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Typhoon-Induced Ocean Waves and Stokes Drift:A Case Study of Typhoon Mangkhut(2018)

China Ocean Engineering 2024年第4期38卷 711-724页

作者： WU Zhi-yuan GAO Kai CHEN Jie ZHANG Hao-jian DENG Bin jiang Chang-bo LIU yi-zhuang LYU Zhao YAN Ren School of Hydraulic and Environmental Engineering Changsha University of Science&TechnologyChangsha 410114China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210024China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China School of Civil Engineering Hunan University of TechnologyZhuzhou 412007China

Ocean waves and Stokes drift are generated by *** study investigated the characteristics of ocean waves and wave-induced Stokes drift and their effects during Typhoon Mangkhut using European Centre for MediumRange Weather Forecasts(ECMWF)ERA5 datasets and observational *** results revealed that the typhoon generated intense cyclones and huge typhoon waves with a maximum wind speed of 45 m/s,a minimum pressure of955 h Pa,and a maximum significant wave height of 12 *** Stokes drift caused by typhoon waves exceeded 0.6m/s,the Stokes depth scale exceeded 18 m,and the maximum Stokes transport reached 6 m^(2)/*** spatial distribution of 10-m wind speed,typhoon wave height,Stokes drift,Stokes depth,and Stokes transport during the typhoon was highly correlated with the typhoon *** distribution along the typhoon track showed significant zonal asymmetry,with greater intensity on the right side of the typhoon track than on the left *** findings provide important insights into the impact of typhoons on ocean waves and Stokes drift,thus improving our understanding of the interactions between typhoons and the ocean *** study also investigated the contribution of Stokes transport to the total net transport during typhoons using Ekman-Stokes Numbers as a comparative *** results indicated that the ratio of Stokes transport to the total net transport reached up to 50%within the typhoon radius,while it was approximately 30%outside the *** Stokes transport induced by typhoon waves led to divergence in the transport direction,which resulted in upwelling of the lower ocean as a compensation ***,Stokes transport played a crucial role in the vertical mixing of the ocean during *** findings suggested that Stokes transport should be paid more attention to,particularly in high latitude ocean regions,where strong winds can amplify its effects.

关键词： Stokes drift typhoon waves Ekman-Stokes transport vertical mixing Typhoon Mangkhut

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Primary vulvar melanoma in a 27-year-old pregnant woman: a case report and literature review

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International Journal of Dermatology and Venereology 2019年第1期2卷 47-50页

作者： Xian-Hong Yang Yan Wang Wei Zhang Li-Ming Huang Bao-Zhu Chang Xue-Bao Shao Fang Fang Jian-Fang Sun yi-qun jiang Department of Dermatopathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Surgery Hospital for Skin Diseases(Institute of Dermatology)Peking Union Medical College and Chinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Physiotherapy Hospital for Skin Diseases(Institute of Dermatology)Peking Union Medical College and Chinese Academy of Medical SciencesNanjingJiangsu 210042China

Introduction Vulvar melanoma is the second most common vulvar malignancy and a significant health issue in *** its low incidence,vulvar melanoma has a poor prognosis with a high tendency to metastasize due to delayed *** women are postmenopausal and aged 50 to 70 years at the time of diagnosis[1].The occurrence of vulvar malignant melanoma (MM) at <30 years of age is extremely *** herein describe a case of primary vulvar MM in a 27-year-old woman during her first pregnancy.

关键词： postmenopausal Vulvar melanoma literature

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Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 979-990页

