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Evolving molecular subtyping of breast cancer advances precision treatment

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Cancer Biology & Medicine 2024年第9期21卷 731-739页

作者： Rui Shan Lei-Jie Dai Zhi-ming Shao yi-Zhou Jiang Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Breast cancer is the second most prevalent cancer *** 2022,approximately 2.3 million newly diagnosed cases of female breast cancer occurred worldwide,and more than 665 thousand people lost their lives to this disease^... 详细信息

关键词： breast cancer Breast

Supramolecular polymer network constructed by a functionalized polyimidazolium salt derived from metal-carbene template approach

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Science China Chemistry 2024年第4期67卷 1224-1228页

作者： ming-ming Gan Zi-En Zhang yi-Fan Zhang Heng Zhang Li-ying Sun ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China

In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane *** strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal *** by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane *** obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.

关键词： metal-carbene template crown ether polyimidazolium salt host-guest chemistry

Can the integration between urban and rural areas be realized?A new theoretical analytical framework

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Journal of Geographical Sciences 2024年第1期34卷 3-24页

作者： wang yi LU Yuqi ZHU yingming Research Base of Jiangsu Industrial Cluster School of Economics and ManagementNanjing University of Science and TechnologyNanjing 210094China School of Geography Nanjing Normal UniversityNanjing 210023China

Urban-rural integration is an advanced form resulting from the future evolution of urban-rural ***,little research has explored whether urban and rural areas can move from dual segmentation to integrated development from a theoretical or empirical *** on the research framework of welfare economics,which offers an appealing paradigm to frame the underlying game between cities and villages,this study clarifies the ideal state of urban-rural *** then proposes a series of basic assumptions,and constructs a corresponding objective function and its ***,it assesses the possibility of seeing the transmutation from division to integration between urban and rural areas with continuous socio-economic *** authors argue that the ideal state of urban-rural integration should be a Pareto-driven optimal allocation of urban-rural resources and outputs,and the maximization of social welfare in the entire *** on a systematic demonstration using mathematical models,the study proposes that urban and rural areas can enter this ideal integrated development pattern when certain parameter conditions are *** general,this study demonstrates the theoretical logic and scientific foundations of urban-rural integration,enriches theoretical studies about urban-rural relationships,and provides basic theoretical support for large developing countries to build a coordinated and orderly urban-rural community with a shared future.

关键词： urban-rural integration development ideal state parameter conditions welfare economics theoretical framework

A Novel Supercapacitor Degradation Prediction Using a 1D Convolutional Neural Network and Improved Informer Model

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Protection and Control of Modern Power Systems 2024年第4期9卷 51-68页

作者： Hao Zhang Zhenxiao yi Le Kang yi Zhang Kai wang the College of Materials Science and Engineering Xi’an University of Science and Technol-ogyXi’an 710054China the School of Electrical Engineering Qingdao UniversityQingdao 266071China the School of Energy Sciences and Engineering Nanjing Tech UniversityNanjing 211816China

Safety and reliability are crucial for the next-generation supercapacitors used in energy storage systems,while accurate prediction of the degradation trajectory and remaining useful life(RUL)is essential for analyzing degradation and evaluating performance in energy storage *** study proposes a novel data processing and improved one-dimensional convolutional neural network(1D CNN)-informer framework for robust RUL *** data preprocessing,all data from two structures are adjusted to a unified format,and cross-entropy loss is used to couple the 1D CNN and ***,the minimum-maximum feature scaling method is used for normalization to accelerate the training process in reaching the minimum cost function.A relative position encoding algorithm is introduced to improve the Informer model,enabling it to better learn the sequence relationships between data and effectively reduce prediction *** data in dif-ferent working conditions are used to validate the proposed *** with other existing methods,the maximum root mean square error is reduced by 32.71%,the mean absolute error is reduced by 28.50%,and R^(2) is increased by 4.79%.The strategy considers the complementarity between two single models,which can extract features and enrich local details,as well as enhance the model’s global perception *** experimental results demonstrate that the proposed model achieves high-precision and robust RUL prediction,thereby pro-moting the industrial application of supercapacitors.

