Dietary sodium acetate and sodium butyrate attenuate intestinal damage and improve lipid metabolism in juvenile largemouth bass(Micropterus salmoides)fed a high carbohydrate diet by reducing endoplasmic reticulum stress

作     者：Liulan Zhao Liangshun Cheng Yifang Hu Xiaohui Li Yihui Yang Jin Mu Lianfeng Shen Guojun Hu Kuo He Haoxiao Yan Qiao Liu Song Yang Liulan Zhao;Liangshun Cheng;Yifang Hu;Xiaohui Li;Yihui Yang;Jin Mu;Lianfeng Shen;Guojun Hu;Kuo He;Haoxiao Yan;Qiao Liu;Song Yang

作者机构：College of Animal Science and TechnologySichuan Agricultural UniversityChengduSichuan611130China 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2024年第16卷第1期

页      面：443-456页

核心收录：

学科分类：090801[农学-水产养殖] 0908[农学-水产] 09[农学] 

基　　金：sponsored by Natural Science Foundation of Sichuan Province(2023NSFSC1220) 

主　　题：Sodium acetate Sodium butyrate High carbohydrate diet Endoplasmic reticulum stress Intestine health Lipid metabolism 

摘      要：High-carbohydrate(HC)diets decrease the intestinal levels of sodium acetate(SA)and sodium butyrate(SB)and impair the gut health of largemouth bass;however,SA and SB have been shown to enhance immunity and improve intestinal health in farmed ***,the present study was to investigate the effects of dietary SA and SB on HC diet-induced intestinal injury and the potential mechanisms in juvenile largemouth *** experiment set five isonitrogenous and isolipidic diets,including a lowcarbohydrate diet(9%starch)(LC),a high carbohydrate diet(18%starch)(HC),and the HC diet supplemented with 2 g/kg SA(HCSA),2 g/kg SB(HCSB)or a combination of 1 g/kg SA and 1 g/kg SB(HCSASB).The feeding experiment was conducted for 8 weeks.A total of 525 juvenile largemouth bass with an initial body weight of 7.00±0.20 g were *** results showed that dietary SA and SB improved the weight gain rate and specific growth rate(P0.05)and ameliorated serum parameters(alkaline phosphatase,acid phosphatase,glutamate transaminase,and glutamic oxaloacetic transaminase)(P0.05).And,importantly,dietary SA and SB repaired the intestinal barrier by increasing the expression levels of zonula occludens-1,occludin,and claudin-7(P0.05),reduced HC-induced intestinal damage,and alleviated intestinal inflammation and cell apoptosis by attenuating HC-induced intestinal endoplasmic reticulum stress(P0.05).Further results revealed that dietary SA and SB reduced HC-induced intestinal fat deposition by inhibiting adipogenesis and promoting lipolysis(P0.05).In summary,this study demonstrated that dietary SA and SB attenuated HC-induced intestinal damage and reduced excessive intestinal fat deposition in largemouth bass.