Effect of ultrasonic modification on the protective activity of Flammulina velutipes polysaccharide to prevent ethanol-induced injury on GES-1 cells

作     者：Jinrong Xiao Xin Chen Jingsi Zhang Yifan Wang Lei Zhong Qiping Zhan Qiuhui Hu Liyan Zhao Jinrong Xiao;Xin Chen;Jingsi Zhang;Yifan Wang;Lei Zhong;Qiping Zhan;Qiuhui Hu;Liyan Zhao

作者机构：College of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China College of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第6期

页      面：2451-2459页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083202[工学-粮食、油脂及植物蛋白工程] 

基　　金：supported by the Special Funds for Scientific and Technological Achievement Transformation Project in Jiangsu Province(BA2021062) 

主　　题：Flammulina velutipes polysaccharide Ultrasonic modification GES-1 cell Gastric ulcer Ethanol-induced injury 

摘      要：Flammulina velutipes(***)polysaccharides were modified by ultrasound at the rated power of 150 W and 900 *** monosaccharide composition,ultraviolet-visible,and Fourier transform infrared spectral characteristics of *** polysaccharides(FVP)and their ultrasonic modification products(U-FVPs)were *** protective effects of FVP and U-FVPs on human gastric mucosal cells GES-1 were confi rmed for the first *** mole ratios of glucose and galactose were decreased and the mole ratio of mannose was increased after ultrasonic *** with the original FVP and the FVP modifi ed by ultrasound of 150 W(U-FVP1),the FVP modifi ed by ultrasound of 900 W(U-FVP2)could better prevent ethanol-induced damage to GES-1 *** increasing ultrasound intensity,the protective effect of FVPs on GES-1 cells was significantly enhanced by more effective prevention of intracellular reactive oxygen species(ROS)production and more promotion of expression of triglyceride factor 2(TFF2),prostaglandin E2(PGE2),epidermal growth factor(EGF),and transforming growth factorβ1(TGF-β1)*** ultrasonic modifi cation might be an effective way to develop novel *** polysaccharides that could effectively resist the gastric injury caused by excessive alcohol consumption.