检索结果-南通市图书馆

Dietary sodium acetate and sodium butyrate attenuate intestinal damage and improve lipid metabolism in juvenile largemouth bass(Micropterus salmoides) fed a high carbohydrate diet by reducing endoplasmic reticulum stress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2024年第1期16卷 443-456页

作者： liulan Zhao Liangshun Cheng yifang Hu Xiaohui Li Yihui Yang Jin Mu Lianfeng Shen Guojun Hu Kuo He Haoxiao Yan Qiao liu Song Yang College of Animal Science and Technology Sichuan Agricultural University

High-carbohydrate(HC) diets decrease the intestinal levels of sodium acetate(SA) and sodium butyrate(SB) and impair the gut health of largemouth bass; however, SA and SB have been shown to enhance immunity and improve intestinal health in farmed animals. Thus, the present study was to investigate the effects of dietary SA and SB on HC diet-induced intestinal injury and the potential mechanisms in juvenile largemouth bass. The experiment set five isonitrogenous and isolipidic diets, including a lowcarbohydrate diet(9% starch)(LC), a high carbohydrate diet(18% starch)(HC), and the HC diet supplemented with 2 g/kg SA(HCSA), 2 g/kg SB(HCSB) or a combination of 1 g/kg SA and 1 g/kg SB(HCSASB).The feeding experiment was conducted for 8 weeks. A total of 525 juvenile largemouth bass with an initial body weight of 7.00 ± 0.20 g were used. The results showed that dietary SA and SB improved the weight gain rate and specific growth rate (P<0.05) and ameliorated serum parameters(alkaline phosphatase, acid phosphatase, glutamate transaminase, and glutamic oxaloacetic transaminase)(P<0.05). And, importantly, dietary SA and SB repaired the intestinal barrier by increasing the expression levels of zonula occludens-1, occludin, and claudin-7(P<0.05), reduced HC-induced intestinal damage, and alleviated intestinal inflammation and cell apoptosis by attenuating HC-induced intestinal endoplasmic reticulum stress(P<0.05). Further results revealed that dietary SA and SB reduced HC-induced intestinal fat deposition by inhibiting adipogenesis and promoting lipolysis(P<0.05). In summary, this study demonstrated that dietary SA and SB attenuated HC-induced intestinal damage and reduced excessive intestinal fat deposition in largemouth bass.

关键词： Sodium acetate Sodium butyrate High carbohydrate diet Endoplasmic reticulum stress Intestine health Lipid metabolism

Efficient blue light-responsed dithienylethenes with exceptional photochromic performance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第3期34卷 392-395页

作者： Ziyong Li Xinyu Gao Haining Zhang Xiaoxie Ma yifang liu Hui Guo Jun Yin College of Food and Drug College of Chemistry and Chemical EngineeringLuoyang Key Laboratory of Organic Functional MoleculesLuoyang Normal UniversityLuoyang 471934China College of Chemistry Key Laboratory of Pesticide and Chemical BiologyMinistry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCentral China Normal UniversityWuhan 430079China

Three novel dithienylethenes modified by bifluoroboron β-diketonate fragments have been successfully developed. Upon blue light irradiation, they reached photostationary state within 2-5 s, as well as 100% conversion ratio and photocyclization quantum yield of > 0.70. Such fascinating photochromism were endowed by collaborative role of electron-withdrawing effect of BF_(2)bdk group to reduce HOMO-LUMO electronic gap for the open isomer, together with intramolecular hydrogen bonds and CH-π interactions favoring antiparallel conformation fixation. Moreover, they displayed specific discrimination and photoswitchable bacterial imaging for S. aureus.

