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Digital twin driven and intelligence enabled content delivery in end-edge-cloud collaborative 5G networks

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Digital Communications and Networks 2024年第2期10卷 328-336页

作者： Bo yi Jianhui Lv Xingwei Wang Lianbo Ma min Huang College of Computer Science and Engineering Northeastern UniversityShenyang110169China Pengcheng Lab. Shenzhen518055China College of Software Northeastern UniversityShenyang110819China College of Information Science and Engineering Northeastern UniversityShenyang110819China

The rapid development of 5G/6G and AI enables an environment of Internet of Everything(IoE)which can support millions of connected mobile devices and applications to operate smoothly at high speed and low ***,these massive devices will lead to explosive traffic growth,which in turn cause great burden for the data transmission and content *** challenge can be eased by sinking some critical content from cloud to *** this case,how to determine the critical content,where to sink and how to access the content correctly and efficiently become new *** work focuses on establishing a highly efficient content delivery framework in the IoE *** particular,the IoE environment is re-constructed as an end-edge-cloud collaborative system,in which the concept of digital twin is applied to promote the *** on the digital asset obtained by digital twin from end users,a content popularity prediction scheme is firstly proposed to decide the critical content by using the Temporal Pattern Attention(TPA)enabled Long Short-Term Memory(LSTM)***,the prediction results are input for the proposed caching scheme to decide where to sink the critical content by using the Reinforce Learning(RL)***,a collaborative routing scheme is proposed to determine the way to access the content with the objective of minimizing *** experimental results indicate that the proposed schemes outperform the state-of-the-art benchmarks in terms of the caching hit rate,the average throughput,the successful content delivery rate and the average routing overhead.

关键词： Digital twin IoE Content delivery Caching Routing

Evolving molecular subtyping of breast cancer advances precision treatment

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Cancer Biology & Medicine 2024年第9期21卷 731-739页

作者： Rui Shan Lei-Jie dai Zhi-ming Shao yi-Zhou Jiang Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Breast cancer is the second most prevalent cancer *** 2022,approximately 2.3 million newly diagnosed cases of female breast cancer occurred worldwide,and more than 665 thousand people lost their lives to this disease^... 详细信息

关键词： breast cancer Breast

Photoinduced bismuth vanadate-catalyzed C(sp^(2))-H functionalization

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Chinese Chemical Letters 2024年第3期35卷 1-2页

作者： Rong-Nan yi Wei-min He Key Laboratory of Food&Environment&Drug Monitoring and Testing of Universities in Hunan Province Hunan Police AcademyChangsha 410138China School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China

Visible light-induced organic reactions have gained much attention in recent years due to their mild conditions and high efficiency[1,2].In this context,many efficient photocatalysts including transition metal complex... 详细信息

关键词： bismuth catalyzed gained

Theoretical study on magnetocaloric effect and its electric-field regulation in CrI_(3)/metal heterostructure

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 134-141页

作者： Weiwei He Ziming Tang Qihua Gong min yi Wanlin Guo State Key Laboratory of Mechanics and Control for Aerospace Structures Key Laboratory for Intelligent Nano Materials and Devices of Ministry of EducationInstitute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNanjing 210016China MIIT Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China

The extraordinary properties of a heterostructure by stacking atom-thick van der Waals(vdW)magnets have been extensively ***,the magnetocaloric effect(MCE)of heterostructures that are based on monolayer magnets remains to be ***,we deliberate MCE of vd W heterostructure composed of a monolayer CrI_(3)and metal atomic layers(Ag,Hf,Au,and Pb).It is revealed that heterostructure engineering by introducing metal substrate can improve MCE of CrI_(3),particularly boosting relative cooling power to 471.72μJ m^(-2)and adiabatic temperature change to 2.1 K at 5 T for CrI_(3)/*** improved MCE is ascribed to the enhancement of magnetic moment and intralayer exchange coupling in CrI_(3)due to the CrI_(3)/metal heterointerface induced charge *** field is further found to tune MCE of CrI_(3)in heterostructures and could shift the peak temperature by around 10 K in CrI_(3)/Hf,thus manipulating the working temperature window of *** theoretical results could enrich the research on low-dimensional magnetocaloric materials.

