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大厚度TC4钛合金激光增材连接过程分区组织调控

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中国有色金属学报 2024年第4期34卷 1285-1299页

作者：吕飞阅王磊磊高转妮张家豪黎一帆李琳沁占小红南京航空航天大学材料科学与技术学院南京211106

针对大厚度钛合金构件激光增材连接过程中热累积效应导致的组织粗化及性能劣化问题,本文开展了微观组织分区调控研究,分析了厚板不同位置的晶粒尺寸与析出相形态随着激光功率与扫描速率的变化规律,形成了激光增材连接件分区组织调控方... 详细信息

针对大厚度钛合金构件激光增材连接过程中热累积效应导致的组织粗化及性能劣化问题,本文开展了微观组织分区调控研究,分析了厚板不同位置的晶粒尺寸与析出相形态随着激光功率与扫描速率的变化规律,形成了激光增材连接件分区组织调控方法。结果表明:通过改变激光功率来调控组织形态的参数灵敏度较高,针对激光增材连接过程热累积效应导致的组织粗化问题,需改变激光扫描速率来调控试样中上部及顶部的组织形态。当激光有效能量为5.46×10^(5) J时,增材连接试样的抗拉强度高达915 MPa左右,同时断口韧窝尺寸较大,材料塑韧性较优异。因此,在激光增材连接过程中进行分区组织调控,可实现连接件整体力学性能的显著提升。

关键词：激光增材连接 TC4钛合金有效激光能量微观组织分区调控

CIS controls the functional polarization of GM-CSF-derived macrophages

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Cellular & Molecular Immunology 2023年第1期20卷 65-79页

作者： Shengbo zhang Jai Rautela Naiara G.Bediaga Tatiana B.Kolesnik Yue You Junli Nie Laura F.Dagley Justin Bedo Hanqing Wang Li Sun Robyn Sutherland Elliot Surgenor Nadia Iannarella Rhys Allan Fernando Souza-Fonseca-Guimaraes Yi Xie Qike Wang Yuxia zhang Yuekang Xu Stephen L.Nutt Andrew M.Lew Nicholas D.Huntington Sandra E.Nicholson Michaël Chopin yifan zhan Walter and Eliza Hall Institute of Medical Research ParkvilleVICAustralia Department of Medical Biology University of MelbourneParkvilleVICAustralia Department of Biochemistry and Molecular Biology Biomedicine Discovery InstituteMonash UniversityClaytonVICAustralia oNKo-Innate Pty Ltd Moonee PondsVICAustralia Department of Computing and Information Systems University of MelbourneParkvilleVICAustralia Department of Respiratory Medicine Guangzhou Institute of PediatricsGuangzhou Women and Children’s Medical CentreState Key Laboratory of Respiratory DiseasesGuangzhou Medical UniversityGuangzhouGuangdongChina College of Biological Science Anhui Normal UniversityHefeiChina University of Queensland Diamantina Institute University of QueenslandTranslational Research InstituteBrisbaneQLDAustralia Program in Cardiovascular and Metabolic Disorders Duke-NUS Medical SchoolDukeSingapore Drug Discovery Shanghai Huaota BiopharmShanghaiChina

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macrophages (MØs) with opposing functions, namely, proinflammatory M1-like MØs and immunosuppressive M2-like MØs. Despite the importance of these opposing biological outcomes, the intrinsic mechanism that regulates the functional polarization of MØs under GM-CSF signaling remains elusive. Here, we showed that GM-CSF-induced MØ polarization resulted in the expression of cytokine-inducible SH2-containing protein (CIS) and that CIS deficiency skewed the differentiation of monocytes toward immunosuppressive M2-like MØs. CIS deficiency resulted in hyperactivation of the JAK-STAT5 signaling pathway, consequently promoting downregulation of the transcription factor Interferon Regulatory Factor 8 (IRF8). Loss- and gain-of-function approaches highlighted IRF8 as a critical regulator of the M1-like polarization program. In vivo, CIS deficiency induced the differentiation of M2-like macrophages, which promoted strong Th2 immune responses characterized by the development of severe experimental asthma. Collectively, our results reveal a CIS-modulated mechanism that clarifies the opposing actions of GM-CSF in MØ differentiation and uncovers the role of GM-CSF in controlling allergic inflammation.

