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Usefulness of mizoribine administration in children with frequently relapsing nephrotic syndrome, and the relationship between pharmacokinetic parameters and efficacy: a multicenter prospective cohort study in China

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World Journal of Pediatrics 2019年第3期15卷 262-269页

作者： Zheng-Kun Xia Yuan-Fu Gao Li-ping Rong Xi-Qiang dang Qian Shen Xiao-Yun Jiang Zhu-Wen yi Hong Xu Department of Pediatrics Jinling HospitalNanjing University School of MedicineNanjing 210002China Department of Pediatrics The First Affiliated Hospital of Sun Yat—Sen UniversityGuangzhou 510080China Department of Pediatric Nephrology Children’s Medical CenterSecond Xiangya HospitalCentral South University Changsha 410011China Department of Nephrology and Rheumatology Children’s Hospital of Fudan UniversityShanghai 201102China

Background Mizoribine (MZR) is an immunosuppressant used to treat adult *** is little experience with the drug in treating Chinese children with frequently relapsing nephrotic syndrome (FRNS).We investigated the efficacy and safety for treating MZR with ***,the relationship between efficacy and serum concentration was *** A prospective multicenter observational 12-month study was performed for evaluating the usefulness of MZR with *** MZR concentration was measured,and the relationships between pharmacokinetic parameters (Cmax,AUC),number of relapses,and urinary protein were *** Eighty-two pediatric patients from four hospitals were treated with MZR and *** treatment significantly reduced the number of relapses and steroid doses.A correlation between pharmacokinetic parameters and relapses was observed,which fits well with the sigmoidal Emax *** in the relationship between pharmacokinetic parameters and urinary proteins,it was recognized that there was a threshold in the pharmacokinetic parameters for the therapeutic effect similar to the results obtained with the sigmoidal Emax *** patients (13.4%) experienced mild adverse *** MZR therapy was effective in reducing the number of relapses and steroid *** severe adverse reactions were *** effective serum concentrations were estimated to be Cmax > about 2 μg/mL or AUC > about 10 lag h/*** and steroid treatment were effective and safe for pediatric FRNS.

关键词： Frequently relapsing nephrotic syndrome Mizoribine Pharmacokinetic parameters

Effect of Nb and Mo on the Microstructure, Mechanical Properties and Ductility-Dip Cracking of Ni–Cr–Fe Weld Metals

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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 928-939页

作者： Xu Zhang Dian-Zhong Li yi-yi Li Shan-ping Lu Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences

A series of Ni-Cr-Fe welding wires with different Nb and Mo contents were designed to investigate the effect of Nb and Mo on the rnicrostructure, mechanical properties and the ductility-dip cracking susceptibility of the weld metals by optical microscopy （OM）, scanning electron microscopy, X-ray diffraction as well as the tensile and impact tests. Results showed that large Laves phases formed and distributed along the interdendritic regions with high Nb or Mo addition. The Cr-carbide （M23C6） was suppressed to precipitate at the grain boundaries with high Nb addition. Tensile testing indicates that the ultimate strength of weld metals increases with Nb or Mo addition. However, the voids formed easily around the large Laves phases in the interdendritic area during tensile testing for the weld metal with high Mo content. It is found that the tensile fractographs of high Mo weld metals show a typical feature of interdendritic fracture. The high Nb or Mo addition, which leads to the formation of large Laves phases, exposes a great weakening effect on the impact toughness of weld metals. In addition, the ductility-dip cracking was not found by OM in the selected cross sections of weld metals with different Nb additions. High Nb addition can eliminate the ductility-dip cracking from the Ni-Cr-Fe weld metals effectively.

关键词： Nb Mo Laves phase Microstructure Mechanical properties

Crystallization,Mechanical,Thermal and Rheological Properties of Polypropylene Composites Reinforced by Magnesium Oxysulfate Whisker

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Chinese Journal of Polymer Science 2017年第5期35卷 659-671页

作者： Li dang Xue-ying Nai Xin Liu Dong-hai Zhu Ya-ping Dong 李武 Key Laboratory of Salt Lake Resources Chemistry Qinghai Institute of Salt LakesChinese Academy of Sciences Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt Lakes Chinese Academy of Sciences University of Chinese Academy of Sciences

