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Rare Metals 2024年第6期43卷 2747-2757页

作者： Xi-Di sun Jun-Yang An yi-qi.sun Xin Guo Jing Wu Jiang-Bo Hua Meng-Rui Su yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China

Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare *** devices can be seamlessly integrated with human ***,most high-precision microstructures and complex patterns are difficult to fabricate due to the limitations of conventional fabrication solutions,resulting in suboptimal performance under practical ***,a liquid-metal stretchable system utilizing natural leaf veins was reported as microstructures,which was based on a biomimetic concept and utilized an all-solution process for the preparation of complex *** systems are ultra-high tensile(800%tensile strain),environmentally stable(20 days)and mechanically durable(300-cycle).The system can accurately recognize the wearer's finger bending level as well as simple gesture *** the same time,the system acts as a wearable heater,which can realize the fast heating behavior of heating up to 50℃in 3 min under the human body-safe voltage(1.5 V).The tensile stability is demonstrated by the heterogeneous integration of lasers(405 nm)with the system interconnects for a stretchable and wearable light source.

关键词： Stretchable electronics Liquid metal Stretchable conductor Vein Bionicist electronics

Exploring hidden-charm and hidden-strange hexaquark states from lattice QCD

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 30-37页

作者： Hang Liu Jinchen He Liuming Liu Peng sun Wei Wang yi-Bo Yang qi-An Zhang INPAC Key Laboratory for Particle Astrophysics and Cosmology(MOE)Shanghai Key Laboratory for Particle Physics and CosmologySchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Maryland Center for Fundamental Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland 20742USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Beijing 100049/Hangzhou 310024China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Physics Beihang UniversityBeijing 102206China

Based on five different ensembles of newly generated(2+1)-flavor configurations with pion mass of approximately mπ■(140-310)MeV,we present a lattice analysis of hidden-charm and hidden-strange hexaquarks with the quark content■.The correlation matrices of two types of operators with JPC=0++,0-+,1++and 1--are simulated to extract the masses of the hexaquark candidates,which are subsequently extrapolated to the physical pion mass and continuum *** results indicate that ground state masses are below the■threshold and provide a characteristic signal for the experimental discovery of hexaquark candidates,which may enrich the versatile structure of multiquarks;moreover,it is an indispensable step to decipher the nonperturbative nature of the fundamental interactions of quarks and gluons.

关键词： quantum chromodynamics lattice QCD multiquark states

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di Wu yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Recent Progress on Water-based Liquid Embolic Agents in Endovascular Treatment

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 776-785页

作者： qi, yi Fan, Hailong Hokkaido Univ Dept Hematol Fac Med Sapporo 0608638 Japan Hokkaido Univ Grad Sch Med Sapporo 0608638 Japan Hokkaido Univ Inst Chem React Design & Discovery WPI ICReDD Sapporo 0010021 Japan

Vascular embolization treatment, a minimally invasive surgery for various blood vessel-related conditions, has emerged as a crucial method in treating such as hemorrhage, arteriovenous malformation, aneurysms, and hypervascular tumors. Liquid embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions, expanding the scope of embolization beyond the reach of solid agents. Recent strides in biomaterials and technologies have spurred the development of novel liquid embolic agents, addressing challenges posed by traditional options. This mini-review provides a concise overview of the recent progress in water-based liquid embolic agents, highlighting their potential to overcome limitations associated with current embolic materials. By presenting selected research outcomes, we illuminate advancements that enhance the efficacy of liquid embolic agents. Furthermore, the review outlines essential properties for effective liquid embolic agents, offering insights for future developments in this field.

