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Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

Neuroscience Bulletin 2024年第1期40卷 113-126页

作者： Jieyu Qi Wenjuan Huang yicheng lu Xuehan Yang Yinyi Zhou Tian Chen Xiaohan Wang Yafeng Yu Jia-Qiang Sun Renjie Chai State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Hospital of Southeast University Nanjing 210096China First Affiliated Hospital of Soochow University Suzhou 215006China Department of Otolaryngology-Head and Neck Surgery The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100101China

Hearing loss has become increasingly prevalent and causes considerable disability,thus gravely burdening the global *** loss of hair cells is a main cause of sensorineural hearing loss,and currently,the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids,but these are of limited benefit in *** is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective *** present,how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing ***-ple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells,and in this article,we first review the principal mechanisms underlying hair cell *** then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration,and we summarize current achievements in hair cell ***,we discuss potential future approaches,such as small molecule drugs and gene therapy,which might be applied for regenerating functional hair cells in the clinic.

关键词： Hearing loss Cochlea-Stem cell Hair cell regeneration

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髂动脉的流-固耦合模型及脉搏波传播特性分析

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生物医学工程学杂志 2024年第2期41卷 351-359页

作者：孙雪航李本森卢意成缪馥星宁波大学冲击与安全工程教育部重点实验室浙江宁波315211

本文研究髂动脉分叉几何特性对脉搏波传播特性的影响,应用多物理场分析软件,分别建立了基于髂动脉的直管分叉和曲管分叉流-固双向耦合有限元分析模型,对比分析了血管分叉角度对脉搏波传播特性的影响。研究发现,分叉几何特性对髂动脉脉... 详细信息

本文研究髂动脉分叉几何特性对脉搏波传播特性的影响,应用多物理场分析软件,分别建立了基于髂动脉的直管分叉和曲管分叉流-固双向耦合有限元分析模型,对比分析了血管分叉角度对脉搏波传播特性的影响。研究发现,分叉几何特性对髂动脉脉搏波传播有明显影响,在一个心动周期内,这两种模型预测的压力脉搏波和速度脉搏波幅值在血管分叉前一致度较高;分叉后,曲管分叉模型预测的脉搏波幅值较低、压降小,更符合人体实际情况。另外,分叉点处伴随着血管壁的应力集中现象,速度脉搏波幅值出现瞬时增加,这与分叉部位容易出现动脉狭窄和硬化等现象相一致。本文的初步研究结果将为脉搏波形用于动脉疾病的诊断提供一定的参考。

关键词：压力脉搏波速度脉搏波血管分叉流-固耦合分析数值模拟

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A Simple Synthesis of Tetraamino-[60]Fullerene Epoxides as Potential Antitumor Drug Candidates

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CCS Chemistry 2024年第10期6卷 2392-2399页

作者： yicheng lu Jie Li Xiaolong Liu Dan He Libin Yang Wei Zhou Xie Wang Shanshan Chen Shiliang Chen Yating Liu Xin Wang Jiao Li Jiawei Huo Yang Liu Zehu Wang Meihan Liu Yijun Wang Yamin Li Fuwen Zhao Shumu Li Jinchao Wei Jianan Liu Wei Li Chunru Wang Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100190 The National Center for Nanoscience and Technology Beijing 100190 Central South University Changsha410082 Hunan Hangzhou Institute of Medicine(HIM) Chinese Academy of SciencesHangzhou310092 Zhejiang Cancer Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100069 Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190 Beijing FULLCAN Biotechnology Co. Beijing 100085

Amphiphilic aminated fullerenes have a broad margin of safety and significant antitumor ***,we develop a simple and versatile synthesis strategy for tetraamino-[60]fullerene epoxide(C_(60)(NR^(1)R^(2))_(4)O)using C_(60)Cl_(6)as a precursor,which notably reduces the reaction time to less than 1 h while retaining a high yield of over 80%with both cyclic and linear secondary amine substrates even at the gram *** molecular structure of C_(60)(NR^(1)R^(2))_(4)O is first validated by single-crystal diffraction,and a two-step reaction mechanism comprising nucleophilic substitution of Cl and the oxidative elimination of Cl_(2)is proposed based on experimental verification and density functional theory simulation.A set of water-soluble aminated C_(60)(NR^(1)R^(2))_(4)O was prepared in large quantities,and in vitro antitumor evaluation unveiled the critical role that terminal primary amino moieties of C_(60)(NR^(1)R^(2))_(4)O play in their antineoplastic *** work provides an effective synthesis method for aminated C_(60)(NR^(1)R^(2))_(4)O,facilitating the development of fullerene-derived tumor-targeted drugs.

