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Spatiotemporal variations of parameters of internal solitary waves in the northern South China Sea

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Journal of Oceanology and Limnology 2024年第2期42卷 421-438页

作者： Yu’ang LIU yifei JIANG Xiaojiang ZHANG Zhiyuan WANG Yu CAO Huizan WANG College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410000China

The dynamic parameters for internal solitary waves(ISWs)derived from the extended Korteweg-de Vries(eKdV)equation play an important role in the understanding and prediction of *** spatiotemporal variations of the dynamic parameters of the ISWs in the northern South China Sea(SCS)were studied based on the reanalysis of long-term temperature and salinity *** results for spectrum analysis show that there are definite geographical differences for the periodic variation of the parameters:in shallow water,all parameters vary with a wave period of one year,while in deep water wave components of the parameters at other frequencies *** wavelet analysis,the wavelet power spectral densities in deep water exhibited an inter-annual variation *** example,the wave component of the dispersion coefficient with a wave period of about half a year reached its power peak once every two *** on previous work,this inter-annual variation pattern was deduced to be caused by dynamic *** further work on the regulatory mechanisms,empirical orthogonal function(EOF)decomposition was *** was found that the modes of the dispersion coefficient have different geographical distributions,explaining the reason why the wave components in different frequencies appeared in different *** numerical simulation results confirm that the variations in the parameters of the ISWs derived from the eKdV equation could affect the waveforms significantly because of changes in the polarity of the ***,the periodic variations of the dynamic parameters are related to the geographical location because of dynamic processes operating.

关键词： internal solitary waves(ISWs) dynamic parameters eKdV equation spatiotemporal variation polarity empirical orthogonal function(EOF)decomposition

Merging non-covalent and covalent crosslinking:En route to single chain nanoparticles

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Chinese Chemical Letters 2024年第6期35卷 307-311页

作者： yifei Zhang Yuncong Xue Laiwei Gao Rui Liao Feng Wang Fei Wang CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Department of Neurosurgical The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineHefei 230026China

Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's folding *** covalent crosslinking toward the formation of single-chain nanoparticles encounters complex energy landscapes,leading to the potential occurrence of misfolding *** noncovalent crosslinking can circumvent this issue,the resulting single-chain nanoparticles exhibit lower structural stability compared to their covalently crosslinked *** this study,we present a novel approach for the synthesis of single-chain nanoparticles,achieved through the combination of non-covalent and covalent intramolecular *** grafted onto the linear polymer form intrachain non-covalent stacks aided by hydrogen bonds,leading to the formation of non-covalently crosslinked single-chain *** nanoparticles undergo conversion to covalently crosslinked nanostructures through subsequent photo-irradiation using[2+2]photocycloaddition,a process facilitated by the supramolecular confinement ***,the resulting single-chain nanoparticles demonstrate both intrachain folding efficiency and substantial stability,offering significant potential for advancing applications across diverse fields.

关键词： Single chain nanoparticles Intrachain folding Supramolecular confinement Cyanostilbenes [2+2]photocycloaddition

Impact of mechanical compaction on crop growth and sustainable agriculture

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 243-252页

作者： Zijian LONG yifei WANG Baoru SUN Xiaoyan TANG Kemo JIN College of Resources and Environmental Sciences National Academy of Agriculture Green DevelopmentKey Laboratory of Plant–Soil Interactions(Ministry of Education)China Agricultural UniversityBeijing 100193China College of Resources Sichuan Agricultural UniversityChengdu 611130China

With the development of agricultural technology to meet the growing demands of a rapidly increasing population and economic development,intensive agriculture practices have been widely adopted globally. However,this intensification has resulted in adverse consequences for soil structure due to intensified farming activities and increased usage of heavy farm *** particular concern is soil compaction, which leads to the degradation of physical, chemical and biological properties of the soil. Soil compaction negatively impacts crop growth, reduces yields and poses a significant threat to food security and the overall sustainability of agricultural *** these challenges, this review aims to deepen understanding of the factors contributing to soil compaction and to develop effective mitigation strategies. By doing so, it is intended to attenuate the adverse impacts of soil compaction, improve soil structure, increase crop yield and ultimately enhance the sustainability of agricultural practices.