关键词： Endovascular treatment Lquid embolic agent Hydrogel TRANSCATHETER ARTERIAL EMBOLIZATION BENIGN PROSTATIC HYPERPLASIA ELASTINLIKE PROTEIN POLYMER HEPATOCELLULAR-CARCINOMA POTENTIAL APPLICATION METHYLACRYLATE) NANOGEL VASCULAR OCCLUSION IN-VIVO PH HYDROGELS

Improved Twin Support Vector Machine Algorithm and Applications in Classification Problems

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China Communications 2024年第5期21卷 261-279页

作者： sun yi Wang Zhouyang Beijing University of Posts and Telecommunications School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and Telecommunications International School

The distribution of data has a significant impact on the results of *** the distribution of one class is insignificant compared to the distribution of another class,data imbalance *** will result in rising outlier values and ***,the speed and performance of classification could be greatly *** the above problems,this paper starts with the motivation and mathematical representing of classification,puts forward a new classification method based on the relationship between different classification *** with the vector characteristics of the actual problem and the choice of matrix characteristics,we firstly analyze the orderly regression to introduce slack variables to solve the constraint problem of the lone *** we introduce the fuzzy factors to solve the problem of the gap between the isolated points on the basis of the support vector *** introduce the cost control to solve the problem of sample ***,based on the bi-boundary support vector machine,a twostep weight setting twin classifier is *** can help to identify multitasks with feature-selected patterns without the need for additional optimizers,which solves the problem of large-scale classification that can’t deal effectively with the very low category distribution gap.

关键词： fuzzy ordered regression(OR) relaxing variables twin support vector machine

Differences in vascular endothelial function and serum proteome between obese people with phlegm-dampness constitution and balanced constitution

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Journal of Traditional Chinese Medicine 2024年第1期44卷 188-196页

作者： ZHU Linghui sun Ziwei GUAN Yuanyuan LIU Meiyi ZHENG yi YU Ruoxi WANG qi LI Lingru School of Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To evaluate the extent of vascular endothelial dysfunction and preliminary identify serum protein biomarkers associated with obese individuals at risk for cardiovascular disease(CVD).METHODS:Fifteen obese volunteers with the phlegmdampness constitution or balanced constitution were recruited for this study *** clinical baseline data was collected,and the vascular endothelial function was evaluated using the EndoPAT?.Blood samples were collected for the serum proteome *** differences in the serum protein expression levels between the two groups were detected and the protein interaction network analysis,correlation analysis,receiver operating characteristic(ROC)curve analysis,and random forest model investigation were ***:There were no statistical differences found in the baseline *** vascular endothelial function,the reactive hyperemia index(RHI)of the phlegm-dampness constitution obese group was significantly lower than that of the balanced constitution obese group(1.46±0.30 vs 2.82±0.78,P<0.0001),indicating vascular endothelial *** are 66 differentially expressed serum proteins between the two *** A2(Apo A2),angiotensin-converting enzyme 2(ACE-2),interleukin-33(IL-33),and forkhead box P3(FoxP3)showed significant differences and area under curve values of their ROC curves were greater than 0.7 and correlated significantly with ***:Vascular endothelial dysfunction was present in the phlegm-dampness constitution obese ***,alterations in the expression levels of key serum proteins,including Apo A2,ACE-2,IL-33,and Fox P3 could serve as potential biomarkers in the obese population at risk of CVD.

关键词： obesity phlegm-dampness constitution vascular endothelial function proteome reactive hyperemia index

Neddylation Regulation of Immune Responses

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Research 2024年第3期2023卷 545-559页

作者： Hongmei Mao Xin Lin yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for Immunology School of MedicineTsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Cancer Center of Zhejiang University Hangzhou 310029China Zhejiang Provincial Clinical Research Center for Cancer HangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences HangzhouZhejiang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China.

Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关键词： activation thereby initiating

One-shot Face Reenactment with Dense Correspondence Estimation

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Machine Intelligence Research 2024年第5期21卷 941-953页

作者： Yunfan Liu qi Li Zhenan sun School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Center for Research on Intelligent Perception and Computing Institute of AutomationChinese Academy of SciencesBeijing100190China

One-shot face reenactment is a challenging task due to the identity mismatch between source and driving *** existing methods fail to completely eliminate the interference of driving subjects’identity information,which may lead to face shape distortion and undermine the realism of reenactment *** solve this problem,in this paper,we propose using a 3D morphable model(3DMM)for explicit facial semantic decomposition and identity *** of using 3D coefficients alone for reenactment control,we take advantage of the generative ability of 3DMM to render textured face *** proxies contain abundant yet compact geometric and semantic information of human faces,which enables us to compute the face motion field between source and driving images by estimating the dense *** this way,we can approximate reenactment results by warping source images according to the motion field,and a generative adversarial network(GAN)is adopted to further improve the visual quality of warping *** experiments on various datasets demonstrate the advantages of the proposed method over existing state-of-the-art benchmarks in both identity preservation and reenactment fulfillment.