关键词： magnetocaloric effect heterostructure metal substrate

Used car price prediction based on XGBoost and retention rate

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The Journal of China Universities of Posts and Telecommunications 2024年第3期31卷 72-79页

作者： Shen Yutian Chen Jian dai min Zhang Sirui Xu Jing Wang Qing College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China College of Economics and Management Southeast University Chengxian CollegeNanjing 210088China Shandong Shuncheng Automobile Trade Co. LtdJinan 250000China

In order to improve the accuracy of used car price prediction,a machine learning prediction model based on the retention rate is proposed in this ***,a random forest algorithm is used to filter the variables in the *** main characteristic variables that affect used car prices,such as new car price,service time,mileage and so on,are filtered ***,the linear regression classification method is introduced to classify the test data into high and low retention rate *** that,the extreme gradient boosting(XGBoost)regression model is built for the two datasets *** prediction results show that the comprehensive evaluation index of the proposed model is 0.548,which is significantly improved compared to 0.488 of the original XGBoost ***,compared with other representative machine learning algorithms,this model shows certain advantages in terms of mean absolute percentage error(MAPE),5%accuracy rate and comprehensive evaluation *** a result,the retention rate-based machine learning model established in this paper has significant advantages in terms of the accuracy of used car price prediction.

关键词： random forest data dimensionality reduction extreme gradient boosting(XGBoost) retention rate price prediction

Study on the Performance of the GRANDProto300 Particle Detector Array by Simulation

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Research in Astronomy and Astrophysics 2024年第1期24卷 173-177页

作者： Fu-Lin dai Quan-Bu Gou Xiaoyuan Huang yi-Qing Guo Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The Giant Radio Array for Neutrino Detection(GRAND)is a proposed large-scale observatory designed to detect cosmic rays,gamma-rays,and neutrinos with energies exceeding 100 Pe *** GRANDProto300 experiment is proposed as the early stage of the GRAND project,consisting of a hybrid array of radio antennas and scintillator *** latter,as a mature and traditional detector,is used to cross-check the nature of the candidate events selected from radio *** this study,we developed a simulation software called G4GRANDProto300,based on the Geant4 software package,to optimize the spacing of the scintillator detector array and to investigate its effective *** analysis was conducted at various zenith angles under different detector spacings,including 300,500,600,700,and 900 *** results indicate that,for large zenith angles used to search for cosmic-ray in the GRAND project,the optimized effective area is with a detector spacing of 500 *** G4GRANDProto300 software that we developed could be used to further optimize the layout of the particle detector array in future work.

关键词： astroparticle physics instrumentation:detectors (ISM:)cosmic rays

Activation of glutamatergic neurons in the somatosensory cortex promotes remyelination in ischemic vascular dementia

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Fundamental Research 2024年第1期4卷 188-198页

作者： yi-Ting Zhou Da-Dao An yi-Xin Xu ying Zhou Qing-Qing Li Hai-Bin dai Xiang-Nan Zhang yi Wang min Lou Zhong Chen Wei-Wei Hu Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Basic Medical SciencesCollege of Pharmaceutical SciencesZhejiang University School of MedicineHangzhou 310058China Department of Pharmacy Sir Run Run Shaw HospitalHangzhou 310012China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology the Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310003China