关键词： Soil compaction mechanical compaction bio-tillage agricultural production

Precise genome-editing in human diseases:mechanisms,strategies and applications

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1065-1085页

作者： Yanjiang Zheng yifei Li Kaiyu Zhou Tiange Li Nathan J.VanDusen Yimin Hua Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pediatrics Herman B Wells Center for Pediatric ResearchIndiana University School of MedicineIndianapolisIN 46202USA

Precise genome-editing platforms are versatile tools for generating specific,site-directed DNA insertions,deletions,and *** continuous enhancement of these tools has led to a revolution in the life sciences,which promises to deliver novel therapies for genetic *** genome-editing can be traced back to the 1.50s with the discovery of DNA’s doublehelix and,after 70 years of development,has evolved from crude in vitro applications to a wide range of sophisticated capabilities,including in vivo ***,precise genome-editing faces constraints such as modest efficiency,delivery challenges,and off-target *** this review,we explore precise genome-editing,with a focus on introduction of the landmark events in its history,various platforms,delivery systems,and ***,we discuss the landmark events in the history of precise ***,we describe the current state of precise genome-editing strategies and explain how these techniques offer unprecedented precision and versatility for modifying the human ***,we introduce the current delivery systems used to deploy precise genome-editing components through DNA,RNA,and ***,we summarize the current applications of precise genome-editing in labeling endogenous genes,screening genetic variants,molecular recording,generating disease models,and gene therapy,including ex vivo therapy and in vivo therapy,and discuss potential future advances.

关键词： precise generating editing

Enhanced gas production and CO_(2) storage in hydrate-bearing sediments via pre-depressurization and rapid CO_(2) injection

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Chinese Journal of Chemical Engineering 2024年第3期67卷 126-134页

作者： Hongnan Chen yifei Sun Bojian Cao Minglong Wang Ming Wang Jinrong Zhong Changyu Sun Guangjin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China School of Chemistry and Chemical Engineering Changsha University of Science&TechnologyChangsha 410114China

Carbon emission reduction and clean energy development are urgent demands for mankind in the coming *** an efficient CO_(2) storage method can significantly reduce CO_(2) emissions in the short *** this study,we attempted to construct sediment samples with different residual CH_(4) hydrate amounts and reservoir conditions,and then investigate the potentials of both CO_(2) storage and enhanced CH_(4) recovery in depleted gas hydrate deposits in the permafrost and ocean zones,*** results demonstrate that CO_(2) hydrate formation rate can be significantly improved due to the presence of residual hydrate seeds;However,excessive residual hydrates in turn lead to the decrease in CO_(2) storage *** by the T-P conditions of the reservoir,the storage amount of liquid CO_(2) can reach 8 times that of gaseous CO_(2),and CO_(2) stored in hydrate form reaches 2-4 ***,we noticed two other advantages of this *** is that CO_(2) injection can enhance CH_(4) recovery rate and increases CH_(4) recovery by 1.%-20%.The second is that hydrate saturation in the reservoir can be restored to 20%-40%,which means that the solid volume of the reservoir avoids serious ***,this is crucial for protecting the goaf *** summary,this approach is greatly promising for high-efficient CO_(2) storage and safe exploitation of gas hydrate.

关键词： Hydrate Depressurization CO_(2) storage CH_(4) production Reservoir remediation

Self-confocal NIR-II fluorescence microscopy for multifunctional in vivo imaging

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 105-119页

作者： Jing Zhou Tianxiang Wu Runze Chen Liang Zhu Hequn Zhang yifei Li Liying Chen Jun Qian State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058P.R.China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058P.R.China College of Biomedical Engineering and Instrument Science Interdisciplinary Institute of Neuroscience and Technology(ZIINT)Zhejiang UniversityHangzhou 310027P.R.China

Fluorescence imaging in the second near-infrared window(NIR-II,900–1.80 nm)with less scattering background in biological tissues has been combined with the confocal microscopic system for achieving deep in vivo imaging with high spatial ***,the traditional NIR-IIfluorescence confocal microscope with separate excitation focus and detection pinhole makes it possess low confocal e±ciency,as well as di±cultly to *** types of upgraded NIR-IIfluorescence confocal microscopes,sharing the same pinhole by excitation and emission focus,leading to higher confocal e±ciency,are built in this *** type is-ber-pinhole-based confocal microscope applicable to CW laser *** is constructed forfluorescence intensity imaging with large depth,high stabilization and low cost,which could replace multiphotonfluorescence microscopy in some applications(e.g.,cerebrovascular and hepatocellular imaging).The other type is air-pinhole-based confocal microscope applicable to femtosecond(fs)laser *** can be employed not only for NIR-IIfluorescence intensity imaging,but also for multi-channelfluorescence lifetime imaging to recognize different structures with similarfluorescence ***,it can be facilely combined with multiphotonfluorescence microscopy.A single fs pulsed laser is utilized to achieve up-conversion(visible multiphotonfluorescence)and down-conversion(NIR-II one-photonfluorescence)excitation simultaneously,extending imaging spectral channels,and thus facilitates multi-structure and multi-functional observation.

