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Chinese Chemical Letters 2017年第3期28卷 537-540页

作者： Juan Ren yi-yun wang Ru-Xia Fenga Xiang-Lei Kong The State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin 300071 China

Threonine-substituted serine octamer ions were generated by electrospray ionization（ESI） and investigated by mass spectrometry and infrared photodissociation（IRPD） spectroscopy. IRPD spectra of[L-Ser_7＋ L/D-Thr_1]H~＋and [L-Ser_6＋ L/D-Thr_2]H~＋were obtained in the range of 2700–3600 cm^（-1）. Chiral differentiation was achieved by comparing their IRPD spectra. The main difference located in the range of 3300–3500 cm^（-1）. And the results indicate the substitution of L-Ser by D-Thr could weaken the intermolecular H-bonds and loosen the original structures of serine octamers.

关键词： IRPD spectroscopy Threonine Serine octamer Chiral differentiation Mass spectrometry

On the Least Eigenvalue of Graphs with Cut Vertices

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Journal of Mathematical Research and Exposition 2010年第6期30卷 951-956页

作者： yi wang yun QIAO yi Zheng FAN School of Mathematical Sciences Anhui UniversityAnhui 230039P.R.China

Let ψ be a certain set of graphs.A graph is called a minimizing graph in the set ψ if its least eigenvalue attains the minimum among all graphs in ψ.In this paper,we determine the unique minimizing graph in ψn,whe... 详细信息

关键词： adjacency matrix least eigenvalue minimizing graph cut vertex.

Effect of Antibiotic Treatment on Toxin Production by Alexandrium tamarense

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Biomedical and Environmental Sciences 2003年第4期16卷 340-347页

作者： CHANG-HAI wang, yi-yun wang, yiNG-yiNG SUN, AND XIAN-TANG XIEDepartment of Bioengineering, Dalian University of Technology, Dalian 116024, Liaoning, China Department of Bioengineering Dalian University of Technology Dalian 116024 Liaoning Chin

Objective Impact of the presence of bacteria associated with a marine dinoflagellate, Alexandrium tamarense CI01, on the growth and toxin production of the algae in batch culture was investigated. Methods Pronounced changes in the activities of the algal culture were observed when the culture was treated with different doses of a mixture of penicillin and streptomycin. Results In the presence of antibiotics at the initial concentration of 100 u/mL in culture medium, both algal growth and toxin yield increased markedly. When the concentration of antibiotics was increased to 500 u/mL, the microalgal growth was inhibited, but resumed in a few days to eventually reach the same level of growth and toxin production as at the lower dose of the antibiotics. When the antibiotics were present at a concentration of 1 000 u/mL, the algal growth was inhibited permanently. Conclusions The results indicate that antibiotics can enhance algal growth and toxin production not only through their inhibition of the growth and hence competition for nutrients, but also through their effects on the physiology of the algae.

关键词： Alexandrium tamarense Harmful algal bloom Antibiotic Toxin Saxitoxin

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun yun Wen-Biao Han yi-Yang Guo He wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

Influence of PPV,PRV and PRRSV on Efficacy of the Lapinized Hog Cholera Vaccine and Pathogenicity of Classical swine fever virus

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Journal of Integrative Agriculture 2012年第11期11卷 1892-1897页

作者： NING yi-bao ZHAO yun wang Qin FAN Xue-zheng QIN Yu-ming ZHANG Guang-chuan XU Lu QIU Hui-shen wang Zai-shi SONG Li SHEN Qing-chun ZHAO Qi-zu China National Classical Swine Fever Reference Laboratory/China Institute of Veterinary Drug Control Beijing 100081 P.R. China