作者： yi-Mei Wang Zheng-Wei Luo Yu-Lin Shu Xiu Zhou Lin-Qing Wang Chun-Hong Liang Chao-qun Wu Chang-Ping Li Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)is the primary risk factor for gastric cancer(GC),the Wnt/β-Catenin signaling pathway is closely linked to *** has a high mortality rate and treatment cost,and there are no drugs to prevent the progression of gastric precancerous lesions to ***,it is necessary to find a novel drug that is inexpensive and preventive to against *** To explore the effects of *** and Moluodan on the Wnt/β-Catenin signaling pathway and precancerous lesions of GC(PLGC).METHODS Mice were divided into the control,N-methyl-N-nitrosourea(MNU),***+MNU,and Moluodan *** first created an *** infection model in the ***+MNU and Moluodan groups.A PLGC model was created in the remaining three groups except for the control *** was fed to mice in the Moloudan group ad *** general condition of mice were observed during the whole experiment *** tissues of mice were grossly and microscopically *** quantitative real-time PCR(qRT-PCR)and Western blotting analysis,the expression of relevant genes were *** Mice in the ***+MNU group showed the worst performance in general condition,gastric tissue visual and microscopic observation,followed by the MNU group,Moluodan group and the control ***-PCR and Western blotting analysis were used to detect the expression of relevant genes,the results showed that the ***+MNU group had the highest expression,followed by the MNU group,Moluodan group and the control *** *** can activate the Wnt/β-catenin signaling pathway,thereby facilitating the development and progression of *** suppressed the activation of the Wnt/β-catenin signaling pathway,thereby decreasing the progression of PLGC.

关键词： Helicobacter pylori Gastric cancer Wnt/β-catenin signaling pathway Moluodan

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Transcriptome-Wide Identification and Functional Analysis of PgSQE08-01 Gene in Ginsenoside Biosynthesis in Panax ginseng ***.

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 313-327页

作者： Lei Zhu Lihe Hou Yu Zhang Yang jiang yi Wang Meiping Zhang Mingzhu Zhao Kangyu Wang College of Life Science Jilin Agricultural UniversityChangchun130118China Jilin Engineering Research Center Ginseng Genetic Resources Development and Utilization Changchun130118China Jilin Academy of Vegetable and Flower Sciences Changchun130033China

Panax ginseng *** an important plant species used in traditional Chinese medicine,whose primary active ingredient is a *** biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural ***,the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary *** epoxidase(SQE)is a key enzyme in the mevalonic acid pathway,which affects the biosynthesis of secondary metabolites such as *** ginseng transcriptome,expression,and ginsenoside content databases,this study employed bioinformatic methods to systematically analyze the genes encoding SQE in *** first selected six PgSQE candidates that were closely involved in ginsenoside biosynthesis and then identified PgSQE08-01 to be highly associated with ginsenoside ***,we constructed the overexpression vector pCAMBIA3301-PgSQE08-01 and the RNAi vector pART27-PgSQE08-01 and transformed ginseng adventitious roots using Agrobacterium rhizogenes,to obtain positive hairy-root ***,quantitative reverse transcriptionpolymerase chain reaction and high-performance liquid chromatography were used to determine the expression of relevant genes and ginsenoside content,***,we focused on the function of PgSQE08-01 gene,which was noted to be involved in ginsenoside ***,these findings not only provided a molecular basis for the identification of important functional genes in ginseng but also enriched genetic resources for the biosynthesis of ginsenosides using synthetic biology.

关键词： Panax ginseng pgSQE08-01 gene squalene epoxidase ginsenoside ginseng hairy roots

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Stigma-Specific Comparative Proteomic Analysis Reveals the Distyly Response to Self-Incompatibility in Plumbago auriculata Lam

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 681-697页

作者： Di Hu Shouli yi Di Lin Suping Gao Ting Lei Wenji Li Tingdan Xu Songlin jiang School of Fine Arts and Calligraphy Sichuan Normal UniversityChengdu610000China Sichuan Certification and Accreditation Association Chengdu610000China College of Landscape Architecture Sichuan Agricultural UniversityChengdu610000China School of Design Chongqing Industry Polytechnic CollegeChongqing401120China

In plants,heteromorphic self-incompatibility(HetSI)is a strategy for avoiding self-pollination and promoting outcrossing,and during this process,numerous protein-protein interaction events occur between the pistil and *** studies in Primula and Fagopyrum that focused on HetSI systems have provided interesting insights;however,the molecular mechanism underlying HetSI remains largely *** this study,we profiled the proteome of Plumbago auriculata stigmas before and after self-incompatible(SI)and self-compatible(SC)*** analyses were conducted by 4D-DIA(Four-dimensional data independent acquisition),a promising technology that increases the sensitivity and reduces the spectral complexity of proteomic analysis by adding a fourth dimension,ion *** results revealed 33387 peptides and 5311 proteins in all *** pathways in which the differentially expressed proteins(DEPs)identified in the P×P(Pin style self-pollinated with pin pollen)***(Pin style)and T×T(Thrum style self-pollinated with thrum pollen)***(Thrum style)comparisons were significantly enriched were biosynthesis of secondary metabolites and pentose and glucuronate *** the P×T(Pin style cross-pollinated with thrum pollen)*** and T×P(Thrum style cross-pollinated with pin pollen)*** comparison,the top three pathways were biosynthesis of secondary metabolites,pentose and glucuronate interconversions,and phenylpropanoid *** phenylpropanoid biosynthesis,cutin,suberine and wax biosynthesis,and flavonoid biosynthesis pathways were enriched in the P×T vs.P×P comparison,and starch and sucrose metabolism,glycerophospholipid metabolism,and alpha-linolenic acid metabolism were abundant in the T×T vs.T×P *** enriched pathways between PS and TS were the biosynthesis of secondary metabolites,phenylpropanoid biosynthesis,and pentose and glucuronate ***-incompatibility protein S1(SI S1),Mitogen-activated protein ki

