Usefulness of mizoribine administration in children with frequently relapsing nephrotic syndrome, and the relationship between pharmacokinetic parameters and efficacy: a multicenter prospective cohort study in China

作     者：Zheng-Kun Xia Yuan-Fu Gao Li-Ping Rong Xi-Qiang Dang Qian Shen Xiao-Yun Jiang Zhu-Wen Yi Hong Xu 

作者机构：Department of PediatricsJinling HospitalNanjing University School of MedicineNanjing 210002China Department of PediatricsThe First Affiliated Hospital of Sun Yat—Sen UniversityGuangzhou 510080China Department of Pediatric NephrologyChildren’s Medical CenterSecond Xiangya HospitalCentral South University Changsha 410011China Department of Nephrology and RheumatologyChildren’s Hospital of Fudan UniversityShanghai 201102China 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2019年第15卷第3期

页      面：262-269页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a grant from the medical innovation team project of Jiangsu Province China 

主　　题：Frequently relapsing nephrotic syndrome Mizoribine Pharmacokinetic parameters 

摘      要：Background Mizoribine (MZR) is an immunosuppressant used to treat adult *** is little experience with the drug in treating Chinese children with frequently relapsing nephrotic syndrome (FRNS).We investigated the efficacy and safety for treating MZR with ***,the relationship between efficacy and serum concentration was *** A prospective multicenter observational 12-month study was performed for evaluating the usefulness of MZR with *** MZR concentration was measured,and the relationships between pharmacokinetic parameters (Cmax,AUC),number of relapses,and urinary protein were *** Eighty-two pediatric patients from four hospitals were treated with MZR and *** treatment significantly reduced the number of relapses and steroid doses.A correlation between pharmacokinetic parameters and relapses was observed,which fits well with the sigmoidal Emax *** in the relationship between pharmacokinetic parameters and urinary proteins,it was recognized that there was a threshold in the pharmacokinetic parameters for the therapeutic effect similar to the results obtained with the sigmoidal Emax *** patients (13.4%) experienced mild adverse *** MZR therapy was effective in reducing the number of relapses and steroid *** severe adverse reactions were *** effective serum concentrations were estimated to be Cmax about 2 μg/mL or AUC about 10 lag h/*** and steroid treatment were effective and safe for pediatric FRNS.