Polypropylene （PP） composites containing magnesium oxysulfate whisker （MOSw） or lauric acid （LA） modified MOSw （LAMOSw） were prepared via melt mixing in a torque rheometer. The heterogeneous nucleating effect of LAMOSw was clearly observed in polarized light microscopy （PLM） pictures with the presence of an abundance of small spherulites. MOSw exhibited no nucleation effect and formed a few spherulites with large size. Compared with PP/MOSw composites, PP/LAMOSw exhibited better impact strength, tensile strength and nominal strain at break, ascribing to three possible reasons：（i） more β-crystal PP formed, （ii） better dispersity of LAMOSw in PP matrix and （iii） the plasticizing effect of LA. The results of dynamic mechanical thermal analysis （DMTA） indicated that brittleness of the PP matrix at low temperature was improved by the addition of LAMOSw, while the interracial interactions between MOSw and PP matrix were actually weakened by LA, as evidenced by the higher tan8 values over the entire range of test temperatures. In terms of the rheological properties of the composites, both the η＊ and G＇ at low frequencies increase with the addition of MOSw or LAMOSw, indicating that the PP matrix was transformed from liquid-like to solid-like. However, a network of whiskers did not form because no plateau was found in the G＇ at low frequencies. With low filler content, LAMOSw produced a stronger solid-like behavior than MOSw mainly due to the better dispersion of the LAMOSw in PP matrix. However, for highly-filled composites, the η＊ of PP/LAMOSw at low frequencies was smaller than that of PP/MOSw composite, since the particle- particle contact effect played a major role.

关键词： PP/MOSw composites Crystallization Thermal properties Mechanical properties Rheological properties

Limit Cycle Containing Nine Critical Points in its Interior for a Class of Cubic Systems

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Journal of Central South University 2000年第2期12卷 111-112页

作者： Liu yi-rong Xiao ping Department of Applied Mathematics and Applied Software Central South University of TechnologyChangsha 410083China

Discuss a class of real planar cubic systems with a critical point O (0,0) of nine orders and obtain the conditions for its limit cycle surrounding the origin, and prove that when small pertubations of coefficients are made, the critical point O (0,0) of nine orders is split into nine real simple critical points and the limit cycle surrounding the origin becomes the limit cycle containing nine critical points in its interior.

关键词： cubic systems critical point of nine orders limit cycle

The Relationship between the Rise Width and the Full Width of γ-ray Burst Pulses and Its Implications

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Chinese Journal of Astronomy and Astrophysics 2006年第1期6卷 52-60页

作者： Rui-Jing Lu yi-ping Qin Ting-Feng yi National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Kunming 650011 Department of Physics Guangxi University Nanning Guangxi 530004 Graduate University of Chinese Academy of Sciences Beijing 100049

We investigate the relationship between the rise width and the full width of gamma-ray burst pulses. Theoretical analysis shows that either width is proportional to Г^-2△τθ,FWHMRc/c（Г the Lorentz factor of the bulk motion, △τθ,FWHM a local pulse＇s width, Rc the radius of fireballs and c the velocity of light）. We study the relationship for four samples of observed pulses. We find：（1） merely the curvature effect could reproduce the relationship between the rise and full widths with the same slope as derived from the model of Qin et al.; （2） gamma-ray burst pulses, selected from both the short and long GRBs, follow the same sequence in the rise width vs. full width diagram, with the shorter pulses at one end; （3） all GRBs may intrinsically result from local Gaussian pulses. These features place constraints on the physical mechanism（s） for producing long and short GRBs.

关键词： gamma rays: bursts - gamma rays: theory methods: data analysis

Can the bump in the composite spectrum of GRB 910503 be an emission line feature of gamma-ray bursts?

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Chinese Journal of Astronomy and Astrophysics 2005年第6期5卷 627-635页

作者： yi-ping Qin Fu-Wen Zhang National Astronomical Observatories Yunnan Observatory Chinese Academ）： of SciencesKunming 650011 Physics Department Guangxi University Nanning 530004 Graduate University of Chinese Academy of Sciences Beijing 100049

Appearing in the composite spectral data of BATSE, EGRET and COMPTEL for GRB 910503, there is a bump at around 1600keV. We perform a statistical analysis on the spectral data, trying to find out if the bump could be accounted for by a blue-shifted and significantly broadened rest frame line due to the Doppler effect of an expanding fireball surface. We made an F-test and adopted previously proposed criteria. The study reveals that the criteria are well satisfied and the feature can be interpreted as the blue shifted 6.4 keV line. From the fit with this line taken into account, we find the Lorentz factor of this source to be F = 116-9^＋9 （at the 68% confident level, △X^2 = 1） and the rest frame spectral peak energy to be E0,p=2.96-0.18^＋0.24 ke *** the existence of the emission line feature requires other independent tests to confirm, the analysis suggests that it is feasible to detect emission line features in the high energy range of GRB spectra when taking into account the Doppler effect of fireball expansion.