关键词： CIS GM-CSF Macrophage M2 M1

基于机器学习的卫星遥感水质富营养化评价——以合肥市环城河为例

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华东师范大学学报（自然科学版） 2024年第1期 1-8,112页

作者：张勇王慧朱传华周浩詹宇李灿肖逸凡杨丽丽刘佳奇安徽建筑大学环境与能源工程学院合肥230601 安徽建筑大学环境污染控制与废弃物资源化利用安徽省重点实验室合肥230601 荆州水务集团有限公司湖北荆州434000

以合肥市环城河为研究对象,使用线性回归、随机森林、支持向量回归和套索回归等机器学习模型挖掘Landsat8卫星数据和水质参数之间的关系,对遥感影像值的反射率和水质参数进行建模,并比较了4种不同模型的表现.结果显示,随机森林模型的表... 详细信息

以合肥市环城河为研究对象,使用线性回归、随机森林、支持向量回归和套索回归等机器学习模型挖掘Landsat8卫星数据和水质参数之间的关系,对遥感影像值的反射率和水质参数进行建模,并比较了4种不同模型的表现.结果显示,随机森林模型的表现最好,对TN、TP、NH3-N反演模型的精度都能达到0.7以上;反演的水质参数浓度分布图表明TN、TP在环城河东北段的污染最严重,而NH3-N则在西南段的污染最严重;从水体富营养化分布图可以看出,环城河东段水体呈现中度营养状态.

关键词：机器学习 Landsat8 富营养化评价

儿童友好城市的规划与实践研究——以《上海市浦东新区儿童友好城区规划导则》的编制和实施为例

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世界建筑 2024年第6期 20-24页

作者：于一凡詹烨罗贤吉法国高等社会科学院同济大学建筑与城市规划学院同济大学上海市城市更新及其空间优化技术重点实验室全龄友好城市研究中心同济大学上海同济城市规划设计研究院有限公司

推进儿童友好城市建设面临着两个亟待解决的关键问题:一是如何通过规划编制将儿童友好理念融入城市发展整体目标,二是如何针对多元空间层次和对象有序推进规划实践。《上海市浦东新区儿童友好城区规划导则》的编制和实施,对此开展了有... 详细信息

推进儿童友好城市建设面临着两个亟待解决的关键问题:一是如何通过规划编制将儿童友好理念融入城市发展整体目标,二是如何针对多元空间层次和对象有序推进规划实践。《上海市浦东新区儿童友好城区规划导则》的编制和实施,对此开展了有益的探索。规划立足儿童视角和儿童需求,着眼于利用好资源、设计好过程和使用好证据的规划过程,兼顾“标准化举措保底线”和“因地制宜创特色”的规划设计思路,针对三级三类空间对象构建了规划干预框架,推进了一批有示范效应的实践项目。通过主体协同联动推进规划实施,形成了可资借鉴的浦东经验。

关键词：儿童友好城市规划导则浦东新区

Effect of ultrasonic modification on the protective activity of Flammulina velutipes polysaccharide to prevent ethanol-induced injury on GES-1 cells

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Food Science and Human Wellness 2023年第6期12卷 2451-2459页