关键词： Self-confocal fiber-pinhole air-pinhole multi-channe fluorescence lifetime imaging multi-color imaging

Whole-genome sequencing in medicinal plants:current progress and prospect

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Science China(Life Sciences) 2024年第2期67卷 258-273页

作者： yifei Pei Liang Leng Wei Sun Baocai Liu Xue Feng Xiwen Li Shilin Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Agricultural Bioresource Fujian Academy of Agricultural SciencesFuzhou 350003China

Advancements in genomics have dramatically accelerated the research on medicinal plants,and the development of herbgenomics has promoted the“Project of 1. Medicinal Plant Genome”to decipher their genetic ***,it is difficult to obtain their high-quality whole genomes because of the prevalence of polyploidy and/or high genomic *** genomes of 1.3 medicinal plants were published until September *** published genome sequences were investigated in this review,covering their classification,research teams,ploidy,medicinal functions,and sequencing *** than 1.000 institutes or universities around the world and 50 countries are conducting research on medicinal plant *** species account for a majority of sequenced medicinal *** whole genomes of plants in the Poaceae family are the most *** 40%of the published papers studied species with tonifying,replenishing,and heat-cleaning medicinal *** plants are still in the process of domestication as compared with crops,thereby resulting in unclear genetic backgrounds and the lack of pure lines,thus making their genomes more difficult to *** addition,there is still no clear routine framework for a medicinal plant to obtain a high-quality whole ***,a clear and complete strategy has been originally proposed for creating a high-quality whole genome of medicinal ***,whole genome-based biological studies of medicinal plants,including breeding and biosynthesis,were *** also advocate that a research platform of model medicinal plants should be established to promote the genomics research of medicinal plants.

关键词： herbgenomics whole genome high throughput sequencing research strategy model species application

P2Y1.receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： Shan Luo yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1.receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1.receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1.receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1.receptor purinergic receptor

Regenerative treatment of ophthalmic diseases with stem cells:Principles,progress,and challenges

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Advances in Ophthalmology Practice and Research 2024年第2期4卷 52-64页

作者： yifei Niu Junfeng Ji Ke Yao Qiuli Fu Eye Center of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Zhejiang Provincial Key Lab of Ophthalmology HangzhouZhejiang ProvinceChina Center of Stem Cell and Regenerative Medicine School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine HangzhouChina

Background:Degenerate eye disorders,such as glaucoma,cataracts and age-related macular degeneration(AMD),are prevalent causes of blindness and visual impairment *** eye disorders,including limbal stem cell deficiency(LSCD),dry eye diseases(DED),and retinitis pigmentosa(RP),result in symptoms such as ocular discomfort and impaired visual function,significantly impacting quality of *** therapies are limited,primarily focus on delaying disease progression,while emerging stem cell therapy directly targets ocular tissues,aiming to restore ocular function by reconstructing ocular *** text:The utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant,owing to the regenerative and malleable properties of stem cells and their functional ***,stem cell therapy for ophthalmopathy involves various cell types,such as embryonic stem cells(ESCs),induced pluripotent stem cells(iPSCs),mesenchymal stem cells(MSCs),and retinal progenitor cells(RPCs).In the current article,we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the *** therapies aim to address the loss of functional cells,restore damaged ocular tissue and or in a paracrine-mediated *** also provide an overview of the ocular disorders that stem cell therapy is targeting,as well as the difficulties and opportunities in this ***:Stem cells can not only promote tissue regeneration but also release exosomes to mitigate inflam-mation and provide neuroprotection,making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms.

关键词： Stem cell Ocular diseases Induced pluripotent stem cells Mesenchymal stem cells Cataracts Glaucoma Diabetic retinopathy Retinal degenerative diseases