关键词： Supercapacitors remaining useful life convolution neural network transformer informer

Odorant-binding protein 19 in Monochamus alternatus involved in the recognition of a volatile strongly emitted from ovipositing host pines

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Insect Science 2024年第1期31卷 134-146页

作者： Ruinan Yang Dongzhen Li Shancheng yi yi Wei Manqun wang Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanChina Key Laboratory of Forest Protection of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijingChina

Monochamus alternatus is the primary carrier of pine wood nematodes,which pose a serious threat to Pinus *** many *** emerging *** adults feed on heathy host pines,while matured adults transfer to stressed host pines for mating and *** odorant-binding proteins(OBPs)of *** have been proved to aid in the complex process of host *** clarify the corresponding relations between OBPs and pine volatiles,more OBPs need to be *** this research,MaltOBP19 showed a specific expression in the antennae and mouthparts of ***,and it was marked in 4 types of antenna sensilla by *** binding assays demonstrated the high binding affinity of MaltOBP19 with camphene and myrcene in *** Y-tube olfactory experiments,*** adults were attracted by camphene and RNAi of OBP19 via microinjection significantly decreased their attraction *** induced phobotaxis,but RNAi had no significant effect on this ***,we found that ingesting dsOBP19 produced by a bacteria-expressed system with a newly constructed vector could lead to the knockdown of *** results suggest that MaltOBP19 may play a role in the process of host conversion via the recognition of camphene,which has been identified to be strongly released in stressed host *** addition,it is proved that knockdown of OBP can be achieved by oral administration of bacteria-expressed double-stranded RNA in *** adults,providing a new perspective in the control of ***.

关键词： bacteria-expressed dsRNA camphene Japanese pine sawyer beetle MaltOBP19 RNAi stressed host pines

Electrochemical Analysis of Single Glucose Oxidase with a Nanopipette

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Chemical Research in Chinese Universities 2024年第2期40卷 272-278页

作者： wang Yongyong MA Hui LONG yi-Tao yiNG yi-Lun School of Chemistry and Chemical Engineering Molecular Sensing and Imaging Center(MSIC)Nanjing UniversityNanjing210023P.R.China

Nanopore-based electrochemical technique is a promising tool for detecting single ***,detecting single proteins using a nanopipette in their native state without labeling is challenging due to the rapid translocation,which results in an inefficient signal *** our study,we finely tuned the driving force equilibrium between electrophoretic force(EPF)and electroosmotic flow(EOF)inside the nanopipette for efficient sensing of single glucose oxidase(GOD)*** duration time of GOD within the nanopipette is extended to about 4 *** strategy provided clear ionic current signals with a signal-to-noise ratio of *** EPF increased in the direction opposite to the motion of GOD,we observed a nonlinear growth in GOD’s duration *** extended the duration to about 4.4 times longer at−1000 mV compared to at−800 ***,nanopore-based electrochemical sensing could be used for single GOD molecule analysis as an ultrasensitive method.

关键词： Nanopore Single-molecule analysis Glucose oxidase Electrophoretic force Electroosmotic flow

Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1869-1879页

作者： Li-ming Chen Min Kang Jun-yi wang San-Hua Xu Cheng Chen Hong Wei Qian Ling Liang-Qi He Jie Zou yi-Xin wang Xu Chen Ping ying Hui Huang yi Shao Rui Wu Department of Rheumatology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina The First School of Clinical Medicine of Nanchang University Jiangxi Medical College of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200030China