作者： Jinrong Xiao Xin Chen Jingsi zhang yifan Wang Lei Zhong Qiping zhan Qiuhui Hu Liyan Zhao College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Food Science and Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Flammulina velutipes(F.velutipes)polysaccharides were modified by ultrasound at the rated power of 150 W and 900 W.The monosaccharide composition,ultraviolet-visible,and Fourier transform infrared spectral characteristics of F.velutipes polysaccharides(FVP)and their ultrasonic modification products(U-FVPs)were determined.The protective effects of FVP and U-FVPs on human gastric mucosal cells GES-1 were confi rmed for the first time.The mole ratios of glucose and galactose were decreased and the mole ratio of mannose was increased after ultrasonic modification.Compared with the original FVP and the FVP modifi ed by ultrasound of 150 W(U-FVP1),the FVP modifi ed by ultrasound of 900 W(U-FVP2)could better prevent ethanol-induced damage to GES-1 cells.With increasing ultrasound intensity,the protective effect of FVPs on GES-1 cells was significantly enhanced by more effective prevention of intracellular reactive oxygen species(ROS)production and more promotion of expression of triglyceride factor 2(TFF2),prostaglandin E2(PGE2),epidermal growth factor(EGF),and transforming growth factorβ1(TGF-β1)mRNA.The ultrasonic modifi cation might be an effective way to develop novel F.velutipes polysaccharides that could effectively resist the gastric injury caused by excessive alcohol consumption.

关键词： Flammulina velutipes polysaccharide Ultrasonic modification GES-1 cell Gastric ulcer Ethanol-induced injury

Spatio-temporal analysis of human wellbeing and its coupling relationship with ecosystem services in Shandong province, China

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Journal of Geographical Sciences 2023年第2期33卷 392-412页

作者： WANG Chao WANG Xuan WANG yifan zhan Jinyan CHU Xi TENG Yanmin LIU Wei WANG Huihui State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Research Center for Eco-environmental Engineering Dongguan University of TechnologySongshan LakeDongguan 523808GuangdongChina College of Geography and Environment Shandong Normal UniversityJinan 250014China

Rapid economic and social change promotes to improve human wellbeing(HW),but poses threats to ecosystems and the environment.Studying the coupling relationship between HW and ecosystem services(ES)is crucial for informing high-quality development.Firstly,we built a comprehensive index system for HW assessment,and evaluated HW for 17 prefecture-level cities in Shandong province,China,from 2000 to 2018.Then,we quantified ES based on land use data.Finally,we assessed the coupling coordination degree and analyzed the relationships between HW and each type of ES value.The results were as follows:(1)HW values increased overall in Shandong,with the highest value in Jinan(0.8034)and the lowest value in Heze(0.4965)in 2018.(2)The total ES values for the 17 cities increased slightly.The ranking of 17 cities according to the ES value per unit area was different from the ranking according to the total ES value.(3)All 17 cities in Shandong were in the coordinated development phase after 2015,with increasing coupling coordination degrees.There were clear positive relationships between HW and ES.General and specific policy recommendations were proposed,providing scientific evidence and a reference for Shandong’s urban management and policy formulation.

关键词： land use coupling human wellbeing ecosystem services Shandong

太湖沿岸浅水湖泊生态修复过程中生态系统健康评价

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华东师范大学学报（自然科学版） 2024年第1期 17-28页

作者：张勇李灿张华林詹宇王慧肖逸凡杨丽丽刘佳奇蒯正龙安徽建筑大学环境与能源工程学院合肥230601 安徽建筑大学环境污染控制与废弃物资源化利用安徽省重点实验室合肥230601 昆山市水务局江苏昆山215300

为评估生态修复过程中太湖沿岸浅水湖泊的生态系统健康状况,于2022年对金墅港圩地水体进行了调查.构建了水生态健康综合评估指标体系,由目标层、准则层、指标层构成.其中,准则层由功能性、完整性、稳定性3项组成,指标层由综合水质、营... 详细信息

为评估生态修复过程中太湖沿岸浅水湖泊的生态系统健康状况,于2022年对金墅港圩地水体进行了调查.构建了水生态健康综合评估指标体系,由目标层、准则层、指标层构成.其中,准则层由功能性、完整性、稳定性3项组成,指标层由综合水质、营养状态等14个大项参数和pH值、温度、溶解氧等28个小项参数构成,采用层次分析法分别确定了准则层和指标层的权重系数,再使用比值法统一量纲.结果表明,在生态修复过程中,功能评价指数在秋季达到最高,完整性评价指数在秋、冬两季优于春、夏两季,稳定性评价指数在夏季最高,有70%的点位处于“健康”水平,水生态健康综合评价指数持续上升.说明生态修复工程有效地促进了水生态系统的重建与恢复,这不仅对后续的修复和管理有重要意义,而且能为其他湖泊的水生态修复和评价提供借鉴.

