Advances in extracellular vesicle-based combination therapies for spinal cord injury

作     者：Tingting Wang Guohao Huang Zhiheng Yi Sihan Dai Weiduan Zhuang Shaowei Guo Tingting Wang;Guohao Huang;Zhiheng Yi;Sihan Dai;Weiduan Zhuang;Shaowei Guo

作者机构：Department of NeurologyThe First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina Department of Biomedical EngineeringShantou UniversityShantouGuangdong ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第2期

页      面：369-374页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant,No.2020LKSFG02C(to Qiang Fang and SG) the National Natural Science Foundation of China,No.82201511(to SG) the Guangdong Basic and Applied Basic Research Foundation,Nos.2021A1515110873(to SG),2022A1515110139(to TW) the Medical Scientific Research Foundation of Guangdong Province,No.A2022077(to SG) 

主　　题：biomaterials combination therapy drug delivery exosomes extracellular vesicles functional recovery hydrogels scaffolds spinal cord injury tissue engineering 

摘      要：Spinal cord injury is a severe insult to the central nervous system that causes persisting neurological *** currently available treatments involve surgical,medical,and rehabilitative ***,none of these techniques can markedly reverse neurological ***,extracellular vesicles from various cell sources have been applied to different models of spinal cord injury,thereby generating new cell-free therapies for the treatment of spinal cord ***,the use of extracellular vesicles alone is still associated with some notable shortcomings,such as their uncertainty in targeting damaged spinal cord tissues and inability to provide structural support to damaged ***,this paper reviews the latest combined strategies for the use of extracellular vesicle-based technology for spinal cord injury,including the combination of extracellular vesicles with nanoparticles,exogenous drugs and/or biological scaffold materials,which facilitate the targeting ability of extracellular vesicles and the combinatorial effects with extracellular *** also highlight issues relating to the clinical transformation of these extracellular vesicle-based combination strategies for the treatment of spinal cord injury.