1 and thyroid *** and methods: We measured the HYAL1 methylation level in formalin-fixed paraffin-embedded(FFPE) tissues of 195 early-stage PTC(91.05% PTC at stage Ⅰ) and 195 age-and gender-matched benign tumors collected during 2019-2020. The median(interquartile range, IQR) ages of malignant and benign cases were 51.00(44.00-57.00) and 53.00(46.00-60.25) years old, respectively. Females accounted for 78.95%(150/190) in both PTC and benign cases. Protein expression of HYAL1 was evaluated in another 55 pairs of early-stage PTC(89.09% PTC at stage Ⅰ) and benign tumors collected during 2013-2016, of which 34 pairs of cases were females. The median age was 43.00(31.00-51.00)and 47.00(36.00-52.00) years in PTC and benign *** methylation was quantified by matrixassisted laser desorption ionization time-of-flight mass spectrometry and protein expression was detected by immunohistochemical(IHC) staining. Binary logistic regression and Mann-Whitney U test were used for the data analysis. Two-sided P values < 0.05 were considered as statistically

关键词： Thyroid nodules HYAL1 Identification DNA methylation Protein

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The association between MGRN1 methylation in peripheral bloo...

Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Shuifang Lei Lixi Li Qiming yin yifei yin Fei Ma Rongxi Yang Nanjing Medical University 国家癌症中心肿瘤内科徐州医科大学附属淮安医院淮安市第二人民医院甲状腺与乳腺外科

Aims: Mahogunin ring finger 1(MGRN1), an E3 ubiquitin ligase of the Really Interesting New Gene finger family, plays a pivotal role in many biological and cellular mechanisms. The DNA hypomethylation in MGRN1 has been reported to be associated with breast cancer(BC) in the Caucasian ***, the association has not been studied in other population. In this case-control study, we attempted to study the relationship between MGRN1 DNA methylation and BC in the Chinese *** and Methods: 4 MGRN1 CpG sites were quantitatively measured through mass spectrometry in the case-control study with 234 sporadic BC cases and 222 controls. The interquartile analysis was performed by calculating the quartiles from the methylation data from the total participants. The logistic regression adjusted for covariants and non-parametric tests were used to investigate the association between MGRN1 methylation level and the status of ***: We observed four MGRN1 CpG sites(MGRN1pG, MGRN1pG, MGRN1pG,4)were associated with BC. A significant tendency was also found for two MGRN1 CpG sites(P≤ 0.016,Table 1). In addition, we found significant associations between BC and altered MGRN1 methylation at different age groups, mostly in women at postmenopausal(age ≥ 50 years old, odds ratios(ORs)per-10% methylation: 1.58-1.85, P ≤ 0.031 for three of four CpG loci;age < 50 years old, ORs per-10% methylation = 0.77, P=0.033 for one CpG site, Table 2). This age-related MGRN1 methylation was also modified by the status of human epidermal growth factor receptor 2(HER2)(HER2 negative,ORs per-10% methylation: 0.86-1.28, P ≤ 0.045 for all four CpG loci;HER2 positive, ORs per-10%methylation = 0.79, P = 0.022 for one CpG site, Table 2).Conclusion: In the Chinese population, we reported a significant association between BC and the bloodbased MGRN1 methylation modified by age and the status of HER2. Above all, this study provided evidence of potential DNA methylation markers for early

关键词： Chinese population Breast cancer MGRN1 Methylation Blood

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第6期22卷 492-503页

作者： Xi WANG Chunyan DAI yifei yin Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU Key Laboratory of Digestive Pathophysiology of Zhejiang Province the First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityHangzhou 310006China College of Life and Environmental Sciences Hangzhou Normal UniversityHangzhou 310036China Research Center of Blood Transfusion Medicine Ministry of Education Key Laboratory of Laboratory MedicineDepartment of Blood TransfusionZhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhou 310014China

Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer *** the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)*** particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling ***,the combination of the two inhibitors resulted in a reduced tumor burden in *** evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer.

关键词： Gastrointestinal cancers JAK2/STAT3 pathway ERK pathway Crosstalk Apoptosis

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未成年人刑事司法制度的完善

贸大法律评论 2020年第1期 22-30页

作者：尹艺霏对外经济贸易大学法学院

当前我国未成年人犯罪形势依然严峻。我国未成年人刑事司法制度的构建与完善虽取得了一定的成果,但仍存在诸多问题和不足:与未成年人人身权利密切相关的未成年人刑事诉讼制度在一定程度上仍依附于传统的刑事法律体系,仍未完全独立;现行... 详细信息

当前我国未成年人犯罪形势依然严峻。我国未成年人刑事司法制度的构建与完善虽取得了一定的成果,但仍存在诸多问题和不足:与未成年人人身权利密切相关的未成年人刑事诉讼制度在一定程度上仍依附于传统的刑事法律体系,仍未完全独立;现行的刑事责任年龄设置已不能满足当前惩罚犯罪、保障人权的需求;我国针对未成年人出台的专门立法缺乏强制责任追究机制,所起到的实际作用十分有限;针对未成年人设置的处遇机制不完善等。应完善独立的未成年人刑事诉讼制度,并将相对刑事责任年龄的起点适当下调至12周岁,同时健全未成年人保护及预防未成年人犯罪责任机制,构建司法化的罪错未成年人收容教养制度。

