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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients incapacitated.Repetitive transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological conditions.Over the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and connectivity.It has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological insult.However,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of studies.This study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated mechanisms.This review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s disease.Apoptotic mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also highlighted.Finally,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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论清中后期花部戏本的体制嬗继

戏剧艺术 2024年第1期 110-120,152页

作者：王—冰三江学院文学与新闻传播学院

清中后期花部戏本,具有承继副末开场的报条,存在以[点绛唇]开场和段落性“同韵”的音乐现象,出现了灵活使用脚色的新变化。这些体制特征与传奇体制存在承继关系。清中后期花部戏本体制嬗继,反映了戏曲史发展过程中戏曲体制观念的格律性... 详细信息

清中后期花部戏本,具有承继副末开场的报条,存在以[点绛唇]开场和段落性“同韵”的音乐现象,出现了灵活使用脚色的新变化。这些体制特征与传奇体制存在承继关系。清中后期花部戏本体制嬗继,反映了戏曲史发展过程中戏曲体制观念的格律性和统一性。花部戏体制的嬗继,揭示了“花”“雅”之间紧密承续的历史事实。

关键词：花部抄本报条点绛唇同韵体制嬗继

Link Budget and Enhanced Communication Distance for Ambient Internet of Things

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ZTE Communications 2024年第1期22卷 16-23页

作者： YANG yibing LIU Ming XU Rongtao wang Gongpu GONG Wei School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026China

Backscatter communications will play an important role in connecting everything for beyond 5G(B5G)and 6G systems.One open challenge for backscatter communications is that the signals suffer a round-trip path loss so that the communication distance is short.In this paper,we first calculate the communication distance upper bounds for both uplink and downlink by measuring the tag sensitivity and reflection coefficient.It is found that the activation voltage of the envelope detection diode of the downlink tag is the main factor limiting the back-scatter communication distance.Based on this analysis,we then propose to implement a low-noise amplifier(LNA)module before the envelope detection at the tag to enhance the incident signal strength.Our experimental results on the hardware platform show that our method can increase the downlink communication range by nearly 20 m.

关键词： ambient IoT(AIoT) B5G backscatter communication link budget low-noise amplifier(LNA) Release 19 tag chip sensitivity upper bounds

Link Budget and Enhanced Communication Distance for Ambient Internet of Things

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ZTE Communications 2024年

作者： YANG yibing LIU Ming XU Rongtao wang Gongpu GONG Wei School of Electronic and Information Engineering Beijing Jiaotong University School of Computer Science and Technology University of Science and Technology of China School of Computer and Information Technology Beijing Jiaotong University

Backscatter communication， a key technology for ambient Internet of Things (ambient IoT)， will play an important role in connecting everything for beyond 5G (B5G) and 6G systems. One open challenge for backscatter communications is that the signals suffer a round-trip path loss so that the communication distance is short， which motivates our present work. In this paper， we first calculate communication distance upper bounds for both uplink and downlink by measuring the tag sensitivity and reflection coefficient. It is found that the activation voltage of the envelope detection diode of the downlink tag is the main factor limiting the backscatter communication distance. Based on this analysis， we then propose to implement a low-noise amplifier (LNA) module before the envelope detection at the tag to enhance the incident signal strength. Our experimental results on the hardware platform show that our method can increase the downlink communication range by nearly 20 m.