关键词：太湖流域生态修复水生态系统健康评价体系

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低成本TDR设备土壤含水率试验研究

低温建筑技术 2024年第4期46卷 50-53页

作者：陈俊羽张扬詹杰盛亦凡尹鑫晟浙大城市学院工程学院杭州310015 浙江省城市盾构隧道安全建造与智能养护重点实验室杭州310015 城市基础设施智能化浙江省工程研究中心杭州310015

因为土体含水量会影响土体的物理特性,土壤含水率监测成为了岩土工程中一项重要的内容。目前市场上常用的TDR监测设备价格昂贵,且操作繁杂。文中根据时域反射技术原理(Time Domain Reflectometry,TDR)提出了低成本TDR设备土壤含水率集... 详细信息

因为土体含水量会影响土体的物理特性,土壤含水率监测成为了岩土工程中一项重要的内容。目前市场上常用的TDR监测设备价格昂贵,且操作繁杂。文中根据时域反射技术原理(Time Domain Reflectometry,TDR)提出了低成本TDR设备土壤含水率集成监测技术。文中先是自主设计TDR元件,以降低工艺制造成本。然后编写MATLAB1.0分析软件进行数据自动分析。最后通过探针长度测量试验和土壤含水量测量试验,为TDR在土壤含水量测量方面的应用提供了参考。

关键词： TDR含水率测量土壤含水率监测时域反射技术

Effects of cosolvents on CO_(2) displacement of shale oil and carbon storage

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Petroleum Exploration and Development 2023年第6期50卷 1509-1518页

作者： zhanG yifan WANG Lu ZOU Rui ZOU Run MENG zhan HUANG Liang LIU Yisheng LEI Hao College of Energy Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu 610059China School of Petroleum Engineering Southwest Petroleum UniversityChengdu 610500China Research Institute of Exploration and Development Sinopec Jianghan Oilfield CompanyWuhan 430223China

Molecular dynamics method was used to establish composite wall/inorganic nanopores of three pore sizes, three shale oil systems, five CO_(2)-cosolvent systems, and pure CO_(2) system. The process of CO_(2)-cosolvent displacement of crude oil in shale nanopores and carbon storage was simulated and the influencing factors of displacement and storage were analyzed. It is shown that the attraction of the quartz wall to shale oil increases with the degree of hydroxylation. The higher the degree of quartz hydroxylation, the more difficult it is to extract the polar components of shale oil. Nanopore size also has a great impact on shale oil displacement efficiency. The larger the pore size, the higher the shale oil displacement efficiency. The closer the cosolvent molecules are to the polarity of the shale oil, the higher the mutual solubility of CO_(2) and shale oil. The more the non-polar components of shale oil, the lower the mutual solubility of CO_(2) and shale oil with highly polar cosolvent. Ethyl acetate is more effective in stripping relatively high polar shale oil, while dimethyl ether is more effective in stripping relatively low polar shale oil. Kerogen is highly adsorptive, especially to CO_(2). The CO_(2) inside the kerogen is not easy to diffuse and leak, thus allowing for a stable carbon storage. The highest CO_(2) storage rate is observed when dimethyl ether is used as a cosolvent, and the best storage stability is observed when ethyl acetate is used as a cosolvent.

关键词： molecular dynamics shale oil nanopore carbon dioxide cosolvent displacement efficiency storage effect