Classical swine fever caused by Classical swine fever virus （CSFV） is a serious problem for swine industries in developing countries, which successful control of the disease have been relying on vaccination. However, classical swine fever still occurs in some immunized swine herds for various reasons. In this study, we conducted animal experiments to examine the influence of single or mixed infection with Porcine parvo virus （PPV）, Pseudorabies virus （PRV） and Porcine reproductive and respiratory syndrome virus （PRRSV） on the protective immunity induced by the Lapinized hog cholera virus （HCLV） vaccine and the pathogenicity of CSFV. In experiment 1, pigs were first inoculated with PPV, PRV or PRRSV, then immunized with HCLV, and finally challenged with a highly virulent CSFV Shimen strain. All of the pigs immunized with HCLV survived after the challenge, while all of the pigs in the non-immunized control group died after the challenge. The pigs in the group immunized with HCLV did not show any clinical symptoms of classical swine fever and were negative with CSFV after the challenge. The pigs infected with the non-CSFV before HCLV immunization did not display any clinical symptoms after the challenge with CSFV Shiman strain, but 11 of the 12 pigs were positive with CSFV. In experiment 2, pre-infections with PPV, PRV, and PRRSV were followed by inoculation with a low-virulence CSFV strain （CSFV 39）, and then the pigs were challenged with the CSFV Shimen strain. Infections by either PPV, PRV or PRRSV did not enhance the virulence of CSFV-39, but pigs infected by a mixture of the 3 viruses developed clinical symptoms after inoculation with CSFV-39. The mixed infection also increased mortality caused by the challenge with the CSFV Shimen strain. Together, these results showed PPV, PRV and PRRSV infections in pigs can reduce the efficacy of the HCLV vaccine and enhance the pathogenicity of CSFV, which may partly explain the immunization failure against CSFV in some swine

关键词： Lapinized hog cholera virus vaccination pathogenicity mixed infection influence

Origin of the Oligocene Tuolangla porphyry-skarn Cu-W-Mo deposit in Lhasa terrane,southern Tibet

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China Geology 2020年第3期3卷 369-384页

作者： Yong Huang Ming-hua Ren Wei Liang Guang-ming Li Kelly Heilbronn Zuo-wen Dai yi-yun wang Li Zhang Chengdu Center China Geological SurveyMinistry of Natural ResourcesChengdu 610081China Department of Geoscience University of NevadaLas VegasNV 89154-4010USA Economic Geology Research Center James Cook UniversityTownsville 4811Australia College of Earth Sciences Chengdu University of TechnologyChengdu 610059China

Although some porphyry-skarn deposits occur in post-collisional extensional settings,the post-collisional deposits remain poorly *** the authors describe the igneous geology,and mineralization history of Tuolangla,a newly-discovered porphyry-skarn Cu-W-Mo deposit in southern Tibet that belongs to the post-collisional *** deposit is associated with Lower Cretaceous Bima *** was intruded by granodiorite porphyry intrusions at about 23.1 *** investigation indicated that mineralization is spatially and temporally associated with granodiorite *** yielded a Re-Os weighted mean age of 23.5±0.3 Ma and is considered to represent the age of skarn mineralization at the ***δ^34S values of sulfides,concentrated in a range between 0.6‰to 3.4‰,show that the sulfur has a homogeneous source with characteristics of magmatic *** Pb isotopic compositions of sulfides indicate that ore-forming metal materials were derived from the mantle and ancient *** granodiorite porphyry displays high SiO2(68.78%–69.75%)and K2O(3.40%–3.56%)contents,and relatively lower Cr(2.4×10^-6–4.09×10^-6),Ni(2.79×10^-6–3.58×10^-6)contents,and positiveεHf(t)values(7.7–12.9)indicating that the mineralization porphyry was derived from the partial melting of juvenile lower *** Tuolangla deposit is located in the central part of Zedang *** terrane was once considered an ancient *** terrane is in tectonic contact with Cretaceous ophiolitic rocks to its south and Mesozoic continental margin arc volcanics and intrusions of the Gangdese batholith of the Lhasa terrane to its ***,the authors proposed that the Oligocene porphyry skarn Cu-W-Mo mineralization is probably associated with the Zedang *** finding may clarify why the Oligocene(about 23 Ma)deposits are found only in the Zedang area and why mineralization types of the Oligocene mineralization are considerably different from those of the Miocene(17–14 Ma)mine

关键词： Porphyry skarn type Cu-W-Mo deposit Geochronology Re-Os isotopic age Zircon U-Pb isotopic age Tuolangla Gangdese belt Tibet China

Coordinated Control Strategy of New Energy Power Generation System with Hybrid Energy Storage Unit

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Energy Engineering 2025年第1期122卷 167-184页

作者： yun Zhang ZifenHan Biao Tian Ning Chen yi Fan School of Mechano-Electronic Engineering Xidian UniversityXi’an710071China Electric Power Control Center State Grid Gansu Electric Power CompanyLanzhou730030China Electric Power Control Center State Grid Gansu Electric Power Company Zhangye Power Supply BranchZhangye734000China

The new energy power generation is becoming increasingly important in the power *** as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power *** solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage ***,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage ***,the fuzzy control algorithm is introduced to balance the power between energy *** this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current *** is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.

