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Wireless closed-loop deep brain stimulation using microelectrode array probes

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第10期25卷 803-823页

作者： Qianli JIA Yaoyao LIU Shiya LV yiding wang Peiyao JIAO Wei XU Zhaojie XU Mixia wang Xinxia CAI State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural *** in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in *** technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases *** the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently *** this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this *** technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.

关键词： Deep brain stimulation(DBS) Wireless closed-loop deep brain stimulation(CL-DBS)microsystem Microelectrode array(MEA)probe Optical stimulation Electrical stimulation

Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex

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Microsystems & Nanoengineering 2022年第5期8卷 171-181页

作者： Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan yiding wang Botao Lu Jingyu Xie Yuchuan Dai Yilin Song Enhui He Shihong Xu Juntao Liu Mixia wang Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex(MEC)carry the vital function of serving as a metric for the surrounding *** this mechanism processes only spatial information or involves nonspatial information remains ***,we fabricated an MEC-shaped microelectrode array(MEA)to detect the variation in neural spikes and local field potentials of the MEC when rats forage in a square enclosure with a planar,three-dimensional object and social landmarks in *** results showed that grid cells exhibited rate remapping under social conditions in which spike firing fields closer to the social landmark had a higher firing ***,global remapping showed that hexagonal firing patterns were rotated and scaled when the planar landmark was replaced with object and social *** addition,when grid cells were activated,the local field potentials were dominated by the theta band(5–8 Hz),and spike phase locking was observed at troughs of theta *** results suggest the pattern separation mechanism of grid cells in which the spatial firing structure and firing rate respond to spatial and social information,respectively,which may provide new insights into how the brain creates a cognitive map.

关键词： mapping hexagonal microelectrode

Influence of O_2/Ar ratio on the properties of transparent conductive niobium-doped ZnO films

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Chinese Science Bulletin 2009年第13期54卷 2217-2220页

作者： CAO Feng wang yiding LIU KuiXue YIN JingZhi LONG BeiHong LI Li ZHANG Yu CHEN XiaMei State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun130012 China

Niobium-doped ZnO transparent conductive films are deposited on glass substrates by radio frequency sputtering at 300℃.The influence of O2/Ar ratio on the structural,electrical and optical properties of the as-deposited films is investigated by X-ray diffraction,Hall measurement and optical transmission *** lowest resistivity of 4.0×10-4Ω·cm is obtained from the film deposited at the O2/Ar ratio of 1/*** average optical transmittance of the films is over 90%.

关键词： ZnO薄膜透明导电光学性能铌掺杂 Hall测量射频溅射玻璃基板薄膜沉积

Detection of neuronal defensive discharge information transmission and characteristics in periaqueductal gray double-subregions using PtNP/PEDOT:PSS modified microelectrode arrays

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Microsystems & Nanoengineering 2023年第3期9卷 319-331页

作者： Botao Lu Penghui Fan Ming Li yiding wang Wei Liang Gucheng Yang Fan Mo Zhaojie Xu Jin Shan Yilin Song Juntao Liu Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Threatened animals respond with appropriate defensive behaviors to *** has been accepted that midbrain periaqueductal gray(PAG)plays an essential role in the circuitry system and organizes defensive behavioral ***,the role and correlation of different PAG subregions in the expression of different defensive behaviors remain largely ***,we designed and manufactured a microelectrode array(MEA)to simultaneously detect the activities of dPAG and vPAG neurons in freely behaving *** improve the detection performance of the MEAs,PtNP/PEDOT:PSS nanocomposites were modified onto the ***,the predator odor was used to induce the rat’s innate fear,and the changes and information transmission in neuronal activities were detected in the dPAG and *** results showed that the dPAG and vPAG participated in innate fear,but the activation degree was distinct in different defense *** flight,neuronal responses were stronger and earlier in the dPAG than the vPAG,while vPAG neurons responded more strongly during *** applying high-performance MEA,it was revealed that neural information spread from the activated dPAG to the weakly activated *** research also revealed that dPAG and vPAG neurons exhibited different defensive discharge characteristics,and dPAG neurons participated in the regulation of defense responses with burst-firing *** slow activation and continuous firing of vPAG neurons cooresponded with the regulation of long-term freezing *** results demonstrated the important role of PAG neuronal activities in controlling different aspects of defensive behaviors and provided novel insights for investigating defense from the electrophysiological perspective.

关键词： microelectrode freezing modified

White-light-emitting diodes using GaN-excited CdSe/CdS/ZnS quantum dots

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Particuology 2014年第4期12卷 90-93页

作者： Yijun Lin Yu Zhang Jia Zhao Pengfei Gu Ke Bi Qiuran Zhang Hairong Chu Tieqiang Zhang Tian Cui yiding wang Jun Zhao William W.Yu State Key Laboratory on Integrated Optoelectronics and College of Electronic Science and EngineeringJilin University State Key Laboratory of Superhard Materials and College of PhysicsJilin University Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences Department of Chemistry and Physics Louisiana State University.ShreveportLA 71115USA College of Material Science and Engineering.Qingdao University of Science and Technology

Fluorescence-based white-light-emitting diodes （WLEDs） were fabricated using blue GaN chips and green- and red-emitting CdSe/CdS/ZnS quantum dots （QDs）. The coordinate and color temperature of the WLEDs could be varied because of the size-tunable emission of CdSe QDs from 510 to 620 nm. Warm and cold white emissions were confirmed with the color temperature ranging from 4000 to 9000 K. Color coordinates were analyzed at different bias. The fast enhancement of blue emission resulted in the shift of color coordinates to the cold side. The stability of white emission during operation was analyzed; stable spectra were achieved within 90 min.

