Prognostic Factors Related to In-hospital Death in Children with Biliary Atresia:Analysis of a Nationwide Inpatient Database
作者机构：Liver Transplantation CenterBeijing Friendship HospitalCapital Medical UniversityBeijingChina National Clinical Research Center for Digestive DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Critical Liver DiseasesLiver Research CenterBeijing Friendship HospitalCapital Medical UniversityBeijingChina Clinical Center for Pediatric Liver TransplantationCapital Medical UniversityBeijingChina National Clinical Research Center for Cardiovascular DiseasesFuwai Hospital Chinese Academy of Medical SciencesShenzhenGuangdong ProvinceChina China Standard Medical Information Research CenterShenzhenGuangdongChina Clinical Trial UnitPrecision Medicine InstituteFirst Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2023年第11卷第2期
页 面：416-424页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by grants from Capital’s Funds for Health Improvement and Research (Grant Number:2020-1-2024) Research Foundation of Beijing Friendship Hospital,Capital Medical University (No.yyqdkt2017-27)
主 题：Biliary atresia In-hospital death Liver transplantation Kasai portoenterostomy
摘 要：Background and Aims:Patients with biliary atresia(BA)are prone to hepatic decompensation,which might eventually lead to *** study aimed to identify the possible risk factors affecting in-hospital death in BA patients in ***:We collected data from the Hospital Quality Monitoring System,a national inpatient *** patients aged up to 2 years old with a diagnosis of BA were *** subjects were divided to three groups,including Kasai portoenterostomy(KP),liver transplantation(LT),and no *** regression with Firth’s method was performed to identify potential influencing variables associated with in-hospital ***:During the year 2013 to 2017,there were 14,038 pediatric admissions with a diagnosis of *** proportion of in-hospital death in pediatric BA admissions was 1.08%.Compared with patients under six months,there was a higher risk of in-hospital death for children aged six months to 1 year and 1–2 years *** signs,including cirrhosis,variceal bleeding,and hepatic encephalopathy,were significantly associated with the risk of in-hospital *** no surgery group,compared to those in Beijing and Shanghai,BA patients admitted in other districts had a lower risk of in-hospital death(OR=0.39,95%CI:0.21,0.70).However,in the LT group,patients admitted in other districts had a higher risk of in-hospital death(OR=9.13,95%CI:3.99,20.87).Conclusions:In-hospital survival remains unsatisfactory for pediatric BA patients with severe ***,more resources and training for BA treatment,especially LT,are essential for districts with poor medical care in the future.
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