关键词： Heteromorphic self-incompatibility Plumbago auriculata proteomics 4D-DIA

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Heparin is an effective treatment for preventing liver failure after hepatectomy

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World Journal of Gastroenterology 2024年第22期30卷 2881-2892页

作者： Zhi-ying Xu Min Peng Ming-Ming Fan Qi-Fei Zou yi-Ran Li Dong jiang Hepatic Surgery IV Shanghai Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND Posthepatectomy liver failure(PHLF)is one of the most important causes of death following liver ***,an established anticoagulant,can protect liver function through a number of mechanisms,and thus,prevent liver *** To look at the safety and efficacy of heparin in preventing hepatic dysfunction after *** The data was extracted from Multiparameter Intelligent Monitoring in Intensive Care III(MIMIC-III)v1.4 pinpointed patients who had undergone hepatectomy for liver cancer,subdividing them into two cohorts:Those who were injected with heparin and those who were *** statistical evaluations used were unpaired ttests,Mann-Whitney U tests,chi-square tests,and Fisher’s exact tests to assess the effect of heparin administration on PHLF,duration of intensive care unit(ICU)stay,need for mechanical ventilation,use of continuous renal replacement therapy(CRRT),incidence of hypoxemia,development of acute kidney injury,and ICU *** regression was utilized to analyze the factors related to PHLF,with propensity score matching(PSM)aiming to balance the preoperative disparities between the two *** In this study,1388 patients who underwent liver cancer hepatectomy were *** yielded 213 matched pairs from the heparin-treated and control *** univariate analyses indicated that heparin potentially reduces the risk of PHLF in both matched and unmatched *** analysis in the matched cohorts confirmed a significant association,with heparin reducing the risk of PHLF(odds ratio:0.518;95%confidence interval:0.295-0.910;P=0.022).Additionally,heparin treatment correlated with improved short-term postoperative outcomes such as reduced ICU stay durations,diminished requirements for respiratory support and CRRT,and lower incidences of hypoxemia and ICU *** Liver failure is an important hazard following hepatic *** ICU care heparin administration has been proved to decr

关键词： Liver resection Posthepatectomy liver failure Prophylactic treatment Heparin Prognosis of hepatectomy

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6PPD-quinone affects the photosynthetic carbon fixation in cyanobacteria by extracting photosynthetic electrons

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The Innovation 2024年第4期5卷 75-83,74页

作者： Xiuqi You Ximin Chen yi jiang Huan Chen Juan Liu Zhen Wu Weiling Sun Jinren Ni Key Laboratory of Water and Sediment Sciences Ministry of EducationCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems Beijing 100871China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China Department of Environmental Engineering and Earth Sciences Clemson UniversityClemsonSC 29634USA

Photosynthetic carbon fixation by cyanobacteria plays a pivotal role in the global carbon cycle but is threatened by environmental *** date,the impact of quinones,with electron shuttling properties,on cyanobacterial photosynthesis is ***,we present the first study investigating the effects of an emerging quinone pollutant,i.e.,6PPD-Q(N-(1,3-dimethylbutyl)-N0-phenyl-p-phenylenediamine-quinone),on the cyanobacterium Synechocystis *** a 400-generation exposure *** *** distinct sequential phases,including hormesis,toxicity,and eventual recovery,throughout this *** evidence,including results of thylakoid membrane morphological and photosynthetic responses,carbon fixation rate,and key gene/protein analyses,strongly indicates that 6PPD-Q is a potent disruptor of photosynthesis.6PPD-Q accepts photosynthetic electrons at the plastoquinone QB site in photosystem II(PSII)and the phylloquinone A1 site in PSI,leading to a sustained decrease in the carbon fixation of cyanobacteria after an ephemeral *** work revealed the specific mechanism by which 6PPD-Q interferes with photosynthetic carbon fixation in cyanobacteria,which is highly important for the global carbon cycle.