AIM:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(CTD-ILD)and healthy controls(HCs)by optical coherence tomography angiography(OCTA)and to investigate the changes in microvascular density in abnormal ***:For a retrospective case-control study,a total of 16 patients(32 eyes)diagnosed with CTD-ILD were selected as the ILD *** 16 healthy volunteers with 32 eyes,matched in terms of age and sex with the patients,were recruited as control *** macular retina’s superficial retinal layer(SRL)and deep retinal layer(DRL)were examined and scanned using OCTA in each individual *** densities of retinal microvascular(MIR),macrovascular(MAR),and total microvascular(TMI)were calculated and *** in retinal vascular density in the macular region were analyzed using three different segmentation methods:central annuli segmentation method(C1-C6),hemispheric segmentation method[uperior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and Early Treatment Diabetic Retinopathy Study(ETDRS)methods[superior(S),inferior(I),left(L),and right(R)].The data were analyzed using Version 9.0 of GraphPad prism and Pearson ***:The OCTA data demonstrated a statistically significant difference(Pying the ETDRS method,the ILD group displayed substantial drops in superficial retinal S and I(P<0.05),along with notable reductions in deep retinal L,I,and R(P<0.05).In the central annuli segmentation m

关键词： connective tissue disease‑related interstitial lung disease optical coherence tomography angiography microvessel density ocular surface retina

Ignition and Lean Blowout Characteristics of a Reverse-Flow Combustor for an Ultra-Compact Gas Turbine Engine

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Journal of Thermal Science 2024年第5期33卷 1897-1906页

作者： JIN yi HUANG Yakun YAO Kanghong ZHANG Kai wang Yunbiao wang Donghao College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China Low-carbon Aerospace Power Engineering Research Center of Ministry of Education Nanjing 210016China

The flame stability limit and propagation characteristics of a reverse-flow combustor without any flame-stabilized device were experimentally investigated under room temperature and *** results indicate that it is feasible to stabilize the flame in the recirculation zones constructed by the impact jet flow from the primary holes and dilution *** flame projected area is mainly distributed in the recirculation zone upstream of the primary holes,whose presence and absence mark the ignition and *** the ignition process,the growth rate and value of the flame projected area first increase and then decrease with the inlet velocity increasing from 9.4 m/s to 42.1 m/s.A rapid reduction followed by a slow reduction of ignition and lean blowout equivalence ratios is achieved by the increased inlet *** the non-reacting fluid structure in three sections was measured,and detailed velocity profiles were analyzed to improve the understanding of the flame stabilization *** results are conducive to the design of an ultra-compact combustor.

关键词： ultra-compact combustor gas turbine reverse-flow combustor ignition lean blowout

Investigations of the mechanical response of dummy HTPB propellant grain under ultrahigh acceleration overload conditions using onboard flight-test measurements

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Defence Technology（防务技术） 2024年第2期32卷 473-484页

作者： yiming Zhang Ningfei wang Weihua Ma Ran wang Long Bai yi Wu School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Beijing System Design Institute of Electro-mechanic Engineering Beijing 100854China Xi'an Changfeng Research Institute of Mechanism and Electricity Xi'an 710065China

In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measurement system were *** projectiles containing dummy HTPB propellant grains were successfully recovered after the flight tests with an ultrahigh acceleration overload value of 8100 *** onboard-measured time-resolved axial displacement,contact stress and overload values were successfully obtained and *** compression tests of the dummy HTPB propellant used in the gunlaunched tests were carried out at low and intermediate strain rates to characterize the propellant's dynamic properties.A linear viscoelastic constitutive model was employed and applied in finite-element simulations of the projectile-launching *** the launch process,the dummy propellant grain exhibited large deformation due to the high acceleration overload,possibly leading to friction between the motor case and propellant *** calculated contact stress showed good agreement with the experimental results,though discrepancies in the overall displacement of the dummy propellant grain were *** dynamic mechanical response process of the dummy propellant grain was analysed in *** results can be used to estimate the structural integrity of the analysed dummy propellant grain during the gun-launch process.

关键词： Gun-launched flight test Dummy HTPB propellant Onboard measurements Utrahigh overload Mechanical response