关键词： Generative adversarial networks face image manipulation face image synthesis face reenactment 3D morphable model

Development of Wheel-Legged Biped Robots:A Review

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Journal of Bionic Engineering 2024年第2期21卷 607-634页

作者： Xuefei Liu yi sun Shikun Wen Kai Cao qian qi Xiaoshu Zhang Huan Shen Guangming Chen Jiajun Xu Aihong Ji Lab of Locomotion Bioinspiration and Intelligent Robots College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and Astronautics29 Yudao StreetNanjing210016China State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

The wheel-legged biped robot is a typical ground-based mobile robot that can combine the high velocity and high efficiency pertaining to wheeled motion and the strong,obstacle-crossing performance associated with legged *** robots have gradually exhibited satisfactory application potential in various harsh scenarios such as rubble rescue,military operations,and wilderness ***-legged biped robots are divided into four categories according to the open–close chain structure forms and operation task modes,and the latest technology research status is summarized in this *** hardware control system,control method,and application are analyzed,and the dynamic balance control for the two-wheel,biomimetic jumping control for the legs and whole-body control for integrating the wheels and legs are *** summary,it is observed that the current research exhibits problems,such as the insufficient application of novel materials and a rigid–flexible coupling design;the limited application of the advanced,intelligent control methods;the inadequate understanding of the bionic jumping mechanisms in robot legs;and the insufficient coordination ability of the multi-modal motion,which do not exhibit practical application for the wheel-legged biped ***,this study discusses the key research directions and development trends for the wheel-legged biped robots.

关键词： Wheel-legged biped robot Wheeled motion Legged motion Control strategy

NADPH oxidase 4(NOX4)as a biomarker and therapeutic target in neurodegenerative diseases

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Neural Regeneration Research 2024年第9期19卷 1961-1966页

作者： Napissara Boonpraman sun Shin yi BK21 four Program Department of Medical SciencesSoonchunhyang UniversityAsanSouth Korea Department of Biomedical Laboratory Science Soonchunhyang UniversityAsanSouth Korea iConnectome Co.Ltd.CheonanSouth Korea

Diseases like Alzheimer’s and Parkinson’s diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NADPH oxidase 4, is viewed as a potential therapeutic touchstone and indicative marker for these ailments. This in-depth review brings to light distinct features of NADPH oxidase 4, responsible for generating superoxide and hydrogen peroxide, emphasizing its pivotal role in activating glial cells, inciting inflammation, and disturbing neuronal functions. Significantly, malfunctioning astrocytes, forming the majority in the central nervous system, play a part in advancing neurodegenerative diseases, due to their reactive oxygen species and inflammatory factor secretion. Our study reveals that aiming at NADPH oxidase 4 within astrocytes could be a viable treatment pathway to reduce oxidative damage and halt neurodegenerative processes. Adjusting NADPH oxidase 4 activity might influence the neuroinflammatory cytokine levels, including myeloperoxidase and osteopontin, offering better prospects for conditions like Alzheimer’s disease and Parkinson’s disease. This review sheds light on the role of NADPH oxidase 4 in neural degeneration, emphasizing its drug target potential, and paving the path for novel treatment approaches to combat these severe conditions.

关键词： Alzheimer’s disease astrocytes mitochondrial dysfunction myeloperoxidase NADPH oxidase 4 NADPH oxidase 4 inhibitors neurodegenerative diseases osteopontin Parkinson’s disease reactive oxygen species