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Anti-inflammatory effect of amurensin H on asthma-like reaction induced by allergen in sensitized mice

Acta Pharmacologica Sinica 2006年第6期27卷 735-740页

作者： yi-tang li~2 chun-suo yao~3 jin-ye bai~2 man lin~3 gui-fang cheng~(2,4)2 department of pharmacology,institute of materia medica,peking union medical college and chinese academy of medical sciences,beijing 100050,china 3 department of Photochemistry,institute of materia medica,chinese academy of medical sciences and peking union medical college,beijing 100050,china department of pharmacology Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China department of Photochemistry Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Aim:To explore the anti-inflammatory effects of amurensin H on asthma-like reac-tion induced by allergen in sensitized ***:BALB/c mice were sensi-tized by ovalbumin(OVA,ip)on d 0 and d 14 and challenged with 1% OVA on d 18to *** developed airway eosinophilia,mucus hypersecretion,and elevationin cytokine *** were administered amurensin H orally at the doses of 49,70,or 100 mg/kg once every day from d 15 to the last *** lavagefluid(BALF)were collected at 24 h and 48 h after the last OVA *** tumor necrosis factor-α(TNF-α),interleukin 4(IL-4),interleukin 5(IL-5),andinterleukin 13(IL-13)in BALF were measured using EliSA *** counts of macrophages,lymphocytes,neutrophils and eosinophils were per-formed in 200 cells per slide(one slide per animal).Lung tissue sections of 6-μmthickness were stained with Mayer’s hematoxylin and eosin for assessment of cellinfiltration,mucus production,and tissue ***:Oral administrationof amurensin H significantly inhibited OVA-induced increases in total cell counts,eosinophil counts,and TNF-α,IL-4,IL-5 and IL-13 levels in *** addition,amuresin H dramatically decreased OVA-induced lung tissue damage and ***:Amurensin H may have therapeutic potential for thetreatment of allergic airway inflammation.

关键词： amurensin H asthma ovalbumin tumor necrosis factor-α Th2 cells cytokines

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Anti -inflammatory effect of Vam3 on asthmalike reaction induced by allergen in sensitized mice

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中国药理通讯 2005年第3期22卷 46-46页

作者： yi - tang li chun - suo yao jin - ye bai Mao lin gui - fang cheng department of pharmacology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050 department of phytochemistry Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

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