关键词： GaN Quantum dots White-light-emitting diode Stability

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水平对抛式原子干涉陀螺物理系统研制

仪器仪表学报 2022年第12期43卷 87-95页

作者：王先华贾森王一丁中国科学院西安光学精密机械研究所光电技术部西安710119

水平对抛式原子干涉陀螺以物质波和Sagnac效应为基础,能够对其载体在运动过程中水平方向上产生的角速度及角加速度进行高精度测量。陀螺的物理系统为原子的冷却、囚禁、干涉提供超高真空环境和特定磁场环境,并为激光操控和探测原子态提... 详细信息

水平对抛式原子干涉陀螺以物质波和Sagnac效应为基础,能够对其载体在运动过程中水平方向上产生的角速度及角加速度进行高精度测量。陀螺的物理系统为原子的冷却、囚禁、干涉提供超高真空环境和特定磁场环境,并为激光操控和探测原子态提供光学通路,是陀螺的核心部分。为了实现原子干涉测量并满足高精度测量的需求,在分析原子干涉陀螺运行原理的基础上明确了陀螺物理系统的功能及基本结构,理论分析了物理系统的真空度、磁场等关键指标,然后根据分析和设计结果研制了一套水平对抛式原子干涉陀螺物理系统,测量结果显示真空度可稳定维持在10^(-8)Pa量级,利用这套系统获得的冷原子团直径约6 mm、原子数量约8×10^(9)个、原子温度为12.8μK,满足后续原子干涉测量需求。

关键词：原子干涉测量陀螺仪角速度 Sagnac效应

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基于梯度增强的新闻字幕分割算法

计算机辅助设计与图形学学报 2009年第8期21卷 1170-1174页

作者：王一丁蒋小森北方工业大学信息工程学院北京100144

新闻字幕的分割在基于语义的新闻视频检索系统中具有重要的意义,为此提出一种基于梯度增强的新闻字幕分割算法.该算法使用图像多方向梯度的加权和代替图像的标准方差,通过各方向权值的调节加强某些方向的边缘信息,以提高分割效果.与一... 详细信息

新闻字幕的分割在基于语义的新闻视频检索系统中具有重要的意义,为此提出一种基于梯度增强的新闻字幕分割算法.该算法使用图像多方向梯度的加权和代替图像的标准方差,通过各方向权值的调节加强某些方向的边缘信息,以提高分割效果.与一些经典的自适应阈值分割算法相比,该算法不仅能够保留大部分笔画,也能有效地减少断笔问题.基于光学文字识别的实验结果证明了文中算法的有效性.

关键词：文本分割梯度增强光学文字识别新闻视频

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网络知识组织系统表示语言:SKOS

大学图书馆学报 2007年第4期25卷 30-35页

作者：王一丁王军北京大学信息管理系北京100871

网络知识组织系统(NKOS)可用于网络信息资源的组织和检索,弥补目前基于文本匹配的组织检索系统的缺陷。简单知识组织系统(SKOS)是W3C于2004年发布的新的网络知识组织系统表示语言,尽管目前还处于不成熟的发展阶段,但它的简单易用、适用... 详细信息

网络知识组织系统(NKOS)可用于网络信息资源的组织和检索,弥补目前基于文本匹配的组织检索系统的缺陷。简单知识组织系统(SKOS)是W3C于2004年发布的新的网络知识组织系统表示语言,尽管目前还处于不成熟的发展阶段,但它的简单易用、适用范围广等优越性已经引起广泛注意;同样,SKOS作为W3C推荐的受控词表的表示标准,在促进受控词表的实际应用等方面有着非同寻常的意义。该文在NKOS的背景下详细介绍SKOS标准,并简单分析SKOS与其他知识组织系统表示语言的差异,然后举例部分SKOS现有应用,最后对SKOS及NKOS的应用加以展望。

关键词：网络知识组织系统简单知识组织系统概念框架

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利用手背静脉特征进行身份识别的研究

高技术通讯 2014年第6期24卷 632-642页

作者：王一丁曹希北方工业大学信息工程学院北京100144

在持续研究基于手背静脉特征的身份识别方法和按传统识别流程设计了适合用手背静脉特征识别身份的系统的基础上,对手背静脉识别领域的研究成果和关键问题进行了全面且深入的总结和探讨。首先梳理了手背静脉识别的发展历程和研究现状,并... 详细信息

在持续研究基于手背静脉特征的身份识别方法和按传统识别流程设计了适合用手背静脉特征识别身份的系统的基础上,对手背静脉识别领域的研究成果和关键问题进行了全面且深入的总结和探讨。首先梳理了手背静脉识别的发展历程和研究现状,并通过比较不同生物特征包含的熵,论证了手背静脉作为生物特征识别的可行性,接着从图像采集、图像预处理、特征提取和特征匹配四方面对当前国内外研究成果进行了详细的阐述、对比和分析,在探讨手背静脉特征提取算法时,将已有方法分为空域交换和非空域变换,在空域变换基础上又分为纹理特征提取算法和结构特征提取算法。最后指出了当前研究的待解问题和发展趋势。

关键词：手背静脉可行性图像采集预处理特征提取特征匹配