Chronic cerebral hypoperfusion can cause progressive demyelination as well as ischemic vascular dementia,however no effective treatments are ***,based on magnetic resonance imaging studies of patients with white matter damage,we found that this damage is associated with disorganized cortical *** a mouse model,optogenetic activation of glutamatergic neurons in the somatosensory cortex significantly promoted oligodendrocyte progenitor cell(OPC)proliferation,remyelination in the corpus callosum,and recovery of cognitive ability after cerebral *** therapeutic effect of such stimulation was restricted to the upper layers of the cortex,but also spanned a wide time window after ***,enhancement of glutamatergic neuron-OPC functional synaptic connections is required to achieve the protection effect of activating cortical glutamatergic ***,skin stroking,an easier method to translate into clinical practice,activated the somatosensory cortex,thereby promoting OPC proliferation,remyelination and cognitive recovery following cerebral *** summary,we demonstrated that activating glutamatergic neurons in the somatosensory cortex promotes the proliferation of OPCs and remyelination to recover cognitive function after chronic cerebral *** should be noted that this activation may provide new approaches for treating ischemic vascular dementia via the precise regulation of glutamatergic neuron-OPC circuits.

关键词： Chronic cerebral hypoperfusion Optogenetic stimulation Oligodendrocyte progenitor cellIschemic vascular dementia Glutamatergic neuron Remyelination

Photocatalytic minisci-type multicomponent reaction for the synthesis of 1-(halo)alkyl-3-heteroaryl bicyclo[1.1.1] pentanes

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Chinese Chemical Letters 2024年第10期35卷 6-8页

作者： Rong-Nan yi Wei-min He Key Laboratory of Food&Environment&Drug Monitoring and Testing of Universities in Hunan Province Hunan Police Academy.Changsha 410138China School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China

Bioisosteres play an important role in pharmaceutical and agricultural compound design that has been developed to enhance the properties of *** a sp3-rich small ring cage hydrocarbons,bicyclo[1.1.1]pentanes(BCPs)were commonly considered as a bioisostere of the para-substituted arenes,internal alkynes,and tert-butyl groups,and its introduction can significantly improve pharmacokinetic properties,including passive permeability,aqueous solubility,metabolic stability[1].Over the past decades,numerous pharmaceutically relevant molecules with biaryl frameworks were improved by the approach of bioisosteric *** strategies for the synthesis of such BCP-aryls derivatives mostly depend on the stepwise C-C formation via the direct addition to bridgehead C-C bond of[1.1.1]propellane to provide active BCP-intermediates and followed by a second transitionmetal cross-coupling ***,these pioneer works were limited by the low step economy,the use of unstable reagents,and harsh conditions in industrial productions.

关键词： synthesis substituted alkyl

Advances in extracellular vesicle-based combination therapies for spinal cord injury

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Neural Regeneration Research 2024年第2期19卷 369-374页

作者： Tingting Wang Guohao Huang Zhiheng yi Sihan dai Weiduan Zhuang Shaowei Guo Department of Neurology The First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina Department of Biomedical Engineering Shantou UniversityShantouGuangdong ProvinceChina

Spinal cord injury is a severe insult to the central nervous system that causes persisting neurological *** currently available treatments involve surgical,medical,and rehabilitative ***,none of these techniques can markedly reverse neurological ***,extracellular vesicles from various cell sources have been applied to different models of spinal cord injury,thereby generating new cell-free therapies for the treatment of spinal cord ***,the use of extracellular vesicles alone is still associated with some notable shortcomings,such as their uncertainty in targeting damaged spinal cord tissues and inability to provide structural support to damaged ***,this paper reviews the latest combined strategies for the use of extracellular vesicle-based technology for spinal cord injury,including the combination of extracellular vesicles with nanoparticles,exogenous drugs and/or biological scaffold materials,which facilitate the targeting ability of extracellular vesicles and the combinatorial effects with extracellular *** also highlight issues relating to the clinical transformation of these extracellular vesicle-based combination strategies for the treatment of spinal cord injury.

关键词： biomaterials combination therapy drug delivery exosomes extracellular vesicles functional recovery hydrogels scaffolds spinal cord injury tissue engineering