Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression

作     者：Hu Xiao Dechang Wang Ran Huo Yibing Wang Yongqiang Feng Qiang Li 

作者机构：Department of Burn and Plastic Surgery Shandong Provincial Hospital Affiliated to Shandong University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第17期

页      面：1576-1581页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the Shandong Excellent Young Scientist Research Award Fund of the Natural Science Foundation of Shandong Province, No. BS2009YY043 Shandong Medical and Health Science and Technology Development Program for Youth Fund, No. 2009QZ023 the National Natural Science Foundation of China, No. 81272099 

主　　题：neural regeneration innervation nerve growth factor hypertrophic scar keloid mechanical tension wound healing surgery grants-supported paper neuroregeneration 

摘      要：This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension.