检索结果-南通市图书馆

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling Xiao Yue Gong ying-Jia Qi Zhi-Ming Shao yi-zhou jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

引用

Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-Yang Yan Hong Lv Jing-Cheng Yang Chao You Zi-Ang Li Ding Ma yi Xiao Jia Hu Wen-Tao Yang yi-zhou jiang Jun Xu Zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area Institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TNBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TNBC cohort(N=425),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2 mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TNBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank P<0.001).Our prediction framework and neural network models were externally validated on the TNBC cases from TCGA(N=143)and appeared robust to the changes in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

引用

Protein & Cell 2024年第6期15卷 419-440页

作者： Wei Ma Lu Zhang Weilong Chen Zhaoxia Chang Juchuanli Tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun Ding Siqin Li Fengkai Li Qiaodan Deng yifei Yang Tingting Feng Fanrong Zhang Xiying Shao Xueyan He Lixing Zhang Guohong Hu Quentin Liu yi-zhou jiang Shu Zhu Zhi Xiao Dan Su Tong Liu Suling Liu Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesDepartment of OncologyKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Intelligent Pathology Institute and Department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230071China Department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’an 710032China Institute of Immunology CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Pathology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Surgery The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Medical Oncology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Shanghai Institute of Nutrition and Health University of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Department of Breast Surgery Xiangya HospitalChangsha 410008China Department of Breast Surgery Tumor Hospital of Harbin Medic

Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant ***,targeting microbiota to improve the effects of breast cancer therapy has not been investigated in ***,we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis(ETBF)was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant ***,albeit at low biomass,secreted the toxic protein BFT-1 to promote breast cancer cell stemness and *** studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 ***1 was highly expressed on ALDH+breast cancer stem cells(BCSCs)and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation,thereby activating the NOTCH1-HEY1 signaling pathway to increase ***1 inhibition and ETBF clearance increase the chemosensitivity of breast cancer by impairing BCSCs.

关键词： NOD1 breast chemotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer:theory-to-practice

引用

Cancer Biology & Medicine 2023年第2期20卷 98-103页

作者： Hang Zhang Fan Yang yi Xiao yi-zhou jiang Zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer Center、Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Ferroptosis,a type of regulated cell death named one decade ago,is a unique type driven by lipid peroxidation in an iron-dependent *** differs radically from apoptosis and other regulated forms of cell death in both morphology and molecular *** can be triggered by a variety of physiologic conditions and pathologic *** has been growing interest in ferroptosis in recent years,and research on ferroptosis is productive.

关键词： peroxidation death breast

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Breast cancer screening and early diagnosis in Chinese women

引用

Cancer Biology & Medicine 2022年第4期19卷 450-467页

作者： Rui Ding yi Xiao Miao Mo ying Zheng yi-zhou jiang Zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Cancer Prevention Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Precision Cancer Medicine Center Fudan University Shanghai Cancer CenterShanghai 200032China

Breast cancer is the most common malignant tumor in Chinese women,and its incidence is *** screening is an effective method for early tumor detection and improving patient *** this review,we analyze the epidemiological changes and risk factors associated with breast cancer in China and describe the establishment of a screening strategy suitable for Chinese *** patients with breast cancer tend to be younger than Western patients and to have denser ***,the age of initial screening in Chinese women should be earlier,and the importance of screening with a combination of ultrasound and mammography is ***,Chinese patients with breast cancers have several ancestry-specific genetic features,and aiding in the determination of genetic screening strategies for identifying high-risk *** the basis of current studies,we summarize the development of risk-stratified breast cancer screening guidelines for Chinese women and describe the significant improvement in the prognosis of patients with breast cancer in China.

关键词： Breast cancer screening Chinese imaging screening genetic test

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Next-generation antibody-drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer

引用

Cancer Biology & Medicine 2023年第10期20卷 689-694页

作者： Lei-Jie Dai Yu-Wei Li Ding Ma Zhi-Ming Shao yi-zhou jiang Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterShanghai 200032China

The concept of antibody±drug conjugations(ADCs)can be tracked back to the early 20^(th) century when the renowned immunologist,Paul Ehrlich,proposed the idea of a"magic bullet",which utilizes ADCs for targeted destruction of microorganisms and tumor cells^(1).After nearly one century of development,ADCs have emerged as a rather promising approach in the treatment of cancer,especially breast cancer,which is the most common malignant tumor in women^(2).

