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CCS Chemistry 2024年第4期6卷 953-963页

作者： yicong Dai Xucong Teng Difei Hu Qiushuang Zhang Jinghong Li Department of Chemistry Center for Bioanalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084 New Cornerstone Science Laboratory Shenzhen 518054 Beijing Life Science Academy Beijing 102209 Center for Bioanalytical Chemistry Hefei National Laboratory of Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026

Genomic surveillance of monkeypox virus(MPXV)is essential to explore the reason of its unusual *** phylogenomic analysis of the MPXV genome mainly focuses on the effect of amino acid ***,we explore the evolutionary variation of RNA G-quadruplex(RG4)of MPXV and find that the genome evolution of MPXV can also produce new effects through changes in the RG4 *** RG4 is located in MPXV’s only Kelch-like C9L gene,which encodes for an antagonist of the innate immune *** evolution of this virus increases the unfolding kinetic constant of C9L RG4 and promotes the C9 protein level in living ***,all reported MPXV genomes in 2022 carry the C9L-RG4-5 pattern with the highest unfolding kinetic ***,the RG4 ligand,RGB-1,can impede the unfolding of C9L-RG4-5 and thereby reduce the C9 protein *** findings carve out a new path to comprehensively understanding MPXV virology.

关键词： G-quadruplex RNA secondary structure unfolding kinetics monkeypox virus genomic evolution immune evasion

From wound response to repair-lessons from ***

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Cell Regeneration 2021年第1期10卷 44-53页

作者： yicong Ma Jing Xie Chandra Sugiarto Wijaya Suhong Xu The Zhejiang University-University of Edinburgh Institute and Department of Cardiology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Center for Stem Cell and Regenerative Medicine School of Basic Medical SciencesZhejiang UniversityHangzhou 310058China

As a result of evolution,the ability to repair wounds allows organisms to combat environment *** the general process of wound healing at the tissue level has been described for decades,the detailed molecular mechanisms regarding the early wound response and rapid wound repair at the cellular level remain little *** elegans is a model organism widely used in the field of development,neuroscience,programmed cell death *** nematode skin is composed of a large epidermis associated with a transparent extracellular cuticle,which likely has a robust capacity for epidermal ***,until the last decades,relatively few studies had directly analyzed the wound response and repair *** we review recent findings in how *** epidermis responds to wounding and initiates early actin-polymerization-based wound closure as well as later membrane *** also discussed some remained outstanding questions for future study.

关键词： wound healing repair

SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

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Frontiers of Agricultural Science and Engineering 2021年第4期8卷 645-658页

作者： Yong ZHOU Linjuan OUYANG Dahu ZHOU yicong CAI Haohua HE Key Laboratory of Crop Physiology Ecology and Genetic Breeding(Ministry of Education)Jiangxi Agricultural UniversityNanchang 330045China.

Superoxide dismutase(SOD)is an important enzyme in the antioxidant system of plants and plays a vital role in stress responses by maintaining the dynamic balance of reactive oxygen species(ROS)***-wide analysis of the SOD gene family in various plant species has been conducted but little is known about this gene family in watermelon(Citrullus lanatus).Here,eight SOD genes were identified in the watermelon genome and are designated Cl CSD1-5,Cl FSD1-2 and Cl MSD according to their metal *** analysis shows that SOD proteins from various plant species can be classified into five groups and members in the same group possess the same metal cofactor and similar subcellular *** analysis of the Cl SOD genes indicates that they had tissue-specific expression patterns with high expression in different tissues including the leaves,flowers and *** addition,the expression of Cl SOD genes differed appreciably under salinity,drought and abscisic acid(ABA)treatments,indicating that they may be involved in ROS scavenging under different abiotic stresses via an ABA-dependent signaling *** results lay the foundation for elucidating the function of Cl SOD genes in stress tolerance and fruit development in watermelon.

关键词： abiotic stress expression analysis phylogeny SOD superoxide dismutase watermelon

Combined analysis of transcriptomics and metabolomics revealed complex metabolic genes for diterpenoids biosynthesis in different organs of Anoectochilus roxburghii

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Chinese Herbal Medicines 2023年第2期15卷 298-309页

作者： yicong Wei Jiayuan Zhang Keming Qi Ye Li Ying Chen College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China College of Landscape and Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China

Objective:Diterpenoids with a wide variety of biological activities from Anoectochilus roxburghii,a precious medicinal plant,are important active ***,due to the lack of genetic information on the metabolic process of diterpenoids in ***,the genes involved in the molecular regulation mechanism of diterpenoid metabolism are still *** study revealed the complex metabolic genes for diterpenoids biosynthesis in different organs of *** by combining analysis of transcriptomics and ***:The differences in diterpenoid accumulation in roots,stems and leaves of *** were analyzed by metabonomic analysis,and its metabolic gene information was obtained by transcriptome ***,the molecular mechanism of differential diterpenoid accumulation in different organs of *** was analyzed from the perspective of gene expression ***:A total of 296 terpenoid metabolites were identified in the five terpenoid metabolic pathways in *** were 38,34,and 18 diterpenoids with different contents between roots and leaves,between leaves and stems,and between roots and stems,***-nine metabolic enzyme genes with 883 unigenes in the diterpenoid synthesis process were identified,and the DXS and FDPS in the terpenoid backbone biosynthesis stage and CPA,GA20ox,GA3ox,GA2ox,and MAS in the diterpenoid biosynthesis stage were predicted to be the key metabolic enzymes for the accumulation of *** addition,14 key transcription factor coding genes were predicted to be involved in the regulation of the diterpenoid *** expression of genes such as GA2ox,MAS,CPA,GA20ox and GA3ox might be activated by some of the 14 transcription *** transcription factor NTF-Y and PRE6 were predicted to be the most important transcription ***:This study determined 29 metabolic enzyme genes and predicted 14 transcription factors involved in the molecular regulation

关键词： Anoectochilus roxburghii(Wall.)Lindl. diterpenoid metabolic pathway leaves metabolomics roots stems transcriptome

Cucumber malate decarboxylase,CsNADP-ME2,functions in the balance of carbon and amino acid metabolism in fruit

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Horticulture Research 2023年第12期10卷 70-83页

作者： Nan Shan Youjun Zhang yicong Guo Wenna Zhang Jing Nie Alisdair R.Fernie Xiaolei Sui Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops College of HorticultureChina Agricultural UniversityBeijing 100193China Jiangxi Province Key Laboratory of Root and Tuber Crops Biology(Jiangxi Agricultural University) Nanchang 330045China Max Planck Institute of Molecular Plant Physiology Potsdam-Golm 14476 Germany

Central metabolism produces carbohydrates and amino acids that are tightly correlated to plant growth and thereby crop *** is reported to link mitochondrial respiratory metabolism with cytosolic biosynthetic *** the function of malate metabolism-related enzymes in providing carbon has been characterized in some plants,evidence for this role in the fleshy fruit of cucumber is ***,radiolabeled bicarbonate fed into the xylem stream from the cucumber roots was incorporated into amino acids,soluble sugars,and organic acids in the exocarp and vasculature of *** activities of decarboxylases,especially decarboxylation from NADP-dependent malic enzyme(NADP-ME),were higher in cucumber fruit than in the leaf *** localization revealed that CsNADP-ME2 was mainly located in the exocarp and vascular bundle system of *** and gas-exchange analysis indicated that overexpression of CsNADP-ME2 could promote carbon flux into soluble sugars and starch in *** studies combined with metabolic profiling revealed that the downregulation of CsNADP-ME2 in RNA interference(RNAi)lines caused the accumulation of its substrate,malate,in the *** addition to inhibition of glycolysis-related gene expression and reduction of the activities of the corresponding enzymes,increased amino acid synthesis and decreased sugar abundance were also observed in these *** opposite effect was found in CsNADP-ME2-overexpressing lines,suggesting that there may be a continuous bottom-up feedback regulation of glycolysis in cucumber ***,our studies indicate that CsNADP-ME2 may play potential roles in both central carbon reactions and amino acid metabolism in cucumber fruits.