关键词：未成年人犯罪刑事司法制度未成年人保护

林改,山西发展的动力之源——浅谈林改与山西发展

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经济师 2009年第12期 46-48页

作者：尹怡斐天津大学文法学院南开大学金融学系天津300000

2008年6月,党中央、国务院颁发《关于全面推行集体林权制度改革的意见》,这是我国继30年前实行家庭联产承包责任制之后深化农村改革的又一次重大战略决策。山西省是一个多山的省份,全省山区、丘陵区面积占80%,57个贫困县也基本都集中在... 详细信息

2008年6月,党中央、国务院颁发《关于全面推行集体林权制度改革的意见》,这是我国继30年前实行家庭联产承包责任制之后深化农村改革的又一次重大战略决策。山西省是一个多山的省份,全省山区、丘陵区面积占80%,57个贫困县也基本都集中在山区。可以说,山区是山西省经济社会发展最薄弱的环节,是社会主义新农村建设的难点和重点。而且作为全国的能源重化工基地,大量开采煤炭资源在保障国家建设的同时,对山西省的生态环境造成严重破坏,环境污染严重。通过集体林权制度改革改善生态、治理环境,重新调整整体发展的大框架,以实现科学发展的重要任务,对于山西省来说显得尤为重要和迫切。

关键词：集体林权制度改革山西省现代林业科学发展

Derivation and characterization of human embryonic stem cell lines from poor quality embryos

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Journal of Genetics and Genomics 2009年第4期36卷 229-239页

作者： Weiqiang Liu, yifei yin, Xiaolin Long, Yumei Luo, Yonghua Jiang, Wenhong Zhang, Hongzi Du, Shaoying Li, Yuhong Zheng, Qing Li, Xinjie Chen, Baoping Liao, Guohong Xiao, Weihua Wang, Xiaofang Sun Guangzhou Key Laboratory of Reproductive and Genetics Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China Institute of Gynecology and Obstetrics The Third Affiliated Hospital of Guangzhou Medical College Guangzhou Key Laboratory of Reproductive and Genetics Guangzhou 510150

Poor quality embryos discarded from in vitro fertilization （IVF） laboratories are good sources for deriving human embryonic stem cell （hESC） lines. In this study, 166 poor quality embryos donated from IVF centers on day 3 were cultured in a blastocyst medium for 2 days, and 32 early blastocysts were further cultured in a blastocyst optimum culture medium for additional 2 days so that the inner cell masses （ICMs） could be identified and isolated easily. The ICMs of 17 blastocysts were isolated by a mechanical method, while those of the other 15 blastocysts were isolated by immunosurgery. All isolated ICMs were inoculated onto a feeder layer for subcultivation. The rates of ICM attachment, primary ICM colony formation and the efficiency of hESC derivation were similar between the ICMs isolated by the two methods （P〉0.05）. As a result, four new hESC lines were established. Three cell lines had normal karyotypes and one had an unbalanced Robertsonian translocation. All cell lines showed normal hESC characteristics and had the differentiation ability. In conclusion, we established a stable and effective method for hESC isolation and culture, and it was confirmed that the mechanical isolation was an effective method to isolate ICMs from poor embryos. These results further indicate that hESC lines can be derived from poor quality embryos discarded by IVF laboratories.

关键词： embryonic stem ceils poor quality embryos inner cell mass mechanical isolation immunosurgery

类型教育背景下高职院校模块化课程体系构建研究——以汽车检测与维修技术专业为例

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中国职业技术教育 2024年第23期 67-76页

作者：刘兴恕关志伟尹艺霏湖南汽车工程职业大学天津中德应用技术大学党委

类型教育背景下高职院校课程改革既要符合职业性又要体现高等性。模块化课程体系以实践应用能力为本位,具有较强的灵活性,适应学生个性化学习的需求。通过厘清模块化课程体系构建的理念,并以职业领域工作过程为基础,结合高职院校汽车检... 详细信息

类型教育背景下高职院校课程改革既要符合职业性又要体现高等性。模块化课程体系以实践应用能力为本位,具有较强的灵活性,适应学生个性化学习的需求。通过厘清模块化课程体系构建的理念,并以职业领域工作过程为基础,结合高职院校汽车检测与维修技术专业实践,分析基于职业能力的模块化课程目标定位、基于典型工作任务的模块化课程内容选择与组织、基于工作过程系统化的模块化课程实施设计、基于典型产品的模块化课程评价改革等要素,提出以行业产教融合共同体为基础,构建模块化课程目标定位机制;以课程资源为支撑,构建模块化课程内容选择与组织机制;以“三教”改革为核心,构建模块化课程实施设计机制;以赛促评,构建模块化课程评价改革机制,以达到推动高职院校专业课程改革,促进职业教育高质量发展的目的。

关键词：职业教育类型教育高职院校模块化课程体系汽车检测与维修技术专业