关键词： gamma-rays bursts - gamma-rays theory - radiation mechanisms nonthermal - relativity

GRAPHICAL-BASED RELIABILITY EVALUATION OF MULTIPLE DISTINCT PRODUCTION LINES

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Journal of Systems Science and Systems Engineering 2013年第1期22卷 73-92页

作者： yi-Kuei LIN ping-Chen CHANG Department of Industrial Management National Taiwan University of Science & Technology

This paper proposes a graphical-based methodology to evaluate the performance of a manufacturing system in terms of network *** focus on a manufacturing system which consists of multiple distinct production lines.A transformation technique is developed to build the manufacturing system as a manufacturing *** such a manufacturing network,the capacity of each machine is multistate due to failure,partial failure,or ***,this manufacturing network is also regarded as a multistate *** evaluate the probability that the manufacturing network can meet a given demand,where the probability is referred to as the system reliability.A simple algorithm integrating decomposition technique is proposed to generate the minimal capacity vectors that machines should provide to eventually satisfy *** system reliability is derived in terms of such capacity vectors afterwards.A practical application in the context of IC card manufacturing system is utilized to demonstrate the performance evaluation procedure.

关键词： Graphical-based methodology transformation decomposition multiple distinct production lines system reliability

T-cell receptor-engineered T cells for cancer treatment： current status and future directions

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Protein & Cell 2018年第3期9卷 254-266页

作者： Yu ping Chaojun Liu yi Zhang Biotherapy Center The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China Cancer Center The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China Engineering Key Laboratory for Cell Therapy of Henan Province Zhengzhou 450052 China

T-cell receptor （TCR）-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR- engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The success of these trials provided the foundation for clinical trials, including recent clinical successes using TCR- engineered T cells to target New York esophageal squamous cell carcinoma （NY-ESO-1）. These successes demonstrate the potential of this approach to treat cancer. In this review, we provide a perspective on the current and future applications of TCR-engineered T cells for the treatment of cancer. Our summary focuses on TCR activation and both pre-clinical and clinical applications of TCR-engineered T cells. We also discuss how to enhance the function of TCR-engineered T cells and prolong their longevity in the tumor microenvironment.

关键词： T-cell receptor tumor antigen TCR- engineered T cells neoantigen tumor microenvironment

Numerical simulation of effect of various parameters on atomization in an annular slit atomizer

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Journal of Iron and Steel Research International 2023年第6期30卷 1128-1141页

作者： yi Wang yi-chen dang Xiao-qing Chen Bao Wang Zhong-qiu Liu Jian-an Zhou Chang-yong Chen The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

As the width-thickness ratio of the discrete nozzle atomizer’s discrete hole greatly influences the loss of atomizing gas flow rate,the discrete nozzle atomizer was transformed into an annular slit atomizer with the same total nozzle outlet area.A numerical simulation study on the effect of various parameters on the atomization in the annular slit atomizer was carried out by coupling both the large eddy simulation(LES)and volume of fluid(VOF)model,which is based on the applicability of LES in capturing the breakup behavior of transient liquid droplets and the advantage of VOF method in directly capturing the phase *** simulation results showed that the increase in the atomization pressure makes the gas gain higher momentum,while the increase in the nozzle intersection angle decreases the distance between the nozzle exit and the computational domain *** increase in these two variables results in enhancing the gas-liquid interaction in the primary atomization zone and the formation of more aluminum droplets *** is considered that the atomization effect becomes better when atomization pressure is 2.5 MPa,and the nozzle intersection angle is 60°.Industrial tests showed that the aluminum powder prepared by the optimized annular slit atomizer has a finer mean particle size and a higher yield of fine *** numerical simulation results agree well with the industrial test data of the powder particle size.

关键词： Annular slit atomizer Volume of fluid model Atomization process Atomization pressure Nozzle intersection angle Atomization effect