关键词： sugar carbon thereby

Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment

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Nano Research 2022年第1期15卷 728-737页

作者： Shiqi Huang Lang Deng Hanming Zhang Luyao Wang yicong Zhang Qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China

Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung,leading to sharply reduced patients'survival *** treating these tumors thus could improve late stage melanoma with lung *** this study,we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA)decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and paclitaxel(PTX)to lung melanoma tumor sites(TRAIL-[ND-PTX]^(CR(NMe)EKA)).These nanodisks displayed better tumor-targeting and penetration capability than spherical nanoparticles,while the fibronectin-targeting CR(NMe)EKA motif also increased the tumor accumulation of loaded *** combined usage of TRAIL and PTX both killed tumor cells and reduced local nutrition supply,leading to stronger overall anti-tumor *** TRAIL-[ND-PTX]^(CR(NMe)EKA)system performed remarkably better than free paclitaxel and also significantly elongated survival rate of melanoma lung metastasis bearing mice,without displaying significant ***,this designing strategy and the fabricated nanoplatform possess potential for further development.

关键词： nanodisks Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA) tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) lung melanoma metastasis tumor-targeting

Health assessment of plantations based on LiDAR canopy spatial structure parameters

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International Journal of Digital Earth 2022年第1期15卷 712-729页

作者： Pengyu Meng Hong Wang Shuhong Qin Xiuneng Li Zhenglin Song yicong Wang Yi Yang Jay Gao School of Hydrology and Water resources Hohai UniversityNanjingPeople’s Republic of China School of Earth Science and Engineering Hohai UniversityNanjingPeople’s Republic of China School of Environment Faculty of ScienceUniversity of AucklandAucklandNew Zealand

The Yellow River Delta(YRD)has China's largest artificial Robinia pseudoacacia forest,which was planted in the late 1970s and suffered extensive dieback in the *** health grade of the *** forest(named canopy vigor grade,CVG)could be achieved by using high-resolution images and canopy vigor indicators(CVIs).However,a previous study showed that there was no significant correlation between CVG and the field-estimated aboveground biomass(AGB)of *** ***,this study aims to construct forest health indicators(FHIs)based on canopy spatial structure parameters extracted from *** FHIs included Weibull_α(the scale parameter of the Weibull density function that reflects the shape of the tree canopy),VCI(vertical complexity index),sdCC(the standard deviation of canopy cover),H99(the 99th percentile height)and cvLAD(the coefficient of variation of leaf area density),and could significantly distinguish three forest health grades(FHG)(p<0.05).The FHG was positively correlated with forest AGB(rs=0.51,p=0.004),and the similarity value with CVG was 63.33%.The results of this study confirmed that the FHIs can reflect both canopy vigor and tree productivity,and distinguish forest health status without prior classification information.

关键词： Forest health indicators LiDAR structural parameter Robinia pseudoacacia forest the Yellow River Delta

Observations on a magnetotactic bacteria-grazing ciliate in sediment from the intertidal zone of Huiquan Bay,China

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Journal of Oceanology and Limnology 2021年第6期39卷 2053-2062页

作者： Si CHEN Kaixuan CUI Wenyan ZHANG yicong ZHAO Tian XIAO Hongmiao PAN Wuchang ZHANG Long-Fei WU CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China International Associated Laboratory of Evolution and Development of Magnetotactic Multicellular Organisms(LIA-MagMC) CNRS-CASQingdao 266071China Aix Marseille Univ CNRSLCBIM2BIMMMarseille 13009France

Magnetotactic bacteria(MTB)are a group of prokaryotes having the ability to orient and swim along geomagnetic field lines because they contain intracellular magnetosomes that are synthesized through a biomineralization *** have recently also been found in unicellular eukaryotes,which are referred to as magnetically responsive protists(MRPs).The magnetosomes have three origins in *** this study,we characterized a MTB-grazing ciliated MRP that was magnetically collected from intertidal sediment of Huiquan Bay,Qingdao,*** on 18S rRNA gene sequence analysis,the ciliated MRP was tentatively identified as Uronemella parafi lificum *** transmission electron microscopy,we observed that magnetosomes having 2-3 shapes were randomly distributed within this *** X-ray spectroscopy and high-resolution transmission electron microscopy images of the magnetosomes were consistent with them being composed of *** having the same shape and mineral composition were also detected in MTB that occurred in the same environment as the ciliated *** analysis showed that the size and shape of the magnetosomes in the ciliated MRP were similar to those in *** results suggest that this ciliated MRP can graze,ingest,and digest various types of *** is certainly worth noting that this is the first record of MRPs in Asian aquatic sediment and suggesting they might be widely *** results also support the assertion that MRPs probably contribute to the ecological cycles of iron,and expand possibilities for research into the mechanism of magnetoreception in eukaryotes.

关键词： magnetically responsive protist ciliate magnetotactic bacteria magnetosome graze magnetoreception

Stereodivergent Benzylic Substitution of Racemic Secondary Benzyl Esters Enabled by Pd/Cu Dual Catalysis

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CCS Chemistry 2024年第10期6卷 2452-2464页

作者： Youbin Peng Guanlin Li Chongyu Han yicong Luo Xiaohong Huo Wanbin Zhang Shanghai Key Laboratory of Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240

Transition-metal-catalyzed asymmetric benzylic substitution of racemic benzyl esters is an efficient and straightforward route towards the construction of benzylic stereocenters but remains a challenge,due to the difficulty encountered in the suppression ofβ–H elimination and asymmetric ***,we successfully developed a highly diastereo-and enantioselective benzylic substitution of racemic 1-(aryl)alkyl esters with aldimine esters enabled by Pd/Cu dual *** array of enantioenrichedα-benzyl substitutedα-amino acids containing vicinal stereocenters were prepared with high levels of diastereo-and enantioselectivities(up to>20:1 dr and>99%ee)and the practicability of the products was further illustrated via their diverse *** dynamic kinetic asymmetric transformation process of the racemic benzyl esters was investigated experimentally and by computational studies.

关键词： amino acids asymmetric catalysis benzylic substitution bimetallic catalysis stereodivergent synthesis

Asymmetric synthesis of bedaquiline based on bimetallic activation and non-covalent interaction promotion strategies

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Science China Chemistry 2022年第10期65卷 1968-1977页

作者： Feng Gao Jing Li tanveer Ahmad yicong Luo Zhenfeng Zhang Qianjia Yuan Xiaohong Huo Tao Song Wanbin Zhang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

Bedaquiline(BDQ),approved by Food and Drug Administration(FDA)in 2012 as the first anti-tuberculosis-specific drug in the last 40 years,is viewed as one of the world’s most promising treatments for tuberculosis(TB).Due to the stereoselective construction of the Csp^(3)–Csp^(3)bond with vicinal stereocenters of BDQ and its analogues being an unsolved challenge,there have not been any reports concerning its asymmetric synthesis for the current industrial production process until ***,we have successfully developed a cooperative bimetallic system for the asymmetric synthesis of BDQ under the guidance of density functional theory(DFT)*** on the optimized conditions,BDQ could be synthesized with excellent enantioselectivity(>99%ee)and diastereoselectivity(16:1 dr).A 5-g scale reaction was also conducted with comparably excellent results,showing its potential for industrial application.

关键词： asymmetric synthesis bedaquiline bimetallic system industrial synthetic process DFT computation

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