关键词： Dithienylethene Photochromism Fluorescent switching behavior Visible light Bifluoroboronβ-diketonate(BF_(2)bdk) Bacterial imaging

在线全文

学校读者我要写书评

暂无评论

先秦时期城市水利考古初论

考古 2024年第6期 75-82,F0002页

作者：刘亦方张东南开大学历史学院天津市300350 中国社会科学院考古研究所北京市100101

城市水利是城市基础设施的重要组成部分,所有中国古代城市均与水资源的合理利用和管控息息相关,古代城市水利理应成为城市考古的重点关注对象。基于文献记载和考古新发现,有学者对汉长安城及其所在区域的水利设置进行了全面研究,首次提... 详细信息

城市水利是城市基础设施的重要组成部分,所有中国古代城市均与水资源的合理利用和管控息息相关,古代城市水利理应成为城市考古的重点关注对象。基于文献记载和考古新发现,有学者对汉长安城及其所在区域的水利设置进行了全面研究,首次提出了“城市水利考古”概念。

关键词：先秦时期城市水利考古学术史方法论

Epidemiological Study of Outpatients in Rabies Post-Exposure Prophylaxis Clinics—Tianjin Municipality,China,2020

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2021年第39期3卷 822-824页

作者： yifang liu Lin Li Jie Lyu Cheng Su Tianjin Centers for Disease Control and Prevention TianjinChina.

Summary What is already known on this topic?Rabies remains a serious public health problem in China.The only way to prevent the fatal disease was through timely and adequate post-exposure prophylaxis(PEP).What is added by this report?Among all the 126,133 cases visited Tianjin PEP clinics during 2020,more than 90%of the patients were injured by domestic dogs or cats,and about 70%of the animals received vaccination.Most outpatients have knowledge of rabies and show high compatibility with PEP.

关键词： Tianjin compatibility Rabies

中国式现代化问题的若干空间哲学话语分析与重建

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

东南学术 2024年第1期 1-14,247页

作者：刘怀玉张一方南京大学马克思主义社会理论研究中心暨哲学系云南大学哲学系

中国式现代化既是一个社会历史发展问题,也是一个社会空间重构问题。新时代中国特色社会主义的成功实践呼唤着中国现代性空间哲学话语的自主建构。要讨论中国式现代化的空间话语生成逻辑问题,其一,要批判性反思并超越西方现代化理论对... 详细信息

中国式现代化既是一个社会历史发展问题,也是一个社会空间重构问题。新时代中国特色社会主义的成功实践呼唤着中国现代性空间哲学话语的自主建构。要讨论中国式现代化的空间话语生成逻辑问题,其一,要批判性反思并超越西方现代化理论对中国式现代化的“历史目的论”式抽象逻辑强制与“西方中心论”化空间话语;其二,要借鉴并超越作为西方现代化理论替代者的所谓“全球现代性理论”与“世界体系论”的历史-空间哲学话语对于中国式现代化意义的理解;其三,借鉴大陆中心论与海洋中心论的世界地缘政治哲学对中国式现代化意义的专业化实证性研究的贡献并克服其局限性;其四,消化与吸收“本土派现代化”理论对中国式现代化的深入研究成果并反思其空间哲学视野上的局限性。从把握资本主义全球化生产逻辑与中国现代化自身的空间生产逻辑辩证互动关系入手,并从中国革命与现代化自身的发展实践出发来理解中国式现代化的历史空间辩证法意义。

关键词：中国式现代化空间哲学话语空间的生产西方现代化全球化地缘政治学

我国企业ESG表现对其经济效益的影响研究——基于沪深上市企业

在线全文

学校读者我要写书评

暂无评论

中国环境管理 2024年第1期16卷 34-41,26页

作者：刘轶芳李霞郑依依刘新波中央财经大学经济学院北京102206 北京大学数学科学学院北京100080 中国社会科学院经济研究所北京100836

随着“碳达峰、碳中和”战略目标的提出,ESG投资概念成为资本市场关注的重点。在ESG信息披露成为企业刚需的时代背景下,企业环境表现与环境信息披露之间的因果关系变得更为复杂,ESG信息披露行为对企业经济效益的影响也有待讨论。为此,... 详细信息