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双路特征提取与度量的少样本细粒度图像分类方法

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天津大学学报（自然科学与工程技术版） 2024年第2期57卷 137-146页

作者：冀中吴伊兵王轩天津大学电气自动化与信息工程学院天津300072

少样本学习旨在利用少量数据训练深度学习模型,并将其快速泛化到新任务中.在这一领域,少样本细粒度图像分类是最具有挑战性的任务之一,原因在于细粒度图像具有类内方差大、类间方差小的特点.为了解决这一问题,本文提出了一种基于距离与... 详细信息

少样本学习旨在利用少量数据训练深度学习模型,并将其快速泛化到新任务中.在这一领域,少样本细粒度图像分类是最具有挑战性的任务之一,原因在于细粒度图像具有类内方差大、类间方差小的特点.为了解决这一问题,本文提出了一种基于距离与方向双重度量的神经网络,分别利用欧氏距离衡量特征间的绝对距离差异和余弦相似度衡量特征间的相对方向差异,以提升度量信息多样性和样本特征的判别性.同时,为了与当前先进的少样本细粒度图像分类方法对比,将特征提取器在不增加深度的前提下设置为双路形式,以适应不同度量方法对嵌入特征信息的需要.此外,设计了彼此分离的通道和空间注意力机制,分别通过自适应通道注意力和空间信息交叉注意力对不同阶段的提取特征进行增强,从而挖掘重要分类信息.最后,通过双相似度模块分别计算两种差异信息的度量结果,并选取一定权重融合得到最终的相似度分数,实现绝对差异与相对差异在度量空间中的协调补充.在4个主流细粒度图像分类数据集上进行实验对比与分析,最终结果表明了所提方法在相同设置下最多实现了7.0%左右的分类准确率提升.

关键词：细粒度图像少样本欧氏距离余弦相似度

Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression

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Neural Regeneration Research 2013年第17期8卷 1576-1581页

作者： Hu Xiao Dechang wang Ran Huo yibing wang Yongqiang Feng Qiang Li Department of Burn and Plastic Surgery Shandong Provincial Hospital Affiliated to Shandong University

This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension.

关键词： neural regeneration innervation nerve growth factor hypertrophic scar keloid mechanical tension wound healing surgery grants-supported paper neuroregeneration

Anti-PD1 antibody and not anti-LAG-3 antibody improves the antitumor effect of photodynamic therapy for treating metastatic breast cancer

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 87-103页

作者： Shan Long yibing Zhao Yuanyuan Xu Bo wang Haixia Qiu Hongyou Zhao Jing Zeng Defu Chen Hui Li Jiakang Shao Xiaosong Li Ying Gu School of Medicine Nankai University Tianjin300072P.R.China Department of Laser Medicine The First Medical Center of Chinese PLA General Hospital Beijing 100853 P.R.China Department of Oncology The Seventh Medical Center of Chinese PLA General Hospital Beijing 100039 P.R.China School of Basic Medicine Guizhou Medical University Guiyang 550025GuizhouP.R.China College of Medical Technology Beijing Institute of Technology Beijing 100081P.R.China Medical School of Chinese PLA Beijing 100853 P.R.China

Photodynamic therapy(PDT)has limited effects in treating metastatic breast cancer.Immune checkpoints can deplete the function of immune cells;however,the expression of immune checkpoints after PDT is unclear.This study investigates whether the limited e±cacy of PDT is due to upregulated immune checkpoints and tries to combine the PDT and immune checkpoint inhibitor to observe the e±cacy.A metastatic breast cancer model was treated by PDT mediated by hematoporphyrin derivatives(HpD-PDT).The anti-tumor effect of HpD-PDT was observed,as well as CD4þT,CD8þT and calreticulin(CRT)by immunohistochemistry and immunofluorescence.Immune checkpoints on T cells were analyzed byflow cytometry after HpD-PDT.When combining PDT with immune checkpoint inhibitors,the antitumor effect and immune effect were assessed.For HpD-PDT at 100 mW/cm2 and 40,60 and 80 J/cm2,primary tumors were suppressed and CD4þT,CD8þT and CRT were elevated;however,distant tumors couldn't be inhibited and survival could not be prolonged.Immune checkpoints on T cells,especially PD1 and LAG-3 after HpD-PDT,were upregulated,which may explain the reason for the limited HpD-PDT effect.After PDT combined with anti-PD1 antibody,but not with anti-LAG-3 antibody,both the primary and distant tumors were signi-cantly inhibited and the survival time was prolonged,additionally,CD4þT,CD8þT,IFN-þCD4þT and TNF-þCD4þT cells were signi-cantly increased compared with HpD-PDT.HpD-PDT could not combat metastatic breast cancer.PD1 and LAG-3 were upregulated after HpD-PDT.Anti-PD1 antibody,but not anti-LAG-3 antibody,could augment the antitumor effect of HpD-PDT for treating metastatic breast cancer.