关键词： carbon extracting sustained

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Research progress on the development of hepatocyte growth factor/c-Met signaling pathway in gastric cancer:A review

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3397-3409页

作者： Wu-Jie Wei Ya-Li Hong yi Deng Guan-Liang Wang jiang-Tao Qiu Fang Pan Department of Oncology People's Hospital of Chongqing HechuanChongqing 401520China Department of Cardiovascular People's Hospital of Chongqing HechuanChongqing 401520China Intensive Care Unit People's Hospital of Chongqing HechuanChongqing 401520China Department of Gastrointestinal Surgery Beijing Tsinghua Changgung HospitalBeijing 100084China

Hepatocyte growth factor(HGF)and its receptor,c-Met,play important roles in the occurrence,development,and treatment of gastric cancer(GC).This review explored the function of the HGF/c-Met signaling pathway in GC and its potential targeted therapeutic *** one of the most common malignant tumors worldwide,GC has a complex pathogenesis and limited therapeutic ***,a thorough understanding of the molecular mechanism of GC is very important for the development of new therapeutic *** HGF/c-Met signaling pathway plays an important role in the proliferation,migration,and invasion of GC cells and has become a new therapeutic *** review summarizes the current research progress on the role of HGF/c-Met in GC and discusses targeted therapeutic strategies targeting this signaling pathway,providing new ideas and directions for the treatment of GC.

关键词： Targeted therapy Hepatocyte growth factor c-Met Gastric cancer Prognosis assessment Review

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Highly efficient room temperature phosphorescent liquid crystalline polymer optical waveguides for advanced optoelectronics

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Science China Chemistry 2024年第10期67卷 3450-3457页

作者： Jie Li Yan Guan Wei Xia Jin-Kang Chen jiang Huang yi Chen Qi Lin Er-Qiang Chen He-Lou Xie Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education and Key Laboratory of Advanced Functional Polymer Materials of CollegesUniversities of Hunan Province and College of ChemistryXiangtan UniversityXiangtan 411105China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Active organic optical waveguide materials(OOWMs)incorporating room temperature phosphorescence(RTP)hold significant promise for diverse applications in photonic and optoelectronic *** this potential,realizing active RTP optical waveguides with large-sized ordered structures and minimal light loss remains a formidable *** address this issue,we present a groundbreaking thermoplastic active OOWM with low light loss,leveraging room temperature phosphorescent liquid crystalline polymer(LCP).This innovative material can be easily synthesized through the copolymerization of phosphorescent and liquid crystalline *** resulting RTP copolymer exhibits a nematic liquid crystal phase with a phosphorescence lifetime of approximately 0.15 ms and an afterglow duration of around 1 *** the excellent processability of LCP,we successfully produce meter-scale fibers via melt *** RTP LCP fibers,characterized by a high orientation of mesogens along the fiber axis,demonstrate superior light confinement and efficient light conduction compared to unoriented samples,resulting in a low optical loss coefficient of 0.13 dB/***,the thermal responsiveness of the RTP LCP optical waveguide enables its use as a photo *** pioneering work paves the way for the design of new OOWMs tailored for advanced photonics and optoelectronics devices.

关键词： room temperature phosphorescence liquid crystalline polymer active optical waveguide

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Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy:Network pharmacology analysis and experimental validation

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World Journal of Diabetes 2024年第9期15卷 1942-1961页

作者： yi-Fan Yang Ling Yuan Xiang-Yang Li Qian Liu Wen-Jie jiang Tai-Qiang Jiao Jia-Qing Li Meng-yi Ye Yang Niu yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes *** blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is ***,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic *** To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo *** This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular ***,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully *** mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin *** was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core *** Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using *** analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR *** docking prediction indica

关键词： Diabetic retinopathy Network pharmacology Animal models Oxidative stress Inflammatory

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