随着“碳达峰、碳中和”战略目标的提出,ESG投资概念成为资本市场关注的重点。在ESG信息披露成为企业刚需的时代背景下,企业环境表现与环境信息披露之间的因果关系变得更为复杂,ESG信息披露行为对企业经济效益的影响也有待讨论。为此,本文根据数据可得性筛选得到2008—2020年我国沪深板块上市的3685家企业上市公司作为研究样本,利用wind数据库、CSMAR上市公司环境研究等数据库,从企业ESG信息披露完整性及实际风险两个维度出发构建ESG发展指数,用于全面测度中国企业的ESG发展现状;同时尝试从债权人和股东投资信心等层面探讨企业ESG表现对其经济效益的传导机理。结果表明:企业ESG表现对于其经济效益呈现正向显著影响,且这种影响效应对于不同ESG表现水平和不同产权性质的企业具有异质性。影响路径分析结果显示,企业ESG表现能够提升投资者信心,进而显著改善了企业经济效益。

关键词： ESG发展指数经济效益信息披露完整性实际环境风险

在线全文

学校读者我要写书评

暂无评论

“斯密问题”的由来、新表征与破解机理

经济论坛 2024年第2期 27-38页

作者：刘一方山西财经大学经济学院山西太原030006

“斯密问题”由德国历史学派提出并在学术界引发热议,主要形成了矛盾论、统一论和依情境讨论三种观点。随着时代的发展,“斯密问题”在理论层面表现为行为主体“利己”与“顾他”间的矛盾,现实层面表现为道德建设与经济发展失衡的非偶... 详细信息

“斯密问题”由德国历史学派提出并在学术界引发热议,主要形成了矛盾论、统一论和依情境讨论三种观点。随着时代的发展,“斯密问题”在理论层面表现为行为主体“利己”与“顾他”间的矛盾,现实层面表现为道德建设与经济发展失衡的非偶然性。这两个新的表征成为各国亟待解决的问题。根据桑塔费学派思想,各主体的行为选择不单出于“顾己”动机,还受环境、文化、习俗等影响产生“顾他”动机。要解决这一问题必须兼顾外在力量推动和内在动力驱动,形成“有效市场、有为政府、有爱社会”是破解机理的核心所在。党的二十大进一步指出完善三次分配的重要性,体现出构建有爱社会对推进共同富裕具有极强的潜在力。

关键词：斯密问题桑塔费学派顾他偏好共同富裕第三次分配

Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2021年第4期13卷 408-421页

作者： Lizhong Sun Libang He Wei Wu Li Luo Mingyue Han yifang liu Shijie Shi Kaijing Zhong Jiaojiao Yang Jiyao Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqingChina

Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation.Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function,but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions.In this study,we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation(early pulpitis as the model)with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo.Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide(E.coli LPS)with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways.Moreover,nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects,attenuating inflammatory conditions in the early stage.Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage,which widens the potential cell types for inflammation regulation.

关键词： inflammation treatment nanoparticles

The multifaceted functions of cGAS

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2022年第5期14卷 16-26页

作者： Haipeng liu Fei Wang Yajuan Cao yifang Dang Baoxue Ge Clinical and Translational Research Center Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Shanghai Key Laboratory of Tuberculosis Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Central Laboratory Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China

Pattern recognition receptors arecritical forthe sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunityandshaping ofadaptive immunity.The identification of 2'3'-cyclic guanosine monophosphate-adenosine monophosphate(cGAMP)synthase(cGAS)as a major cytosolic DNA receptor is a milestone in the field of DNA sensing.The engagement of cGAS by double-stranded DNA from different origins,including invading pathogens,damaged mitochondria,ruptured micronuclei,and genomic DNA results in the generation of cGAMP and activation of stimulator of interferon genes,which thereby activates innate immunity mainly characterized by the activation of type I interferon response.In recent years,great progress has been made in understanding the subcellular localization and novel functions of cGAS.In this review,we particularlyfocus on summarizingthe multifaceted roles ofcGAS in regulating senescence,autophagy,cell stemness,apoptosis,angiogenesis,cell proliferation,antitumor effect,DNA replication,DNA damage repair,micronucleophagy,as well as cell metabolism.

关键词： cyclic GMP-AMP synthase(cGAS) stimulator of interferon genes(STING) DNA sensing innate immunity micronucleophagy