关键词： breast Ehrlich treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Safety and effectiveness of vonoprazan-based rescue therapy for Helicobacter pylori infection

引用

World Journal of Gastroenterology 2023年第20期29卷 3133-3144页

作者： Jing Yu yi-Ming Lv Peng Yang yi-zhou jiang Xiang-Rong Qin Xiao-Yong Wang Department of Gastroenterology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Vonoprazan(VPZ)-based regimens are an effective first-line therapy for Helicobacter pylori(***)***,their value as a rescue therapy needs to be *** To assess a VPZ-based regimen as *** rescue *** This prospective,single-center,clinical trial was conducted between January and August *** with a history of *** treatment failure were administered 20 mg VPZ twice daily,750 mg amoxicillin 3 times daily,and 250 mg Saccharomyces boulardii(***)twice daily for 14 d(14-d VAS regimen).VPZ and *** were taken before meals,while amoxicillin was taken after *** 3 d after the end of eradication therapy,all patients were asked to fill in a questionnaire to assess any adverse events they may have *** least 4-6 wk after the end of eradication therapy,eradication success was assessed using a 13C-urea breath test,and factors associated with eradication success were *** Herein,103 patients were assessed,and 68 patients were finally *** included patients had 1-3 previous eradication *** overall eradication rates calculated using intention-to-treat and per-protocol analyses were 92.6%(63/68)and 92.3%(60/65),*** eradication rate did not differ with the number of treatment failures(P=0.433).The rates of clarithromycin,metronidazole,and levofloxacin resistance were 91.3%(21/23),100.0%(23/23),and 60.9%(14/23),*** were no cases of resistance to tetracycline,amoxicillin,or *** 60.9%(14/23)patients,the *** isolate was resistant to all 3 antibiotics(clarithromycin,metronidazole,and levofloxacin);however,eradication was achieved in 92.9%(13/14)*** patients showed metronidazole resistance,and had an eradication rate of 91.3%(21/23).The eradication rate was higher among patients without anxiety(96.8%)than among patients with anxiety(60.0%,P=0.025).No severe adverse events occurred;most adverse events were mild and

关键词： Vonoprazan Saccharomyces boulardii Rescue therapy Helicobacter pylori Eradication Anxiety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulation of rhizosphere microenvironment by rice husk ash for reducing the accumulation of cadmium and arsenic in rice

引用

Journal of Environmental Sciences 2024年第2期136卷 1-10页

作者： yi jiang Ya Liu Xuantao yi Peng Zeng Bohan Liao Hang zhou Jiaofeng Gu College of Environmental Science and Engineering Central South University of Forestry and TechnologyChangsha 410004China Hunan Engineering Laboratory for Control of Rice Quality and Safety Changsha 410004China

It is important to reduce Cd and As content in brown rice in contaminated paddy *** conducted research on the effects of rice husk ash (RHA) on the Cd and As in the rhizosphere microenvironment (soil,porewater,and iron plaque) and measured the Cd,As,and Si content in rice *** main elements in RHA were Si (29.64%) and O (69.17%),which had the maximum adsorption capacity for Cd was 42.49 mg/kg and for As was 18.62 mg/*** pH and available Si content increased,while soil available Cd and As decreased following application of 0.5%–2%*** promote the transformation of Cd to insoluble fraction,while As was transformed from a poorly soluble form to a more active *** reduced Cd content and increased Si content in porewater,and reduced As only at the later rice growth *** increased the amount of iron plaque,thereby decreasing the Cd content in iron plaque,while increased the As content in *** and inorganic As content in brown rice were decreased,to 0.31 mg/kg and 0.18 mg/kg,*** decrease of Cd in brown rice was due to the decrease of Cd mobility in soil,thereby reducing root accumulation,while the decrease of As in brown rice was affected by the transport from roots to ***,RHA can be considered as a safe and efficient in-situ remediation amendment for Cd and As co-contaminated paddy soil.

