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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang Li Mingwei Chen Jiayun Chen ge Song Chuanbin Yang Yali Song Jigang wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IgFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCg+and KLF2+epithelium are key features and may be the potential mechanisms underlyi.g the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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张大千在成都的艺术活动

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文史杂志 2025年第1期235卷 62-66页

作者：汪毅内江市张大千纪念馆

张大千在成都的艺术活动以及离蓉后对成都的思念,表现了他对故乡的一片深情,彰显了其艺术人生的“成都意义”。

关键词：成都美术写诗成都成都日记

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FOCAD基因复合杂合变异致儿童重型先天性肝病1例

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中华儿科杂志 2025年第1期63卷 90-91页

作者：李艺佩郭张妍王义西安交通大学附属儿童医院重症医学科西安

患儿, 女, 2月6日龄, 以"皮肤黄染10 d"入院。家系全外显组测序结果提示FOCAD基因存在NM001375567.1:c.4203C>g（***1401*）和c.2303dupC（***769Phefs*54）复合杂合变异。诊断为FOCAD基因变异致儿童重型先天性肝病。以保肝降酶对症支...

患儿, 女, 2月6日龄, 以"皮肤黄染10 d"入院。家系全外显组测序结果提示FOCAD基因存在NM001375567.1:c.4203C>g（***1401*）和c.2303dupC（***769Phefs*54）复合杂合变异。诊断为FOCAD基因变异致儿童重型先天性肝病。以保肝降酶对症支持治疗为主, 经治疗16 d, 好转出院, 出院后继续口服药物治疗。19 d后因凝血功能异常再次入院, 治疗4 d, 基因结果回报异常, 家属放弃治疗, 2个月后死亡。

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CHINA ＆ ASEAN： LOOKINg TOWARD THE FUTURE——wang yi： CHINA’S FOREIgN POLICY ENTERS A NEW ERA

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China Report ASEAN 2018年第1期3卷 18-23页

作者： wang yi China's Foreign

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High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

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Tungsten 2025年第1期 50-70页

作者： yi Li Bei-Qi wang Xin-yin Zhang Shi-Jie wang Cong-yi Li Hui-Long Yang Ran-Ran Su Tong Liu School of Mechanical Engineering Shanghai Jiao Tong University College and graduate School of Arts and Sciences University of Virginia global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

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Upholding Multilateralism, Fairness and Justice and Promoting Mutually Beneficial Cooperation——Keynote Speech by State Councilor and Foreign Minister wang yi At the International Seminar on global Digital governance

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Peace 2020年第3期 24-26页

作者： wang yi 不详

Beijing,8 September 2020 Distinguished guests,Colleagues,Ladies and gentlemen,Friends,We are meeting under the theme"Seizing Digital Opportunities for Cooperation and Development",a topic that is highly relevant.

关键词： Seminar holding Minister

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“共建共治共享”的乡村治理共同体何以建构

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河北学刊 2025年第1期45卷 193-201页

作者：王春城郭一文燕山大学公共管理学院河北省高校人文社会科学重点研究基地燕山大学县域振兴发展政策研究中心

以“共建共治共享”为导向建构乡村治理共同体,是回应新时代中国乡村治理诉求的必然要求,而现实图景的生成,需要从学理上探究其系统建构逻辑,明确其价值意蕴、要素体系与行动框架。顺应乡村治理方向的时代变迁,建构乡村治理共同体,要响... 详细信息

以“共建共治共享”为导向建构乡村治理共同体,是回应新时代中国乡村治理诉求的必然要求,而现实图景的生成,需要从学理上探究其系统建构逻辑,明确其价值意蕴、要素体系与行动框架。顺应乡村治理方向的时代变迁,建构乡村治理共同体,要响应政治价值、社会价值和公共价值,这些价值意蕴促使乡村治理共同体成为提升乡村治理效能的重要途径。乡村治理共同体的核心内涵集中体现在组织、价值、行动、利益等要素的关联契合之中,组织架构、价值理念、行动指向、利益成果可作为乡村治理共同体的建构体系。以价值意蕴的指引和要素体系的支撑为基础,乡村治理共同体建构的具体行动可通过以主体互嵌优化乡村治理结构、以价值融通重塑乡村治理理念、以协同共治完善乡村治理方式、以利益聚合共享乡村治理成果四个方面入手,以乡村治理共同体推进乡村治理的网络化、共识化、协同化和共享化,从而以“共建共治共享”的共同体塑造乡村治理新格局。

关键词：乡村治理共同体共建共治共享

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[Determination of 12 halogenated organic pollutants in edible fish by ultra performance liquid chromatography-high resolution mass spectrometry combined with ultrasound-assisted extraction and gel permeation chromatography purification]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 68-77页

作者： yi-Zhe Zhu Rui-Fen Zheng Zi-Hao Fan Ling Liu Jing-Yao Ye Kai wang Cai-Ming Tang Research Center for Eco-Environmental Engineering Dongguan University of Technology Dongguan 523808 China. guangdong Key Laboratory of Environmental Resources Utilization and Protection Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China.

Halogenated organic pollutants (HOPs) have attracted considerable attention owing to their persistence, bioaccumulation, and toxicity. The development of methods to detect HOPs in fish is challenging owing to the compositional complexity of fish matrices, which contain high levels of lipids and relatively low concentrations of HOPs. In addition, the lipophilicity of most HOPs renders their extraction difficult. Moreover, the simultaneous determination of multiple HOPs to achieve the high-throughput screening of these analytes is complex. In this study, a reliable and efficient pretreatment method based on ultrasound-assisted extraction, gel permeation chromatography purification, and ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) was developed for the determination of 12 HOPs in edible fish. The procedures of sample extraction and purification and LC-HRMS detection parameters were optimized to improve the performance of the method. Fresh fish samples were thoroughly rinsed with water, and non-edible parts, including the skin, bones, and phosphorus, were removed. The fish were weighed, cut into small pieces, and vacuum freeze-dried for 48 h. Subsequently, a freeze grinder was used to grind the dried fish into a fine powder. Exactly 2 g of the fish powder was weighed, fortified with isotope-labeled internal standards of the HOPs, and allowed to stand for 5 min. Methanol-acetonitrile (1∶1, v/v) was then added, followed by vortex mixing and ultrasonication. After centrifugation, the supernatant was transferred to a fresh tube. The extraction process was repeated twice and all extracts were combined. The extract was evaporated under a gentle nitrogen flow and redissolved in a mixture of ethyl acetate-cyclohexane (1∶1, v/v). The sample mixture was cleaned using gel permeation chromatography, and the eluate was collected and concentrated under a nitrogen flow. Sample residuals were reconstituted with water-methanol (1∶1, v/v) prior to

关键词： edible fish gel permeation chromatography (gPC) halogenated organic pollutants (HOPs) ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS)

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang guohui Song Zhenhai wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（gC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of gC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards gC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of gC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrendg male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher gC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Visible-light-mediated tungsten-catalyzed C-H amination of unactivated alkanes with nitroarenes

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Science China Chemistry 2022年第4期65卷 678-685页

作者： Qing wang Shengyang Ni Xiaochen wang yi wang yi Pan State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Alkylamines are important motifs in pharmaceutical and material *** existing reports of C-H amination are limited to ammonia,diazo and azide nitrogen *** work describes a rapid construction of C-N bonds from accessible nitroarene and alkane feedstock under decatungstate catalysis.A variety of C-H precursors including gaseous,linear,cyclic and benzylic hydrocarbons could adopt this protocol to afford the corresponding alkylamines in high efficiency.

关键词： amination photoredox light alkane nitrobenzene

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