关键词： tetraamino-fullerene epoxides simple synthesis C_(60)Cl_(6) water-soluble aminated fullerene antitumor

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1Cr5Mo管法兰焊缝在线开裂失效原因分析

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金属加工（热加工） 2024年第5期 25-29页

作者：卢一城福建联合石油化工有限公司福建泉州362000

石化装置因压力管道泄漏而不能正常运行,对主要影响因素管法兰开裂焊缝进行追查,并对管法兰开裂焊缝进行失效分析。经过对泄漏管法兰试件的观察与分析,管法兰焊缝热影响区出现开裂,且开裂模式为脆性延迟断裂,机理为应力腐蚀开裂。发生... 详细信息

石化装置因压力管道泄漏而不能正常运行,对主要影响因素管法兰开裂焊缝进行追查,并对管法兰开裂焊缝进行失效分析。经过对泄漏管法兰试件的观察与分析,管法兰焊缝热影响区出现开裂,且开裂模式为脆性延迟断裂,机理为应力腐蚀开裂。发生应力腐蚀的原因应是由于焊缝热影响区组织存在淬硬马氏体,导致硬度严重超标,在湿硫化氢作用下产生应力腐蚀开裂。淬硬马氏体的形成应与焊后热处理质量和检测质量有关。

关键词：法兰焊缝失效分析改进措施

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蜂群信息采集技术研究进展和应用展望

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福建农林大学学报（自然科学版） 2024年第4期53卷 501-509页

作者：陆亦澄刘瑶刘升平郑火青浙江大学动物科学学院浙江杭州310058 中国农业科学院农业信息研究所北京100081

综述了国内外蜂群信息采集技术相关研究进展,对所采用的技术进行总结,并展望未来发展方向,以期为我国养蜂生产及相关产业的信息化发展提供借鉴。

关键词：蜂群信息采集声音监测图像监测温度监测信息化数字化

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Association between plasma growth differentiation factor 15 levels and pre-eclampsia in China

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Chronic Diseases and Translational Medicine 2024年第2期10卷 140-145页

作者： Shuhong Xu yicheng lu Mengxin Yao Zhuoqiao Yang Yan Chen Yaling Ding Yue Xiao Fei Liang Jiani Qian Jinchun Ma Songliang Liu Shilan Yan Jieyun Yin Qiuping Ma Taicang Affiliated Hospital of Soochow University The First People's Hospital of TaiCangSoochow UniversitySuzhouJiangsuChina Department of Epidemiology and Health Statistic Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable DiseasesSuzhou Medical College of Soochow UniversitySuzhouJiangsuChina Changshu Hospital Affiliated to Nanjing University of Chinese Medicine SuzhouJiangsuChina Department of Chronic Disease Gusu Center for Disease Control and PreventionSuzhouJiangsuChina Huzhou First People's Hospital HuzhouZhejiangChina

Background Growth differentiation factor-15(GDF-15)is a stress response protein and is related to cardiovascular diseases(CVD).This study aimed to investigate the association between GDF-15 and pre-eclampsia(PE).Method The study involved 299 pregnant women,out of which 236 had normal pregnancies,while 63 participants had *** serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits and then translated into multiple of median(MOM)to avoid the influence of gestational week at blood *** models were performed to estimate the association between GDF-15 MOM and PE,presenting as odd ratios(ORs)and 95%confidence intervals(CIs).Results MOM of GDF-15 in PE participants was higher compared with controls(1.588 vs.1.000,p1)had a 4.74-fold(95%CI=2.23–10.08,p<0.001)increased risk of PE,adjusted by age,preconceptional body mass index,gravidity,and *** These results demonstrated that higher levels of serum GDF-15 were associated with ***-15 may serve as a biomarker for diagnosing PE.

关键词： growth differentiation factor 15 macrophage inhibiting cytokine 1 pre-eclampsia

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果糖在肝胰岛素抵抗发生机制中的作用

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解剖学杂志 2024年第2期47卷 95-100页

作者：杨佳叶卢奕成张晓明浙江大学医学院基础医学系杭州310058

随着经济发展,糖尿病已成为全球最常见的慢性病之一,其中肝胰岛素抵抗是2型糖尿病发生发展的重要原因之一。笔者从果糖通过肝脂质从头合成增加、肝细胞脂肪酸氧化减弱、肝细胞氧化应激激活以及肝炎症反应增强等途径,致使胰岛素通路障碍... 详细信息

随着经济发展,糖尿病已成为全球最常见的慢性病之一,其中肝胰岛素抵抗是2型糖尿病发生发展的重要原因之一。笔者从果糖通过肝脂质从头合成增加、肝细胞脂肪酸氧化减弱、肝细胞氧化应激激活以及肝炎症反应增强等途径,致使胰岛素通路障碍,以及果糖对胰岛素通路的直接作用等机制作一综述,为肥胖、2型糖尿病等与肝胰岛素抵抗密切相关的疾病防治提供新的思路和方法。

关键词：肝果糖胰岛素抵抗糖尿病

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Establishing a cat model of chronic optic nerve compression injury

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Neural Regeneration Research 2009年第6期4卷 462-467页