关键词： Rice husk ash(rha) Cadmium Arsenic Silicon Rice Soil

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inflammatory response-based subtyping and potential therapeutic strategies for triple-negative breast cancer

引用

Reproductive and Developmental Medicine 2023年第3期7卷 156-165页

作者： Ze-Qing Li Wen-Juan Zhang yi-zhou jiang Zhi-Ming Shao Ding Ma Jiong Wu Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterShanghai 200032China Department of OncologyShanghai Medical College Fudan UniversityShanghai 200032.China

objective:Inflammatory response plays a crucial role in the development and treatment of ***,the role of inflammatory response in triple-negative breast cancer(TNBC)remains *** on the heterogeneity of the inflammatory response,we classified TNBC,elucidated its subtype features,and revealed potential therapeutic ***:We established inflammatory response subtyping based on the RNA sequencing data of TNBCs derived from a cohort at the Fudan University Shanghai Cancer Center(FUSCC).Next,we explored the features and potential therapeutic strategies for each subgroup by analyzing transcriptome *** a machine-learning method,we validated and generalized the TNBC inflammatory response subtypes in an external ***:A total of 360 TNBC samples and 88 normal tissues were collected from a cohort at *** with TNBC were divided into four inflammatory response groups(IRGs)based on the expression of inflammatory response genes:high inflammatory response gene expression with pronounced pyroptosis phenotype and high immune cellinfiltration(IRG 1),low inflammatory response gene expression and low immune cell infiltration(IRG 2),ITGB8 specific inflammatory response with a predominant proliferation phenotype(IRG 3),and low M1/M2 ratio with a marked angiogenesis phenotype(IRG 4).Relapse-free survival(RFS)was better in iRG 1 and 2 and worse in IRG 3 and *** to their poor prognosis,we mainly focused on IRG 3 and IRG 4 to investigate potential treatment ***8 was highly expressed in IRG 3;thus,targeting ITGB8 may be a potential therapeutic strategy for patients in IRG *** 4 had a lower M1/M2 ratio and a marked angiogenesis phenotype;therefore,therapeutic strategies,such as anti-angiogenesis or M2 to M1 repolarization of macrophages,could be recommended for these ***,we validated and generalized the TNBC inflammatory response subtyping in an external dataset using a machine-learning ***

关键词： Inflammatory response Triple-negative breast cancer Precise treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prognostic Factors Related to In-hospital Death in Children with Biliary Atresia:Analysis of a Nationwide Inpatient Database

引用

Journal of Clinical and Translational Hepatology 2023年第2期11卷 416-424页

作者： Yu Shi yi-zhou jiang Guang-Peng zhou ying Shi Lan-Xia Gan Yuan-Yuan Kong Hai-Bo Wang Zhi-Jun Zhu Li-ying Sun Liver Transplantation Center Beijing Friendship HospitalCapital Medical UniversityBeijingChina National Clinical Research Center for Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Critical Liver Diseases Liver Research CenterBeijing Friendship HospitalCapital Medical UniversityBeijingChina Clinical Center for Pediatric Liver Transplantation Capital Medical UniversityBeijingChina National Clinical Research Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical SciencesShenzhenGuangdong ProvinceChina China Standard Medical Information Research Center ShenzhenGuangdongChina Clinical Trial Unit Precision Medicine InstituteFirst Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina

Background and Aims:Patients with biliary atresia(BA)are prone to hepatic decompensation,which might eventually lead to *** study aimed to identify the possible risk factors affecting in-hospital death in BA patients in ***:We collected data from the Hospital Quality Monitoring System,a national inpatient *** patients aged up to 2 years old with a diagnosis of BA were *** subjects were divided to three groups,including Kasai portoenterostomy(KP),liver transplantation(LT),and no *** regression with Firth’s method was performed to identify potential influencing variables associated with in-hospital ***:During the year 2013 to 2017,there were 14,038 pediatric admissions with a diagnosis of *** proportion of in-hospital death in pediatric BA admissions was 1.08%.Compared with patients under six months,there was a higher risk of in-hospital death for children aged six months to 1 year and 1–2 years *** signs,including cirrhosis,variceal bleeding,and hepatic encephalopathy,were significantly associated with the risk of in-hospital *** no surgery group,compared to those in Beijing and Shanghai,BA patients admitted in other districts had a lower risk of in-hospital death(OR=0.39,95%CI:0.21,0.70).However,in the LT group,patients admitted in other districts had a higher risk of in-hospital death(OR=9.13,95%CI:3.99,20.87).Conclusions:In-hospital survival remains unsatisfactory for pediatric BA patients with severe ***,more resources and training for BA treatment,especially LT,are essential for districts with poor medical care in the future.

关键词： Biliary atresia In-hospital death Liver transplantation Kasai portoenterostomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：