Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear
作者机构：State Key Laboratory of Digital Medical EngineeringDepartment of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Hospital of Southeast UniversityNanjing 210096China First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Otolaryngology-Head and Neck SurgeryThe First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Otolaryngology Head and Neck SurgerySichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Co-Innovation Center of NeuroregenerationNantong UniversityNantong 226001China Institute for Stem Cell and RegenerationChinese Academy of ScienceBeijing 100101China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2024年第40卷第1期
页 面：113-126页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学]
基 金：supported by grants from the National Key R&D Program of China(2021YFA1101300,2021YFA1101800,2020YFA0112503) the National Natural Science Foundation of China(82030029,81970882,82000984,92149304) the Science and Technology Department of Sichuan Province(2021YFS0371) the Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022) the China National Postdoctoral Program for Innovative Talents(BX20200082) the China Postdoctoral Science Foundation(2020M681468) the Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2104)
主 题：Hearing loss Cochlea-Stem cell Hair cell regeneration
摘 要：Hearing loss has become increasingly prevalent and causes considerable disability,thus gravely burdening the global *** loss of hair cells is a main cause of sensorineural hearing loss,and currently,the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids,but these are of limited benefit in *** is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective *** present,how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing ***-ple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells,and in this article,we first review the principal mechanisms underlying hair cell *** then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration,and we summarize current achievements in hair cell ***,we discuss potential future approaches,such as small molecule drugs and gene therapy,which might be applied for regenerating functional hair cells in the clinic.
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