关键词： Photovoltaic power suppression hybrid energy storage unit variationalmodal decomposition fuzzy control power distribution control

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小鼠胎肝细胞透明质酸3D培养体系的建立

生物化学与生物物理进展 2018年第5期45卷 567-574页

作者：颜洁心王怡王韫芳广西医科大学南宁530021 北京军事科学院军事医学研究院卫生勤务与血液研究所再生医学研究室北京100039

为了利用透明质酸建立小鼠胎肝细胞3D培养体系,分离获得胚胎12~14d胎肝细胞,利用KM培养基进行初步2D肝干/祖细胞的筛选培养,并利用透明质酸及KM培养基配制水凝胶建立3D细胞培养体系.胎肝细胞在2D体系中呈现克隆状生长.分离培养获得的肝... 详细信息

为了利用透明质酸建立小鼠胎肝细胞3D培养体系,分离获得胚胎12~14d胎肝细胞,利用KM培养基进行初步2D肝干/祖细胞的筛选培养,并利用透明质酸及KM培养基配制水凝胶建立3D细胞培养体系.胎肝细胞在2D体系中呈现克隆状生长.分离培养获得的肝干/祖细胞,克隆在透明质酸建立的3D培养体系保持增殖活性,并进一步获得肝细胞功能特性,表现为3D培养上清中白蛋白合成和尿素水平显著增加.定量PCR结果显示,随着3D培养时间的延长,其肝细胞干性标志如AFP、CK19、Ep CAM、Prox1等表达水平都大幅度降低且接近成年小鼠肝脏表达水平.本研究成功建立基于透明质酸的小鼠胎肝细胞的3D无血清培养体系,并可促进小鼠胎肝细胞的肝细胞功能进一步成熟.

关键词：胎肝细胞 3D培养透明质酸

IoT Empowered Early Warning of Transmission Line Galloping Based on Integrated Optical Fiber Sensing and Weather Forecast Time Series Data

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Computers, Materials & Continua 2025年第1期82卷 1171-1192页

作者： Zhe Li yun Liang Jinyu wang Yang Gao State Grid Henan Electric Power Company Electric Power Scientific Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China

Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power *** early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false *** address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather ***,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused ***,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network ***,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this ***,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.

关键词： Optical fiber sensing multi-source data fusion early warning of galloping time series data IoT adaptive weighted learning irregular time series perception closed-loop attention mechanism

Risk factors and drug resistance in early-onset neonatal group B streptococcal disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第12期19卷 973-978页

作者： ying-wei wang Yao-qiang DU Xiao-lin MIAO Guang-yong YE yi-yun wang Ai-bo XU yun-zhong JING Yu TONG Kai XU Mei-qin ZHENG Dong CHEN Zhen wang Department of Laboratory Medicine Tiantai People's Hospital Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical College Department of Infectious Diseases Eye Hospital of Wenzhou Medical University Department of Laboratory Medicine Women's Hospital Zhejiang University School of Medicine Department of Laboratory Medicine Wenzhou People's Hospital Department of Laboratory Medicine The Sixth People Hospital of Wenzhou

In recent years,group B streptococcus (GBS) has become an important pathogen that causes infections in many neonatal organs,including the brain, hmg,and eye (Ballard et al.,2016).A series of studies performed on GBS infections in western countries have revealed that GBS is one of the primary patho-gens implicated in perinatal infection,and GBS infections are a major cause of neonatal morbidity and mortality in the United States (Decheva et al.,2013).

关键词：新生儿无乳链球菌风险因素耐药性