关键词： Photodynamic therapy anti-PD1 antibody anti-LAG-3 antibody anti-tumor im-mune effects metastatic breast cancer

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基于TEM喇叭的电磁脉冲辐射天线优化设计

强激光与粒子束 2024年第4期36卷 89-95页

作者：周星芦艺兵赵敏王平平陆军工程大学石家庄校区电磁环境效应重点实验室石家庄050003

针对TEM喇叭天线终端反射大、低频辐射效率低的问题,对其进行了仿真优化设计。采用时域分析方法,分析了端部加载电阻与背部加载电阻的低频补偿方法,对TEM喇叭天线的尺寸、极板顶角等结构参数进行了优化,采用末端卷边结构,提升了辐射场... 详细信息

针对TEM喇叭天线终端反射大、低频辐射效率低的问题,对其进行了仿真优化设计。采用时域分析方法,分析了端部加载电阻与背部加载电阻的低频补偿方法,对TEM喇叭天线的尺寸、极板顶角等结构参数进行了优化,采用末端卷边结构,提升了辐射场的峰值场强与脉宽。根据仿真优化结果,研制了长度2.5 m、天线极板间张角45°、天线极板顶角45°的TEM喇叭天线,通过实测验证了仿真结果。结果表明,加载电阻可以有效降低反射,背部加载电阻方式的峰值场强和脉宽比端部加载电阻高,且采用4个电阻并联加载的效果较好;适当增加天线长度、极板顶角以及极板间夹角可以提高天线辐射性能。该研究结果为TEM喇叭天线在辐射式核电磁脉冲试验系统的应用提供了参考。

关键词： TEM喇叭天线核电磁脉冲天线尺寸优化加载电阻天线结构优化

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水平轴风电机组叶片摆振与挥舞机理建模

机械工程学报 2024年第3期60卷 131-142页

作者：王思清滕伟王罗刘宇彭迪康马志勇柳亦兵华北电力大学电站能量传递转化与系统教育部重点实验室北京102206 中国长江三峡集团有限公司北京100038 中国绿发投资集团有限公司北京100020

水平轴风电机组叶片振动机理建模是研究叶片振动规律及进行故障诊断的基础。基于多坐标变换,考虑塔影效应、几何非线性和桨距角变化等因素的影响,建立结构动力学与空气动力学耦合的水平轴风电机组叶片摆振、挥舞振动机理模型。以某2 MW... 详细信息

水平轴风电机组叶片振动机理建模是研究叶片振动规律及进行故障诊断的基础。基于多坐标变换,考虑塔影效应、几何非线性和桨距角变化等因素的影响,建立结构动力学与空气动力学耦合的水平轴风电机组叶片摆振、挥舞振动机理模型。以某2 MW风电机组柔性叶片以及某场站3 MW风电机组叶片为对象,构建了多体动力学模型,分别与GH Bladed软件计算结果和机组实测数据相比,具有较高的吻合度。基于此模型,研究了稳态工况下,塔影效应、几何非线性以及桨距角变化对叶片运行参数和振动的影响。结果表明,叶片轴向推力和转矩在塔影区有明显下降,同时挥舞方向振动在塔影区存在显著波动。叶片的侧向弯曲刚度随着方位角的变化呈谐波式变化,转速影响叶片侧向弯曲刚度大小。当风速过大时,叶片通过桨距角变化可以有效抑制振动。

关键词：空气动力学结构动力学塔影效应几何非线性摆振与挥舞