作者： Feng Yu Shaoji Yuan Rongwei Zhang yicheng lu Meiqing Lou Department of Neurosurgery General Hospital of Jinan Military Area Command of Chinese PLA Jinan 250031 Shandong Province China Department of Neurosurgery Changzheng Hospital Second Military Medical University of Chinese PLA Shanghai 200003 China

BACKGROUND： An animal model of chronic optic nerve injury is necessary to further understand the pathological mechanisms involved. OBJECTIVE： To establish a stabilized, chronic, optic nerve crush model, which is similar to the clinical situation to explore histopathological and optic electrophysiological changes involved in this injury. DESIGN, TIME AND SETTING： A randomized and controlled animal trial was performed at Shanghai Institute of Neurosurgery from May to October 2004, MATERIALS： A BAL3XRAY undetachable balloon and Magic-BD catheter were provided by BLAT, France; JX-2000 biological signal processing system by Second Military Medical University of Chinese PLA, China; inverted phase contrast microscopy by Olympus, Japan. METHODS： A total of twenty normal adult cats were randomly assigned to control （n = 5） and model （n = 15） groups, according to different doses of contrast agent injected through balloons as follows： 0.2 mL injection, 0.25 mL injection, and 0.35 mL injection, with each group containing 5 animals. Imitating the clinical pterion approach, the optic nerves were exposed using micro-surgical methods. An engorged undetachable balloon was implanted beneath the nerve and connected to a catheter. Balloon size was controlled with a contrast agent injection （0.1 mL/10 min） to form an occupying lesion model similar to sellar tumors. MAIN OUTCOME MEASURES： The visually evoked potential examination was used to study optical electrophysiology changes in pre-post chronic optical nerve injury. Ultrastructural pathological changes to the optic nerve were analyzed by electron microscopy. RESULTS： During the early period （day 11 after modeling）, visually evoked potential demonstrated no significant changes. In the late period （day 51 after modeling）, recorded VEP demonstrated that P1 wave latency was prolonged and P1 wave amplitude was obviously reduced. Following injury, the endoneurium, myelin sheath, lamella, axolemma, and axon appeared disordered. CONCluSION

关键词： optic nerve injury evoked potential visual sensation feline disease models, animal

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生物毒素研究进展

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军事医学 2024年第1期48卷 52-57页

作者：卢奕成李蒙刘婷张慧刘楠王增明郑爱萍军事科学院军事医学研究院毒物药物研究所北京100850

生物毒素是由特定的微生物、植物、动物等产生的具有毒性的分子构成。由于毒素来源广泛且毒性极强,越来越多的蛋白质和非蛋白质毒素的可用性被研究,其中一部分被用于军事目的并开发为生物毒素战剂。该文论述了生物毒素的分类及作用机制... 详细信息

生物毒素是由特定的微生物、植物、动物等产生的具有毒性的分子构成。由于毒素来源广泛且毒性极强,越来越多的蛋白质和非蛋白质毒素的可用性被研究,其中一部分被用于军事目的并开发为生物毒素战剂。该文论述了生物毒素的分类及作用机制,并对其防治策略及治疗应用进展进行了综述。

关键词：生物毒素战剂解毒剂抗毒素治疗

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Analysis of thermal management and anti-mechanical abuse of multi-functional battery modules based on magneto-sensitive shear thickening fluid

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 529-542页

作者： Yang XIONG Bo lu yicheng SONG Junqian ZHANG Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China

Electric vehicles(EVs)have garnered significant attention as a vital driver of economic growth and environmental ***,ensuring the safety of high-energy batteries is now a top priority that cannot be overlooked during large-scale *** paper proposes an innovative active protection and cooling integrated battery module using smart materials,magneto-sensitive shear thickening fluid(MSTF),which is specifically designed to address safety threats posed by lithium-ion batteries(LIBs)exposed to harsh mechanical and environmental *** theoretical framework introduces a novel approach for harnessing the smoothed-particle hydrodynamics(SPH)methodology that incorporates the intricate interplay of non-Newtonian fluid behavior,capturing the fluid-structure coupling inherent to the *** approach is further advanced by adopting an enhanced Herschel-Bulkley(H-B)model to encapsulate the intricate rheology of the MSTF under the influence of the magnetorheological effect(MRE)and shear thickening(ST)*** simulation results show that in the case of cooling,the MSTF is an effective cooling medium for rapidly reducing the *** terms of mechanical abuse,the MSTF solidifies through actively applying the magnetic field during mechanical compression and impact within the battery module,resulting in 66%and 61.7%reductions in the maximum stress within the battery jellyroll,and 31.1%and 23%reductions in the reaction force,*** mechanism effectively lowers the risk of short-circuit *** groundbreaking concepts unveiled in this paper for active protection battery modules are anticipated to be a valuable technological breakthrough in the areas of EV safety and lightweight/integrated design.

关键词： magneto-sensitive shear thickening fluid(MSTF) battery module impact protection temperature control integrated design

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